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175 条记录 (耗时 0.077 秒)

    Process for producing penicillin
    21.
    发明申请
    Process for producing penicillin 审中-公开
    生产青霉素的方法

    公开(公告)号：US20070042457A1

    公开(公告)日：2007-02-22

    申请号：US10575560

    申请日：2004-10-14

    申请人： Kurt Schoergendorfer ,  Hubert Kurnsteiner

    发明人： Kurt Schoergendorfer ,  Hubert Kurnsteiner

    IPC分类号： C12P37/00 ,  C07H21/04 ,  C12N9/10 ,  C12N1/16 ,  C12N15/74

    CPC分类号： C12N9/1288

    摘要： The invention relates to isolated nucleic acid molecules, which code for a new protein of Penicillium chrysogenum, vectors which comprise a nucleic acid molecule of this kind, host cells which are transformed with such a nucleic acid molecule or vector, and a process for the production of penicillin using such transformed host cells.

    摘要翻译： 本发明涉及分离的核酸分子，其编码产黄青霉的新蛋白质，包含这种核酸分子的载体，用这种核酸分子或载体转化的宿主细胞，以及生产过程 的青霉素使用这种转化的宿主细胞。

    27411, a novel human PGP synthase
    22.
    发明申请
    27411, a novel human PGP synthase 审中-公开

    公开(公告)号：US20060205053A1

    公开(公告)日：2006-09-14

    申请号：US11369106

    申请日：2006-03-06

    申请人： Rachel Meyers

    发明人： Rachel Meyers

    IPC分类号： C12N9/10 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C12N9/1288

    摘要： The present invention relates to a newly identified human PGP synthase. The invention also relates to polynucleotides encoding the PGP synthase. The invention further relates to methods using the PGP synthase polypeptides and polynucleotides as a target for diagnosis and treatment in PGP synthase-mediated or -related disorders. The invention further relates to drug-screening methods using the PGP synthase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the PGP synthase polypeptides and polynucleotides. The invention further relates to procedures for producing the PGP synthase polypeptides and polynucleotides.

    PROTEIN GLYCOSYLATION MODIFICATION IN METHYLOTROPHIC YEAST
    28.
    发明申请
    PROTEIN GLYCOSYLATION MODIFICATION IN METHYLOTROPHIC YEAST 有权
    蛋白质糖蛋白在甲基黄酮中的修饰

    公开(公告)号：US20040018588A1

    公开(公告)日：2004-01-29

    申请号：US10185475

    申请日：2002-06-26

    发明人： Roland Contreras ,  Nico L.M. Callewaert ,  Steven C. J. Geysens ,  Vladimir Kaigorodov ,  Vervecken Wouter

    IPC分类号： C12P021/02 ,  C12N009/24 ,  C07H021/04 ,  C12N001/18 ,  C12N015/74

    CPC分类号： C12Y302/01114 ,  C12N9/1288 ,  C12N9/2488 ,  C12N15/815 ,  C12Y302/01024

    摘要： The present invention provides genetically engineered strains of methylotrophic yeast including Pichia and especially Pichia pastoris capable of producing proteins with reduced or modified glycosylation. Methods of producing glycoproteins with reduced and/or modified glycosylation using such genetically engineered strains of Pichia are also provided. Vectors, which comprise coding sequences for null-1,2-mannosidase I, glucosidase II, GlcNAc-tranferase I and mannosidase II or comprising OCH1 disrupting sequence, for transforming methylotrophic yeasts are contemplated by the present invention. Kit for providing the comtemplated vectors are also included in this invention.

    摘要翻译： 本发明提供了遗传工程改造的甲基营养酵母菌株，包括毕赤酵母，特别是巴斯德毕赤酵母能够产生具有降低或修饰的糖基化的蛋白质。 还提供了使用这种遗传工程改造的毕赤酵母菌株生产具有还原和/或修饰的糖基化的糖蛋白的方法。 包含用于转化甲基营养酵母的α-1,2-甘露糖苷酶I，葡糖苷酶II，GlcNAc转移酶I和甘露糖苷酶II或包含OCH1破坏序列的编码序列的载体被本发明考虑。 用于提供comtemplated载体的试剂盒也包括在本发明中。

    Substrate analogs for MurG, methods of making same and assays using same
    29.
    发明申请
    Substrate analogs for MurG, methods of making same and assays using same 失效
    MurG的底物类似物，制备方法和使用相同的测定法

    公开(公告)号：US20020182661A1

    公开(公告)日：2002-12-05

    申请号：US10127639

    申请日：2002-04-22

    发明人： Suzanne Walker Kahne ,  Hongbin Men ,  Peter Park ,  Min Ge

    IPC分类号： C12Q001/48

    CPC分类号： C12N9/1288 ,  A61K38/00 ,  C07H11/04 ,  Y10S530/812

    摘要： General methods for monitoring the activity of MurG, a GlcNAc transferase involved in bacterial cell wall biosynthesis, is disclosed. More particularly, the synthesis of simplified substrate analogs of Lipid I (the natural substrate for MurG), which function as acceptors for UDP-GlcNAc in an enzymatic reaction catalyzed by MurG, is described. Assays using the substrate analogs of the invention are further disclosed, which are useful for identifing a variety of other substrates, including inhibitors of MurG activity, for facilitating mechanistic and/or structural studies of the enzyme and for other uses. High throughput assays are also described.

    摘要翻译： 公开了用于监测参与细菌细胞壁生物合成的GlcNAc转移酶的MurG的活性的一般方法。 更具体地说，描述了由MurG催化的酶反应中用作UDP-GlcNAc的受体的脂质I（MurG的天然底物）的简化底物类似物的合成。 进一步公开了使用本发明的底物类似物的测定法，其可用于鉴定多种其它底物，包括MurG活性抑制剂，用于促进酶和/或其它用途的机械和/或结构研究。 还描述了高通量测定。

    32670, novel human phosphatidylserine synthase-like molecules and uses thereof
    30.
    发明授权
    32670, novel human phosphatidylserine synthase-like molecules and uses thereof 失效
    32670，新型人磷脂酰丝氨酸合酶样分子及其用途

    公开(公告)号：US06489152B1

    公开(公告)日：2002-12-03

    申请号：US09790838

    申请日：2001-02-22

    申请人： Rachel Meyers

    发明人： Rachel Meyers

    IPC分类号： C12N912

    CPC分类号： C12N9/1288

    摘要： Novel human phosphatidylserine synthase-like polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length human phosphatidylserine synthase-like proteins, the invention further provides isolated human phosphatidylserine synthase-like fusion proteins, antigenic peptides, and anti-human phosphatidylserine synthase-like antibodies. The invention also provides human phosphatidylserine synthase-like nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a human phosphatidylserine synthase-like gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 公开了新型人磷脂酰丝氨酸合酶样多肽，蛋白质和核酸分子。 除了分离的全长人磷脂酰丝氨酸合酶样蛋白之外，本发明还提供了分离的人磷脂酰丝氨酸合酶样融合蛋白，抗原肽和抗人磷脂酰丝氨酸合酶样抗体。 本发明还提供了人类磷脂酰丝氨酸合酶类核酸分子，含有本发明的核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中人磷脂酰丝氨酸合酶样基因具有的非人类转基因动物 被引入或中断。 还提供了利用本发明组合物的诊断，筛选和治疗方法。