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    METHOD OF MAKING FLUORINATED ALKOXY CARBOXYLIC ACIDS AND PRECURSORS THEREOF
    44.
    发明申请
    METHOD OF MAKING FLUORINATED ALKOXY CARBOXYLIC ACIDS AND PRECURSORS THEREOF 有权
    制备氟化烷氧基羧酸及其前体的方法

    公开(公告)号：US20110245520A1

    公开(公告)日：2011-10-06

    申请号：US13133734

    申请日：2009-11-24

    申请人： Tilman Zipplies ,  Klaus Hintzer ,  Oleg Shyshkov

    发明人： Tilman Zipplies ,  Klaus Hintzer ,  Oleg Shyshkov

    IPC分类号： C07C247/04 ,  C07C51/08

    CPC分类号： C07C255/13 ,  C07C51/08 ,  C07C59/135 ,  C07C67/08 ,  C07C69/708 ,  C07C247/04 ,  C07C253/14

    摘要： A method for preparing saturated partially fluorinated alkoxy carboxylic acids or salts thereof by treating a compound: (II), where Rf represents a fluorinated, linear or branched alkyl residue interruptible by one or more oxygen atoms, n is 0 or 1, with a Z-anion in a reaction medium comprising water and an organic solvent, where the Z-anion is selected from CN—, SCN— and OCN— or combinations thereof. A method of making partially fluorinated ethers of the general formula (I) wherein Rf is defined as above, n is 0 or 1, and Z is nitrile (—CN), azide (—N3), thiocyanate (—SCN) or cyanate (—OCN) group, said method comprising treating a fluorinated olefin of the general formula (II) wherein the Z-anion is CN—, OCN—, SCN— or N3−. A compound of the general formula (I) as previously described where Z is selected from SCN, OCN and N3.

    摘要翻译： 通过处理化合物（II）制备饱和部分氟化的烷氧基羧酸或其盐的方法，其中Rf表示可被一个或多个氧原子中断的氟化的直链或支链烷基，n为0或1，Z为 阴离子在包含水和有机溶剂的反应介质中，其中Z-阴离子选自CN-，SCN-和OCN-或其组合。 制备通式（I）的部分氟化醚的方法，其中Rf定义如上，n为0或1，Z为腈（-CN），叠氮化物（-N 3），硫氰酸酯（-SCN）或氰酸酯 -OCN）基团，所述方法包括处理通式（II）的氟化烯烃，其中Z-阴离子是CN-，OCN-，SCN-或N 3 - 。 其中Z选自SCN，OCN和N 3，如前所述的通式（I）的化合物。

    Selective and specific preparation of discrete PEG compounds
    45.
    发明授权
    Selective and specific preparation of discrete PEG compounds 有权
    离散PEG化合物的选择性和具体制备

    公开(公告)号：US07888536B2

    公开(公告)日：2011-02-15

    申请号：US11203950

    申请日：2005-08-15

    申请人： Paul D. Davis ,  Edward C. Crapps

    发明人： Paul D. Davis ,  Edward C. Crapps

    IPC分类号： C07C43/11

    CPC分类号： C07C41/16 ,  C07C247/04 ,  C07C319/12 ,  C08G65/331 ,  C08L71/02 ,  Y02P20/55 ,  C07C323/12 ,  C07C43/164 ,  C07C43/1785 ,  C07C43/11

    摘要： Aspects of the present invention are directed to novel methods for making discrete polyethylene compounds selectively and specifically to a predetermined number of ethylene oxide units. Methods which can be used to build up larger dPEG compounds (a) containing a wider range of utility to make useful homo- and heterofunctional and branched species, and (b) under reaction configurations and conditions that are milder, more efficient, more diverse in terms of incorporating useful functionality, more controllable, and more versatile then any conventional method reported in the art to date. In addition, the embodiments of the invention allow for processes that allow for significantly improving the ability to purify the intermediates or final product mixtures, making these methods useful for commerial manufacturing dPEGs. Protecting groups and functional groups can be designed to make purification at large scale a practical reality. The novel dPEG products form the compositional and material basis for making other novel compounds of valuable application in the fields of diagnostics and therapeutics, amongst others.

    摘要翻译： 本发明的方面涉及选择性地且具体地制备离散聚乙烯化合物至预定数量的环氧乙烷单元的新方法。 可用于建立较大的dPEG化合物的方法（a），其具有更广泛的用途以实现有用的同功和异功能和支链物质，以及（b）在温和，更有效，更多样化的反应配置和条件下 迄今为止本领域所报道的任何常规方法，结合有用的功能，更可控和更通用的术语。 此外，本发明的实施方案允许允许显着提高纯化中间体或最终产物混合物的能力的方法，使得这些方法对于商业制造dPEG有用。 保护群体和功能团体可以设计成大规模净化实际的现实。 新型dPEG产品形成了其他新型化合物在诊断和治疗领域的有价值应用的组成和物质基础。