公开(公告)号：US20200315618A1

公开(公告)日：2020-10-08

申请号：US16906229

申请日：2020-06-19

申请人： MEDI FUTURES CO., LTD.

发明人： Ji Hwan KIM

IPC分类号： A61B17/06 ,  A61L17/10 ,  D02G3/44 ,  D02J3/02

摘要： A three-dimensional thread making method using ultrasonic waves is provided. The method includes inserting a yarn into a position corresponding to an engraved pattern of a mold base between an ultrasonic wave generator and the mold base at positions adjacent to each other, applying ultrasonic waves to the yarn while the ultrasonic wave generator pressurizes the yarn, and injecting a medical anti-loosening member made in a form of the engraved pattern due to the ultrasonic waves. The medical anti-loosening member includes a medical three-dimensional thread formed to have a plurality of protrusions facing each other on both sides and a medical anti-loosening screw.

公开(公告)号：US20200240044A1

公开(公告)日：2020-07-30

申请号：US16813430

申请日：2020-03-09

申请人： Tepha, Inc.

发明人： Amit Ganatra ,  Fabio Felix ,  Bhavin Shah ,  Matthew Bernasconi ,  Said Rizk ,  David P. Martin ,  Simon F. Williams

IPC分类号： D01F6/62 ,  A61L17/10 ,  A61L31/14 ,  D01D5/08 ,  B29C55/00 ,  A61L31/06 ,  D02G3/04 ,  D01F8/14 ,  B29K73/00 ,  B29K673/00 ,  B29L31/00

摘要： Resorbable multifilament yarns and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yarns and fibers are produced by cold drawing the multifilament yarns and monofilament fibers before hot drawing the yarns and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yarns and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yarns have tenacities higher than 8.1 grams per denier, and in vivo, retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo. The monofilament fibers have tensile strengths higher than 500 MPa. These yarns and fibers may be used to make various medical devices for various applications.

公开(公告)号：US20200239622A1

公开(公告)日：2020-07-30

申请号：US16844436

申请日：2020-04-09

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

发明人： Jianjun Cheng ,  Hanze Ying ,  Yanfeng Zhang

IPC分类号： C08G18/79 ,  C08G18/81 ,  C08G18/76 ,  C08G18/32 ,  C08G18/67 ,  A61L27/18 ,  A61L17/10 ,  A61K47/34 ,  C08G18/24 ,  C08G18/75

摘要： The present invention relates to polymers having dynamic urea bonds and more specifically to polymers having hindered urea bonds (HUBs). The present invention also relates to: (a) malleable, repairable, and reprogrammable shape memory polymers having HUBs, (b) reversible or degradable (e.g., via hydrolysis or aminolysis) linear, branched or network polymers having HUBs, and (c) to precursors for incorporation of HUBs into these polymers. The HUB technology can be applied to and integrated into a variety of polymers, such as polyureas, polyurethanes, polyesters, polyamides, polycarbonates, polyamines, and polysaccharides to make linear, branched, and cross-linked polymers. Polymers incorporating the HUBs can be used in a wide variety of applications including plastics, coatings, adhesives, biomedical applications, such as drug delivery systems and tissue engineering, environmentally compatible packaging materials, and 4D printing applications.

公开(公告)号：US10722388B2

公开(公告)日：2020-07-28

申请号：US15716620

申请日：2017-09-27

申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Soo Hyun Kim ,  Young Mee Jung ,  Seung Hyuk Im

IPC分类号： A61F2/91 ,  A61L31/06 ,  A61L31/14 ,  A61L17/10 ,  A61L17/14 ,  D02J1/22 ,  A61F2/88 ,  B29C71/02

摘要： A solid-state drawing method for preparing a surgical suture or a biodegradable stent having improved flexibility and mechanical strength. The method for preparing a biodegradable stent includes (a) providing a biodegradable filament that comprises a material which is biodegradable; (b) solid-state drawing the biodegradable filament to provide a drawn biodegradable filament; (c) shaping the drawn biodegradable filament to provide a shaped biodegradable filament; and (d) annealing the shaped biodegradable filament to provide the biodegradable stent, wherein the biodegradable filament has a draw ratio that ranges from 1.1 to 5.0; and wherein the draw ratio is calculated by Equation 1 below: Draw ratio=(LSSD/LO)2, where LO is length of the biodegradable filament before the solid-state drawing, and LSSD is the length of the biodegradable filament after the solid-state drawing.

公开(公告)号：US20200009038A1

公开(公告)日：2020-01-09

申请号：US16557878

申请日：2019-08-30

申请人： Allergan Holdings France S.A.S.

发明人： Geoffrey C. GURTNER ,  Kenneth N. HORNE ,  Jayakumar RAJADAS

IPC分类号： A61K8/73 ,  A61K31/728 ,  B29C48/05 ,  A61L27/20 ,  A61L31/04 ,  C08L5/08 ,  A61K8/65 ,  A61K8/02 ,  A61L17/10 ,  A61L15/28 ,  A61L17/06 ,  C08B37/08 ,  A61K8/42 ,  A61L17/00 ,  A61L17/04 ,  A61L27/54 ,  A61Q19/08

摘要： The present invention provides threads of hyaluronic acid, and/or derivatives thereof, methods of making thereof and uses thereof, for example, in aesthetic applications (e.g., dermal fillers), surgery (sutures), drug delivery, etc.

公开(公告)号：US10376226B2

公开(公告)日：2019-08-13

申请号：US15465148

申请日：2017-03-21

申请人： S. Jackson, Inc.

发明人： Janko Jackson ,  Stephen L. Jackson ,  Crayton G. Toney

IPC分类号： A61B6/12 ,  A61L17/10 ,  A61L27/18 ,  A61L27/50 ,  A61L27/56 ,  A61B5/055 ,  A61B5/00 ,  A61B6/00 ,  A61B8/08 ,  A61B17/06 ,  A61F2/00 ,  A61L17/04 ,  A61B90/00

摘要： A method of in vivo monitoring the condition of an internal body repair in which an imageable, non-absorbable repair device having non-absorbable, particulate imaging material substantially uniformly dispersed therein has been surgically inserted, including: in vivo sensing of dimensional deformation of or imaging material concentration changes in said repair device during the post-surgical healing process; comparing the sensed values with a previously developed correlation between said sensed values and the values at which failure occurs of comparable repair devices; wherein said sensed values relative to the repair device's failure values, considered in conjunction with the anticipated time for complete healing of said repair, provides information as to the condition of the repair.

公开(公告)号：US20190071796A1

公开(公告)日：2019-03-07

申请号：US16083774

申请日：2017-03-13

申请人： The Johns Hopkins University

发明人： Kunal S. Parikh ,  Himat Patel ,  Justin Hanes

IPC分类号： D01D5/00 ,  D01F1/10 ,  D01H7/02 ,  A61L17/10 ,  A61L31/06 ,  A61L17/00 ,  A61L31/14 ,  A61L17/12

摘要： A system for forming twisted or aligned electrospun fibers has been developed. The collector for the electrospun fibers is capable of rotation. In some instances, fibers are formed between two collectors, at least one of which rotates to twist the fibers into a multifilament bundle with increased strength. In a second embodiment, a cylindrical collector rotates, and charged polymer jet uniformly coats the surface of the collector. When a drum collector rotates at a high speed, electrospun fibers align and form an array. Optionally, different active agents can be included in the electrospinning solutions to form fiber constructs with different strengths and controlled release profiles, providing a reproducible method to generate complexed structures based on electrospun fibers and controlled drug delivery profiles.

公开(公告)号：US20190022271A1

公开(公告)日：2019-01-24

申请号：US16141364

申请日：2018-09-25

申请人： Riverpoint Medical, LLC

发明人： Patrick Edward Ferguson ,  Patrick Joseph Ferguson

IPC分类号： A61L17/10 ,  A61L17/12

摘要： A suture that includes an exterior braid of more than 50% ultra-high molecular weight polyethylene fibers, defining a lumen having a lumen diameter. In addition, the suture material includes an interior core, comprised of fibers and having a diameter that is less than 55% of the diameter of said lumen, and wherein the interior core includes four or fewer fibers.

公开(公告)号：US10092673B2

公开(公告)日：2018-10-09

申请号：US13878236

申请日：2011-07-29

申请人： Wiebke Schmitz ,  Julia Schmidt ,  Bernd Schlesselmann ,  Gunter Scharfenberger

发明人： Wiebke Schmitz ,  Julia Schmidt ,  Bernd Schlesselmann ,  Gunter Scharfenberger

IPC分类号： A61L15/22 ,  D01D10/02 ,  A61L26/00 ,  A61L27/56 ,  A61L17/10 ,  A61L27/16 ,  A61L15/42 ,  A61L15/24 ,  A61L27/52 ,  D01F6/50 ,  D01F6/14 ,  D01F8/10 ,  D01F6/34

摘要： A plurality of fibers or one-dimensional, two-dimensional, or three-dimensional fibrous structures are provided, having fibers from a first raw fiber material. The first raw fiber material contains unsubstituted or partially substituted polyvinyl alcohol and/or unsubstituted or partially substituted polyvinyl alcohol copolymer. The fibers can be crosslinked by tempering the fibers or fibrous structures, with the result that the fibers or the fibrous structure are configured to be gel, in particular hydrogel, fibers or fibrous structures and have excellent stability.

公开(公告)号：US20180209073A1

公开(公告)日：2018-07-26

申请号：US15924693

申请日：2018-03-19

申请人： Tepha, Inc.

发明人： Amit Ganatra ,  Fabio Felix ,  Bhavin Shah ,  Matthew Bernasconi ,  Said Rizk ,  David P. Martin ,  Simon F. Williams

IPC分类号： D01F6/62 ,  D01D5/08 ,  A61L31/06 ,  A61L31/14 ,  B29C55/00 ,  A61L17/10 ,  D01F8/14 ,  D02G3/04 ,  B29K73/00 ,  B29K673/00 ,  B29L31/00

CPC分类号： D01F6/625 ,  A61L17/105 ,  A61L31/06 ,  A61L31/148 ,  B29C55/005 ,  B29K2073/00 ,  B29K2673/00 ,  B29L2031/731 ,  D01D5/08 ,  D01F8/14 ,  D02G3/04 ,  D10B2331/04 ,  D10B2331/041 ,  D10B2401/063 ,  D10B2509/04 ,  D10B2509/08

摘要： Resorbable multifilament yarns and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yarns and fibers are produced by cold drawing the multifilament yarns and monofilament fibers before hot drawing the yarns and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yarns and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yarns have tenacities higher than 8.1 grams per denier, and in vivo, retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo. The monofilament fibers have tensile strengths higher than 500 MPa. These yarns and fibers may be used to make various medical devices for various applications.