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公开(公告)号：US10005743B2
公开(公告)日：2018-06-26
申请号：US15192098
申请日：2016-06-24
发明人： Likan Liang , Padmanabh P. Bhatt , David Dain , Jean-Philippe Taquet , Aleksandr Pechenov , Alexei Tchesnokov , Reynold Mariaux
IPC分类号： C07D265/30 , C07D265/32 , C07C215/08 , C07C217/34
CPC分类号： C07D265/30 , C07C215/08 , C07C217/34 , C07D265/32
摘要： Provided here are methods of manufacture of viloxazine and its various salts, as well as viloxazine-related compounds, such as novel intermediate reaction products and polymorphs thereof. In particular, the methods provide a substantially pure API of viloxazine HCl while avoiding undesirable impurities. The methods further provide for separating, identifying, and characterizing novel polymorphs of viloxazine. Further provided are methods for synthesis and identification and characterization of novel intermediates of viloxazine, as well as for some important metabolites and precursors of metabolites of viloxazine.
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公开(公告)号：US20160256465A1
公开(公告)日：2016-09-08
申请号：US15157549
申请日：2016-05-18
IPC分类号： A61K31/5375 , A61K9/14 , A61K9/50 , A61K9/20
CPC分类号： A61K31/5375 , A61K9/00 , A61K9/146 , A61K9/2054 , A61K9/485 , A61K9/4866 , A61K9/50
摘要： Modified release formulations of viloxazine and methods of administering the same are disclosed. High-drug load formulations of viloxazine are further disclosed.
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公开(公告)号：US09351975B2
公开(公告)日：2016-05-31
申请号：US14836179
申请日：2015-08-26
发明人： Padmanabh P. Bhatt , Argaw Kidane , Kevin Edwards
CPC分类号： A61K31/55 , A61K9/0073 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/205 , A61K9/2054 , A61K2800/56
摘要： Controlled-release preparations of oxcarbazepine and derivatives thereof for once-a-day administration are disclosed. The inventive compositions comprise solubility- and/or release enhancing agents to provide tailored drug release profiles, preferably sigmoidal release profiles. Methods of treatment comprising the inventive compositions are also disclosed.
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公开(公告)号：US20160030355A1
公开(公告)日：2016-02-04
申请号：US14881374
申请日：2015-10-13
发明人： Argaw Kidane , Padmanabh P Bhatt
IPC分类号： A61K9/20 , A61K31/192 , A61K9/28 , A61K9/00
CPC分类号： A61K9/282 , A61K9/0004 , A61K9/1623 , A61K9/1652 , A61K9/2013 , A61K9/2077 , A61K9/28 , A61K9/2826 , A61K9/286 , A61K31/192 , A61K31/557 , A61K31/5575 , A61K31/5585
摘要： An oral osmotic pharmaceutical delivery system comprises a highly water-soluble drug exhibiting an erratic or an incomplete release profile when formulated in an elementary osmotic pump delivery system and at least one release enhancing agent.
摘要翻译： 口服渗透药物递送系统包含当配制在基本渗透泵递送系统和至少一种释放增强剂中时表现出不稳定或不完全释放特征的高度水溶性药物。
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35.发明申请公开(公告)号：US20150290202A1
公开(公告)日：2015-10-15
申请号：US14634281
申请日：2015-02-27
IPC分类号： A61K31/5375
CPC分类号： A61K31/5375 , A61K31/00
摘要： The invention comprises a method for treatment of ADHD or ADHD-related disorders by a pharmaceutical agent exhibiting combined serotonergic or noradrenergic reuptake transporters and monoamine receptor activity.
摘要翻译： 本发明包括通过显示组合的5-羟色胺能或去甲肾上腺素能再摄取转运蛋白和单胺受体活性的药物治疗ADHD或ADHD相关疾病的方法。
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公开(公告)号：US09119792B2
公开(公告)日：2015-09-01
申请号：US14445234
申请日：2014-07-29
发明人： Padmanabh P. Bhatt , Argaw Kidane , Kevin Edwards
CPC分类号： A61K31/55 , A61K9/0073 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/205 , A61K9/2054 , A61K2800/56
摘要： Controlled-release preparations of oxcarbazepine and derivatives thereof for once-a-day administration are disclosed. The inventive compositions comprise solubility- and/or release enhancing agents to provide tailored drug release profiles, preferably sigmoidal release profiles. Methods of treatment comprising the inventive compositions are also disclosed.
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公开(公告)号：US20150141645A1
公开(公告)日：2015-05-21
申请号：US14608262
申请日：2015-01-29
发明人： Martin HANBAUER , Zarghun NAZIR , Peter HILDEBRAND , Attilia FIGINI , Likan LIANG , Tiziano FUMAGALLI
IPC分类号： C07D209/08
CPC分类号： C07D209/08 , C07D295/13
摘要： The present invention is directed towards novel methods of synthesis of molindone, synthesis of the intermediates of molindone, and high-purity compositions of molindone. In particular, the invention relates to the methods of synthesis of molindone through the Mannich reaction.
摘要翻译： 本发明涉及新戊烯二酮的合成方法，莫丹多酮的中间体的合成，以及莫丹多酮的高纯度组合物。 特别地，本发明涉及通过曼尼希反应合成莫林多酮的方法。
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公开(公告)号：US08992989B2
公开(公告)日：2015-03-31
申请号：US14499462
申请日：2014-09-29
发明人： Likan Liang , Hua Wang , Padmanabh P. Bhatt , Michael L. Vieira
IPC分类号： A61K9/14 , A61K9/50 , A61K31/357 , A61K47/48
CPC分类号： A61K9/5042 , A61K9/1652 , A61K9/1676 , A61K9/209 , A61K9/5047 , A61K9/5078 , A61K9/5084 , A61K31/357 , A61K31/7048 , A61K45/06 , A61K47/48969 , A61K47/6951 , B82Y5/00 , Y02A50/465
摘要： Pharmaceutical compositions of topiramate for once-a-day oral administration are provided. The formulations comprise a sustained-release component and an optional immediate-release component, the compositions of which can be selectively adjusted, respectively, to release the active ingredient along a pre-determined release profile. Method of treating or preventing pathological disorders in mammalian subjects comprising the administration of the novel formulations disclosed herein is also provided.
摘要翻译： 提供了托吡酯每日一次口服给药的药物组合物。 制剂包含缓释组分和任选的快速释放组分，其组合物可分别选择性地调节以沿预定释放曲线释放活性成分。 还提供了治疗或预防哺乳动物受试者中包括施用本文公开的新型制剂的病理学障碍的方法。
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公开(公告)号：US08957206B2
公开(公告)日：2015-02-17
申请号：US13834097
申请日：2013-03-15
发明人： Martin Hanbauer , Zarghun Nazir , Peter Hildebrand , Attilia Figini , Likan Liang , Tiziano Fumagalli
IPC分类号： C07D413/12 , C07D209/08
CPC分类号： C07D209/08 , C07D295/13
摘要： The present invention is directed towards novel methods of synthesis of molindone, synthesis of the intermediates of molindone, and high-purity compositions of molindone. In particular, the invention relates to the methods of synthesis of molindone through the Mannich reaction.
摘要翻译： 本发明涉及新戊烯二酮的合成方法，莫丹多酮的中间体的合成，以及莫丹多酮的高纯度组合物。 特别地，本发明涉及通过曼尼希反应合成莫林多酮的方法。
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公开(公告)号：US20150024055A1
公开(公告)日：2015-01-22
申请号：US14506899
申请日：2014-10-06
发明人： Likan Liang , Padmanabh P. BHATT , Hua WANG
IPC分类号： A61K47/48 , A61K47/38 , A61K47/22 , A61K47/36 , A61K47/46 , A61K47/14 , A61K47/26 , A61K47/10 , A61K31/35 , A61K47/20
CPC分类号： A61K47/46 , A61K9/1652 , A61K9/19 , A61K9/5036 , A61K9/5047 , A61K31/35 , A61K47/10 , A61K47/14 , A61K47/20 , A61K47/22 , A61K47/26 , A61K47/36 , A61K47/38 , A61K47/61
摘要： The present invention provides enhanced immediate release formulations of topiramate, in which 80% of the active ingredient is released in the period of time of not more than 30 min. These formulations may be advantageously used for the treatment of acute neurological conditions, such as migraine.
摘要翻译： 本发明提供托吡酯的增强的立即释放制剂，其中80％的活性成分在不超过30分钟的时间内释放。 这些制剂可有利地用于治疗急性神经病症，例如偏头痛。
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