公开(公告)号：US09750790B2

公开(公告)日：2017-09-05

申请号：US15383962

申请日：2016-12-19

Applicant: AGRICULTURAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Jiunn-Horng Lin ,  Jyh-Perng Wang ,  Ming-Wei Hsieh ,  Zeng-Weng Chen ,  Chien-Yu Fang ,  Hsueh-Tao Liu ,  Ping-Cheng Yang

IPC: A61K39/385 ,  A61K39/02 ,  A61K39/00

CPC classification number: A61K39/0241 ,  A61K39/0208 ,  A61K45/06 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/55505 ,  C07K14/30 ,  C12N15/70

Abstract: Provided in the present invention are anti-Mycoplasma spp. subunit vaccines, especially proteins suitable for being used as the active ingredient of the Mycoplasma spp. subunit vaccines, and a vaccine prepared therefrom. Upon experimenting, it is confirmed that the proteins can elicit an immune response having sufficient strength to avoid the infection of Mycoplasma spp. in pigs. The vaccine can comprise one of the aforementioned proteins as an active ingredient, or can comprise two or more of the proteins to form a form of cocktail vaccine. The vaccine of the present invention is not only more safe than conventional vaccines, but also has equivalent or even better immune effects.

公开(公告)号：US20170173147A1

公开(公告)日：2017-06-22

申请号：US15448077

申请日：2017-03-02

Applicant: Advanced BioNutrition Corp.

Inventor： MORDECHAI HAREL ,  BRIAN CARPENTER

IPC: A61K39/39 ,  A61K9/50 ,  C12N7/00 ,  A61K39/12 ,  A61K39/21 ,  A61K39/02 ,  A61K39/145

CPC classification number: A61K39/39 ,  A61K9/0043 ,  A61K9/006 ,  A61K9/5015 ,  A61K39/00 ,  A61K39/0208 ,  A61K39/0233 ,  A61K39/0241 ,  A61K39/12 ,  A61K39/145 ,  A61K39/21 ,  A61K2039/522 ,  A61K2039/5254 ,  A61K2039/5258 ,  A61K2039/541 ,  A61K2039/542 ,  A61K2039/543 ,  A61K2039/552 ,  A61K2039/55555 ,  A61K2039/55583 ,  C12N7/00 ,  C12N2720/10011 ,  C12N2720/10023 ,  C12N2720/10034 ,  C12N2740/10011 ,  C12N2740/10034 ,  C12N2760/10034 ,  C12N2760/16011 ,  C12N2760/16022 ,  C12N2760/16034

Abstract: The invention relates to a composition and a method for manufacturing semi-dry or dry particles containing a mucoadhesive polymer and a bioactive agent such as, but not limited to, an Immunogenic Substance (e.g., a vaccine), that allows the oral or nasal administration and delivery of the bioactive agent essentially unaltered to mucosal surfaces in the animal, including an aquatic animal.

公开(公告)号：US09662385B2

公开(公告)日：2017-05-30

申请号：US14013299

申请日：2013-08-29

Applicant: Zoetis Services LLC

Inventor： Paul Joseph Dominowski ,  Ramasamy Mannar Mannan ,  Richard Lee Krebs ,  James Richard Thompson ,  Tedd Alan Childers ,  Mary Kathryn Olsen ,  Robert John Yancey, Jr. ,  Risini Dhammika Weeratna ,  Shucheng Zhang ,  Cedo Martin Bagi

IPC: A61K45/00 ,  A61K39/39 ,  A61K39/00 ,  A61K39/012 ,  A61K39/02 ,  A61K39/108 ,  A61K39/12 ,  A61K39/145 ,  A61K39/15 ,  A61K39/21 ,  A61K39/215 ,  A61K39/002

CPC classification number: A61K39/39 ,  A61K39/0011 ,  A61K39/002 ,  A61K39/012 ,  A61K39/0208 ,  A61K39/0241 ,  A61K39/0258 ,  A61K39/12 ,  A61K39/145 ,  A61K39/15 ,  A61K39/21 ,  A61K39/215 ,  A61K2039/521 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/54 ,  A61K2039/55 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/55577 ,  C12N2720/12334 ,  C12N2720/12351 ,  C12N2740/13034 ,  C12N2740/13051 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2770/20034 ,  C12N2770/20051 ,  C12N2770/24334 ,  C12N2770/24351 ,  Y02A50/474

Abstract: This invention relates to adjuvant formulations comprising various combinations of triterpenoids, sterols, immunomodulators, polymers, and Th2 stimulators; methods for making the adjuvant compositions; and the use of the adjuvant formulations in immunogenic and vaccine compositions with different antigens. This invention further relates to the use of the formulations in the treatment of animals.

公开(公告)号：US09650600B2

公开(公告)日：2017-05-16

申请号：US14712393

申请日：2015-05-14

Applicant: Zoetis Services LLC

Inventor： Jeffrey E. Galvin ,  Gregory P. Nitzel ,  John Keith Garrett ,  James R. Kulawik, II ,  Tracy L. Ricker ,  Megan Marie Smutzer

IPC: C12N1/36 ,  A61K39/02 ,  C07K14/30 ,  A61K39/295 ,  A61K39/12 ,  A61K39/00

CPC classification number: A61K39/0241 ,  A61K39/0208 ,  A61K39/12 ,  A61K39/295 ,  A61K39/39 ,  A61K2039/521 ,  A61K2039/5252 ,  A61K2039/552 ,  A61K2039/55566 ,  A61K2039/70 ,  C07K14/30 ,  C12N1/36 ,  C12N2750/10021 ,  C12N2750/10034 ,  C12N2750/10063 ,  C12N2770/10034

Abstract: This invention provides an immunogenic composition including a soluble portion of a Mycoplasma hyopneumoniae (M.hyo) whole cell preparation, wherein the soluble portion of the M.hyo preparation is substantially free of both (i) IgG and (ii) immunocomplexes comprised of antigen bound to immunoglobulin.

公开(公告)号：US09642902B2

公开(公告)日：2017-05-09

申请号：US14655210

申请日：2014-01-21

Applicant: London School of Hygiene and Tropical Medicine

Inventor： Brendan Wren ,  Jon Cuccui ,  Madeleine Moule

IPC: A61K39/02 ,  A61K39/00 ,  A61K49/00 ,  A61K47/48 ,  C07K14/21 ,  C12M1/00 ,  A61K45/06 ,  C07K14/195

CPC classification number: A61K39/0208 ,  A61K45/06 ,  A61K47/646 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/57 ,  A61K2039/575 ,  A61K2039/6031 ,  A61K2039/6037 ,  A61K2039/6068 ,  A61K2039/70 ,  C07K14/195 ,  C07K14/21 ,  C12M23/00

Abstract: The disclosure relates to a glycoconjugate vaccine conferring protection against Francisella tularensis infections and a method to manufacture a glycoconjugate antigen.

公开(公告)号：US20170106072A1

公开(公告)日：2017-04-20

申请号：US15119661

申请日：2015-02-18

Applicant: ADVAXIS, INC.

Inventor： Robert PETIT

IPC: A61K39/02 ,  C07K14/195 ,  A61K45/06 ,  A61K39/00 ,  C12Q1/68 ,  G01N33/574

CPC classification number: A61K39/0208 ,  A61K39/0005 ,  A61K39/0011 ,  A61K45/06 ,  A61K2039/52 ,  A61K2039/522 ,  A61K2039/53 ,  A61K2039/572 ,  C07K14/195 ,  C07K2319/00 ,  C07K2319/95 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/574

Abstract: This invention provides methods and compositions for using evaluating biomarker expression in a disease and providing a multi-targeted Listeria-based immunotherapeutic approach against said disease. In a related aspect, the invention relates to a method of treating a disease in a subject, the method comprising the steps of: a. obtaining a biological sample from said subject; b. evaluating the expression of a predetermined number of biomarkers in said biological sample; c. administering to said subject a composition comprising a recombinant Listeria strain, said strain comprising a nucleic acid sequence encoding at least one fusion protein, wherein said fusion protein comprises a biomarker identified in said biological sample, wherein said biomarker is associated with said disease, wherein said biomarker is fused to a PEST-containing polypeptide, and wherein each fusion protein within said Listeria comprises a different biomarker, thereby treating said disease in said subject.

公开(公告)号：US09603924B2

公开(公告)日：2017-03-28

申请号：US14775003

申请日：2014-03-14

Applicant: INTERVET INTERNATIONAL B.V. ,  INTERVET INC.

Inventor： Brad Eddy ,  Zhisong Qiao ,  Kevin O'Connell

IPC: A61K39/39 ,  A61K39/155 ,  C12N7/00 ,  A61K39/215 ,  A61K39/265 ,  A61K39/102 ,  A61K39/02 ,  A61K39/12 ,  A61K39/245 ,  A61K47/26 ,  A61K47/18 ,  A61K39/00

CPC classification number: A61K39/39 ,  A61K39/02 ,  A61K39/0208 ,  A61K39/102 ,  A61K39/12 ,  A61K39/155 ,  A61K39/215 ,  A61K39/245 ,  A61K39/265 ,  A61K47/183 ,  A61K47/26 ,  A61K2039/5254 ,  A61K2039/552 ,  A61K2039/55583 ,  A61K2039/70 ,  C12N7/00 ,  C12N2710/16734 ,  C12N2760/12234 ,  C12N2760/18034 ,  C12N2760/18634 ,  C12N2770/20034 ,  C12N2770/24333 ,  C12N2770/24334

Abstract: The present invention discloses liquid stable bovine vaccines that comprise a live attenuated virus, and a sugar alcohol. The present invention also discloses the manufacture of such vaccines and methods of protecting an animal by administration of such vaccines.

公开(公告)号：US20170023586A1

公开(公告)日：2017-01-26

申请号：US15189062

申请日：2016-06-22

Applicant: Immport Therapeutics, Inc.

Inventor： Philip Felgner ,  Xiaowu Liang ,  Maria Laura Gennaro

IPC: G01N33/68

CPC classification number: C12N15/1068 ,  A61K39/015 ,  A61K39/0208 ,  A61K39/0225 ,  A61K39/04 ,  A61K39/098 ,  A61K39/118 ,  A61K39/12 ,  A61K39/245 ,  A61K39/285 ,  A61K39/385 ,  A61K2039/60 ,  C07K14/005 ,  C12N2710/16621 ,  C12N2710/16622 ,  C12N2710/16634 ,  C12N2710/24122 ,  C12N2710/24134 ,  G01N33/566 ,  G01N33/56911 ,  G01N33/56916 ,  G01N33/56927 ,  G01N33/5695 ,  G01N33/56983 ,  G01N33/56994 ,  G01N33/6854 ,  G01N2333/35 ,  G01N2469/20 ,  Y02A50/401 ,  Y02A50/412

Abstract: Contemplated compositions, devices, and methods are drawn to various antigens from the pathogen M. tuberculosis and their use in vaccines, therapeutic agents, and various diagnostic tests. In particularly preferred aspects, the antigens are immunodominant and have quantified and known relative reactivities with respect to sera of a population infected with the pathogen, and/or have a known association with a disease parameter

Abstract translation: 研究的组合物，装置和方法被描绘为来自病原体结核分枝杆菌的各种抗原及其在疫苗，治疗剂和各种诊断测试中的用途。 在特别优选的方面，抗原是免疫显性的，并且相对于感染病原体的群体的血清具有定量和已知的相对反应性，和/或具有与疾病参数的已知关联

公开(公告)号：US09463239B2

公开(公告)日：2016-10-11

申请号：US14048757

申请日：2013-10-08

Applicant: GEORGIA REGENTS RESEARCH INSTITUTE, INC.

Inventor： David Munn ,  Andrew Mellor

IPC: A61K31/405 ,  A61K39/39 ,  A61K31/343 ,  A61K31/381 ,  A61K31/704 ,  A61K39/00 ,  A61K39/002 ,  A61K39/02 ,  A61K39/04 ,  A61K39/21 ,  A61K39/245 ,  C12N7/00

CPC classification number: A61K39/39 ,  A61K31/343 ,  A61K31/381 ,  A61K31/405 ,  A61K31/704 ,  A61K39/0011 ,  A61K39/002 ,  A61K39/0208 ,  A61K39/04 ,  A61K39/21 ,  A61K39/245 ,  A61K2039/55511 ,  C12N7/00 ,  C12N2710/16134 ,  C12N2710/16171 ,  C12N2740/16034 ,  C12N2740/16071 ,  Y02A50/409 ,  Y02A50/411

Abstract: The present invention provides improved treatment methods by the administration of both an inhibitor of indoleamine-2,3-dioxygenase in addition to the administration of an additional therapeutic agent.

公开(公告)号：US20160279222A1

公开(公告)日：2016-09-29

申请号：US15034330

申请日：2014-11-13

Applicant: UNIVERSITY OF OSLO ,  NMBU VETERINÆRHØGSKOLEN ,  VETERINÆRINSTITUTTET

Inventor： Hanne WINTHER-LARSEN ,  Espen BRUDAL ,  Duncan COLQUHOUN

IPC: A61K39/02

CPC classification number: A61K39/0233 ,  A61K39/0208 ,  A61K2039/552

Abstract: The disclosure relates to outer membrane vesicles from Francisella and Piscirickettsia, and their use in vaccine compositions. In particular, the present disclosure relates to compositions and methods useful in inducing protective immunity against francisellosis or salmon rickettsial septicaemia (SRS) in fish.

Abstract translation: 本公开内容涉及来自弗朗西斯菌属（Filisella）和薄煎饼（Piscidickicickettsia）的外膜囊泡及其在疫苗组合物中的用途。 特别地，本公开内容涉及用于诱导针对鱼类中的弗朗西斯特氏菌病或鲑鱼立克次体败血病（SRS）的保护性免疫的组合物和方法。