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公开(公告)号：US10434135B2
公开(公告)日：2019-10-08
申请号：US15556963
申请日：2016-03-14
发明人： Sang Jun Kim , Young Mee Jung , Soo Hyun Kim
摘要： A pharmaceutical composition for preventing or treating arthritis, which comprises synthetic polypeptides; injections for preventing or treating arthritis; and a pharmaceutical composition for inducing differentiation of cartilage cells are described herein. Synthetic polypeptides of the present invention consisting of a polypeptide represented by SEQ ID NO: 1 and a polypeptide represented by SEQ ID NO: 2 have activity for recruiting stem cells to an arthritis region, inhibit apoptosis of cartilage cells, and exhibit anti-inflammatory activity and activity for promoting regeneration of cartilage cells. Thus, unlike a conventional arthritis treatment agent, the synthetic polypeptides can improve cartilage damage, can inhibit degenerative changes per se and can, at the same time, exhibit an effect as a stem cell treatment agent, and thereby can be usefully utilized as an arthritis prevention or treatment agent.
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2.发明申请PREPARATION METHOD OF FLEXIBLE POLYLACTIDE STEREOCOMPLEX AND THE COMPOUND THEREOF 审中-公开柔性聚合物立体异构体及其化合物的制备方法公开(公告)号：US20150057385A1
公开(公告)日：2015-02-26
申请号：US14519841
申请日：2014-10-21
发明人： Chae Hwan Hong , Do Suck Han , Soo Hyun Kim , Young Mee Jung
CPC分类号： C08G63/08 , C08G63/81 , C08J9/28 , C08J2367/04 , Y02P20/544
摘要： Disclosed are a polylactide stereocomplex with improved thermal stability and thus improved processability and a method for preparing the same. In order to confer flexibility to polymer chains, D-type polylactide polymer containing a small amount of caprolactone (poly D-lactide-caprolactone copolymer) is synthesized and it is uniformly mixed with L-type single-phase polylactide to prepare a flexible polylactide stereocomplex. Since the polylactide stereocomplex having flexible polymer chains has superior heat resistance and mechanical stability and experiences little decrease of the degree of stereocomplex formation even after thermal processing, the polylactide stereocomplex having improved thermal stability can be advantageously used for engineering plastics requiring high strength and good thermal stability, alternative materials for general-use plastics, high-performance medical materials, or the like because of its remarkably improved processability.
摘要翻译： 公开了具有改进的热稳定性和因此改善的加工性的聚交酯立体络合物及其制备方法。 为了赋予聚合物链柔性，合成含有少量己内酯（聚D-丙交酯 - 己内酯共聚物）的D型聚丙交酯聚合物，并将其与L型单相聚丙交酯均匀混合以制备柔性聚交酯立体络合物 。 由于具有柔性聚合物链的聚交酯立体络合物具有优异的耐热性和机械稳定性，并且即使在热加工后也几乎不降低立体复合物形成程度，所以具有改善的热稳定性的聚交酯立体络合物可有利地用于需要高强度和良好热的工程塑料 稳定性，一般用途塑料的替代材料，高性能医疗材料等，因为其显着改进的加工性能。
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公开(公告)号：US11607474B2
公开(公告)日：2023-03-21
申请号：US16875107
申请日：2020-05-15
摘要： The present invention relates to a method for preparing of a nerve conduit using bio-printing technology and a nerve conduit prepared by the same, and it can easily prepare a nerve conduit by simulating a nerve bundle and nerve tissue, and the like, by three-dimensionally printing bio-ink comprising a neuronal regeneration material on one side of a porous polymer scaffold.
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公开(公告)号：US11920118B2
公开(公告)日：2024-03-05
申请号：US17081723
申请日：2020-10-27
发明人： Young Mee Jung , Soo Hyun Kim , Justin Jihong Chung , Jin Yoo , Tae Hee Kim
IPC分类号： C12M1/00
摘要： Provided are a method for fabricating a highly elastic porous polymer membrane, a method for manufacturing a cell culture system using a porous polymer membrane fabricated by the fabrication method, and a cell culture system manufactured by the manufacturing method. The porous polymer membrane can be fabricated by spin coating a mixture solution containing a biodegradable elastomeric polymer and a water-soluble moisture absorbent in an optimum ratio while maintaining a high relative humidity. The porous polymer membrane has a uniform thickness and a uniform pore size and is highly elastic. In addition, the thickness and pore size of the porous polymer membrane can be controlled. The porous polymer membrane can induce active cell-cell interaction during cell co-culture due to its high porosity. The porous polymer membrane enables control over cell alignment or array due to its high biocompatibility and elasticity. The porous polymer membrane can be utilized in a platform for inducing stem cell differentiation, a lab-on-a-chip, a synthetic skin simulant platform, etc.
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公开(公告)号：US10537663B2
公开(公告)日：2020-01-21
申请号：US15800436
申请日：2017-11-01
发明人： Young Mee Jung , Soo Hyun Kim , Yoo Jin Seo
摘要： A method for preparing a decellularized tissue-based hydrogel with maximized ability of preserving various tissue-derived proteins, growth factors and cytokines by using a supercritical fluid-organic solvent system through (a) a step of decellularizing a biological tissue by bringing the same to contact with a supercritical fluid and an organic solvent at the same time; (b) a step of washing the decellularized tissue; (c) a step of preparing a decellularized tissue solution by mixing the washed decellularized tissue with one selected from an enzyme solution, an acidic solution and a mixture thereof; (d) a step of titrating the decellularized tissue solution to pH 5.5-7.8 by treating with a basic solution; and (e) a step of allowing the titrated decellularized tissue solution to stand at 30-40° C. and utilizing the same as a tissue engineering material with improved angiogenesis and tissue regeneration abilities.
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公开(公告)号：US10287392B2
公开(公告)日：2019-05-14
申请号：US15717212
申请日：2017-09-27
发明人： Soo Hyun Kim , Young Mee Jung , Seung Hyuk Im
IPC分类号： C08G63/08 , C08G63/664 , G01N25/48
摘要： Disclosed is a method for preparing a poly(L-lactic acid) composite. According to the method, PLLA can be processed without losing its physical properties during thermal processing and can be effectively used to manufacture a final product with improved thermal properties. In addition, the monomer is not thermally decomposed during high-temperature polymerization. Therefore, the poly(L-lactic acid) composite can be prevented from browning. Also disclosed is a poly(L-lactic acid) composite prepared by the method.
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公开(公告)号：US20180042984A1
公开(公告)日：2018-02-15
申请号：US15556963
申请日：2016-03-14
发明人： Sang Jun Kim , Young Mee Jung , Soo Hyun Kim
CPC分类号： A61K38/08 , A61K9/0019 , A61K9/06 , A61K35/28 , A61K38/046 , A61K38/10 , A61K38/16 , A61K47/26
摘要： The present invention relates to: a pharmaceutical composition for preventing or treating arthritis, which comprises synthetic polypeptides; injections for preventing or treating arthritis; and a pharmaceutical composition for inducing differentiation of cartilage cells. Synthetic polypeptides of the present invention consisting of a polypeptide represented by SEQ ID NO: 1 and a polypeptide represented by SEQ ID NO: 2 have activity for recruiting stem cells to an arthritis region, inhibit apoptosis of cartilage cells, and exhibit anti-inflammatory activity and activity for promoting regeneration of cartilage cells. Thus, unlike a conventional arthritis treatment agent, the synthetic polypeptides can improve cartilage damage, can inhibit degenerative changes per se and can, at the same time, exhibit an effect as a stem cell treatment agent, and thereby can be usefully utilized as an arthritis prevention or treatment agent.
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公开(公告)号：US11000989B2
公开(公告)日：2021-05-11
申请号：US15786686
申请日：2017-10-18
发明人： Young Mee Jung , Soo Hyun Kim , Su Hee Kim
IPC分类号： B29C64/314 , B29C64/106 , B33Y80/00 , A61L27/14 , A61L27/58 , A61L31/14 , C08G63/08 , C08K5/00 , C08K3/08 , B29C64/209 , B33Y10/00 , B33Y70/00 , C08K5/1545 , A61L27/50 , A61L27/18
摘要： A method for preparing a highly elastic biodegradable three-dimensional structure includes (a) mixing poly(lactide-co-ε-caprolactone) (PLCL) with at least one biocompatible heat stabilizer that is biocompatible with the PLCL, that is a heat stabilizer for the PLCL, and that is selected from the group consisting of α-tocopherol, barium-zinc, calcium-zinc, vitamin B, and combinations thereof to provide a solvent-free mixture; and (b) carrying out three-dimensional printing with the solvent-free mixture by heating the mixture at 150-250° C. for 5-20 minutes to provide a heated mixture; and ejecting the heated mixture through a nozzle. The three-dimensional structure maintains mechanical properties even after three-dimensional printing, by adding a biocompatible heat stabilizer to poly(L-lactide-co-ε-caprolactone). The three-dimensional structure is useful as a scaffold for tissue engineering.
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9.发明申请公开(公告)号：US20200376167A1
公开(公告)日：2020-12-03
申请号：US16875107
申请日：2020-05-15
摘要： The present invention relates to a method for preparing of a nerve conduit using bio-printing technology and a nerve conduit prepared by the same, and it can easily prepare a nerve conduit by simulating a nerve bundle and nerve tissue, and the like, by three-dimensionally printing bio-ink comprising a neuronal regeneration material on one side of a porous polymer scaffold.
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公开(公告)号：US10722388B2
公开(公告)日：2020-07-28
申请号：US15716620
申请日：2017-09-27
发明人： Soo Hyun Kim , Young Mee Jung , Seung Hyuk Im
摘要： A solid-state drawing method for preparing a surgical suture or a biodegradable stent having improved flexibility and mechanical strength. The method for preparing a biodegradable stent includes (a) providing a biodegradable filament that comprises a material which is biodegradable; (b) solid-state drawing the biodegradable filament to provide a drawn biodegradable filament; (c) shaping the drawn biodegradable filament to provide a shaped biodegradable filament; and (d) annealing the shaped biodegradable filament to provide the biodegradable stent, wherein the biodegradable filament has a draw ratio that ranges from 1.1 to 5.0; and wherein the draw ratio is calculated by Equation 1 below: Draw ratio=(LSSD/LO)2, where LO is length of the biodegradable filament before the solid-state drawing, and LSSD is the length of the biodegradable filament after the solid-state drawing.
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