公开(公告)号：US08790298B2

公开(公告)日：2014-07-29

申请号：US13473988

申请日：2012-05-17

申请人： Nabil Dib

发明人： Nabil Dib

IPC分类号： A61M29/00 ,  A61M25/00 ,  A61M39/08 ,  A61M25/10 ,  A61M25/01 ,  A61M39/10

CPC分类号： A61M25/0023 ,  A61M25/0071 ,  A61M25/0075 ,  A61M25/1002 ,  A61M39/105 ,  A61M2025/0183 ,  A61M2025/1059 ,  A61M2025/1084 ,  A61M2025/1097 ,  A61M2039/085 ,  A61M2205/3334 ,  A61M2206/18

摘要： A system for moving particles suspended in a first fluid, and for infusing them into the stream of a second fluid, includes a catheter with a multi-lumen distal separator. The separator is formed with a plurality of parallel lumens, wherein each lumen has a predetermined diameter. Importantly, the diameter of each lumen is dimensioned to sequentially receive particles therethrough, to prevent the particles from flocculating before they enter the stream of the second fluid. A recollection chamber in fluid communication with the separator allows for reconsolidation of the fluid after leaving the separator and for minimizing the damage caused to the vessel when the fluid exits the catheter. An inflatable balloon, affixed to the outside of the catheter, can be provided to regulate flow of the second fluid and thereby facilitate entry of the particles into the stream of the second fluid and increase retention of particles in targeted tissue.

摘要翻译： 用于移动悬浮在第一流体中的颗粒并将其注入第二流体的流中的系统包括具有多腔远端分离器的导管。 分离器形成有多个平行的管腔，其中每个内腔具有预定的直径。 重要的是，每个内腔的直径的尺寸被设计成顺序地接收通过其中的颗粒，以防止颗粒在它们进入第二流体流之前絮凝。 与分离器流体连通的回收室允许在离开分离器之后重新固结流体，并且当流体离开导管时最小化对血管的损害。 可以提供固定到导管外侧的可充气气球，以调节第二流体的流动，从而促进颗粒进入第二流体的流中并增加颗粒在目标组织中的保留。

公开(公告)号：US20140051997A1

公开(公告)日：2014-02-20

申请号：US13763592

申请日：2013-02-08

申请人： ADVANCED CATHETER THERAPIES

发明人： C. Rex TEESLINK ,  Drik V. Hoyns

IPC分类号： A61M5/00

CPC分类号： A61M25/1011 ,  A61B1/04 ,  A61B17/12045 ,  A61B17/12109 ,  A61B17/12136 ,  A61B2017/00893 ,  A61B2017/12127 ,  A61M1/0088 ,  A61M5/007 ,  A61M39/24 ,  A61M2025/0183 ,  A61M2025/1013 ,  A61M2025/105 ,  A61M2025/1052 ,  A61M2025/1079 ,  A61M2025/1093 ,  A61M2025/1097 ,  A61M2205/3306 ,  A61M2205/3337 ,  A61M2205/3344

摘要： Catheters for occluding, visualizing, irrigating, evacuating, and delivering agents to a treatment area are disclosed. The catheters comprise a catheter body comprising five lumens, first and second occlusion balloons coupled to the catheter body, an optional space-occupying balloon coupled to the catheter body and disposed between the first and second occlusion balloons, and an optional visualization means that enables visualization between the first and second occlusion balloons. Methods for using these catheters are also disclosed. A method comprises inflating the first and second occlusion balloons, inflating the space-occupying balloon, allowing fluid to exit via an evacuation lumen, optionally irrigating or aspirating to facilitate fluid exit via said lumen, and delivering an agent to a treatment area via the agent lumen.

摘要翻译： 公开了用于闭塞，可视化，灌溉，撤离和递送药物到治疗区域的导管。 所述导管包括导管主体，所述导管主体包括耦合到所述导管主体的五个腔体，第一和第二闭塞球囊，耦合到所述导管主体并且设置在所述第一和第二闭塞气球之间的任选占空间球囊，以及允许可视化的可选可视化装置 在第一和第二遮挡气球之间。 还公开了使用这些导管的方法。 一种方法包括使第一和第二闭塞气囊膨胀，使空间占据的气囊膨胀，使得流体经由排空腔排出，任选地冲洗或吸入以促进经由所述内腔的流体出口，以及经由该试剂将药剂递送至治疗区域 流明。

公开(公告)号：US20130289528A1

公开(公告)日：2013-10-31

申请号：US13859395

申请日：2013-04-09

申请人： Grifols, S.A.

发明人： Dean Chamberlain ,  Valery Novokhatny ,  David Fineberg

IPC分类号： A61M25/10

CPC分类号： A61M25/10 ,  A61B17/1204 ,  A61B17/12109 ,  A61B17/12136 ,  A61B17/12172 ,  A61M25/00 ,  A61M25/0026 ,  A61M25/0043 ,  A61M25/0082 ,  A61M25/104 ,  A61M2025/0004 ,  A61M2025/0018 ,  A61M2025/0057 ,  A61M2025/0096 ,  A61M2025/105 ,  A61M2025/1052 ,  A61M2025/1081 ,  A61M2025/1097

摘要： Devices, systems, and methods for delivery of therapeutics, in particular thrombolytic agents, in particular plasmin, are provided. The devices, systems, and methods also provide for occlusion of a vessel or graft distal and/or proximal to a treatment zone. Also provided are devices, systems, and methods that trap emboli.

公开(公告)号：US20130281926A1

公开(公告)日：2013-10-24

申请号：US13806492

申请日：2011-06-22

申请人： Maxime Raux ,  Armelle Nicolas-Robin

发明人： Maxime Raux ,  Armelle Nicolas-Robin

IPC分类号： A61M1/36 ,  A61B17/12 ,  A61M25/00

CPC分类号： A61M1/3653 ,  A61B17/12109 ,  A61B17/12136 ,  A61M1/3613 ,  A61M1/3659 ,  A61M25/0026 ,  A61M25/007 ,  A61M25/1002 ,  A61M2025/1052 ,  A61M2025/1097

摘要： The invention relates to a cannula for medical use, which is obstructed at the distal end thereof and which has an occlusion balloon enabling regionalization of the extracorporeal circulation, it being possible for said cannula to be multiperforated.

摘要翻译： 本发明涉及一种用于医疗用途的套管，其在其远端处被阻塞并且具有能够使体外循环区分化的闭塞球囊，所述插管可以多孔穿孔。

公开(公告)号：US08486014B2

公开(公告)日：2013-07-16

申请号：US13072689

申请日：2011-03-26

申请人： John Kelly ,  Brian Kelly ,  Herinaina Rabarimanantsoa-Jamous

发明人： John Kelly ,  Brian Kelly ,  Herinaina Rabarimanantsoa-Jamous

IPC分类号： A61M25/00

CPC分类号： A61M25/1002 ,  A61M25/1029 ,  A61M25/104 ,  A61M2025/1084 ,  A61M2025/1097

摘要： A balloon dilatation catheter for use in a valvuloplasty procedure includes a catheter shaft and a spiral perfusion balloon mounted thereon. The perfusion balloon is formed from an inflatable tube that is in fluid communication with a catheter shaft inflation lumen. The inflatable tube is coiled into a series of windings that in an inflated configuration form a cylindrical or hourglass profile. In the inflated configuration, inner surfaces of the coiled windings of the inflatable tube define a perfusion lumen to allow blood flow through the perfusion balloon. Adjacent windings may be secured together with a flexible adhesive and/or a support weave formed from one or more filaments of material that criss-crosses between the adjacent windings along substantially the entire length of the spiral perfusion balloon.

摘要翻译： 用于瓣膜成形术的球囊扩张导管包括安装在其上的导管轴和螺旋灌注球囊。 灌注气球由与导管轴膨胀腔流体连通的可充气管形成。 可膨胀管被卷成一系列绕组，其以膨胀构型形成圆柱形或沙漏型。 在充气构造中，可膨胀管的线圈绕组的内表面限定了灌注腔，以允许血液流过灌注球囊。 相邻绕组可以用柔性粘合剂和/或由沿着螺旋形灌注气球的整个长度在相邻绕组之间交叉的一个或多个材料丝构成的支撑织物固定在一起。

公开(公告)号：US08262611B2

公开(公告)日：2012-09-11

申请号：US13228922

申请日：2011-09-09

申请人： C. Rex Teeslink ,  Dirk V. Hoyns

发明人： C. Rex Teeslink ,  Dirk V. Hoyns

IPC分类号： A61M25/00

CPC分类号： A61M25/1011 ,  A61B1/04 ,  A61B17/12045 ,  A61B17/12109 ,  A61B17/12136 ,  A61B2017/00893 ,  A61B2017/12127 ,  A61M1/0088 ,  A61M5/007 ,  A61M39/24 ,  A61M2025/0183 ,  A61M2025/1013 ,  A61M2025/105 ,  A61M2025/1052 ,  A61M2025/1079 ,  A61M2025/1093 ,  A61M2025/1097 ,  A61M2205/3306 ,  A61M2205/3337 ,  A61M2205/3344

摘要： Catheters for occluding, visualizing, irrigating, evacuating, and delivering agents to a treatment area are disclosed. The catheters comprise a catheter body comprising five lumens, first and second occlusion balloons coupled to the catheter body, an optional space-occupying balloon coupled to the catheter body and disposed between the first and second occlusion balloons, and an optional visualization means that enables visualization between the first and second occlusion balloons. Methods for using these catheters are also disclosed. A method comprises inflating the first and second occlusion balloons, inflating the space-occupying balloon, allowing fluid to exit via an evacuation lumen, optionally irrigating or aspirating to facilitate fluid exit via said lumen, and delivering an agent to a treatment area via the agent lumen.

公开(公告)号：US20120215202A1

公开(公告)日：2012-08-23

申请号：US13405995

申请日：2012-02-27

申请人： Arthur A. Bertolero ,  Raymond S. Bertolero ,  Jerome B. Riebman

发明人： Arthur A. Bertolero ,  Raymond S. Bertolero ,  Jerome B. Riebman

IPC分类号： A61M25/10

CPC分类号： A61B17/29 ,  A61B1/05 ,  A61B1/313 ,  A61B17/00234 ,  A61B17/0206 ,  A61B17/2812 ,  A61B17/320016 ,  A61B17/8085 ,  A61B46/10 ,  A61B90/36 ,  A61B90/37 ,  A61B90/50 ,  A61B2017/00199 ,  A61B2017/00243 ,  A61B2017/0046 ,  A61B2017/2904 ,  A61B2017/2905 ,  A61B2017/2946 ,  A61M1/3659 ,  A61M25/0029 ,  A61M25/0032 ,  A61M25/1027 ,  A61M2025/0031 ,  A61M2025/1052 ,  A61M2025/1086 ,  A61M2025/1097 ,  A61M2210/127

摘要： An extracorporeal circulation catheter has three independent channels and an expandable balloon at one end of the catheter. The first channel allows for delivery of blood to a patient in an amount sufficient to maintain the patient's metabolism and perfusion throughout the treatment or surgery. The second channel is integrated into the wall of the first channel and is suitable for delivering a fluid (e.g., for cardioplegia) to the heart. A third channel is integrated into the wall of the first channel and is suitable for delivering a fluid to the balloon for its expansion when positioned in the ascending aorta to occlude the flow of blood to the heart. The first channel accounts for at least about 70% of the total channel volume.

摘要翻译： 体外循环导管具有三个独立的通道和在导管的一端的可膨胀气囊。 第一通道允许以足以在整个治疗或手术中维持患者的新陈代谢和灌注的量向患者输送血液。 第二通道被集成到第一通道的壁中并且适合于向心脏递送流体（例如用于心脏停搏）。 第三通道被集成到第一通道的壁中，并且适于在定位在升主动脉中时将流体输送到气囊用于其膨胀，以将血液流动阻塞到心脏。 第一个频道至少占总频道的70％左右。

公开(公告)号：US20120116438A1

公开(公告)日：2012-05-10

申请号：US13351962

申请日：2012-01-17

申请人： Amr SALAHIEH ,  Alan SCHAER ,  Jeff KROLIK ,  John SPIRIDIGLIOZZI ,  Suresh PAI ,  Tom SAUL

发明人： Amr SALAHIEH ,  Alan SCHAER ,  Jeff KROLIK ,  John SPIRIDIGLIOZZI ,  Suresh PAI ,  Tom SAUL

IPC分类号： A61B17/12 ,  A61B17/00

CPC分类号： A61M25/0071 ,  A61M25/0054 ,  A61M25/0068 ,  A61M25/0074 ,  A61M25/0075 ,  A61M25/008 ,  A61M25/0082 ,  A61M25/0097 ,  A61M25/04 ,  A61M25/09 ,  A61M25/1002 ,  A61M2025/0079 ,  A61M2025/0096 ,  A61M2025/0681 ,  A61M2025/105 ,  A61M2025/1097 ,  A61M2202/0468 ,  A61M2202/0484 ,  A61M2202/049 ,  A61M2202/20 ,  A61M2210/12

摘要： Disrupting tissue and devices and systems for disrupting tissue. The disclosure describes ways to deliver moieties to a target tissue, where the target tissue in general is not at the point of introduction, in such a way that minimal damage is produced in the tissue at the point of introduction. In some embodiments this is accomplished by jetting fluid at high velocity into the target tissue. The disclosure further describes novel agents deliverable in such systems for use in remodeling tissues. Some of these agents comprise a liquid while others do not. Additionally, although not specifically described in detail much of the disclosure may additionally be used in the delivery of therapeutic drugs.

摘要翻译： 破坏组织和破坏组织的装置和系统。 本公开描述了将靶向组织递送到目标组织的方法，其中目标组织通常不在引入点，其方式是在引入点时在组织中产生最小损伤。 在一些实施例中，这是通过将流体高速喷射到目标组织来实现的。 本公开进一步描述了可用于重组组织的这种系统中可递送的新型试剂。 这些药剂中的一些包含液体，而另一些则不含。 另外，虽然没有详细描述，但是公开的许多内容可以另外用于递送治疗药物。

公开(公告)号：US20110313341A1

公开(公告)日：2011-12-22

申请号：US13221514

申请日：2011-08-30

申请人： Ghassan S. Kassab

发明人： Ghassan S. Kassab

IPC分类号： A61M1/00

CPC分类号： A61M27/00 ,  A61B5/02152 ,  A61M1/3653 ,  A61M1/3659 ,  A61M25/007 ,  A61M2025/1052 ,  A61M2025/1097 ,  A61M2205/3523 ,  A61M2205/3561

摘要： Devices, systems, and methods for organ retroperfusion. In at least one embodiment of a method of organ perfusion of the present disclosure, the method comprises the steps of positioning at least part of a first catheter having a cannula within an artery of a patient, the first catheter configured to permit arterial blood to flow therethrough and further configured to permit a portion of the arterial blood to flow through the cannula, positioning at least part of a second catheter within a vein of the patient at or near a target organ, the second catheter configured to receive some or all of the portion of the arterial blood, and connecting the cannula of the first catheter to a portion of the second catheter so that some or all of the portion of the arterial blood flowing through the cannula is provided into the vein to treat a condition or disease of the target organ.

摘要翻译： 用于器官后灌注的装置，系统和方法。 在本公开的器官灌注方法的至少一个实施例中，该方法包括以下步骤：将具有套管的第一导管的至少一部分定位在患者的动脉内，第一导管配置成允许动脉血流动 穿过并进一步构造成允许动脉血的一部分流过套管，将至少部分第二导管定位在患者的静脉内或在靶器官附近，该第二导管配置成接收部分或全部的 动脉血的一部分，并且将第一导管的插管连接到第二导管的一部分，使得流过插管的动脉血液的一部分或全部部分被提供到静脉中，以治疗这种疾病或疾病 目标器官

公开(公告)号：US20110282274A1

公开(公告)日：2011-11-17

申请号：US13041102

申请日：2011-03-04

申请人： Richard Eustis Fulton, III

发明人： Richard Eustis Fulton, III

IPC分类号： A61M1/00 ,  A61F2/01

CPC分类号： A61M25/1018 ,  A61B5/02152 ,  A61B17/12036 ,  A61B17/12045 ,  A61B17/12109 ,  A61B17/12136 ,  A61B17/12168 ,  A61B17/12172 ,  A61B2090/065 ,  A61F2/013 ,  A61M1/1006 ,  A61M1/1008 ,  A61M1/101 ,  A61M1/1018 ,  A61M1/1086 ,  A61M1/122 ,  A61M1/125 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/36 ,  A61M1/3615 ,  A61M1/367 ,  A61M1/3679 ,  A61M25/007 ,  A61M25/0074 ,  A61M25/0082 ,  A61M25/04 ,  A61M25/1011 ,  A61M2025/1015 ,  A61M2025/1052 ,  A61M2025/1097

摘要： An example of recovery catheter assembly comprises an actuator element and a mechanically radially expandable and contractible recovery device operably connected to the actuator element. The recovery device has proximal and distal blocking portions and a central portion therebetween. The recovery device is at least partially placeable in a first, radially collapsed configuration and in a second, radially expanded configuration by manipulation of the actuator element. When in the second, radially expanded configuration, the proximal and distal blocking portions have radial dimensions greater than the radial dimension of the central portion thereby at least partially defining a collection chamber at the central portion.

摘要翻译： 恢复导管组件的示例包括致动器元件和可操作地连接到致动器元件的机械可径向膨胀和收缩的恢复装置。 恢复装置具有近端和远端阻塞部分以及它们之间的中心部分。 恢复装置至少部分地可置于第一径向收缩构型中，并且通过操纵致动器元件在第二径向扩张构型中。 当处于第二径向扩张构型时，近端和远端阻挡部分的径向尺寸大于中心部分的径向尺寸，从而至少部分地在中心部分限定收集室。