公开(公告)号：US20190300492A1

公开(公告)日：2019-10-03

申请号：US16189299

申请日：2018-11-13

申请人： Supernus Pharmaceuticals, Inc.

发明人： Likan LIANG ,  Padmanabh P. BHATT ,  David DAIN ,  Jean-Philippe TAQUET ,  Aleksandr PECHENOV ,  Alexei TCHESNOKOV ,  Reynold MARIAUX

IPC分类号： C07D265/30 ,  C07C215/08 ,  C07C217/34 ,  C07D265/32

摘要： Provided here are methods of manufacture of viloxazine and its various salts, as well as viloxazine-related compounds, such as novel intermediate reaction products and polymorphs thereof. In particular, the methods provide a substantially pure API of viloxazine HCl while avoiding undesirable impurities. The methods further provide for separating, identifying, and characterizing novel polymorphs of viloxazine. Further provided are methods for synthesis and identification and characterization of novel intermediates of viloxazine, as well as for some important metabolites and precursors of metabolites of viloxazine.

公开(公告)号：US20160304475A1

公开(公告)日：2016-10-20

申请号：US15192098

申请日：2016-06-24

申请人： Supernus Pharmaceuticals, Inc.

发明人： Likan LIANG ,  Padmanabh P. BHATT ,  David DAIN ,  Jean-Philippe TAQUET ,  Aleksandr PECHENOV ,  Alexei TCHESNOKOV ,  Reynold MARIAUX

IPC分类号： C07D265/30

CPC分类号： C07D265/30 ,  C07C215/08 ,  C07C217/34 ,  C07D265/32

摘要： Provided here are methods of manufacture of viloxazine and its various salts, as well as viloxazine-related compounds, such as novel intermediate reaction products and polymorphs thereof. In particular, the methods provide a substantially pure API of viloxazine HCl while avoiding undesirable impurities. The methods further provide for separating, identifying, and characterizing novel polymorphs of viloxazine. Further provided are methods for synthesis and identification and characterization of novel intermediates of viloxazine, as well as for some important metabolites and precursors of metabolites of viloxazine.

公开(公告)号：US20220024885A1

公开(公告)日：2022-01-27

申请号：US17393834

申请日：2021-08-04

申请人： Supernus Pharmaceuticals, Inc.

发明人： Likan LIANG ,  Padmanabh P. BHATT ,  David DAIN ,  Jean-Philippe TAQUET ,  Aleksandr PECHENOV ,  Alexei TCHESNOKOV ,  Reynold MARIAUX

IPC分类号： C07D265/30 ,  C07C217/34 ,  C07D265/32 ,  C07C215/08

摘要： Provided here are methods of manufacture of viloxazine and its various salts, as well as viloxazine-related compounds, such as novel intermediate reaction products and polymorphs thereof. In particular, the methods provide a substantially pure API of viloxazine HCl while avoiding undesirable impurities. The methods further provide for separating, identifying, and characterizing novel polymorphs of viloxazine. Further provided are methods for synthesis and identification and characterization of novel intermediates of viloxazine, as well as for some important metabolites and precursors of metabolites of viloxazine.

公开(公告)号：US20180265482A1

公开(公告)日：2018-09-20

申请号：US15988190

申请日：2018-05-24

申请人： Supernus Pharmaceuticals, Inc.

发明人： Likan LIANG ,  Padmanabh P. BHATT ,  David DAIN ,  Jean-Philippe TAQUET ,  Aleksandr PECHENOV ,  Alexei TCHESNOKOV ,  Reynold MARIAUX

IPC分类号： C07D265/30 ,  C07C215/08 ,  C07C217/34 ,  C07D265/32

CPC分类号： C07D265/30 ,  C07C215/08 ,  C07C217/34 ,  C07D265/32

摘要： Provided here are methods of manufacture of viloxazine and its various salts, as well as viloxazine-related compounds, such as novel intermediate reaction products and polymorphs thereof. In particular, the methods provide a substantially pure API of viloxazine HCl while avoiding undesirable impurities. The methods further provide for separating, identifying, and characterizing novel polymorphs of viloxazine. Further provided are methods for synthesis and identification and characterization of novel intermediates of viloxazine, as well as for some important metabolites and precursors of metabolites of viloxazine.