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45 条记录 (耗时 0.012 秒)

    Secure tag validation
    41.
    发明授权
    Secure tag validation 有权
    安全标签验证

    公开(公告)号：US07495234B2

    公开(公告)日：2009-02-24

    申请号：US11435929

    申请日：2006-05-17

    申请人： Joseph D. Roth

    发明人： Joseph D. Roth

    IPC分类号： G01N21/64

    CPC分类号： G01N21/6408 ,  G01N21/643 ,  G01N2021/6415 ,  G07D7/12

    摘要： A device for validating a secure tag comprises: an optical source (such as one or more LEDs); a processor coupled to the optical source for controlling emissions therefrom; and a luminescence detector coupled to the processor. The processor is programmed to control the optical source to create a first and a second pulse sequence having first and second excitation parameters respectfully. The processor is also programmed to control the luminescence detector to measure first and second luminescence in response to the first and second pulse sequences respectively. The processor is programmed to validate the secure tag in the event that the first and second luminescence meet an acceptance criterion. A method of validating a secure tag is also described.

    摘要翻译： 用于验证安全标签的装置包括：光源（诸如一个或多个LED）; 耦合到光源的处理器，用于控制从其发射的处理器; 以及耦合到处理器的发光检测器。 处理器被编程以控制光源以产生具有第一和第二激励参数的第一和第二脉冲序列。 处理器还被编程为控制发光检测器以分别响应于第一和第二脉冲序列来测量第一和第二发光。 处理器被编程为在第一和第二发光满足接受标准的情况下验证安全标签。 还描述了验证安全标签的方法。

    Optical detector for enzyme activation
    42.
    发明授权
    Optical detector for enzyme activation 有权
    用于酶活化的光学检测器

    公开(公告)号：US07473548B2

    公开(公告)日：2009-01-06

    申请号：US10423112

    申请日：2003-04-25

    申请人： Orhan Soykan ,  Maura G. Donovan ,  Amy E. Thompson

    发明人： Orhan Soykan ,  Maura G. Donovan ,  Amy E. Thompson

    IPC分类号： C12M1/34

    CPC分类号： A61B5/14546 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/4839 ,  A61B5/7203 ,  C12Q1/37 ,  C12Q1/56 ,  G01N21/6428 ,  G01N21/8507 ,  G01N33/86 ,  G01N2021/6415 ,  G01N2021/6441 ,  G01N2021/6484 ,  G01N2021/8528

    摘要： Activation of an enzyme in a bodily fluid is detected based on the amount of cleavage of a substrate for the enzyme. The substrate is tagged with two fluorescent dyes—a donor and an acceptor. The tagged substrate is presented to the bodily fluid. A device emits energy at a first wavelength into the bodily fluid, and detects energy at second and third wavelengths emitted by the dyes in response to the energy at the first wavelength. Prior to enzymatic cleavage of the substrate, the acceptor emits energy at the third wavelength in response to energy at the second wavelength received through fluorescent resonant energy transfer (FRET) from the donor. After enzymatic cleavage of the substrate, the donor emits energy at the second wavelength. The device can determine the concentration of activated enzyme within the bodily fluid based on the relative intensities of energy at the second and third wavelengths.

    摘要翻译： 基于酶的底物的切割量检测体液中酶的活化。 用两种荧光染料 - 供体和受体标记底物。 标记的基质被呈现给体液。 器件将第一波长的能量发射到体液中，并响应于第一波长的能量，检测由染料发射的第二和第三波长处的能量。 在衬底的酶切割之前，受体以响应于通过来自供体的荧光共振能量转移（FRET）接收的第二波长的能量而在第三波长处发射能量。 在酶切割底物之后，供体在第二波长处发射能量。 该装置可以基于在第二和第三波长处的能量的相对强度来确定体液内活化酶的浓度。

    Multi-photon endoscopic imaging system
    44.
    发明授权
    Multi-photon endoscopic imaging system 有权
    多光子内窥镜成像系统

    公开(公告)号：US07091500B2

    公开(公告)日：2006-08-15

    申请号：US10600675

    申请日：2003-06-20

    申请人： Mark J Schnitzer

    发明人： Mark J Schnitzer

    IPC分类号： G01N21/64

    CPC分类号： G01N21/6458 ,  A61B5/0084 ,  A61B5/0086 ,  G01N2021/6415 ,  G02B23/26

    摘要： An imaging system includes a pulsed laser, a pre-compensator for chromatic dispersion, a transmission optical fiber, and a GRIN lens. The pre-compensator chirps optical pulses received from the laser. The transmission optical fiber transports the chirped optical pulses from the pre-compensator. The GRIN lens receives the transported optical pulses from the transmission optical fiber. The GRIN lens has a wider optical core than the transmission optical fiber and substantially narrows the transported optical pulses received from the transmission optical fiber.

    摘要翻译： 成像系统包括脉冲激光器，用于色散的预补偿器，透射光纤和GRIN透镜。 预补偿器啁啾从激光器接收的光脉冲。 传输光纤传输来自预补偿器的啁啾光脉冲。 GRIN透镜从传输光纤接收传输的光脉冲。 GRIN透镜具有比传输光纤更宽的光纤，并且基本上使从传输光纤接收的传输的光脉冲变窄。

    Delay time modulation femtosecond time-resolved scanning probe microscope apparatus
    45.
    发明申请
    Delay time modulation femtosecond time-resolved scanning probe microscope apparatus 失效
    延迟时间调制飞秒时间分辨扫描探针显微镜装置

    公开(公告)号：US20050035288A1

    公开(公告)日：2005-02-17

    申请号：US10496571

    申请日：2002-11-25

    申请人： Hidemi Shigekawa ,  Osamu Takeuchi ,  Mikio Yamashita ,  Ryuji Morita

    发明人： Hidemi Shigekawa ,  Osamu Takeuchi ,  Mikio Yamashita ,  Ryuji Morita

    IPC分类号： G01J1/42 ,  G01J3/28 ,  G01J3/433 ,  G01N21/64 ,  G01Q30/00 ,  G01Q30/02 ,  G01Q60/10 ,  G01Q60/24 ,  G01N13/12 ,  G01N13/16

    CPC分类号： G01J3/433 ,  G01J3/2889 ,  G01J2001/4242 ,  G01N21/6408 ,  G01N21/6458 ,  G01N2021/6415 ,  G01Q30/02 ,  G01Q60/12 ,  Y10S977/85

    摘要： Disclosed is a measuring apparatus for a physical phenomenon by photoexcitation, in particular a delay time modulated and time-resolved, scanning probe microscope apparatus providing an ultimate resolution both temporal and spatial. The apparatus comprises an ultrashort laser pulse generator (2); a delay time modulating circuit (6) which splits an ultrashort laser pulse (3) produced by the ultrashort laser pulse generator (2) into two and which also modulates a delay time td between the two ultrashort laser pulses (4 and 5) with a frequency (ω); a scanning probe microscope (17); and a lock-in detection unit (8) which performs lock-in detection with the delay time modulation frequency (ω) of a probe signal (11) from the scanning probe microscope (17). It can detect the delay time dependency of the probe signal (11) as its differential coefficient to the delay time, with no substantial influence from fluctuations in the intensity of ultrashort laser pulses (3) while preventing the probe apex (19) from thermal expansion and shrinkage by repeated irradiation with ultrashort laser pulses (3). A photoexcited physical phenomenon dependent on a delay time between ultrashort laser pulses can thus be measured at a temporal resolution in the order of femtoseconds and at a spatial resolution in the order of angstroms.

    摘要翻译： 公开了一种通过光激发的物理现象的测量装置，特别是延迟时间调制和时间分辨的扫描探针显微镜装置，其提供了时间和空间上的最终分辨率。 该装置包括超短激光脉冲发生器（2）; 延迟时间调制电路（6），其将由超短激光脉冲发生器（2）产生的超短激光脉冲（3）分成两部分，并且还用一个第二超短激光脉冲（4和5）调制两个超短激光脉冲（4和5）之间的延迟时间td 频率（ω）; 扫描探针显微镜（17）; 以及锁定检测单元（8），其利用来自扫描探针显微镜（17）的探测信号（11）的延迟时间调制频率（ω）执行锁定检测。 探测信号（11）的延迟时间依赖性可以作为其延迟时间的微分系数，而不会因为超短激光脉冲（3）的强度的波动带来实质的影响，同时防止探头顶点（19）的热膨胀 以及通过用超短激光脉冲（3）重复照射来收缩。 因此，依赖于超短激光脉冲之间的延迟时间的光激发物理现象可以以飞秒级的时间分辨率和以埃的空间分辨率测量。