公开(公告)号：US20150367147A1

公开(公告)日：2015-12-24

申请号：US14841586

申请日：2015-08-31

Applicant: Acoustic MedSystems, Inc.

Inventor： Everette C. Burdette ,  Dana Deardorff

IPC: A61N7/02

CPC classification number: A61N7/02 ,  A61B2017/00261 ,  A61N2007/0021 ,  A61N2007/0078

Abstract: An ultrasound device and method for the treatment of intervertebral disc tissue for remediation of back pain. An applicator comprises a catheter and/or needle with a distal tip including one or more ultrasound transducer crystals. The crystals produce high-powered ultrasound energy that is transmitted and absorbed in the disc tissue. The resulting temperature elevation of the disc tissue shrinks the collagen fibers in the surrounding tissue, and/or destroying small nerves that may have invaded and innervated the surrounding degenerated tissue, and can provide increased structural integrity and disc support for the fragmented nucleus pulposus to relieve pressure on the spinal nerves.

Abstract translation: 一种用于治疗椎间盘组织以治疗背部疼痛的超声装置和方法。 施加器包括具有包括一个或多个超声换能器晶体的远端的导管和/或针。 晶体产生高功率超声能量，其被传播和吸收在椎间盘组织中。 椎间盘组织的所得温度升高使周围组织中的胶原纤维收缩，和/或破坏可能侵入和支配周围的退化组织的小神经，并且可以为碎片髓核提供增加的结构完整性和椎间盘支撑以减轻 对脊神经的压力。

公开(公告)号：US20150251025A1

公开(公告)日：2015-09-10

申请号：US14517998

申请日：2014-10-20

Applicant: Center Of Human-Centered Interaction For Coexistence ,  Korea Institute of Science and Technology ,  Catholic University Industry Academic Cooperation Foundation

Inventor： Bum Jae You ,  Sung On Lee ,  Yong An Chung

IPC: A61N7/00

CPC classification number: A61N7/00 ,  A61B5/4064 ,  A61N2007/0021 ,  A61N2007/0026 ,  G06F1/00

Abstract: The present invention relates to an apparatus for creating a tactile sensation through non-invasive brain stimulation by using ultrasonic waves. The apparatus includes: an ultrasonic transducer module for inputting the ultrasonic waves to stimulate a specific part of the brain of a specified user non-invasively through at least one ultrasonic transducer unit; a compensating module for acquiring information on a range of tactile perception areas in the brain of the specified user and compensating properties of ultrasonic waves to be inputted to the specified user through the ultrasonic transducer unit by referring to the acquired information thereon; and an ultrasonic waves generating module for generating ultrasonic waves to be inputted to the specified user through the ultrasonic transducer unit by referring to a compensating value decided by the compensating module.

公开(公告)号：US09119954B2

公开(公告)日：2015-09-01

申请号：US13657464

申请日：2012-10-22

Applicant: Acoustic MedSystems, Inc.

Inventor： Everette C. Burdette ,  Dana Deardorff

IPC: A61N7/00 ,  A61N7/02 ,  A61B17/00

CPC classification number: A61N7/02 ,  A61B2017/00261 ,  A61N2007/0021 ,  A61N2007/0078

Abstract: An ultrasound device and method for the treatment of intervertebral disc tissue for remediation of back pain. An applicator comprises a catheter and/or needle with a distal tip including one or more ultrasound transducer crystals. The crystals produce high-powered ultrasound energy that is transmitted and absorbed in the disc tissue. The resulting temperature elevation of the disc tissue shrinks the collagen fibers in the surrounding tissue, and/or destroying small nerves that may have invaded and innervated the surrounding degenerated tissue, and can provide increased structural integrity and disc support for the fragmented nucleus pulposus to relieve pressure on the spinal nerves.

Abstract translation: 一种用于治疗椎间盘组织以治疗背部疼痛的超声装置和方法。 施加器包括具有包括一个或多个超声换能器晶体的远端的导管和/或针。 晶体产生高功率超声能量，其被传播和吸收在椎间盘组织中。 椎间盘组织的所得温度升高使周围组织中的胶原纤维收缩，和/或破坏可能侵入和支配周围的退化组织的小神经，并且可以为碎片髓核提供增加的结构完整性和椎间盘支撑以减轻 对脊神经的压力。

公开(公告)号：US08934978B2

公开(公告)日：2015-01-13

申请号：US14258802

申请日：2014-04-22

Applicant: Mark E. Deem ,  Hanson Gifford, III ,  Denise Zarins ,  Douglas Sutton ,  Erik Thai ,  Mark Gelfand ,  Howard R. Levin

Inventor： Mark E. Deem ,  Hanson Gifford, III ,  Denise Zarins ,  Douglas Sutton ,  Erik Thai ,  Mark Gelfand ,  Howard R. Levin

IPC: A61B18/12 ,  A61B18/14 ,  A61M5/14 ,  A61N1/04 ,  A61N1/05 ,  A61N1/32 ,  A61N1/36 ,  A61B18/18 ,  A61N5/00 ,  A61B18/00 ,  A61N7/00

CPC classification number: A61N1/36007 ,  A61B8/0891 ,  A61B8/12 ,  A61B18/1206 ,  A61B18/1233 ,  A61B18/1492 ,  A61B18/18 ,  A61B2018/00071 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00505 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00642 ,  A61B2018/00904 ,  A61B2018/126 ,  A61B2018/1467 ,  A61M5/14 ,  A61M25/0023 ,  A61N1/0412 ,  A61N1/05 ,  A61N1/0551 ,  A61N1/18 ,  A61N1/205 ,  A61N1/326 ,  A61N1/327 ,  A61N1/36017 ,  A61N1/36057 ,  A61N1/3606 ,  A61N1/36103 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/36139 ,  A61N5/00 ,  A61N7/00 ,  A61N2007/0021 ,  A61N2007/003

Abstract: Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.

公开(公告)号：US20140094720A1

公开(公告)日：2014-04-03

申请号：US14025586

申请日：2013-09-12

Applicant: Arizona Board of Regents for and on Behalf of Arizona State University

Inventor： William James P. TYLER

IPC: A61N7/00

CPC classification number: A61N7/00 ,  A61B5/0476 ,  A61B5/4836 ,  A61N5/0613 ,  A61N5/062 ,  A61N5/0622 ,  A61N2005/0651 ,  A61N2005/0652 ,  A61N2005/0653 ,  A61N2005/067 ,  A61N2007/0021 ,  A61N2007/0026 ,  A61N2007/0073 ,  A61N2007/0078 ,  C12N5/0619 ,  C12N13/00

Abstract: The present invention comprises methods and devices for modulating the activity or activities of living cells, such as cells found in or derived from humans, animals, plants, insects, microorganisms and other organisms. Methods of the present invention comprise use of the application of ultrasound, such as low intensity, low frequency ultrasound, to living cells to affect the cells and modulate the cells' activities. Devices of the present invention comprise one or more components for generating ultrasound waves, such as ultrasonic emitters, transducers or piezoelectric transducers, composite transducers, CMUTs, and which may be provided as single or multiple transducers or in an array configurations. The ultrasound waves may be of any shape, and may be focused or unfocused.

Abstract translation: 本发明包括用于调节活细胞的活性或活性的方法和装置，例如在人，动物，植物，昆虫，微生物和其他生物体中发现或衍生的细胞。 本发明的方法包括使用超声波（例如低强度，低频超声波）对活细胞的应用来影响细胞并调节细胞的活性。 本发明的装置包括用于产生超声波的一个或多个部件，例如超声波发射器，换能器或压电换能器，复合换能器，CMUT，并且其可被提供为单个或多个换能器或阵列配置。 超声波可以是任何形状，并且可以被聚焦或未被聚焦。

公开(公告)号：US08591419B2

公开(公告)日：2013-11-26

申请号：US13003853

申请日：2009-07-14

Applicant: William James P. Tyler

Inventor： William James P. Tyler

IPC: A61B8/00

CPC classification number: A61N7/00 ,  A61B5/0476 ,  A61B5/4836 ,  A61N5/0613 ,  A61N5/062 ,  A61N5/0622 ,  A61N2005/0651 ,  A61N2005/0652 ,  A61N2005/0653 ,  A61N2005/067 ,  A61N2007/0021 ,  A61N2007/0026 ,  A61N2007/0073 ,  A61N2007/0078 ,  C12N5/0619 ,  C12N13/00

Abstract: The present invention comprises methods and devices for modulating the activity or activities of living cells, such as cells found in or derived from humans, animals, plants, insects, microorganisms and other organisms. Methods of the present invention comprise use of the application of ultrasound, such as low intensity, low frequency ultrasound, to living cells to affect the cells and modulate the cells' activities. Devices of the present invention comprise one or more components for generating ultrasound waves, such as ultrasonic emitters, transducers or piezoelectric transducers, composite transducers, CMUTs, and which may be provided as single or multiple transducers or in an array configurations. The ultrasound waves may be of any shape, and may be focused or unfocused.

Abstract translation: 本发明包括用于调节活细胞的活性或活性的方法和装置，例如在人，动物，植物，昆虫，微生物和其他生物体中发现或衍生的细胞。 本发明的方法包括使用超声波（例如低强度，低频超声波）对活细胞的应用来影响细胞并调节细胞的活性。 本发明的装置包括用于产生超声波的一个或多个部件，例如超声波发射器，换能器或压电换能器，复合换能器，CMUT，并且其可被提供为单个或多个换能器或阵列配置。 超声波可以是任何形状，并且可以被聚焦或未被聚焦。

公开(公告)号：US20130131558A1

公开(公告)日：2013-05-23

申请号：US13300191

申请日：2011-11-18

Applicant: Susan J. Lee

Inventor： Susan J. Lee

IPC: A61N7/00 ,  A61H1/00

CPC classification number: A61N7/00 ,  A61H21/00 ,  A61H23/0236 ,  A61H23/0245 ,  A61H2201/0153 ,  A61H2201/5002 ,  A61H2201/5005 ,  A61H2201/5035 ,  A61H2205/02 ,  A61N2007/0004 ,  A61N2007/0021 ,  A61N2007/0043

Abstract: A system and method for treating, inhibiting or ameliorating Alzheimer's disease in a patient, comprising one or more transducers operatively connected to a power source for radiating vibrational or acoustical energy to the maxilla of the patient, wherein the energy is sufficient to radiate through the paranasal sinuses of the patient to the base of the patient's skull to assist in cerebrospinal fluid clearance and inhibit localized stasis of cerebrospinal fluid in the brain.

Abstract translation: 一种用于治疗，抑制或改善患者中的阿尔茨海默病的系统和方法，包括一个或多个可操作地连接到电源的换能器，用于向患者的上颌骨辐射振动或声能，其中所述能量足以辐射穿过鼻旁 患者鼻窦到患者头骨的基部，以帮助脑脊液清除并抑制脑内脑脊液的局部停滞。

公开(公告)号：US20130116685A1

公开(公告)日：2013-05-09

申请号：US13619950

申请日：2012-09-14

Applicant: Mark Deem ,  Hanson Gifford, III ,  Denise Demarais ,  Douglas Sutton ,  Erik Thai ,  Mark Gelfand ,  Howard R. Levin

Inventor： Mark Deem ,  Hanson Gifford, III ,  Denise Demarais ,  Douglas Sutton ,  Erik Thai ,  Mark Gelfand ,  Howard R. Levin

IPC: A61B18/14

CPC classification number: A61N1/36007 ,  A61B8/0891 ,  A61B8/12 ,  A61B18/1206 ,  A61B18/1233 ,  A61B18/1492 ,  A61B18/18 ,  A61B2018/00071 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00505 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00642 ,  A61B2018/00904 ,  A61B2018/126 ,  A61B2018/1467 ,  A61M5/14 ,  A61M25/0023 ,  A61N1/0412 ,  A61N1/05 ,  A61N1/0551 ,  A61N1/18 ,  A61N1/205 ,  A61N1/326 ,  A61N1/327 ,  A61N1/36017 ,  A61N1/36057 ,  A61N1/3606 ,  A61N1/36103 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/36139 ,  A61N5/00 ,  A61N7/00 ,  A61N2007/0021 ,  A61N2007/003

Abstract: Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.

Abstract translation: 提供使用脉冲电场进行肾神经调节以实现电穿孔或电融合的方法和装置。 预期肾脏神经调节（例如去神经支配）可以减少急性心肌梗塞的扩张，减少或预防与充血性心力衰竭有关的形态学变化的发生，和/或有效治疗 晚期肾脏疾病。 本发明的实施例被配置用于经皮血管内递送脉冲电场以实现这种神经调节。

公开(公告)号：US20130046208A1

公开(公告)日：2013-02-21

申请号：US13657464

申请日：2012-10-22

Applicant: Everette C. Burdette ,  Dana Deardoff

Inventor： Everette C. Burdette ,  Dana Deardoff

IPC: A61N7/00

CPC classification number: A61N7/02 ,  A61B2017/00261 ,  A61N2007/0021 ,  A61N2007/0078

Abstract: An ultrasound device and method for the treatment of intervertebral disc tissue for remediation of back pain. An applicator comprises a catheter and/or needle with a distal tip including one or more ultrasound transducer crystals. The crystals produce high-powered ultrasound energy that is transmitted and absorbed in the disc tissue. The resulting temperature elevation of the disc tissue shrinks the collagen fibers in the surrounding tissue, and/or destroying small nerves that may have invaded and innervated the surrounding degenerated tissue, and can provide increased structural integrity and disc support for the fragmented nucleus pulposus to relieve pressure on the spinal nerves.

Abstract translation: 一种用于治疗椎间盘组织以治疗背部疼痛的超声装置和方法。 施加器包括具有包括一个或多个超声换能器晶体的远端的导管和/或针。 晶体产生高功率超声能量，其被传播和吸收在椎间盘组织中。 椎间盘组织的所得温度升高使周围组织中的胶原纤维收缩，和/或破坏可能侵入和支配周围的退化组织的小神经，并且可以为碎片髓核提供增加的结构完整性和椎间盘支撑以减轻 对脊神经的压力。

公开(公告)号：US08292815B2

公开(公告)日：2012-10-23

申请号：US11818046

申请日：2007-06-12

Applicant: Everette C. Burdette ,  Dana Deardorff

Inventor： Everette C. Burdette ,  Dana Deardorff

IPC: A61B8/00

CPC classification number: A61N7/02 ,  A61B2017/00261 ,  A61N2007/0021 ,  A61N2007/0078

Abstract: An ultrasound device and method for the treatment of intervertebral disc tissue for remediation of back pain. An applicator comprises a catheter and/or needle with a distal tip including one or more ultrasound transducer crystals. The crystals produce high-powered ultrasound energy that is transmitted and absorbed in the disc tissue. The resulting temperature elevation of the disc tissue shrinks the collagen fibers in the surrounding tissue, and/or destroying small nerves that may have invaded and innervated the surrounding degenerated tissue, and can provide increased structural integrity and disc support for the fragmented nucleus pulposus to relieve pressure on the spinal nerves.

Abstract translation: 一种用于治疗椎间盘组织以治疗背部疼痛的超声装置和方法。 施加器包括具有包括一个或多个超声换能器晶体的远端的导管和/或针。 晶体产生高功率超声能量，其被传播和吸收在椎间盘组织中。 椎间盘组织的所得温度升高使周围组织中的胶原纤维收缩，和/或破坏可能侵入和支配周围的退化组织的小神经，并且可以为碎片髓核提供增加的结构完整性和椎间盘支撑以减轻 对脊神经的压力。