Abstract:
A method for the real-time estimation of the total consumption of a fluid, in particular water or gas, distributed from a unit (A) to users (b1, b2 . . . ) via a network of supply pipes (E) with a branch (d1, d2 . . . ), for each user, fitted with a counter (c1, c2 . . . ) of the fluid consumed by the user, which method involves defining cohorts of users having homogeneous behavior with regard to the consumption of fluid; defining, for at least one of these cohorts, a sample of users from the cohort that is statistically sufficient to represent the cohort; fitting only the branches of the users of each sample with a remote reading device (t1, t2, . . . ) for reading the consumption; also fitting remote reading devices to the branches of the users of the other cohorts that have not been sampled; and processing the information provided by the remote reading devices to obtain a real-time value representative of the total consumption of the network.
Abstract:
A method for the real-time estimation of the total consumption of a fluid, in particular water or gas, distributed from a unit (A) to users (b1, b2 . . . ) via a network of supply pipes (E) with a branch (d1, d2 . . . ), for each user, fitted with a counter (c1, c2 . . . ) of the fluid consumed by the user, which method involves defining cohorts of users having homogeneous behaviour with regard to the consumption of fluid; defining, for at least one of these cohorts, a sample of users from the cohort that is statistically sufficient to represent the cohort; fitting only the branches of the users of each sample with a remote reading device (t1, t2, . . . ) for reading the consumption; also fitting remote reading devices to the branches of the users of the other cohorts that have not been sampled; and processing the information provided by the remote reading devices to obtain a real-time value representative of the total consumption of the network.
Abstract:
The invention relates to a cellular microcompartment comprising successively, organized around a lumen, at least one layer of pluripotent cells, an extracellular matrix layer and an outer hydrogel layer. The invention also relates to processes for preparing such cellular microcompartments.
Abstract:
A medical device for the delivery of a therapeutic agent by bioprinting including a rod body including a bioprinting cartridge arranged near the distal end of the rod body including a top layer including a solution containing a therapeutic agent; and an absorbent compound capable of converting light energy from laser radiation into thermal energy and arranged to cause heating of the solution including a therapeutic agent to cause a jet of the solution; an optical fiber extending longitudinally within a lumen of the rod body to deliver laser flow onto the absorbing compound.
Abstract:
The invention relates to an electrochromic device (50). According to the invention, it comprises: —at least one substrate (51); —a first electrode (53) comprising a first opening (52) and a second electrode (54) comprising a second opening (55); —the two electrodes being positioned so that the two openings are opposite each other; —a layer (56) of electrochromic material adapted to be arranged relative to the first opening (52) of the first electrode so as to form at least one electrical contact zone between the layer of electrochromic material and the first electrode, said layer of electrochromic material and said first electrode thus together forming a working electrode and the second electrode forming a counter-electrode; —a layer (57) of electrolyte sandwiched between the working electrode and the counter-electrode; —an electrical power supply means configured to apply an electric voltage to the two electrodes.
Abstract:
Nanostructured surface coating (1) configured to generate visual appearances in a visible spectrum range, comprising: —a first layer comprising a random distribution of nanoparticles (2); —a substrate (3), on which the first layer is arranged; —the nanoparticles having an optical refraction index npart having a value suitable for each individually diffusing the incident light; —the nanoparticles being arranged so that the mean distance between two adjacent particles d is defined in accordance with the following relationship so as to produce interference between the light diffused by the particles: 2 R≤d≤max (λ/np), where R is the smallest geometric radius of a circle surrounding the particle, λ is the greatest wavelength of the visible spectrum, and np is the optical refractive index of the medium in which the nanoparticles are dispersed.
Abstract:
The present invention relates the field of reducing CD95-mediated cell motility in a subject, in particular for their use in the reduction of CD-95 mediated cancer cell motility, the reduction of CD95-mediated lymphocyte motility and/or B cell maturation, or the treatment of B-cell tumors, in a subject. The inventors identified a novel family of compounds having the ability to disrupt CD95/PLCγ1 interaction and to neutralize the CD95-mediated calcium signaling pathway and cell migration in human peripheral blood lymphocytes (PBLs) and Th17 cells. Thus, the present invention relates to compounds of formula (A) as defined in the present text, to a pharmaceutical composition comprising said compounds in a pharmaceutically acceptable medium and to the use of these compounds and compositions as medicament, in particular for their use in the reduction or treatment of the above-mentioned pathologies, and in particular in the treatment of cancers and autoimmune inflammatory disease such as systemic lupus erythematosus, inflammatory condition and Th17-mediated disease.
Abstract:
The invention relates to a process for inscribing a three-dimensional structure formed from variations in refractive index in the bulk of a transparent oxide glass comprising silver ions by femtosecond-laser-beam irradiation, the method comprising: generating a laser beam made up of a series of ultra-brief light pulses of pulse duration shorter than the characteristic time of thermalization of the glass so as to achieve an excitation at the point of irradiation via multi-photon interaction; focusing said beam at a desired depth in the glass; irradiating point by point the glass with said beam so as to form the structure in the glass along a predetermined path, the number of pulses, the repetition rate of the pulses and the irradiance at each irradiation point being controlled to induce an accumulation of silver aggregates localised in an annular peripheral region around an irradiation point, said accumulation of aggregates generating a variation in refractive index in the annular peripheral region around the irradiation point, and to erase a variation in refractive index in a segment of an annular peripheral region generated around another irradiation point when said segment of the peripheral region coincides with a region of the laser beam.
Abstract:
An applanation device designed to be positioned between the eye of a patient and a laser system, to hold the eye in position and create a reference plane for an ophthalmological laser surgery operation, the device comprising: an applanation cone defining an inner space, an upper opening and a lower opening; the applanation cone comprising an upper portion configured to be secured to a projecting portion of a focusing optical unit of the laser system and a lower portion comprising suction means; the lower opening being defined by a lower rim; an applanation glass that is transparent to the laser beam generated by the laser system and is positioned and held by the suction means against the lower rim so as to close the lower opening.
Abstract:
A method for producing a part having improved resistance to oxidation and high temperature-corrosion, includes the formation of an environmental barrier coating on an at least partially ceramic matrix composite material, the environmental barrier coating being formed by direct liquid injection-metal organic chemical vapor deposition.