公开(公告)号：US20140125975A1

公开(公告)日：2014-05-08

申请号：US13668463

申请日：2012-11-05

Applicant: YUNG-CHIEH HSIEH ,  Chiayu AI

Inventor： YUNG-CHIEH HSIEH ,  Chiayu AI

IPC: G01J3/32

CPC classification number: G01J3/32 ,  G01J3/06 ,  G01J3/14 ,  G01J3/18 ,  G01J2003/1243

Abstract: An optical spectrum analyzer is implemented with a detector combined with a tunable filter mounted on a stage capable of 360-degree rotation at a constant velocity. Because of the constant rate of angular change, different portions of the input spectrum are detected at each increment of time as a function of filter position, which can be easily measured with an encoder for synchronization purposes. The unidirectional motion of the mirror permits operation at very high speeds with great mechanical reliability. The same improvements may be obtained using a diffraction grating or a prism, in which case the detector or an intervening mirror may be rotated instead of the grating or prism.

Abstract translation: 光谱分析仪采用与安装在能够以恒定速度360度旋转的平台上的可调滤波器组合的检测器。 由于角度变化的恒定速率，输入频谱的不同部分在每个增量时间上被检测为滤波器位置的函数，这可以通过编码器容易地用于同步目的来测量。 镜子的单向运动允许以非常高的速度运行，具有很大的机械可靠性。 可以使用衍射光栅或棱镜获得相同的改进，在这种情况下，可以旋转检测器或中间镜来代替光栅或棱镜。

公开(公告)号：US20130338479A1

公开(公告)日：2013-12-19

申请号：US13140748

申请日：2009-12-18

Applicant: Brian William Pogue ,  Venkataramanan Krishnaswamy ,  Keith D. Paulsen ,  Pilar Beatriz Garcia Allende ,  Olga Maria Conde ,  José Miguel Lopez-Higuera

Inventor： Brian William Pogue ,  Venkataramanan Krishnaswamy ,  Keith D. Paulsen ,  Pilar Beatriz Garcia Allende ,  Olga Maria Conde ,  José Miguel Lopez-Higuera

IPC: A61B5/00 ,  A61B5/145

CPC classification number: A61B5/0068 ,  A61B5/0059 ,  A61B5/0062 ,  A61B5/0071 ,  A61B5/14546 ,  A61B5/7264 ,  A61B5/7267 ,  A61B5/742 ,  A61B2576/00 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/06 ,  G01J3/10 ,  G01J3/2823 ,  G01N21/4795 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/6417 ,  G01N2021/6471 ,  G01N2021/6484 ,  G01N2201/0221 ,  G01N2201/0618 ,  G01N2201/1296 ,  G06F19/3481 ,  G16H40/63

Abstract: A method and apparatus is described for optically scanning a field of view, the field of view including at least part of an organ as exposed during surgery, and for identifying and classifying areas of tumor within the field of view. The apparatus obtains a spectrum at each pixel of the field of view, and classifies pixels with a kNN-type or neural network classifier previously trained on samples of tumor and organ classified by a pathologist. Embodiments use statistical parameters extracted from each pixel and neighboring pixels. Results are displayed as a color-encoded map of tissue types to the surgeon. In variations, the apparatus provides light at one or more fluorescence stimulus wavelengths and measures the fluorescence light spectrum emitted from tissue corresponding to each stimulus wavelength. The measured emitted fluorescence light spectra are further used by the classifier to identify tissue types in the field of view.

Abstract translation: 描述了用于光学扫描视野的方法和装置，视野包括在外科手术期间暴露的器官的至少一部分，以及用于识别和分类视野内的肿瘤区域。 该装置在视场的每个像素处获得光谱，并且使用先前已经由病理学家分类的肿瘤和器官样本训练的kNN型或神经网络分类器对像素进行分类。 实施例使用从每个像素和相邻像素提取的统计参数。 结果显示为外科医生的组织类型的颜色编码图。 在变型中，该装置在一个或多个荧光刺激波长处提供光，并测量从对应于每个刺激波长的组织发射的荧光光谱。 测量的发射荧光光谱被分类器进一步用于鉴定视野中的组织类型。

公开(公告)号：US08502974B2

公开(公告)日：2013-08-06

申请号：US12994091

申请日：2009-05-21

Applicant: Geir Johnsen

Inventor： Geir Johnsen

IPC: G01J3/28 ,  G01J3/40 ,  H04N9/47 ,  H04N7/18

CPC classification number: G01N21/255 ,  G01J3/0208 ,  G01J3/027 ,  G01J3/0289 ,  G01J3/0291 ,  G01J3/06 ,  G01J3/10 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/42 ,  G01N2201/0218 ,  G01S17/89 ,  G02B21/33

Abstract: An apparatus for placement on or in a body of water for hyperspectral imaging of material in the water comprises an artificial light source and a hyperspectral imager. These are arranged so that in use light exits the apparatus beneath the surface of the water and is reflected by said material before re-entering the apparatus beneath the surface of the water and entering the hyperspectral imager. The hyperspectral imager is adapted to produce hyperspectral image data having at least two spatial dimensions.

Abstract translation: 用于放置在水中或在水中的装置用于水中材料的高光谱成像包括人造光源和高光谱成像器。 这些布置使得在使用中，光从水表面下方离开设备，并且在重新进入设备在水面下方并进入高光谱成像器之前被所述材料反射。 高光谱成像器适于产生具有至少两个空间维度的高光谱图像数据。

公开(公告)号：US20130135484A1

公开(公告)日：2013-05-30

申请号：US13687520

申请日：2012-11-28

Applicant: Nobuyuki SATOH ,  Yasuyuki Suzuki ,  Masato Kobayashi ,  Suguru Yokozawa ,  Tatsuhiko Okada ,  Mamoru Yorimoto ,  Daisaku Horikawa ,  Yuichi Sakurada

Inventor： Nobuyuki SATOH ,  Yasuyuki Suzuki ,  Masato Kobayashi ,  Suguru Yokozawa ,  Tatsuhiko Okada ,  Mamoru Yorimoto ,  Daisaku Horikawa ,  Yuichi Sakurada

IPC: H04N1/00

CPC classification number: H04N1/6033 ,  G01J3/0208 ,  G01J3/0237 ,  G01J3/06 ,  G01J3/46 ,  G01J3/52 ,  G01J3/524 ,  G06K15/027 ,  G06K15/102 ,  G06K2215/0094 ,  G06K2215/101 ,  H04N1/00005 ,  H04N1/00015 ,  H04N1/00023 ,  H04N1/00034 ,  H04N1/00045 ,  H04N1/00047 ,  H04N1/00068 ,  H04N1/00087 ,  H04N1/00278 ,  H04N1/00323 ,  H04N1/0282 ,  H04N1/034 ,  H04N1/41 ,  H04N1/50 ,  H04N1/6008 ,  H04N1/6044 ,  H04N5/2253 ,  H04N5/2254 ,  H04N2201/0082

Abstract: An image capturing unit includes a sensor unit that image-captures a predetermined area including a subject; and a reference chart unit that is arranged in the predetermined area and captured with the subject by the sensor unit.

Abstract translation: 图像拍摄单元包括：图像拍摄包括被摄体的预定区域的传感器单元; 以及参考图表单元，其布置在预定区域中并由传感器单元与被摄体一起捕获。

公开(公告)号：US08411340B2

公开(公告)日：2013-04-02

申请号：US12761819

申请日：2010-04-16

Applicant: Diaa A. Khalil ,  Hisham Haddara

Inventor： Diaa A. Khalil ,  Hisham Haddara

IPC: G02B26/08

CPC classification number: H04N3/08 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/06 ,  G01J3/18 ,  G02B26/0833 ,  G02B26/10 ,  G02B27/1006 ,  G02B27/1066 ,  G02B27/1086 ,  G02B27/14 ,  G02B27/143

Abstract: An optical microscanner achieves wide rotation angles utilizing a curved reflector. The optical microscanner includes a moveable mirror for receiving an incident beam and reflecting the incident beam to produce a reflected beam and a Micro Electro-Mechanical System (MEMS) actuator that causes a linear displacement of the moveable mirror. The curved reflector produces an angular rotation of the reflected beam based on the linear displacement of the moveable mirror.

Abstract translation: 光学显微镜利用弯曲的反射镜实现宽的旋转角度。 光学显微镜包括用于接收入射光束并反射入射光束以产生反射光束的可移动反射镜和引起可动反射镜的线性位移的微机电系统（MEMS）致动器。 弯曲的反射器基于可移动反射镜的线性位移产生反射光束的角度旋转。

公开(公告)号：US20130038872A1

公开(公告)日：2013-02-14

申请号：US13643029

申请日：2011-04-19

Applicant: Katsumi Fujiwara ,  Hiroyuki Katsurada ,  Yuichi Atarashi

Inventor： Katsumi Fujiwara ,  Hiroyuki Katsurada ,  Yuichi Atarashi

IPC: G01J1/42 ,  G01N21/47 ,  G01N21/65 ,  G01J1/04 ,  G01N21/64

CPC classification number: A61B1/00177 ,  A61B1/00179 ,  A61B1/00183 ,  A61B1/0051 ,  A61B1/043 ,  A61B1/05 ,  A61B1/0676 ,  A61B5/0084 ,  A61B5/6853 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/06 ,  G01J3/4406 ,  G01N21/6456 ,  G01N21/65 ,  G02B23/2423 ,  G02B23/2469

Abstract: A probe includes an optical system which irradiates a site of a biological tissue and receives light emitted from the site, and an imaging device. The imaging device is disposed ahead of the optical system closer to the end of the probe. The probe rotates the incident direction of the light and the imaging direction of the imaging device around a rotation axis directed to the longitudinal direction of the probe while fixing an angle between the incident direction and the imaging direction. The optical system receives the light from the site which always falls in the field of view of the imaging device, or brought with a time lag into the field of view of the imaging device as a result of rotation, the light being incident in the direction normal to, or inclined away from the rotation axis.

Abstract translation: 探针包括照射生物组织的部位并接收从该部位发射的光的光学系统和成像装置。 成像装置设置在更靠近探头端部的光学系统的前方。 该探头在成像装置的入射方向和成像装置的成像方向围绕探针的纵向方向的旋转轴线旋转，同时固定入射方向和成像方向之间的角度。 光学系统接收始终落在成像装置的视野中的位置的光，或者作为旋转的结果，以成像装置的视野带来时间滞后，光沿着方向入射 与旋转轴垂直或倾斜。

公开(公告)号：US20120262711A1

公开(公告)日：2012-10-18

申请号：US13445210

申请日：2012-04-12

Applicant: Ryutaro Oda

Inventor： Ryutaro Oda

IPC: G01J3/42 ,  G01J3/443

CPC classification number: G01N21/31 ,  G01J3/0208 ,  G01J3/0216 ,  G01J3/024 ,  G01J3/027 ,  G01J3/06 ,  G01J3/18 ,  G01J3/4406 ,  G01J2003/2869 ,  G01N21/274 ,  G01N21/64 ,  G01N2021/6417

Abstract: A spectrometric measurement device capable of determining an optimal wavelength for detecting an objective component is provided. One mode of the present invention is a fluorescence measurement device for casting an excitation light of a predetermined wavelength into or onto a sample and detecting a predetermined wavelength of light contained in the fluorescence generated from the sample irradiated with the excitation light.

Abstract translation: 提供能够确定用于检测目标成分的最佳波长的光谱测量装置。 本发明的一种模式是用于将预定波长的激发光投射到样品中或在样品上并检测由激发光照射的样品产生的荧光中包含的预定波长的荧光测量装置。

公开(公告)号：US20120200855A1

公开(公告)日：2012-08-09

申请号：US13451621

申请日：2012-04-20

Applicant: David Bonyuet ,  Vidi A. Saptari

Inventor： David Bonyuet ,  Vidi A. Saptari

IPC: G01N21/27

CPC classification number: G01J3/42 ,  G01J3/02 ,  G01J3/0235 ,  G01J3/06 ,  G01J3/32 ,  G01J2003/1247 ,  G01N21/274 ,  G01N21/314 ,  G01N21/33 ,  G01N21/3504 ,  G01N2021/3174 ,  G01N2201/129

Abstract: The invention relates to methods and systems for measuring and/or monitoring the chemical composition of a sample (e.g., a process stream), and/or detecting specific substances or compounds in a sample, using light spectroscopy such as absorption, emission and fluorescence spectroscopy. In certain embodiments, the invention relates to spectrometers with rotating narrow-band interference optical filter(s) to measure light intensity as a function of wavelength. More specifically, in certain embodiments, the invention relates to a spectrometer system with a rotatable filter assembly with a position detector rigidly attached thereto, and, in certain embodiments, the further use of various oversampling methods and techniques described herein, made particularly useful in conjunction with the rotatable filter assembly. In preferred embodiments, the rotatable filter is tilted with respect to the rotation axis, thereby providing surprisingly improved measurement stability and significantly improved control of the wavelength coverage of the filter spectrometer.

Abstract translation: 本发明涉及用于测量和/或监测样品（例如工艺流）的化学成分和/或检测样品中的特定物质或化合物的方法和系统，使用光谱如吸收，发射和荧光光谱法 。 在某些实施例中，本发明涉及具有旋转窄带干涉光学滤波器的光谱仪，以测量作为波长的函数的光强度。 更具体地说，在某些实施例中，本发明涉及一种具有可转动的过滤器组件的光谱仪系统，其中位置检测器与其刚性连接，并且在某些实施例中，进一步使用本文描述的各种过采样方法和技术，特别适用于组合 与可旋转的过滤器组件。 在优选实施例中，可旋转过滤器相对于旋转轴线倾斜，从而提供惊人的改进的测量稳定性并显着改进对过滤光谱仪的波长覆盖的控制。

公开(公告)号：US20120002198A1

公开(公告)日：2012-01-05

申请号：US13062167

申请日：2009-06-08

Applicant: Jhin Sup Jhung ,  Young Soo Son ,  Byoung Min Kim

Inventor： Jhin Sup Jhung ,  Young Soo Son ,  Byoung Min Kim

IPC: G01J3/40 ,  G01J3/28 ,  G02B5/28

CPC classification number: G01J3/1804 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0237 ,  G01J3/0256 ,  G01J3/06 ,  G01J3/1838 ,  G02B5/1828

Abstract: This invention relates to a wavelength tunable spectrometer and a wavelength tuning method thereof, and more particularly to a wavelength tunable spectrometer and a wavelength tuning method thereof which are capable of providing the highest efficiency of wavelength of applied light without replacement of a diffraction grid or without operation of an observed portion. According to embodiments of the present invention, since a spectrum of incident light can be obtained with the optimal diffraction efficiency based on a wavelength of the incident light without motion of a camera for observation and replacement of a diffractor by rotatably arranging a transmission type diffractor to provide an incidence angle to provide the optimal efficiency for a selected wavelength of an external light source to be observed and arranging a mirror to provide light, which is changed in its diffraction angle depending on rotation of the transmission type diffractor and the wavelength of the incident light, on the same output light path irrespective of a change in the rotation of the transmission type diffractor and the wavelength of the incident light, it is possible to reduce a size of the spectrometer, product cost and possibility of failure.

Abstract translation: 本发明涉及一种波长可调光谱仪及其波长调谐方法，更具体地涉及一种波长可调光谱仪及其波长调谐方法，它们能够提供最高的施加光线的波长效率，而不需要更换衍射光栅或不需要 观察部分的操作。 根据本发明的实施例，由于可以通过将透射型衍射器可旋转地布置成透射型衍射器进行观察和替换的摄像机的运动而基于入射光的波长的最佳衍射效率获得入射光的光谱 提供入射角以提供待观察的外部光源的选定波长的最佳效率，并且设置反射镜以提供根据透射型衍射器的旋转和入射波长的其衍射角变化的光 在与透射型衍射器的旋转的变化和入射光的波长无关的情况下，在相同的输出光路上，可以减小光谱仪的尺寸，产品成本和故障的可能性。

公开(公告)号：US08081309B2

公开(公告)日：2011-12-20

申请号：US12591584

申请日：2009-11-24

Applicant: Minoru Kobayashi ,  Taisuke Ota ,  Takahiro Ode

Inventor： Minoru Kobayashi ,  Taisuke Ota ,  Takahiro Ode

IPC: G01J3/30

CPC classification number: G01J3/44 ,  G01J3/0278 ,  G01J3/06 ,  G02B7/36 ,  G02B21/241

Abstract: An optical microscope applies laser light to a sample through the an objective lens, detects reflected light reflected by the sample through the objective lens, changes a focal position of the laser light in an optical axis direction, extracts a focal position for spectrum measurement based on a detection result of the reflected light when the focal position of the laser light is changed, adjusts the focal position to coincide with the extracted focal position, separates outgoing light exiting from the sample by application of the laser light with the adjusted focal position from the laser light, and measures a spectrum of the outgoing light separated from the laser light with a spectroscope.

Abstract translation: 光学显微镜通过物镜对样品施加激光，通过物镜检测由样品反射的反射光，在光轴方向上改变激光的焦点位置，提取用于光谱测量的焦点位置，基于 当激光的焦点位置改变时反射光的检测结果调整焦点位置与提取的焦点位置一致，通过从调色剂焦点位置施加具有激光的出射光， 激光，并用分光镜测量与激光分离的出射光谱。