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公开(公告)号：US10342900B2
公开(公告)日：2019-07-09
申请号：US13591837
申请日：2012-08-22
Applicant: Richard C. Svrluga , Sean R. Kirkpatrick , Stephen M. Blinn
Inventor： Richard C. Svrluga , Sean R. Kirkpatrick , Stephen M. Blinn
IPC: A61L31/16 , A61L27/54 , A61K31/436
Abstract: A method of modifying the surface of a medical device to release a drug in a controlled way by providing a barrier layer on the surface of one or more drug coatings. The barrier layer consists of modified drug material converted to a barrier layer by irradiation by an accelerated neutral beam derived from an accelerated gas cluster ion beam. Also medical devices formed thereby.
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公开(公告)号：US20190137868A1
公开(公告)日：2019-05-09
申请号：US16239272
申请日：2019-01-03
Applicant: Joseph B. Khoury , Laurence B. Tarrant , Sean R. Kirkpatrick
Inventor： Joseph B. Khoury , Laurence B. Tarrant , Sean R. Kirkpatrick
IPC: G03F1/80 , H01L21/265 , H01J37/05 , H01J37/317 , H01L21/311 , H01L21/02 , G03F1/82 , H05H3/02 , H01J37/147
Abstract: A method for preparing a biological material for implanting provides irradiating at least a portion of the surface of the material with an accelerated Neutral Beam.
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公开(公告)号：US20180090295A1
公开(公告)日：2018-03-29
申请号：US15826445
申请日：2017-11-29
Applicant: Sean R. Kirkpatrick , Richard C. Svrluga , Stephen M. Blinn
Inventor： Sean R. Kirkpatrick , Richard C. Svrluga , Stephen M. Blinn
IPC: H01J37/05 , H05H3/02 , H01J37/317 , H01J37/147
CPC classification number: H01J37/05 , H01J37/147 , H01J37/317 , H01J37/3171 , H01J2237/0041 , H01J2237/0812 , H01J2237/15 , H05H1/20 , H05H3/02 , Y10T428/24355 , Y10T428/24479 , Y10T428/30
Abstract: An apparatus and method provided a drug layer formed on a surface region of a medical device, the drug layer comprised of a drug deposition and a carbonized or densified layer formed from the drug deposition by irradiation on an outer surface of the drug deposition, wherein the carbonized or densified layer does not penetrate through the drug deposition and is adapted to release drug from the drug deposition at a predetermined rate.
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44.发明申请公开(公告)号：US20170303383A1
公开(公告)日：2017-10-19
申请号：US15623733
申请日：2017-06-15
Applicant: Sean R. Kirkpatrick , Richard S. Svrluga
Inventor： Sean R. Kirkpatrick , Richard S. Svrluga
CPC classification number: H05H3/00 , H01J37/05 , H01J37/08 , H01J37/147 , H01J37/16 , H01J37/317 , H01J37/3171 , H01J37/32 , H01J2237/0041 , H01J2237/0812 , H01J2237/15 , H01J2237/31701 , H01J2237/334 , H01L21/26506 , H01L21/26513 , H01L21/26566 , H01L21/324 , H01L29/36 , H05H2245/123 , Y10T428/24355 , Y10T428/24479 , Y10T428/30
Abstract: A method of forming a patterned hard mask on a surface of a substrate uses an accelerated neutral beam with carbon atoms.
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45.发明申请公开(公告)号：US20150359636A1
公开(公告)日：2015-12-17
申请号：US14833402
申请日：2015-08-24
Applicant: Joseph Khoury , Laurence B. Tarrant , Sean R. Kirkpatrick , Richard C. Svrluga , Stephen M. Blinn
Inventor： Joseph Khoury , Laurence B. Tarrant , Sean R. Kirkpatrick , Richard C. Svrluga , Stephen M. Blinn
IPC: A61F2/28
CPC classification number: A61F2/28 , A61F2002/2817 , A61F2002/2835 , A61F2310/00359 , A61F2310/00976 , A61L27/3608 , A61L27/54 , A61L2300/414 , A61L2430/02
Abstract: A method of preparing a preformed bone shape for implantation provides irradiating at least a portion of a preformed bone shape by a Neutral Beam derived from a GCIB, and the preformed bone shape so irradiated.
Abstract translation: 制备用于植入的预成型骨形状的方法通过由GCIB得到的中性束和照射预先形成的骨形状，照射预先形成的骨形状的至少一部分。
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Patent Agency Ranking
46.发明授权公开(公告)号：US09144627B2
公开(公告)日：2015-09-29
申请号：US13101757
申请日：2011-05-05
Applicant: Joseph Khoury , Laurence Berlowitz Tarrant , Sean R. Kirkpatrick , Richard C. Svrluga
Inventor： Joseph Khoury , Laurence Berlowitz Tarrant , Sean R. Kirkpatrick , Richard C. Svrluga
CPC classification number: A61L27/18 , A61B2017/00969 , A61L27/38 , A61L2400/18 , A61L2430/10 , A61L2430/40 , H01J37/05 , H01J37/317 , H01J2237/0041 , H01J2237/053 , H01J2237/0812 , H01J2237/0827 , H01J2237/20207 , H01J2237/20214 , C08L71/12 , C08L71/00
Abstract: The invention provides for a method of improving bioactivity of a surface of an implantable object. The invention also provides for a method of improving bioactivity of a surface of biological laboratory ware. The invention further provides a method of attaching cells to an object. The invention even further provides for a method of preparing an object for medical implantation. The invention also provides for an article with attached cell, and for an article for medical implantation. Improvements result from the application of gas-cluster ion beam technology and from the application of neutral beam technology, wherein neutral beams are derived from accelerated gas-cluster ion beams.
Abstract translation: 本发明提供了一种提高可植入物体表面的生物活性的方法。 本发明还提供了一种提高生物实验室器皿表面生物活性的方法。 本发明还提供了将细胞附着到对象的方法。 本发明甚至进一步提供了一种制备用于医学植入的物体的方法。 本发明还提供具有附着细胞的物品和用于医疗植入物品。 改进的结果是应用气体束离子束技术和中性束技术的应用，其中中性束源自加速气体簇离子束。
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47.发明授权公开(公告)号：US09114195B2
公开(公告)日：2015-08-25
申请号：US13922787
申请日：2013-06-20
Applicant: Joseph Khoury , Laurence B. Tarrant , Sean R. Kirkpatrick , Richard C. Svrluga , Stephen M. Blinn
Inventor： Joseph Khoury , Laurence B. Tarrant , Sean R. Kirkpatrick , Richard C. Svrluga , Stephen M. Blinn
CPC classification number: A61F2/28 , A61F2002/2817 , A61F2002/2835 , A61F2310/00359 , A61F2310/00976 , A61L27/3608 , A61L27/54 , A61L2300/414 , A61L2430/02
Abstract: A method of preparing a preformed bone shape for implantation provides irradiating at least a portion of a preformed bone shape by a Neutral Beam derived from a GCIB, and the preformed bone shape so irradiated.
Abstract translation: 制备用于植入的预成型骨形状的方法通过由GCIB得到的中性束和照射预先形成的骨形状，照射预先形成的骨形状的至少一部分。
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公开(公告)号：US20150125510A1
公开(公告)日：2015-05-07
申请号：US14238868
申请日：2012-08-22
Applicant: Sean R. Kirkpatrick , Richard C. Svrluga , Stephen M. Blinn
Inventor： Sean R. Kirkpatrick , Richard C. Svrluga , Stephen M. Blinn
IPC: A61L31/16 , A61L27/54 , A61K31/436
CPC classification number: A61L31/16 , A61K31/436 , A61L27/54 , A61L2300/602 , A61L2300/606 , A61L2300/61 , A61L2400/18 , A61L2420/02
Abstract: A method of modifying the surface of a medical device to release a drug in a controlled way by providing a barrier layer on the surface of one or more drug coatings. The barrier layer consists of modified drug material converted to a barrier layer by irradiation by an accelerated neutral beam derived from an accelerated gas cluster ion beam. Also medical devices formed thereby.
Abstract translation: 一种通过在一种或多种药物涂层的表面上提供阻挡层来改变医疗装置的表面以以受控方式释放药物的方法。 阻挡层由经加速的气体簇离子束衍生的加速中性束照射而被转换成阻挡层的改性药物材料组成。 还由此形成的医疗装置。
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公开(公告)号：US20150024020A1
公开(公告)日：2015-01-22
申请号：US14238364
申请日：2012-08-22
Applicant: Sean R. Kirkpatrick , Richard C. Svrluga , Stephen M. Blinn
Inventor： Sean R. Kirkpatrick , Richard C. Svrluga , Stephen M. Blinn
CPC classification number: A61L31/16 , A61L27/303 , A61L27/34 , A61L27/54 , A61L31/08 , A61L31/084 , A61L31/10 , A61L2300/606 , A61L2300/62 , A61L2420/02 , A61L2420/08 , B05D3/00 , B05D3/068 , B05D7/56
Abstract: An apparatus and method provides a drug layer formed on a surface region of a medical device, the drug layer comprised of a drug deposition and a carbonized or densified layer formed from the drug deposition by irradiation on an outer surface of the drug deposition, wherein the carbonized or densified layer does not penetrate through the drug deposition and is adapted to release drug from the drug deposition at a predetermined rate.
Abstract translation: 一种装置和方法提供了形成在医疗装置的表面区域上的药物层，所述药物层由药物沉积组成，所述药物层由药物沉积的外表面上的药物沉积形成的碳化或致密化层形成，其中， 碳化或致密化层不穿透药物沉积，并且适于以预定速率从药物沉积中释放药物。
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公开(公告)号：US20130218264A1
公开(公告)日：2013-08-22
申请号：US13591837
申请日：2012-08-22
Applicant: Richard C. Svrluga , Sean R. Kirkpatrick , Stephen M. Blinn
Inventor： Richard C. Svrluga , Sean R. Kirkpatrick , Stephen M. Blinn
CPC classification number: A61L31/16 , A61K31/436 , A61L27/54 , A61L2300/602 , A61L2300/606 , A61L2300/61 , A61L2400/18 , A61L2420/02
Abstract: A method of modifying the surface of a medical device to release a drug in a controlled way by providing a barrier layer on the surface of one or more drug coatings. The barrier layer consists of modified drug material converted to a barrier layer by irradiation by an accelerated neutral beam derived from an accelerated gas cluster ion beam. Also medical devices formed thereby.
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