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    THIOL-CONTAINING COMPOUNDS FOR THE REMOVAL OF ELEMENTS FROM CONTAMINATED MILIEU AND METHODS OF USE
    32.
    发明申请
    THIOL-CONTAINING COMPOUNDS FOR THE REMOVAL OF ELEMENTS FROM CONTAMINATED MILIEU AND METHODS OF USE 审中-公开
    用于从污染的米氏液中除去元素的含硫化合物及其使用方法

    公开(公告)号：US20110076246A1

    公开(公告)日：2011-03-31

    申请号：US12892464

    申请日：2010-09-28

    申请人： Boyd E. Haley ,  David A. Atwood

    发明人： Boyd E. Haley ,  David A. Atwood

    IPC分类号： A61K31/795 ,  C07C323/59 ,  C07K5/083 ,  C08F8/34 ,  C07F7/02 ,  A61K31/695 ,  A61K38/06 ,  A61K31/216 ,  A61K31/198 ,  A61P43/00 ,  B01D53/64

    CPC分类号： C07C327/30 ,  A61K31/198 ,  A61K31/216 ,  A61K31/695 ,  A61K31/795 ,  B01D53/64 ,  B01D2253/106 ,  B01D2253/25 ,  B01D2257/60 ,  B01D2257/602 ,  C07B2200/11 ,  C07C323/42 ,  C07C323/59 ,  C07C323/60 ,  C07F7/1804

    摘要： Sulfur-containing ligands and methods of their utilization for binding metals and/or main group elements and removing them from fluids, solids, gases and/or tissues are disclosed. The ligands are of the general structure: where R1 comprises benzene, pyridine, pyridin-4-one, naphthalene, anthracene, phenanthrene or alkyl groups, R2 comprises hydrogen, alkyls, aryls, a carboxyl group, carboxylate esters, organic groups or biological groups, R3 comprises alkyls, aryls, a carboxyl group, carboxylate esters, organic groups or biological groups, X comprises hydrogen, lithium, sodium, potassium, rubidium, cesium, francium, alkyls, aryls, a carboxyl group, carboxylate esters, thiophosphate, N-acetyl cysteine, mercaptoacetic acid, mercaptopropionic acid, thiolsalicylate, organic groups or biological groups, n independently equals 1-10, m=1-6, Y comprises hydrogen, polymers, silicas or silica supported substrates, and Z comprises hydrogen, alkyls, aryls, a carboxyl group, carboxylate esters, a hydroxyl group, NH2, HSO3, halogens, a carbonyl group, organic groups, biological groups, polymers, silicas or silica supported substrates.

    摘要翻译： 公开了含硫配体及其用于结合金属和/或主要元素并将其从流体，固体，气体和/或组织中去除的方法。 配体具有以下通式：其中R1包括苯，吡啶，吡啶-4-酮，萘，蒽，菲或烷基，R2包括氢，烷基，芳基，羧基，羧酸酯，有机基团或生物基团 R 3包括烷基，芳基，羧基，羧酸酯，有机基团或生物基团，X包括氢，锂，钠，钾，铷，铯，ium，烷基，芳基，羧基，羧酸酯，硫代磷酸酯，N 乙酰半胱氨酸，巯基乙酸，巯基丙酸，硫代水杨酸酯，有机基团或生物基团，n独立地等于1-10，m = 1-6，Y包括氢，聚合物，二氧化硅或二氧化硅负载的底物，Z包括氢，烷基， 芳基，羧基，羧酸酯，羟基，NH 2，HSO 3，卤素，羰基，有机基团，生物基团，聚合物，二氧化硅或二氧化硅负载的基质。

    TREATMENT OF CHRONIC ULCEROUS SKIN LESIONS
    36.
    发明申请
    TREATMENT OF CHRONIC ULCEROUS SKIN LESIONS 审中-公开
    治疗慢性非皮肤性皮肤病

    公开(公告)号：US20090148394A1

    公开(公告)日：2009-06-11

    申请号：US11995615

    申请日：2006-07-14

    申请人： Hugh Semple Munro

    发明人： Hugh Semple Munro

    IPC分类号： A61K31/795 ,  A61P17/02 ,  A61P31/00

    CPC分类号： A61K31/795 ,  A61L15/24 ,  A61L15/26 ,  A61L15/60 ,  C08L33/26 ,  C08L101/02

    摘要： The invention provides a method of treating a wound (for example, a chronic ulcerous skin lesion) in a human or non-human mammal (particularly a human). The wound is contacted with a topical hydrogel composition comprising a hydrophilic polymer carrying multiple pendant sulphonyl groups, optionally with multiple pendant carboxylic groups, on each polymer molecule.

    摘要翻译： 本发明提供了治疗人或非人哺乳动物（特别是人）中的伤口（例如，慢性溃疡性皮肤病变）的方法。 将伤口与包含在每个聚合物分子上带有多个侧链磺酰基（任选具有多个侧挂羧基）的亲水性聚合物的局部水凝胶组合物接触。

    Poly(potassium and sodium styrene sulfonate) its manufacture and its uses
    37.
    发明申请
    Poly(potassium and sodium styrene sulfonate) its manufacture and its uses 审中-公开
    聚（苯乙烯磺酸钠和苯乙烯钠）其制造及其用途

    公开(公告)号：US20070053865A1

    公开(公告)日：2007-03-08

    申请号：US11488897

    申请日：2006-07-18

    申请人： Toni Chancellor-Adams ,  Sanjeev Katti ,  Sunil Mhaskar ,  Gerard Palace

    发明人： Toni Chancellor-Adams ,  Sanjeev Katti ,  Sunil Mhaskar ,  Gerard Palace

    IPC分类号： A61K31/74 ,  C08J5/20

    CPC分类号： A61K31/795 ,  A61K31/74 ,  C08F8/44 ,  C08L25/18 ,  A61K2300/00 ,  C08F112/14

    摘要： Antibiotic-associated diarrhea, such as that caused by Clostridium difficile, represents a serious medical complication that can result from administering a broad-spectrum antibiotic to a subject. Such diarrhea leads to significant potassium loss from the subject. The present invention discloses a polymeric therapeutic agent that treats antibiotic-associated diarrhea and is physiologically potassium neutral. This polymer contains polystyrene sodium sulfonate and polystyrene potassium sulfonate repeat units.

    摘要翻译： 抗生素相关性腹泻，例如艰难梭菌引起的腹泻，代表了对受试者施用广谱抗生素可能导致的严重的医学并发症。 这种腹泻导致受试者显着的钾损失。 本发明公开了治疗抗生素相关性腹泻并且是生理钾中性的聚合物治疗剂。 该聚合物含有聚苯乙烯磺酸钠和聚苯乙烯磺酸钾重复单元。

    Poly(diallylamine)-based bile acid sequestrants
    38.
    发明授权
    Poly(diallylamine)-based bile acid sequestrants 有权
    聚（二烯丙基胺）为基础的胆汁酸多价螯合剂

    公开(公告)号：US07125547B2

    公开(公告)日：2006-10-24

    申请号：US10647665

    申请日：2003-08-25

    申请人： Stephen Randall Holmes-Farley ,  Pradeep K. Dhal ,  John S. Petersen

    发明人： Stephen Randall Holmes-Farley ,  Pradeep K. Dhal ,  John S. Petersen

    IPC分类号： A61K31/787 ,  A61P3/06

    CPC分类号： B82Y5/00 ,  A61K31/785 ,  A61K31/787 ,  A61K31/795 ,  A61K47/6949 ,  C08G61/12 ,  Y10S514/824

    摘要： The present invention relates to a method for removing bile acids from a patient and certain polymers of use in the method. The method comprises the step of administering to the patient a therapeutically effective amount of a polymer composition which includes a a poly(diallylamine) polymer which is substituted with hydrophobic groups. The hydrophobic groups can be a substituted or unsubstituted, straight chain or branched C3–C24-alkyl group, an aralkyl group or an aryl group.

    摘要翻译： 本发明涉及一种从患者中除去胆汁酸的方法和本方法中使用的某些聚合物。 该方法包括向患者施用治疗有效量的聚合物组合物的步骤，该聚合物组合物包括被疏水基团取代的聚（二烯丙基胺）聚合物。 疏水基团可以是取代或未取代的直链或支链C 3 -C 24 - 烷基，芳烷基或芳基。

    Proteasome pathway inhibitors and related methods
    39.
    发明申请
    Proteasome pathway inhibitors and related methods 审中-公开
    蛋白酶体途径抑制剂及相关方法

    公开(公告)号：US20050203063A1

    公开(公告)日：2005-09-15

    申请号：US10940502

    申请日：2004-09-13

    申请人： Raymond Deshaies ,  Randall King ,  Rati Verma

    发明人： Raymond Deshaies ,  Randall King ,  Rati Verma

    IPC分类号： A61K20060101 ,  A61K31/195 ,  A61K31/277 ,  A61K31/40 ,  A61K31/44 ,  A61K31/655 ,  A61K31/695 ,  A61K31/785 ,  A61K31/795

    CPC分类号： A61K31/785 ,  A61K31/795

    摘要： The disclosure provides compositions and methods for blocking the proteasome pathway, as well as compounds that block mitotic cell cycle progression. Compounds disclosed include a family of molecules that bind to a multiubiquitin chain attached to a protein and thereby inhibit degradation of that protein by the proteasome pathway. According to another aspect of the disclosure, compounds are provided that inhibit cell cycle progression. Compounds disclosed herein may be formulated for pharmaceutical use and employed in methods for treating cancers or other hyperproliferative disorders.

    摘要翻译： 本公开提供了用于阻断蛋白酶体途径的组合物和方法，以及阻断有丝分裂细胞周期进程的化合物。 所公开的化合物包括结合到与蛋白质连接的多泛素链的分子家族，从而通过蛋白酶体途径抑制该蛋白质的降解。 根据本公开的另一方面，提供抑制细胞周期进程的化合物。 本文公开的化合物可以配制用于药物用途，并用于治疗癌症或其它过度增殖性疾病的方法中。