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公开(公告)号：US20090117150A1
公开(公告)日：2009-05-07
申请号：US12241229
申请日：2008-09-30
Applicant: Hong Jin , Robert Brazas , Bin Lu
Inventor： Hong Jin , Robert Brazas , Bin Lu
CPC classification number: C12N7/045 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/543 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2760/18522 , C12N2760/18534 , C12N2760/18543 , C12N2760/18561 , C12N2800/40 , G01N33/56983 , G01N2469/20 , G01N2500/00
Abstract: The present invention provides recombinant respiratory syncytial viruses that have an attenuated phenotype and that comprise one or more mutations in the viral P, M2-1 and/or M2-2 proteins, as well as live attenuated vaccines comprising such viruses and nucleic acids encoding such viruses. Recombinant RSV P, M2-1 and M2-2 proteins are described. Methods of producing attenuated recombinant RSV, and methods of quantitating neutralizing antibodies that utilize recombinant viruses of family Paramyxoviridae, are also provided.
Abstract translation: 本发明提供具有减毒表型并且包含病毒P，M2-1和/或M2-2蛋白中的一个或多个突变的重组呼吸道合胞病毒，以及包含这样的病毒和编码这种病毒的核酸的活减毒疫苗 病毒 描述了重组RSV P，M2-1和M2-2蛋白。 还提供了产生减毒重组RSV的方法，以及定量利用副粘病毒科重组病毒的中和抗体的方法。
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公开(公告)号：US20100190232A1
公开(公告)日：2010-07-29
申请号：US12537288
申请日：2009-08-07
Applicant: Hong Jin , Robert Brazas , Bin Lu
Inventor： Hong Jin , Robert Brazas , Bin Lu
IPC: C12N7/01
CPC classification number: C12N7/045 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/543 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2760/18522 , C12N2760/18534 , C12N2760/18543 , C12N2760/18561 , C12N2800/40 , G01N33/56983 , G01N2469/20 , G01N2500/00
Abstract: The present invention provides recombinant respiratory syncytial viruses that have an attenuated phenotype and that comprise one or more mutations in the viral P, M2-1 and/or M2-2 proteins, as well as live attenuated vaccines comprising such viruses and nucleic acids encoding such viruses. Recombinant RSV P, M2-1 and M2-2 proteins are described. Methods of producing attenuated recombinant RSV, and methods of quantitating neutralizing antibodies that utilize recombinant viruses of family Paramyxoviridae, are also provided.
Abstract translation: 本发明提供具有减毒表型并且包含病毒P，M2-1和/或M2-2蛋白中的一个或多个突变的重组呼吸道合胞病毒，以及包含这样的病毒的活减毒疫苗和编码这种病毒的核酸 病毒 描述了重组RSV P，M2-1和M2-2蛋白。 还提供了产生减毒重组RSV的方法，以及定量利用副粘病毒科重组病毒的中和抗体的方法。
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公开(公告)号：US20050266026A1
公开(公告)日：2005-12-01
申请号：US11133345
申请日：2005-05-20
Applicant: Erich Hoffmann , Hong Jin , Bin Lu , Gregory Duke , George Kemble , Zhongying Chen
Inventor： Erich Hoffmann , Hong Jin , Bin Lu , Gregory Duke , George Kemble , Zhongying Chen
CPC classification number: C12N15/86 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N15/85 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16162 , C12N2760/16222 , C12N2760/16234 , C12N2760/16243 , C12N2760/16262 , C12N2840/20
Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided.
Abstract translation: 提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。 提供了用于多质粒流感病毒表达系统的双向表达载体。 另外，本发明提供了生产能够在含胚鸡蛋和/或细胞（例如Vero和/或MDCK）中复制的流感病毒的方法，并进一步提供具有增强的复制特征的流感病毒。 还提供了生产在例如25℃下有效复制的冷适应（ca）流感病毒的方法（和包含其的免疫原性组合物）。
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公开(公告)号：US20050176130A1
公开(公告)日：2005-08-11
申请号：US10672302
申请日：2003-09-26
Applicant: Hong Jin , Bin Lu , Xing Cheng , Helen Zhou
Inventor： Hong Jin , Bin Lu , Xing Cheng , Helen Zhou
IPC: A61K20060101 , A61K6/00 , A61K35/76 , A61K39/00 , A61K39/155 , A61P31/14 , C07K14/135 , C12N7/01 , C12N7/04 , C12N15/00 , C12N15/45 , C12N15/86 , C12Q1/68 , C12Q1/70 , G01N33/569
CPC classification number: C12N7/045 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/543 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2760/18522 , C12N2760/18534 , C12N2760/18543 , C12N2760/18561 , C12N2800/40 , G01N33/56983 , G01N2469/20 , G01N2500/00
Abstract: The present invention provides recombinant respiratory syncytial viruses that have an attenuated phenotype and that comprise one or more mutations in the viral P, M2-1 and/or M2-2 proteins, as well as live attenuated vaccines comprising such viruses and nucleic acids encoding such viruses. Recombinant RSV P, M2-1 and M2-2 proteins are described. Methods of producing attenuated recombinant RSV, and methods of quantitating neutralizing antibodies that utilize recombinant viruses of family Paramyxoviridae, are also provided.
Abstract translation: 本发明提供具有减毒表型并且包含病毒P，M2-1和/或M2-2蛋白中的一个或多个突变的重组呼吸道合胞病毒，以及包含这样的病毒的活减毒疫苗和编码这种病毒的核酸 病毒 描述了重组RSV P，M2-1和M2-2蛋白。 还提供了产生减毒重组RSV的方法，以及定量利用副粘病毒科重组病毒的中和抗体的方法。
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公开(公告)号：US08354114B2
公开(公告)日：2013-01-15
申请号：US12090435
申请日：2006-10-17
IPC: A61K39/145 , A61K39/285
CPC classification number: C12N7/00 , A61K35/76 , A61K38/00 , A61K39/12 , A61K39/145 , A61K39/295 , A61K2039/5254 , C07K14/005 , C12N15/86 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16151 , C12N2760/16222 , C12N2760/16234 , C12N2760/16243 , C12N2760/16251
Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics.
Abstract translation: 提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。 提供用于多质粒流感病毒表达系统的双向表达载体。 另外，本发明提供了生产能够在含胚鸡蛋和/或细胞（例如Vero和/或MDCK）中复制的流感病毒的方法，并进一步提供具有增强的复制特征的流感病毒。
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Patent Agency Ranking
公开(公告)号：US08114415B2
公开(公告)日：2012-02-14
申请号：US12254131
申请日：2008-10-20
Applicant: Erich Hoffmann , Hong Jin , Bin Lu , Gregory Duke , George Kemble , Zhongying Chen
Inventor： Erich Hoffmann , Hong Jin , Bin Lu , Gregory Duke , George Kemble , Zhongying Chen
IPC: A61K39/145 , A61K39/00 , A61K39/12 , C12P21/04
CPC classification number: C12N15/86 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N15/85 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16162 , C12N2760/16222 , C12N2760/16234 , C12N2760/16243 , C12N2760/16262 , C12N2840/20
Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided.
Abstract translation: 提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。 提供了用于多质粒流感病毒表达系统的双向表达载体。 另外，本发明提供了生产能够在含胚鸡蛋和/或细胞（例如Vero和/或MDCK）中复制的流感病毒的方法，并进一步提供具有增强的复制特征的流感病毒。 还提供了生产在例如25℃下有效复制的冷适应（ca）流感病毒的方法（和包含其的免疫原性组合物）。
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公开(公告)号：US08012736B2
公开(公告)日：2011-09-06
申请号：US10423828
申请日：2003-04-25
Applicant: Erich Hoffman , Hong Jin , Bin Lu , Greg Duke , George Kemble
Inventor： Erich Hoffman , Hong Jin , Bin Lu , Greg Duke , George Kemble
IPC: C12N7/02
CPC classification number: A61K39/145 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N15/85 , C12N15/86 , C12N15/87 , C12N2760/16122 , C12N2760/16143 , C12N2760/16162 , C12N2760/16222 , C12N2760/16243 , C12N2760/16262
Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided.
Abstract translation: 提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。 提供了用于多质粒流感病毒表达系统的双向表达载体。
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公开(公告)号：US08722059B2
公开(公告)日：2014-05-13
申请号：US13214110
申请日：2011-08-19
Applicant: Erich Hoffman , Hong Jin , Bin Lu , Greg Duke , George Kemble
Inventor： Erich Hoffman , Hong Jin , Bin Lu , Greg Duke , George Kemble
IPC: A61K39/145 , C12N7/00 , C12N7/04
CPC classification number: A61K39/145 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N15/85 , C12N15/86 , C12N15/87 , C12N2760/16122 , C12N2760/16143 , C12N2760/16162 , C12N2760/16222 , C12N2760/16243 , C12N2760/16262
Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided.
Abstract translation: 提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。 提供了用于多质粒流感病毒表达系统的双向表达载体。
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9.发明申请公开(公告)号：US20100062532A1
公开(公告)日：2010-03-11
申请号：US12552018
申请日：2009-09-01
CPC classification number: C12N7/00 , A61K39/12 , A61K39/145 , C07K14/005 , C12N2760/16121 , C12N2760/16122 , C12N2760/16134
Abstract: In certain aspects, the present invention provides methods for increasing the replication capacity of influenza viruses in hens' eggs and/or cell culture, recombinant and/or reassortant influenza viruses with increased replication capacity, and immunogenic and vaccine compositions comprising such recombinant and/or reassortant influenza viruses. In other aspects, the invention further provides nucleic acids encoding influenza genes associated with increased replication capacity, expression vectors comprising the nucleic acids of the invention, methods for making influenza viruses with increased replication capacity, and kits useful for practice of the methods.
Abstract translation: 在某些方面，本发明提供了增加在具有增加的复制能力的母鸡卵和/或细胞培养物，重组和/或重配流感病毒中的流感病毒的复制能力的方法，以及包含这种重组和/或 重配流感病毒。 在其它方面，本发明还提供编码与增加的复制能力相关的流感基因的核酸，包含本发明的核酸的表达载体，具有增加的复制能力的制备流感病毒的方法，以及可用于实施该方法的试剂盒。
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公开(公告)号：US20120020997A1
公开(公告)日：2012-01-26
申请号：US13214110
申请日：2011-08-19
Applicant: Erich Hoffman , Hong Jin , Bin Lu , Greg Duke , George Kemble
Inventor： Erich Hoffman , Hong Jin , Bin Lu , Greg Duke , George Kemble
IPC: A61K39/145 , C12N7/04 , C12N7/00 , C07K14/11 , C40B40/08 , C12N5/00 , C12N7/01 , C07H21/04 , C12N7/02 , C12N15/86
CPC classification number: A61K39/145 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N15/85 , C12N15/86 , C12N15/87 , C12N2760/16122 , C12N2760/16143 , C12N2760/16162 , C12N2760/16222 , C12N2760/16243 , C12N2760/16262
Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided.
Abstract translation: 提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。 提供了用于多质粒流感病毒表达系统的双向表达载体。
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