公开(公告)号：US20170370772A1

公开(公告)日：2017-12-28

申请号：US15539282

申请日：2015-12-23

Applicant: UNIVERSITE BORDEAUX MONTAIGNE ,  UNIVERSITE DE BORDEAUX ,  INSTITUT POLYTECHNIQUE DE BORDEAUX ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Inventor： Aurelie MOUNIER ,  Floréal DANIEL ,  Sylvain LAZARE

IPC: G01J3/10 ,  G01J3/44 ,  G01N21/64

CPC classification number: G01J3/10 ,  G01J3/4406 ,  G01J2003/106 ,  G01N21/645 ,  G01N21/6486 ,  G01N2021/6417 ,  G01N2021/6419

Abstract: An LED spectrofluorometer (100) for analysis of an object (101) includes a light excitation element (11, 112, 113) suitable for illuminating a study zone (101B) of the object with an excitation light beam (1), and an optical routing element (121, 122, 123, 124) suitable for collecting a fluorescent light flux (2) emitted by the study zone excited by the excitation light beam and for routing the fluorescent light flux to an optical spectrometer (131) for analysis of the light spectrum thereof. The light excitation element includes a first light-emitting diode (111) and a second-light emitting diode (112), the first light-emitting diode emitting at a first wavelength (λ1) between 250 and 300 nm and the excitation light beam being formed from one or other of the light beams generated by each light-emitting diode.

公开(公告)号：US09851303B2

公开(公告)日：2017-12-26

申请号：US15316568

申请日：2015-06-03

Applicant: Ludwig-Maximilians-Universität München

Inventor： Robert Alexander Huber ,  Sebastian Karpf ,  Matthias Eibl

IPC: G01N21/64 ,  G01N21/65

CPC classification number: G01N21/6456 ,  G01J3/0218 ,  G01J3/10 ,  G01J3/44 ,  G01J3/4406 ,  G01N21/6408 ,  G01N21/65 ,  G01N2021/6484 ,  G01N2201/06146 ,  G01N2201/0635 ,  G01N2201/105 ,  G01N2201/11 ,  G01N2201/12 ,  H01S3/06712 ,  H01S3/06754 ,  H01S3/094007 ,  H01S3/10015 ,  H01S3/1618 ,  H01S3/2316 ,  H01S3/302 ,  H01S2301/02

Abstract: Described is a system for inducing and detecting multi-photon processes, in particular multi-photon fluorescence or higher harmonic generation in a sample. The system comprises a dynamically-controllable light source, said dynamically-controllable light source comprising a first sub-light source, said first sub-light source being electrically controllable such as to generate controllable time-dependent intensity patterns of light having a first wavelength, and at least one optical amplifier, thereby allowing for active time-control of creation of multi-photon-excitation. The system further comprises a beam delivery unit for delivering light generated by said dynamically-controllable light source to a sample site, and a detector unit or detector assembly for detecting signals indicative of said multi-photon process, in particular multi-photon fluorescence signals or higher harmonics signals.

公开(公告)号：US20170284939A1

公开(公告)日：2017-10-05

申请号：US15531875

申请日：2015-11-19

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Kengo SUZUKI ,  Kazuya IGUCHI

IPC: G01N21/64

CPC classification number: G01N21/645 ,  G01J3/4406 ,  G01N21/636 ,  G01N2021/6417 ,  G01N2021/6469 ,  G01N2021/6471 ,  G01N2021/6484 ,  G01N2201/065 ,  G01N2201/08

Abstract: A spectroscopic measurement apparatus includes a light source, an integrator, a spectroscopic detector, and an analysis unit. The integrator includes an internal space in which a measurement object is disposed, a light input portion for inputting light to the internal space, a light output portion for outputting light from the internal space, a sample attachment portion for attaching the measurement object, and a filter attachment portion for attaching a filter unit. The filter unit has a transmission spectrum in which an attenuation rate for excitation light is larger than an attenuation rate for up-conversion light, and attenuates the light output from the light output portion. The analysis unit analyzes luminous efficiency of the measurement object on the basis of the transmission spectrum data and the spectroscopic spectrum data acquired by the spectroscopic detector.

公开(公告)号：US20170234793A1

公开(公告)日：2017-08-17

申请号：US15586542

申请日：2017-05-04

Applicant: HORIBA INSTRUMENTS INCORPORATED ,  HORIBA ADVANCED TECHNO CO., LTD.

Inventor： Adam Matthew GILMORE

IPC: G01N21/64 ,  C02F1/52 ,  G01N33/18 ,  C02F1/00

CPC classification number: G01N21/645 ,  C02F1/004 ,  C02F1/008 ,  C02F1/52 ,  C02F5/02 ,  C02F2001/007 ,  C02F2209/008 ,  C02F2209/02 ,  C02F2209/06 ,  C02F2209/07 ,  C02F2209/08 ,  C02F2209/11 ,  C02F2209/20 ,  C02F2209/21 ,  G01J3/36 ,  G01J3/42 ,  G01J3/4406 ,  G01N21/274 ,  G01N33/18 ,  G01N33/1806 ,  G01N33/1826 ,  G01N2021/6421 ,  G01N2021/6482 ,  G01N2021/6484 ,  G01N2021/6491 ,  G01N2201/1211

Abstract: A computer-implemented method includes controlling an instrument to measure a fluorescence emission spectrum of a sample including a first peak emission wavelength and at least a second peak emission wavelength, emitted in response to an excitation wavelength and controlling the instrument to measure an absorbance obtained at the excitation wavelength of the sample. The method may include determining, using the computer, a ratio of the measurements at either the second peak emission wavelength, or a sum of measurements at a plurality of peak emission wavelengths including at least the first peak emission wavelength and the second peak emission wavelength, to the first peak emission wavelength, and calculating, using the computer, a value for a quality parameter based on a combination of at least the ratio and the absorbance measurement. The method may include controlling an associated process based on the quality parameter.

公开(公告)号：US20170191932A1

公开(公告)日：2017-07-06

申请号：US15398411

申请日：2017-01-04

Applicant: Damian Kokkin ,  Timothy Steimle

Inventor： Damian Kokkin ,  Timothy Steimle

IPC: G01N21/64

CPC classification number: G01N21/6404 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/433 ,  G01J3/4406 ,  G01N21/645 ,  G01N2021/6406 ,  G01N2021/6419 ,  G01N2021/6473 ,  G01N2021/6478 ,  G01N2021/6482 ,  G01N2021/6484 ,  G01N2021/6491 ,  G01N2201/0612 ,  G01N2201/0833

Abstract: Optical spectroscopy system and method possessing spectral selectivity sufficient to distinguish isotopic line of the metal of interest. Each of the light beams, counter-propagating through vial with vapor of the sample, has been originated from the same light output of the laser source and modulated at a corresponding judiciously-determined frequency. The light-output, in turn, possesses a carrier frequency and two side-band frequencies defined with respect to a mean value of excitation frequencies of isotopes in the vapor.

公开(公告)号：US20170176334A1

公开(公告)日：2017-06-22

申请号：US15150559

申请日：2016-05-10

Applicant: STMicroelectronics (Research & Development) Ltd.

Inventor： Francescopaolo Mattioli Della Rocca ,  John Kevin Moore

IPC: G01N21/64

CPC classification number: G01N21/6428 ,  G01J3/0224 ,  G01J3/2823 ,  G01J3/4406 ,  G01J2003/2806 ,  G01N21/21 ,  G01N21/6408 ,  G01N21/6445 ,  G01N21/6452 ,  G01N21/6454 ,  G01N21/6456 ,  G01N2021/217 ,  G01N2021/6439 ,  G01N2201/0683

Abstract: Photoluminescence from a sample detector is detected using an array of photo-sensitive detectors. At least one first photo-sensitive detector of the array is provided with a first type of linear polarization filter and at least one second photo-sensitive detector is provided with a second type of linear polarization filter. The first type of linear polarization filter has a plane of polarization which is at angled with respect to a plane of polarization of said second type of polarization filter.

公开(公告)号：US20170167978A1

公开(公告)日：2017-06-15

申请号：US15413045

申请日：2017-01-23

Applicant: OmniVision Technologies, Inc.

Inventor： Bowei Zhang

IPC: G01N21/64 ,  C12Q1/68 ,  G01N21/17

CPC classification number: G01N21/6428 ,  B01L3/502715 ,  B01L7/525 ,  B01L2300/044 ,  B01L2300/047 ,  B01L2300/0803 ,  B01L2300/0887 ,  B01L2300/1827 ,  C12Q1/6809 ,  G01J3/4406 ,  G01N21/0332 ,  G01N21/1717 ,  G01N21/6454 ,  G01N21/6456 ,  G01N2021/1731 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6471

Abstract: A method for high-throughput assay processing includes (a) modulating temperature of a plurality of samples disposed in a respective plurality of fluidic channels on an image sensor wafer, including a plurality of image sensors, by heating the image sensor wafer using a heating module thermally coupled with the image sensor wafer, to control reaction dynamics in the samples, and (b) capturing a plurality of fluorescence images of the samples, using the plurality of image sensors, to detect one or more components of the plurality of samples. A method for manufacturing a high-throughput fluorescence imaging system with sample heating capability includes (a) bonding a fluidic wafer, including a plurality of recesses, to an image sensor wafer including a plurality of image sensors, and (b) bonding a heating module, including a heater for generating heat, to the image sensor wafer to thermally couple the heater and the image sensor wafer.

公开(公告)号：US20170108438A1

公开(公告)日：2017-04-20

申请号：US15390128

申请日：2016-12-23

Applicant: BTI HOLDINGS, INC.

Inventor： Oleg ZIMENKOV ,  Xavier AMOURETTI ,  Michael KONTOROVICH ,  Ben NORRIS ,  Richard N. SEARS ,  Dan J. VENDITTI, JR. ,  Christopher MANY ,  Bill ANDERSON ,  Ben KNIGHT ,  James PIETTE ,  Ross PIETTE ,  Joe TOBEY ,  Brian FERRIS

IPC: G01N21/64 ,  G01N21/76

CPC classification number: G01J3/42 ,  G01J3/0218 ,  G01J3/0224 ,  G01J3/0235 ,  G01J3/0264 ,  G01J3/027 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/10 ,  G01J3/4406 ,  G01J3/443 ,  G01N21/64 ,  G01N21/6447 ,  G01N21/6452 ,  G01N21/6456 ,  G01N21/76 ,  G01N2021/6463

Abstract: An apparatus for optically analyzing a sample may include an imaging subsystem that images the sample, one or more analyzing subsystems that analyze the sample, a temperature control subsystem that controls a temperature of the atmosphere within the apparatus, a gas control subsystem that controls a composition of the atmosphere within the apparatus, and a control module that controls the various subsystems of the apparatus.

公开(公告)号：US09618452B2

公开(公告)日：2017-04-11

申请号：US14741629

申请日：2015-06-17

Applicant: National Central University

Inventor： Szu-Yu Chen ,  Poyu Su ,  Chiao-Sheng Lu ,  Yu John Hsu

IPC: G01N21/64 ,  G01J3/02 ,  G01J3/10 ,  G01J3/12 ,  G01J3/28

CPC classification number: G01N21/6458 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/0267 ,  G01J3/04 ,  G01J3/06 ,  G01J3/10 ,  G01J3/12 ,  G01J3/2803 ,  G01J3/2823 ,  G01J3/4406 ,  G01J2003/2813 ,  G01J2003/282 ,  G01N2021/6421 ,  G01N2021/6423 ,  G01N2021/6476 ,  G01N2021/6478

Abstract: A fluorescence hyperspectral microscopy system featuring structured illumination and parallel recording includes a light projection sub-system, a detection sub-system, and an electrical controller. The light projection sub-system includes a digital light processing (DLP) module for generating linear excitation light, a first lens set, an optical path allocation element, and an objective lens. The detection sub-system includes a second lens set, a frequency-dividing reflection element, a two-dimensional light detector, and a light collection element. With the detection sub-system performing detection in conjunction with the light projection sub-system, and the electrical controller controlling the DLP module, a two-dimensional moving platform, and the two-dimensional light detector, the fluorescence hyperspectral microscopy system provides increased resolution and can obtain accurate information in spatial and spectral dimensions and hence a four-dimensional hyperspectral image of the object under detection.

公开(公告)号：US20170074797A1

公开(公告)日：2017-03-16

申请号：US15068486

申请日：2016-03-11

Applicant: KABUSHIKI KAISHA TOSHIBA

Inventor： Kaita IMAI ,  Shouhei KOUSAI

IPC: G01N21/64 ,  G01N33/483 ,  G01N27/02

CPC classification number: G01N21/6486 ,  G01J3/10 ,  G01J3/4406 ,  G01N21/6454 ,  G01N21/6456 ,  G01N21/763 ,  G01N27/028 ,  G01N33/4833 ,  G01N2021/6419 ,  G01N2201/0627

Abstract: According to one embodiment, the illumination device includes a lighting unit and a control unit. The lighting unit emits light at the intensity to be emitted toward the region to be irradiated in a two-dimensional region of a measurement device. The measurement device acquires optical information and biochemical information and/or electrical information for an object corresponding with positional information. The control unit determines the region to be irradiated and the intensity to be emitted, based on the biochemical or electrical information by the measurement device, the positional information of them, and the threshold conditions predetermined, and controls the irradiation of the lighting unit depending on them.

Abstract translation: 根据一个实施例，照明装置包括照明单元和控制单元。 照明单元以测量装置的二维区域中朝向要照射的区域发射的强度发光。 测量装置获取与位置信息对应的物体的光学信息和生化信息和/或电信息。 控制单元基于测量装置的生物化学或电信息，它们的位置信息和预定的阈值条件来确定要照射的区域和要发射的强度，并且根据照明单元的照射来控制照明单元的照射 他们。