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公开(公告)号：US20240261520A1
公开(公告)日：2024-08-08
申请号：US18603017
申请日：2024-03-12
Applicant: MannKind Corporation
Inventor： Chad C. Smutney , P. Spencer Kinsey , Carl R. Sahi , Benoit Adamo , John M. Polidoro , Scott McLean , Dennis Overfield , Anthony Bryant
CPC classification number: A61M15/0045 , A61K9/0075 , A61K38/1709 , A61K38/22 , A61K38/26 , A61K38/28 , A61K47/22 , A61M15/0021 , A61M15/0023 , A61M15/0028 , A61M15/0043 , A61M15/0048 , A61M15/0086 , A61M15/0091 , A61K38/00 , A61M2202/064 , A61M2205/6081 , A61M2206/20
Abstract: A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin, oxyntomodulin and glucagon-like peptide.
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公开(公告)号：US20210244897A1
公开(公告)日：2021-08-12
申请号：US17244730
申请日：2021-04-29
Applicant: MannKind Corporation
Inventor： Chad C. Smutney , Benoit Adamo , John M. Polidoro , P. Spencer Kinsey , Dennis Overfield , Carl R. Sahi , Christine Billings , Mark T. Marino
Abstract: A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of endocrine disease, for example, diabetes and/or obesity.
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公开(公告)号：US20200345957A1
公开(公告)日：2020-11-05
申请号：US16932520
申请日：2020-07-17
Applicant: MannKind Corporation
Inventor： Chad C. Smutney , P. Spencer Kinsey , Carl R. Sahi , Benoit Adamo , John M. Polidoro
Abstract: A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided.
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公开(公告)号：US10751488B2
公开(公告)日：2020-08-25
申请号：US15098219
申请日：2016-04-13
Applicant: MannKind Corporation
Inventor： Chad C. Smutney , P. Spencer Kinsey , Carl R. Sahi , Benoit Adamo , John M. Polidoro
Abstract: A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.
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公开(公告)号：US20160287820A1
公开(公告)日：2016-10-06
申请号：US15182503
申请日：2016-06-14
Applicant: MannKind Corporation
Inventor： Chad C. Smutney , Beniot Adamo , John M. Polidoro , P. Spencer Kinsey , Dennis Overfield , Carl R. Sahi , Christine Billings , Mark T. Marino
CPC classification number: A61M15/0091 , A61K9/0075 , A61K38/28 , A61M15/0021 , A61M15/0028 , A61M15/0043 , A61M2202/064 , A61M2205/6081
Abstract: A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of endocrine disease, for example, diabetes and/or obesity.
Abstract translation: 公开了一种肺部药物递送系统，包括呼吸动力的干粉吸入器和用于递送干粉制剂的药筒。 吸入器和药筒可以配备药物递送制剂，其包含例如二酮哌嗪和活性成分，包括肽和蛋白质如胰岛素和胰高血糖素样肽1，用于治疗内分泌疾病，例如糖尿病和 /或肥胖。
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Patent Agency Ranking
公开(公告)号：US20160228659A1
公开(公告)日：2016-08-11
申请号：US15098219
申请日：2016-04-13
Applicant: MannKind Corporation
Inventor： Chad C. Smutney , P. Spencer Kinsey , Carl R. Sahi , Benoit Adamo , John M. Polidoro
IPC: A61M15/00
Abstract: A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.
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公开(公告)号：US11998683B2
公开(公告)日：2024-06-04
申请号：US17665902
申请日：2022-02-07
Applicant: MannKind Corporation
Inventor： Chad C. Smutney , P. Spencer Kinsey , Carl R. Sahi , Benoit Adamo , John M. Polidoro , Scott McLean , Dennis Overfield , Anthony Bryant
CPC classification number: A61M15/0045 , A61K9/0075 , A61K38/1709 , A61K38/22 , A61K38/26 , A61K38/28 , A61K47/22 , A61M15/0021 , A61M15/0023 , A61M15/0028 , A61M15/0043 , A61M15/0048 , A61M15/0086 , A61M15/0091 , A61K38/00 , A61M2202/064 , A61M2205/6081 , A61M2206/20
Abstract: A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin, oxyntomodulin and glucagon-like peptide.
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公开(公告)号：US20200246561A1
公开(公告)日：2020-08-06
申请号：US16854669
申请日：2020-04-21
Applicant: MANNKIND CORPORATION
Inventor： Dennis Overfield , Carl R. Sahi , Benoit Adamo , P. Kinsey , Scott Mclean , John M. Polidoro , Chad C. Smutney
Abstract: Described herein are interactive apparatus and methods for sensing and measuring real-time characteristic patterns of a subject's use of a dry powder inhalation system. The devices can be used in a wired or wireless communication mode to communicate with a display to assess the subject's usage of the inhalation system, to evaluate the performance of the inhalation system and/or to detect the characteristics profile of a dry powder formulation emitted from the inhalation system in use.
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公开(公告)号：US10675421B2
公开(公告)日：2020-06-09
申请号：US15152965
申请日：2016-05-12
Applicant: MannKind Corporation
Inventor： Dennis Overfield , Carl R. Sahi , Benoit Adamo , P. Spencer Kinsey , Scott McLean , John M. Polidoro , Chad C. Smutney
Abstract: Described herein are interactive apparatus and methods for sensing and measuring real-time characteristic patterns of a subject's use of a dry powder inhalation system. The devices can be used in a wired or wireless communication mode to communicate with a display to assess the subject's usage of the inhalation system, to evaluate the performance of the inhalation system and/or to detect the characteristics profile of a dry powder formulation emitted from the inhalation system in use.
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公开(公告)号：US09662461B2
公开(公告)日：2017-05-30
申请号：US15144651
申请日：2016-05-02
Applicant: MannKind Corporation
Inventor： Chad C. Smutney , Benoit Adamo , John M. Polidoro , P. Spencer Kinsey , Dennis Overfield , Carl Sahi , Christine Billings , Mark T. Marino
CPC classification number: A61M15/0091 , A61M11/06 , A61M15/0021 , A61M15/0025 , A61M15/0028 , A61M15/0043 , A61M2202/064 , A61M2205/6045 , A61M2205/6081
Abstract: A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, small organic molecules, peptides and proteins, including, insulin and glucagon-like peptide 1 for the treatment of disease and disorders, for example, endocrine disease such as diabetes and/or obesity.
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