公开(公告)号：US20230203129A1

公开(公告)日：2023-06-29

申请号：US17786669

申请日：2020-12-16

Applicant: BRACCO IMAGING S.P.A.

Inventor： Erika REITANO ,  Alessandro MAIOCCHI ,  Luisa POGGI ,  Federico CRIVELLIN ,  Simon HUET ,  Mathieu CINIER ,  Olivier KITTEN

IPC: C07K14/71 ,  C07K1/13 ,  G01N33/533

CPC classification number: C07K14/71 ,  C07K1/13 ,  G01N33/533

Abstract: The present invention provides new polypeptide derivatives binding to Human Epidermal Growth Factor Receptor 2 (HER2) and their conjugates thereof, and to their use as a diagnostic agent, particularly for early detection, patient stratification and treatment monitoring of forms of cancer characterized by over-expression of HER2.

公开(公告)号：US20230046541A1

公开(公告)日：2023-02-16

申请号：US17786623

申请日：2020-12-17

Applicant: BRACCO IMAGING S.P.A.

Inventor： Andrea BANIN ,  Laura GALIMBERTI ,  Roberta NAPOLITANO ,  Roberta FRETTA

IPC: C07C229/22 ,  C07C227/18

Abstract: The present invention relates to the calcium complex of (4RS)(4-carboxy-5,8,11-tris(carboxymethyl)-1-phenyl oxa-5,8,11-triazatridecan-13-oato(5-))pentahydrogen (BOPTA) in the form of a salt, to the process for its preparation and to a formulation comprising said salt.

公开(公告)号：US10973934B2

公开(公告)日：2021-04-13

申请号：US16766619

申请日：2019-08-06

Applicant: BRACCO IMAGING S.P.A.

Inventor： Roberta Napolitano ,  Luciano Lattuada ,  Zsolt Baranyai ,  Nicole Guidolin ,  Giuseppe Marazzi

IPC: A61B5/055 ,  A61K49/10 ,  C07F5/00

Abstract: The present invention relates to the RRR/SSS pair of enantiomers of the of Gd(PCTA-tris-glutaric acid), the single enantiomers of the pair, the pharmaceutically acceptable salts thereof, their amide derivatives, and compositions comprising at least 50% of these compounds.

公开(公告)号：US20200379070A1

公开(公告)日：2020-12-03

申请号：US16065302

申请日：2016-12-22

Applicant: BRACCO IMAGING S.P.A.

Inventor： Silvio AIME ,  Dario Livio LONGO ,  Sonia COLOMBO SERRA ,  Lorena CONSOLINO ,  Francesca ARENA

IPC: G01R33/56 ,  A61K49/10 ,  A61B5/055 ,  G01R33/465 ,  G01R33/48

Abstract: The present invention relates to on the use of exogenous agents having a pool of mobile proton(s) in CEST-MR imaging to generate Chemical Exchange Rotation Transfer/based CEST contrast, and to a ratiometric-based CEST-MR procedure that comprises using these exogenous agents to set-up CERT-based concentration-independent CEST MR imaging, and as responsive agents to set-up CERT-based concentration independent responsiveness.

公开(公告)号：US10781188B2

公开(公告)日：2020-09-22

申请号：US16060577

申请日：2016-12-12

Applicant: BRACCO IMAGING S.P.A.

Inventor： Luciano Lattuada ,  Roberta Napolitano ,  Valeria Boi ,  Massimo Visigalli ,  Silvio Aime ,  Giovanni Battista Giovenzana ,  Alberto Fringuello Mingo

IPC: C07D257/02 ,  A61K49/10 ,  C07D401/06

Abstract: The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.

公开(公告)号：US10780184B2

公开(公告)日：2020-09-22

申请号：US16263769

申请日：2019-01-31

Applicant: BRACCO IMAGING S.P.A.

Inventor： Simona Ghiani ,  Alessandro Maiocchi ,  Lara Caminiti ,  Luigi Miragoli

IPC: A61B5/00 ,  A61B8/00 ,  A61B10/00 ,  A61K49/00 ,  A61K9/10 ,  A61K9/51

Abstract: The present invention discloses a solid lipid nanoparticle (SLN) comprising: a) a solid lipid core comprising at least a glyceride and/or at least a fatty acid; b) a mixture of amphiphilic components forming a shell around said core a); c) an alkaline-earth complex with a compound of formula I and/or II: d) at least a fluorescent dye selected from: a cyanine fluorescent dye and/or a polyetherocyclic compound selected from: coumarin, pyrano, quinoline, pyranoquinoline, indole and pyranoindole derivates in acid form or a pharmaceutically acceptable salt thereof. These nanoparticles allow a prolonged blood circulation half-life, show enhanced photostability and improved fluorescence signal. The dye is preserved from degradation and improves the fluorescent quantum yield.

公开(公告)号：US10682427B2

公开(公告)日：2020-06-16

申请号：US15535937

申请日：2015-12-18

Applicant: BRACCO IMAGING S.P.A.

Inventor： Alessandro Maiocchi ,  Chiara Brioschi ,  Fulvio Uggeri ,  Giovanni Valbusa

IPC: A61K49/00 ,  A61B5/00 ,  A61B5/08 ,  A61B10/00

Abstract: The present invention relates to the use of a NIR fluorescent probe comprising an aza-bicycloalkane based cyclic peptide labelled with a Cy5.5 dye moiety in the fluorescence-guided surgery of pathologic regions and to an optical imaging method that comprises using this fluorescent probe for the identification and demarcation of tumor margins during the surgical resection.

公开(公告)号：US10407412B2

公开(公告)日：2019-09-10

申请号：US16060754

申请日：2016-12-12

Applicant: BRACCO IMAGING S.P.A.

Inventor： Valeria Boi ,  Roberta Napolitano ,  Luciano Lattuada

IPC: A61B5/055 ,  C07D403/12 ,  C07D257/02 ,  A61K49/12 ,  A61K49/10

Abstract: The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.

公开(公告)号：US20190209713A1

公开(公告)日：2019-07-11

申请号：US16256749

申请日：2019-01-24

Applicant: BRACCO IMAGING S.P.A.

Inventor： Silvio AIME ,  Daniela DELLI CASTELLI ,  Franco FEDELI ,  Dario Livio LONGO ,  Enzo TERRENO ,  Fulvio UGGERI

IPC: A61K49/10

Abstract: The present invention relates to the use of non-equivalent mobile protons belonging to NMR distinguishable steroisomers of a CEST agent in a ratiometric based CEST imaging procedure and to Lanthanide (III) complex compounds displaying at least two NMR-distinguishable steroisomers in solution useful as concentration independent CEST responsive agents.

公开(公告)号：US20180362476A1

公开(公告)日：2018-12-20

申请号：US16060577

申请日：2016-12-12

Applicant: BRACCO IMAGING S.P.A.

Inventor： Luciano LATTUADA ,  Roberta NAPOLITANO ,  Valeria BOI ,  Massimo VISIGALLI ,  Silvio AIME ,  Giovanni Battista GIOVENZANA ,  Alberto FRINGUELLO MINGO

IPC: C07D257/02 ,  C07D401/06 ,  A61K49/10

Abstract: The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.5