公开(公告)号：US20070053865A1

公开(公告)日：2007-03-08

申请号：US11488897

申请日：2006-07-18

申请人： Toni Chancellor-Adams ,  Sanjeev Katti ,  Sunil Mhaskar ,  Gerard Palace

发明人： Toni Chancellor-Adams ,  Sanjeev Katti ,  Sunil Mhaskar ,  Gerard Palace

IPC分类号： A61K31/74 ,  C08J5/20

CPC分类号： A61K31/795 ,  A61K31/74 ,  C08F8/44 ,  C08L25/18 ,  A61K2300/00 ,  C08F112/14

摘要： Antibiotic-associated diarrhea, such as that caused by Clostridium difficile, represents a serious medical complication that can result from administering a broad-spectrum antibiotic to a subject. Such diarrhea leads to significant potassium loss from the subject. The present invention discloses a polymeric therapeutic agent that treats antibiotic-associated diarrhea and is physiologically potassium neutral. This polymer contains polystyrene sodium sulfonate and polystyrene potassium sulfonate repeat units.

摘要翻译： 抗生素相关性腹泻，例如艰难梭菌引起的腹泻，代表了对受试者施用广谱抗生素可能导致的严重的医学并发症。 这种腹泻导致受试者显着的钾损失。 本发明公开了治疗抗生素相关性腹泻并且是生理钾中性的聚合物治疗剂。 该聚合物含有聚苯乙烯磺酸钠和聚苯乙烯磺酸钾重复单元。

公开(公告)号：US20130137743A1

公开(公告)日：2013-05-30

申请号：US13511768

申请日：2010-11-24

申请人： Hanlan Liu ,  Chris Willis ,  Renu Bhardwaj ,  Diane P. Copeland ,  Abizer Harianawala ,  Jeffrey Skell ,  John Marshall ,  Jianmei Kochling ,  Gerard Palace ,  Judith Peterschmitt ,  Craig Siegel ,  Seng Cheng

发明人： Hanlan Liu ,  Chris Willis ,  Renu Bhardwaj ,  Diane P. Copeland ,  Abizer Harianawala ,  Jeffrey Skell ,  John Marshall ,  Jianmei Kochling ,  Gerard Palace ,  Judith Peterschmitt ,  Craig Siegel ,  Seng Cheng

IPC分类号： C07D319/16 ,  A61K45/06 ,  A61K31/4025

CPC分类号： A61K31/4025 ,  A61K45/06 ,  C07D319/16 ,  C07D405/06

摘要： The hemitartrate salt of a compound represented by the following structural formula: (Formula I Hemitartrate), which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of the Formula (I) Hemitartrate are characterized by a variety of properties and physical measurements. As well, methods of producing crystalline Formula (I) Hemitartrate, and using it to inhibit glucosylceramide synthase or lowering glycosphingolipid concentrations in subjects to treat a number of diseases, are also discussed. Pharmaceutical compositions are also described.

摘要翻译： 公开了由以下结构式表示的化合物的盐酸盐：（式I Hemitartrate），其可用于药物应用。 式（I）的特殊单晶形式酒石酸盐的特征在于多种性质和物理测量。 此外，还讨论了生产结晶式（I）酒石酸盐并使用其抑制葡萄糖神经酰胺合成酶或降低受试者中的糖鞘醇浓度以治疗许多疾病的方法。 还描述了药物组合物。