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公开(公告)号：US20230357173A1
公开(公告)日：2023-11-09
申请号：US18206953
申请日：2023-06-07
IPC分类号： C07D265/30 , B01J31/02
CPC分类号： C07D265/30 , B01J31/0239 , B01J2231/347 , C07B2200/07 , B01J2231/348 , B01J2531/002
摘要： Provided here are methods of making derivatives and prodrugs of substituted morpholines or pharmaceutically acceptable salts thereof. Further provided are methods of making derivatives and prodrugs of substituted morpholines having the following chemical structure:
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公开(公告)号：US11117862B2
公开(公告)日：2021-09-14
申请号：US16863020
申请日：2020-04-30
发明人： Martin Hanbauer , Zarghun Nazir , Peter Hildebrand , Attilia Figini , Likan Liang , Tiziano Fumagalli
IPC分类号： C07D209/08 , C07D295/13
摘要： The present invention is directed towards novel methods of synthesis of molindone, synthesis of the intermediates of molindone, and high-purity compositions of molindone. In particular, the invention relates to the methods of synthesis of molindone through the Mannich reaction.
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公开(公告)号：US11077114B2
公开(公告)日：2021-08-03
申请号：US16175207
申请日：2018-10-30
发明人： Rong-Kun Chang , Michael L. Vieira , Likan Liang , Padmanabh P. Bhatt , Austin B. Huang , Sachin V. Patel
摘要： Formulations of molindone having superior stability and methods of administering same are provided. The formulations may be immediate, modified, or otherwise delayed release formulations of molindone.
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公开(公告)号：US20190300492A1
公开(公告)日：2019-10-03
申请号：US16189299
申请日：2018-11-13
发明人： Likan LIANG , Padmanabh P. BHATT , David DAIN , Jean-Philippe TAQUET , Aleksandr PECHENOV , Alexei TCHESNOKOV , Reynold MARIAUX
IPC分类号： C07D265/30 , C07C215/08 , C07C217/34 , C07D265/32
摘要： Provided here are methods of manufacture of viloxazine and its various salts, as well as viloxazine-related compounds, such as novel intermediate reaction products and polymorphs thereof. In particular, the methods provide a substantially pure API of viloxazine HCl while avoiding undesirable impurities. The methods further provide for separating, identifying, and characterizing novel polymorphs of viloxazine. Further provided are methods for synthesis and identification and characterization of novel intermediates of viloxazine, as well as for some important metabolites and precursors of metabolites of viloxazine.
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公开(公告)号：US20190060323A1
公开(公告)日：2019-02-28
申请号：US16175207
申请日：2018-10-30
发明人： Rong-Kun CHANG , Michael L. VIEIRA , Likan LIANG , Padmanabh P. BHATT , Austin B. HUANG , Sachin V. PATEL
摘要： Formulations of molindone having superior stability and methods of administering same are provided. The formulations may be immediate, modified, or otherwise delayed release formulations of molindone.
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公开(公告)号：US10160733B2
公开(公告)日：2018-12-25
申请号：US15988190
申请日：2018-05-24
发明人： Likan Liang , Padmanabh P. Bhatt , David Dain , Jean-Philippe Taquet , Aleksandr Pechenov , Alexei Tchesnokov , Reynold Mariaux
IPC分类号： C07D265/30 , C07D265/32 , C07C215/08 , C07C217/34
摘要： Provided here are methods of manufacture of viloxazine and its various salts, as well as viloxazine-related compounds, such as novel intermediate reaction products and polymorphs thereof. In particular, the methods provide a substantially pure API of viloxazine HCl while avoiding undesirable impurities. The methods further provide for separating, identifying, and characterizing novel polymorphs of viloxazine. Further provided are methods for synthesis and identification and characterization of novel intermediates of viloxazine, as well as for some important metabolites and precursors of metabolites of viloxazine.
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公开(公告)号：US20180055853A1
公开(公告)日：2018-03-01
申请号：US15782334
申请日：2017-10-12
IPC分类号： A61K31/5377 , A61K31/00
CPC分类号： A61K31/5377 , A61K31/00
摘要： The invention comprises a method of treatment of aggression and similar behavioral syndromes, such as impulsivity and irritability, by a pharmaceutical agent exhibiting combined D2 and D5 antagonistic activity.
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公开(公告)号：US20180029982A1
公开(公告)日：2018-02-01
申请号：US15723515
申请日：2017-10-03
发明人： Martin HANBAUER , Zarghun NAZIR , Peter HILDEBRAND , Attilia FIGINI , Likan LIANG , Tiziano FUMAGALLI
IPC分类号： C07D209/08 , C07D295/13
CPC分类号： C07D209/08 , C07D295/13
摘要： The present invention is directed towards novel methods of synthesis of molindone, synthesis of the intermediates of molindone, and high-purity compositions of molindone. In particular, the invention relates to the methods of synthesis of molindone through the Mannich reaction.
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公开(公告)号：US09855278B2
公开(公告)日：2018-01-02
申请号：US15166816
申请日：2016-05-27
发明人： Padmanabh P. Bhatt , Argaw Kidane , Kevin Edwards
CPC分类号： A61K31/55 , A61K9/0073 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/205 , A61K9/2054 , A61K2800/56
摘要： Controlled-release preparations of oxcarbazepine and derivatives thereof for once-a-day administration are disclosed. The inventive compositions comprise solubility- and/or release enhancing agents to provide tailored drug release profiles, preferably sigmoidal release profiles. Methods of treatment comprising the inventive compositions are also disclosed.
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公开(公告)号：US09802893B2
公开(公告)日：2017-10-31
申请号：US15365566
申请日：2016-11-30
发明人： Martin Hanbauer , Zarghun Nazir , Peter Hildebrand , Attilia Figini , Likan Liang , Tiziano Fumagalli
IPC分类号： C07D209/08 , C07D295/13
CPC分类号： C07D209/08 , C07D295/13
摘要： The present invention is directed towards novel methods of synthesis of molindone, synthesis of the intermediates of molindone, and high-purity compositions of molindone. In particular, the invention relates to the methods of synthesis of molindone through the Mannich reaction.
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