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1.发明申请Apparatus And Method For Surgical Instrument With Integral Automated Tissue Classifier 审中-公开具有整体自动组织分类器的手术器械的装置和方法公开(公告)号：US20130338479A1
公开(公告)日：2013-12-19
申请号：US13140748
申请日：2009-12-18
Applicant: Brian William Pogue , Venkataramanan Krishnaswamy , Keith D. Paulsen , Pilar Beatriz Garcia Allende , Olga Maria Conde , José Miguel Lopez-Higuera
Inventor： Brian William Pogue , Venkataramanan Krishnaswamy , Keith D. Paulsen , Pilar Beatriz Garcia Allende , Olga Maria Conde , José Miguel Lopez-Higuera
CPC classification number: A61B5/0068 , A61B5/0059 , A61B5/0062 , A61B5/0071 , A61B5/14546 , A61B5/7264 , A61B5/7267 , A61B5/742 , A61B2576/00 , G01J3/02 , G01J3/0208 , G01J3/021 , G01J3/0218 , G01J3/06 , G01J3/10 , G01J3/2823 , G01N21/4795 , G01N21/6428 , G01N21/6458 , G01N2021/6417 , G01N2021/6471 , G01N2021/6484 , G01N2201/0221 , G01N2201/0618 , G01N2201/1296 , G06F19/3481 , G16H40/63
Abstract: A method and apparatus is described for optically scanning a field of view, the field of view including at least part of an organ as exposed during surgery, and for identifying and classifying areas of tumor within the field of view. The apparatus obtains a spectrum at each pixel of the field of view, and classifies pixels with a kNN-type or neural network classifier previously trained on samples of tumor and organ classified by a pathologist. Embodiments use statistical parameters extracted from each pixel and neighboring pixels. Results are displayed as a color-encoded map of tissue types to the surgeon. In variations, the apparatus provides light at one or more fluorescence stimulus wavelengths and measures the fluorescence light spectrum emitted from tissue corresponding to each stimulus wavelength. The measured emitted fluorescence light spectra are further used by the classifier to identify tissue types in the field of view.
Abstract translation: 描述了用于光学扫描视野的方法和装置，视野包括在外科手术期间暴露的器官的至少一部分，以及用于识别和分类视野内的肿瘤区域。 该装置在视场的每个像素处获得光谱，并且使用先前已经由病理学家分类的肿瘤和器官样本训练的kNN型或神经网络分类器对像素进行分类。 实施例使用从每个像素和相邻像素提取的统计参数。 结果显示为外科医生的组织类型的颜色编码图。 在变型中，该装置在一个或多个荧光刺激波长处提供光，并测量从对应于每个刺激波长的组织发射的荧光光谱。 测量的发射荧光光谱被分类器进一步用于鉴定视野中的组织类型。
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公开(公告)号：US11813482B2
公开(公告)日：2023-11-14
申请号：US17583167
申请日：2022-01-24
Applicant: Venkataramanan Krishnaswamy , Brian W. Pogue
Inventor： Venkataramanan Krishnaswamy , Brian W. Pogue
CPC classification number: A61N5/1075 , A61N5/1067 , A61N5/1071 , G01T1/22
Abstract: The present invention relates to advanced Cherenkov-based imaging systems, tools, and methods of feedback control, temporal control sequence image capture, and quantification in high resolution dose images. In particular, the present invention provides a system and method for simple, accurate, quick, robust, real-time, water-equivalent characterization of beams from LINACs and other systems producing external-therapy radiation for purposes including optimization, commissioning, routine quality auditing, R&D, and manufacture. The present invention also provides a system and method for rapid and economic characterization of complex radiation treatment plans prior to patient exposure. Further, the present invention also provides a system and method of economically detecting Cherenkov radiation emitted by tissue and other media in real-world clinical settings (e.g., settings illuminated by visible light).
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Patent Agency Ranking
公开(公告)号：US11235177B2
公开(公告)日：2022-02-01
申请号：US16344139
申请日：2017-10-23
Applicant: DOSEOPTICS LLC , Venkataramanan Krishnaswamy , Brian W. Pogue
Inventor： Venkataramanan Krishnaswamy , Brian W. Pogue
Abstract: The present invention relates to advanced Cherenkov-based imaging systems, tools, and methods of feedback control, temporal control sequence image capture, and quantification in high resolution dose images. In particular, the present invention provides a system and method for simple, accurate, quick, robust, real-time, water-equivalent characterization of beams from LINACs and other systems producing external-therapy radiation for purposes including optimization, commissioning, routine quality auditing, R&D, and manufacture. The present invention also provides a system and method for rapid and economic characterization of complex radiation treatment plans prior to patient exposure. Further, the present invention also provides a system and method of economically detecting Cherenkov radiation emitted by tissue and other media in real-world clinical settings (e.g., settings illuminated by visible light).
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公开(公告)号：US20200061391A1
公开(公告)日：2020-02-27
申请号：US16344139
申请日：2017-10-23
Applicant: Venkataramanan KRISHNASWAMY , Brian W. POGUE , DOSEOPTICS LLC
Inventor： Venkataramanan Krishnaswamy , Brian W. Pogue
IPC: A61N5/10
Abstract: The present invention relates to advanced Cherenkov-based imaging systems, tools, and methods of feedback control, temporal control sequence image capture, and quantification in high resolution dose images. In particular, the present invention provides a system and method for simple, accurate, quick, robust, real-time, water-equivalent characterization of beams from LINACs and other systems producing external-therapy radiation for purposes including optimization, commissioning, routine quality auditing, R&D, and manufacture. The present invention also provides a system and method for rapid and economic characterization of complex radiation treatment plans prior to patient exposure. Further, the present invention also provides a system and method of economically detecting Cherenkov radiation emitted by tissue and other media in real-world clinical settings (e.g., settings illuminated by visible light).
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5.发明授权Operative microscope having diffuse optical imaging system with tomographic image reconstruction and superposition in field of view 有权具有扩散光学成像系统的手术显微镜，具有断层图像重建和视野叠加公开(公告)号：US09254103B2
公开(公告)日：2016-02-09
申请号：US13586558
申请日：2012-08-15
Applicant: Venkataramanan Krishnaswamy , Brian William Pogue
Inventor： Venkataramanan Krishnaswamy , Brian William Pogue
CPC classification number: A61B5/0042 , A61B5/0071 , A61B5/0073 , A61B5/14553 , A61B5/7257 , A61B90/20 , A61B2090/366 , G02B21/365 , H04N13/239
Abstract: An imaging system has a microscope having an objective lens and a projection device configured to project spatially modulated light in one of several preselected predetermined pattern through the objective lens and onto tissue. The system camera configured to record an image of the tissue through the microscope and objective lens as illuminated by the spatially modulated light, and an image processor having a memory with a routine for performing spatial Fourier analysis on the image of the tissue to recover spatial frequencies. The image processor also constructs a three dimensional model of the tissue, and performs fitting of at least absorbance and scattering parameters of voxels of the model to match the recovered spatial frequencies. The processor then displays tomographic slices of the three dimensional model.
Abstract translation: 成像系统具有具有物镜的显微镜和投影装置，该投影装置被配置为将经空间调制的光以几种预先选定的预定图案中的一种投影通过物镜投影到组织上。 所述系统照相机被配置为通过由空间调制光照射的显微镜和物镜记录组织的图像，以及具有存储器的图像处理器，该存储器具有用于对组织的图像进行空间傅立叶分析以恢复空间频率 。 图像处理器还构建组织的三维模型，并且对模型的体素的至少吸光度和散射参数进行拟合以匹配恢复的空间频率。 然后处理器显示三维模型的断层图像。
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6.发明申请Operative Microscope Having Diffuse Optical Imaging System With Tomographic Image Reconstruction And Superposition In Field Of View 有权具有漫射光学成像系统的手术显微镜与视野中的断层图像重建和叠加公开(公告)号：US20130044185A1
公开(公告)日：2013-02-21
申请号：US13586558
申请日：2012-08-15
Applicant: Venkataramanan Krishnaswamy , Brian William Pogue
Inventor： Venkataramanan Krishnaswamy , Brian William Pogue
IPC: H04N13/00
CPC classification number: A61B5/0042 , A61B5/0071 , A61B5/0073 , A61B5/14553 , A61B5/7257 , A61B90/20 , A61B2090/366 , G02B21/365 , H04N13/239
Abstract: An imaging system has a microscope having an objective lens and a projection device configured to project spatially modulated light in one of several preselected predetermined pattern through the objective lens and onto tissue. The system camera configured to record an image of the tissue through the microscope and objective lens as illuminated by the spatially modulated light, and an image processor having a memory with a routine for performing spatial Fourier analysis on the image of the tissue to recover spatial frequencies. The image processor also constructs a three dimensional model of the tissue, and performs fitting of at least absorbance and scattering parameters of voxels of the model to match the recovered spatial frequencies. The processor then displays tomographic slices of the three dimensional model.
Abstract translation: 成像系统具有具有物镜的显微镜和投影装置，该投影装置被配置为将经空间调制的光以几种预先选定的预定图案中的一种投影通过物镜投影到组织上。 所述系统照相机被配置为通过由空间调制光照射的显微镜和物镜记录组织的图像，以及具有存储器的图像处理器，该存储器具有用于对组织的图像进行空间傅立叶分析以恢复空间频率的程序 。 图像处理器还构建组织的三维模型，并且对模型的体素的至少吸光度和散射参数进行拟合以匹配恢复的空间频率。 然后处理器显示三维模型的断层图像。
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公开(公告)号：US20220143427A1
公开(公告)日：2022-05-12
申请号：US17583167
申请日：2022-01-24
Applicant: Venkataramanan Krishnaswamy , Brian W. Pogue
Inventor： Venkataramanan Krishnaswamy , Brian W. Pogue
IPC: A61N5/10
Abstract: The present invention relates to advanced Cherenkov-based imaging systems, tools, and methods of feedback control, temporal control sequence image capture, and quantification in high resolution dose images. In particular, the present invention provides a system and method for simple, accurate, quick, robust, real-time, water-equivalent characterization of beams from LINACs and other systems producing external-therapy radiation for purposes including optimization, commissioning, routine quality auditing, R&D, and manufacture. The present invention also provides a system and method for rapid and economic characterization of complex radiation treatment plans prior to patient exposure. Further, the present invention also provides a system and method of economically detecting Cherenkov radiation emitted by tissue and other media in real-world clinical settings (e.g., settings illuminated by visible light).
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