发明申请
US20130137743A1 AMORPHOUS AND A CRYSTALLINE FORM OF GENZ 112638 HEMITARTRATE AS INHIBITOR OF GLUCOSYLCERAMIDE SYNTHASE
审中-公开
作为葡萄糖酸合成酶抑制剂的非晶形态和晶体结构112638 HEMITARTRATE
- 专利标题： AMORPHOUS AND A CRYSTALLINE FORM OF GENZ 112638 HEMITARTRATE AS INHIBITOR OF GLUCOSYLCERAMIDE SYNTHASE
- 专利标题（中）： 作为葡萄糖酸合成酶抑制剂的非晶形态和晶体结构112638 HEMITARTRATE
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申请号： US13511768申请日： 2010-11-24
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公开(公告)号： US20130137743A1公开(公告)日： 2013-05-30
- 发明人: Hanlan Liu , Chris Willis , Renu Bhardwaj , Diane P. Copeland , Abizer Harianawala , Jeffrey Skell , John Marshall , Jianmei Kochling , Gerard Palace , Judith Peterschmitt , Craig Siegel , Seng Cheng
- 申请人： Hanlan Liu , Chris Willis , Renu Bhardwaj , Diane P. Copeland , Abizer Harianawala , Jeffrey Skell , John Marshall , Jianmei Kochling , Gerard Palace , Judith Peterschmitt , Craig Siegel , Seng Cheng
- 申请人地址： US MA Cambridge
- 专利权人： GENZYME CORPORATION
- 当前专利权人： GENZYME CORPORATION
- 当前专利权人地址： US MA Cambridge
- 国际申请： PCT/US2010/057952 WO 20101124
- 主分类号： C07D319/16
- IPC分类号： C07D319/16 ; A61K45/06 ; A61K31/4025
摘要：
The hemitartrate salt of a compound represented by the following structural formula: (Formula I Hemitartrate), which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of the Formula (I) Hemitartrate are characterized by a variety of properties and physical measurements. As well, methods of producing crystalline Formula (I) Hemitartrate, and using it to inhibit glucosylceramide synthase or lowering glycosphingolipid concentrations in subjects to treat a number of diseases, are also discussed. Pharmaceutical compositions are also described.
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