公开(公告)号：US09884332B2

公开(公告)日：2018-02-06

申请号：US14122521

申请日：2012-06-20

Applicant: Huasong Zhou ,  Yangfeng Ji ,  Yongbin Cao ,  Bin Chen

Inventor： Huasong Zhou ,  Yangfeng Ji ,  Yongbin Cao ,  Bin Chen

IPC: A61M11/06 ,  B05B7/04 ,  A61M11/00

CPC classification number: B05B7/0483 ,  A61M11/002 ,  A61M11/06 ,  B05B7/0425

Abstract: A spraying apparatus includes a convergence chamber having a large end and a small end; at least two water inlets provided in the large end of the convergence chamber, each water inlet having a central axis and the at least two water inlets being arranged at convergent angles to each other so that the central axes converge in free space within the convergence chamber; at least one air intake provided in the convergence chamber between the large end and the small end; and a rectifier opening including a throat provided at the small end of the convergence chamber; and a spraying opening, the rectifier opening having a cross-sectional area that continuously increases outwardly from the throat to the spraying opening, and the throat having a cross-sectional area that is one to three times greater than that of a total cross-sectional area of the at least two water inlets.

公开(公告)号：US09878122B2

公开(公告)日：2018-01-30

申请号：US13881651

申请日：2011-10-25

Applicant: Vladimir B. Mikheev ,  William C. Forsythe ,  Benjamin N. Swita

Inventor： Vladimir B. Mikheev ,  William C. Forsythe ,  Benjamin N. Swita

IPC: A61M16/14 ,  A61K9/00 ,  A61M11/06 ,  A61M15/00 ,  A61M16/12 ,  A61M11/00 ,  A61K9/51 ,  A61K9/14

CPC classification number: A61M16/14 ,  A61K9/0078 ,  A61K9/14 ,  A61K9/5115 ,  A61M11/002 ,  A61M11/003 ,  A61M11/06 ,  A61M15/00 ,  A61M15/0086 ,  A61M16/12 ,  A61M2202/0208 ,  A61M2202/025 ,  A61M2202/064 ,  A61M2205/0244

Abstract: The invention provides methods and apparatus for stable generation and delivery of solid nano-particles in aerosols that simultaneously maintain high nano-particle concentration, and which avoid coagulation and agglomeration of the nano-particles. The apparatus includes a Collison nebulizer is in communication with a plenum. The Collison nebulizer includes a port for introducing a helium gas flow into the Collison nebulizer. The plenum includes component(s) for providing flow of uniform axially symmetrical dry air around the nano-particles entrained in the helium gas flow in the plenum. Preferably, the plenum includes an uniformity screen and a reduction in the plenum circumference downstream from the uniformity screen. In some preferred aspects, the invention provides methods of introducing nanoparticles into the lungs of test animals. The present invention allows more than 0.5 mass % of the nano-particles to be deposited in an animal's lungs.

公开(公告)号：US09827382B2

公开(公告)日：2017-11-28

申请号：US15011906

申请日：2016-02-01

Applicant: Boehringer Ingelheim International GmbH

Inventor： Matthias Hausmann ,  Steffen Schuy ,  Joachim Eicher ,  Johannes Geser ,  Martin Meisenheimer ,  Florian Witte

IPC: A61M11/02 ,  A61M11/06 ,  A61M11/00 ,  A61M15/00 ,  B05B11/00

CPC classification number: A61M11/003 ,  A61M11/00 ,  A61M11/007 ,  A61M11/02 ,  A61M11/06 ,  A61M15/009 ,  A61M2205/7545 ,  A61M2205/8281 ,  A61M2207/00 ,  B05B11/00412 ,  B05B11/3001 ,  B05B11/308 ,  B05B11/3091 ,  Y10T29/49826

Abstract: A medical hand-held device, in particular an atomizer, for dispensing a liquid pharmaceutical preparation from a container with a discharge nozzle for the pharmaceutical preparation and located upstream from the discharge nozzle there is a multiple-stage filter system.

公开(公告)号：US20170224937A1

公开(公告)日：2017-08-10

申请号：US15328989

申请日：2015-05-12

Applicant: PARI GmbH Spezialisten für effektive Inhalation

Inventor： Uwe Schuschnig ,  Ulf Krüger ,  Titus Selzer ,  Erman Lu ,  Emir Jelovac ,  Jens Gramann

IPC: A61M11/06 ,  A61M15/00 ,  A61M11/00

CPC classification number: A61M11/06 ,  A61M11/002 ,  A61M11/003 ,  A61M15/00 ,  A61M2205/75 ,  A61M2206/14 ,  A61M2207/00

Abstract: The invention relates to a nebulizer (1) comprising an aerosol generator (6), a nebulizing chamber (5) and an outlet (16), the aerosol generator (6) being designed to release an aerosol into the nebulizing chamber (5) and the outlet (16) being designed to allow the removal of the aerosol from the nebulizing chamber (5). To achieve a high output rate, a wetting surface (2) is provided in the nebulizing chamber (5).

公开(公告)号：US09682202B2

公开(公告)日：2017-06-20

申请号：US14969293

申请日：2015-12-15

Applicant: Boehringer Ingelheim International GmbH

Inventor： Herbert Wachtel

IPC: A61M16/08 ,  A61M11/06 ,  A61M15/00 ,  A61M16/20 ,  A61M11/00 ,  A61M16/12 ,  B05B11/00

CPC classification number: A61M15/0086 ,  A61M11/00 ,  A61M11/007 ,  A61M11/06 ,  A61M15/0013 ,  A61M15/0018 ,  A61M15/0021 ,  A61M15/0065 ,  A61M16/0816 ,  A61M16/12 ,  A61M16/208 ,  B05B11/00412 ,  B05B11/3001 ,  B05B11/3067 ,  B05B11/309 ,  B05B11/3091

Abstract: An inhalation device includes: a chamber for intermediate storage of an aerosol, a first connection for a nebuliser that produces the aerosol, a second connection on a patient side for delivering the aerosol, and a third connection for breathable air, where the chamber is fluidically connected in a valve-free manner on an inlet side to the first connection when the nebuliser is attached, and the chamber is connected to the third connection in parallel on the inlet side via an inlet valve so that the breathable air from the third connection flows into the chamber.

公开(公告)号：US20170156927A1

公开(公告)日：2017-06-08

申请号：US15373232

申请日：2016-12-08

Applicant: Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e.V.

Inventor： Martin RICHTER ,  Axel WILLIE ,  Christian WALD

IPC: A61F9/00 ,  G02C11/00 ,  A61M11/06

CPC classification number: A61F9/0026 ,  A61F9/0008 ,  A61M11/005 ,  A61M11/065 ,  A61M2205/3306 ,  A61M2205/3375 ,  A61M2205/52 ,  A61M2210/0612 ,  A61M2230/005 ,  A61M2230/63 ,  G02C11/00

Abstract: A free jet dosage system serves for administering a fluid into an eye. The free jet dosage system includes a micropump having an inlet and an outlet, the micropump being configured to transfer the fluid from the inlet to the outlet and to dispense the fluid at the outlet to the eye as a free jet. The free jet dosage system further includes a sensor configured to sense the eye and to controller a control, and a micropump, wherein the controller is configured to activate the micropump as soon as the eye is sensed by the sensor.

公开(公告)号：US09662461B2

公开(公告)日：2017-05-30

申请号：US15144651

申请日：2016-05-02

Applicant: MannKind Corporation

Inventor： Chad C. Smutney ,  Benoit Adamo ,  John M. Polidoro ,  P. Spencer Kinsey ,  Dennis Overfield ,  Carl Sahi ,  Christine Billings ,  Mark T. Marino

IPC: A61M15/00 ,  A61M11/06

CPC classification number: A61M15/0091 ,  A61M11/06 ,  A61M15/0021 ,  A61M15/0025 ,  A61M15/0028 ,  A61M15/0043 ,  A61M2202/064 ,  A61M2205/6045 ,  A61M2205/6081

Abstract: A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, small organic molecules, peptides and proteins, including, insulin and glucagon-like peptide 1 for the treatment of disease and disorders, for example, endocrine disease such as diabetes and/or obesity.

公开(公告)号：US09636473B2

公开(公告)日：2017-05-02

申请号：US13966759

申请日：2013-08-14

Applicant: Trudell Medical International

Inventor： Adam Meyer ,  Dan Engelbreth

IPC: A61M16/00 ,  A61M11/06 ,  A61M16/08 ,  A61M16/14 ,  A61M16/20

CPC classification number: A61M16/0006 ,  A61M11/06 ,  A61M16/0057 ,  A61M16/0066 ,  A61M16/0096 ,  A61M16/0816 ,  A61M16/0866 ,  A61M16/14 ,  A61M16/20 ,  A61M16/208

Abstract: An oscillating positive respiratory pressure apparatus and a method of performing oscillating positive respiratory pressure therapy. The apparatus includes a housing having an interior chamber, a chamber inlet, a chamber outlet, an exhalation flow path defined between the inlet and the outlet, and a restrictor member rotatably mounted within the interior chamber. The restrictor member has an axis of rotation that is substantially perpendicular to the flow path at the inlet, and includes at least one blocking segment. Rotation of the restrictor member moves the at least one blocking segment between an open position and a closed position. Respiratory pressure at the chamber inlet oscillates between a minimum when the at least one blocking segment is in the open position and a maximum when the at least one blocking segment is in the closed position. By exhaling into the apparatus, oscillating positive expiratory pressure therapy is administered.

公开(公告)号：US09566211B2

公开(公告)日：2017-02-14

申请号：US13521419

申请日：2010-06-17

Applicant: Peter Brunner ,  Hans Peter Zarfl ,  Bernd Heiko Lindena

Inventor： Peter Brunner ,  Hans Peter Zarfl ,  Bernd Heiko Lindena

IPC: A61H33/06 ,  A61M11/00 ,  A61H35/00 ,  A61M35/00 ,  B05B1/26 ,  B05B5/03 ,  B05B7/00 ,  B05B7/24 ,  A61H33/12 ,  A61H33/14 ,  A61M11/02 ,  A61M11/06 ,  A61M15/00

CPC classification number: A61H33/06 ,  A61H33/12 ,  A61H33/14 ,  A61H35/00 ,  A61H2033/068 ,  A61H2033/141 ,  A61M11/00 ,  A61M11/002 ,  A61M11/02 ,  A61M11/06 ,  A61M15/0028 ,  A61M15/0036 ,  A61M35/00 ,  B05B1/267 ,  B05B5/03 ,  B05B7/0012 ,  B05B7/2424

Abstract: The invention relates to a method and a device for generating a nanoaerosol, wherein at least one fluid to be atomized is atomized in a nozzle via a nozzle opening of the nozzle along a discharge direction in the form of fluid particles, the atomized fluid particles are deflected from the discharge direction and larger fluid particles are at least partially separated from smaller fluid particles, the separated larger fluid particles are returned to the fluid to be atomized and the smaller fluid particles are dispensed onto the environment. A cartridge in which the nozzle and the fluid to be atomized are arranged is used. According to the invention, a stream of a carrier gas is generated in the nozzle and at least one fluid to be atomized is brought into contact with the carrier gas.

Abstract translation: 本发明涉及一种用于产生纳米溶胶的方法和装置，其中待雾化的至少一种流体在喷嘴中通过喷嘴的喷嘴口沿流体颗粒形式的排放方向雾化，雾化的流体颗粒是 从排出方向偏转并且较大的流体颗粒至少部分地与较小的流体颗粒分离，分离的更大的流体颗粒返回到要被雾化的流体，并且较小的流体颗粒被分配到环境中。 使用其中布置有喷嘴和待雾化的流体的墨盒。 根据本发明，在喷嘴中产生载气流，并且使至少一个待雾化的流体与载气接触。

公开(公告)号：US09545490B2

公开(公告)日：2017-01-17

申请号：US14547891

申请日：2014-11-19

Applicant: Takeda GmbH

Inventor： Peter Iwatschenko ,  Gerhard Pohlmann ,  Horst Windt ,  Wolfgang Koch ,  Michel Kist

IPC: A61M11/02 ,  A61M15/00 ,  A61M16/00 ,  A61M11/06 ,  A61M16/20 ,  A61M16/10 ,  A61M16/06 ,  A61M16/08 ,  A61M11/00 ,  B05B7/14

CPC classification number: A61M16/0069 ,  A61M11/001 ,  A61M11/02 ,  A61M11/06 ,  A61M15/0005 ,  A61M15/0006 ,  A61M15/0021 ,  A61M15/0065 ,  A61M15/0085 ,  A61M15/0086 ,  A61M16/0003 ,  A61M16/0666 ,  A61M16/0808 ,  A61M16/0833 ,  A61M16/085 ,  A61M16/1005 ,  A61M16/1065 ,  A61M16/107 ,  A61M16/202 ,  A61M16/208 ,  A61M2016/003 ,  A61M2016/1025 ,  A61M2202/064 ,  A61M2205/07 ,  A61M2205/3334 ,  A61M2205/42 ,  A61M2240/00 ,  B05B7/1413 ,  B05B7/1422

Abstract: The claimed subject matter relates to a device for dosing and aerosolization of aerosolizable material. The device includes a body with an aerosolization channel with a distal attachment for connecting a source of carrier gas. The carrier gas provides pressure pulses to the aerosolization channel. A proximal attachment allows the aerosolized material to move to a reservoir for receiving the aerosolizable material. The reservoir is connected to the body via the the aerosolization channel. At least part of the walls of the device are self-exciting membranes that can be put into oscillation by the pressure pulses.

Abstract translation: 所要求保护的主题涉及可雾化材料的计量和雾化装置。 该装置包括具有雾化通道的主体，其具有用于连接载气源的远端附件。 载气向雾化通道提供压力脉冲。 近端附件允许气雾化材料移动到用于接收可雾化材料的储存器。 储存器通过雾化通道连接到身体。 装置的壁的至少一部分是自激振膜，可通过压力脉冲进入振荡。