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公开(公告)号：US09649369B2
公开(公告)日：2017-05-16
申请号：US14712426
申请日：2015-05-14
Applicant: Zoetis Services LLC
Inventor： Gregory P. Nitzel , Jeffrey E. Galvin , John Keith Garrett , James R. Kulawik, II , Tracy L. Ricker , Megan Marie Smutzer
IPC: A61K39/02 , A61K39/12 , A61K39/295 , A61K39/00
CPC classification number: A61K39/12 , A61K39/0241 , A61K39/105 , A61K39/295 , A61K2039/521 , A61K2039/5252 , A61K2039/552 , A61K2039/55566 , A61K2039/70 , C12N7/00 , C12N2750/10034
Abstract: This invention provides a multivalent immunogenic composition including a soluble portion of a Mycoplasma hyopneumoniae (M. hyo) whole cell preparation; and a porcine circovirus type 2 (PCV2) antigen, wherein the soluble portion of the M. hyo preparation is substantially free of both (i) IgG and (ii) immunocomplexes comprised of antigen bound to immunoglobulin.
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公开(公告)号：US20200330577A1
公开(公告)日：2020-10-22
申请号：US16859093
申请日：2020-04-27
Applicant: Zoetis Services LLC
Inventor： Jeffrey E. Galvin , Gregory P. Nitzel , John Keith Garrett , James R. Kulawik, II , Tracy L. Ricker , Megan Marie Smutzer
Abstract: This invention provides a Mycoplasma hyopneumoniae (M.hyo) antigen that is compatible with antigens from other swine pathogens, wherein the M.hyo antigen is a cell free M.hyo culture supernatant which is substantially free of swine IgG.
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公开(公告)号：US20190209673A1
公开(公告)日：2019-07-11
申请号：US16248239
申请日：2019-01-15
Applicant: Zoetis Services LLC
Inventor： Gregory P. Nitzel , Jeffrey E. Galvin , John Keith Garrett , James R. Kulawik, II , Tracy L. Ricker , Megan Marie Smutzer
IPC: A61K39/12 , A61K39/295 , A61K39/02 , C12N7/00
Abstract: This invention provides a combination of a first vaccine comprising a porcine circovirus type 2 (PCV2) antigen and a Mycoplasma hyopneumoniae (M. hyo) culture supernatant and a second vaccine comprising a porcine reproductive and respiratory syndrome (PRRS) virus antigen, for treating an animal against an infection with PCV2, an infection with M. hyo, and an infection with PRRS virus, wherein the M. hyo culture supernatant has been separated from insoluble cellular material and is substantially free of both IgG and immunocomplexes comprised of antigen bound to immunoglobulin.
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公开(公告)号：US10206991B2
公开(公告)日：2019-02-19
申请号：US15480949
申请日：2017-04-06
Applicant: Zoetis Services LLC
Inventor： Jeffrey E. Galvin , Gregory P. Nitzel , John Keith Garrett , James R. Kulawik, II , Tracy L. Ricker , Megan Marie Smutzer
Abstract: This invention provides an immunogenic composition including the supernatant of a Mycoplasma hyopneumoniae (M.hyo) culture, wherein the supernatant of the M.hyo culture has been separated from insoluble cellular material by centrifugation, filtration, or precipitation and is substantially free of both (i) IgG and (ii) immunocomplexes comprised of antigen bound to immunoglobulin.
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公开(公告)号：US20150283222A1
公开(公告)日：2015-10-08
申请号：US14712426
申请日：2015-05-14
Applicant: Zoetis Services LLC
Inventor： Gregory P. Nitzel , Jeffrey E. Galvin , John Keith Garrett , James R. Kulawik, II , Tracy L. Ricker , Megan Marie Smutzer
CPC classification number: A61K39/12 , A61K39/0241 , A61K39/105 , A61K39/295 , A61K2039/521 , A61K2039/5252 , A61K2039/552 , A61K2039/55566 , A61K2039/70 , C12N7/00 , C12N2750/10034
Abstract: This invention provides a multivalent immunogenic composition including a soluble portion of a Mycoplasma hyopneumoniae (M. hyo) whole cell preparation; and a porcine circovirus type 2 (PCV2) antigen, wherein the soluble portion of the M. hyo preparation is substantially free of both (i) IgG and (ii) immunocomplexes comprised of antigen bound to immunoglobulin.
Abstract translation: 本发明提供了包含猪肺炎支原体（M.hoo）全细胞制剂的可溶性部分的多价免疫原性组合物; 和猪圆环病毒2型（PCV2）抗原，其中M. hyo制剂的可溶部分基本上不含（i）IgG和（ii）由与免疫球蛋白结合的抗原组成的免疫复合物。
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Patent Agency Ranking
公开(公告)号：US10668145B2
公开(公告)日：2020-06-02
申请号：US16248239
申请日：2019-01-15
Applicant: Zoetis Services LLC
Inventor： Gregory P. Nitzel , Jeffrey E. Galvin , John Keith Garrett , James R. Kulawik, II , Tracy L. Ricker , Megan Marie Smutzer
IPC: A61K39/12 , A61K39/295 , A61K39/02 , C12N7/00 , A61K39/00
Abstract: This invention provides a combination of a first vaccine comprising a porcine circovirus type 2 (PCV2) antigen and a Mycoplasma hyopneumoniae (M. hyo) culture supernatant and a second vaccine comprising a porcine reproductive and respiratory syndrome (PRRS) virus antigen, for treating an animal against an infection with PCV2, an infection with M. hyo, and an infection with PRRS virus, wherein the M. hyo culture supernatant has been separated from insoluble cellular material and is substantially free of both IgG and immunocomplexes comprised of antigen bound to immunoglobulin.
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公开(公告)号：US20190134176A1
公开(公告)日：2019-05-09
申请号：US16249031
申请日：2019-01-16
Applicant: Zoetis Services LLC
Inventor： Jeffrey E. Galvin , Gregory P. Nitzel , John Keith Garrett , James R. Kulawik, II , Tracy L. Ricker , Megan Marie Smutzer
Abstract: This invention provides a protein-A or protein-G treated Mycoplasma hyopneumoniae (M.hyo) antigen that is compatible with antigens from other swine pathogens, wherein the M.hyo antigen is an M.hyo culture supernatant.
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公开(公告)号：US09125885B2
公开(公告)日：2015-09-08
申请号：US13850329
申请日：2013-03-26
Applicant: Zoetis Services LLC
Inventor： Gregory P. Nitzel , Jeffrey E. Galvin , John Keith Garrett , James R. Kulawik, II , Tracy L. Ricker , Megan Marie Smutzer
IPC: A61K39/295 , A61K39/02 , A61K39/12 , A61K39/00
CPC classification number: A61K39/12 , A61K39/0241 , A61K39/105 , A61K39/295 , A61K2039/521 , A61K2039/5252 , A61K2039/552 , A61K2039/55566 , A61K2039/70 , C12N7/00 , C12N2750/10034
Abstract: This invention provides a multivalent immunogenic composition including a soluble portion of a Mycoplasma hyopneumoniae (M. hyo) whole cell preparation; and a porcine circovirus type 2 (PCV2) antigen, wherein the soluble portion of the M. hyo preparation is substantially free of both (i) IgG and (ii) immunocomplexes comprised of antigen bound to immunoglobulin.
Abstract translation: 本发明提供了包含猪肺炎支原体（M.hoo）全细胞制剂的可溶性部分的多价免疫原性组合物; 和猪圆环病毒2型（PCV2）抗原，其中M. hyo制剂的可溶部分基本上不含（i）IgG和（ii）由与免疫球蛋白结合的抗原组成的免疫复合物。
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公开(公告)号：US09120859B2
公开(公告)日：2015-09-01
申请号：US13850318
申请日：2013-03-26
Applicant: Zoetis Services LLC
Inventor： Jeffrey E. Galvin , Gregory P. Nitzel , John Keith Garrett , James R. Kulawik , Tracy L. Ricker , Megan Marie Smutzer
CPC classification number: A61K39/0241 , A61K39/0208 , A61K39/12 , A61K39/295 , A61K39/39 , A61K2039/521 , A61K2039/5252 , A61K2039/552 , A61K2039/55566 , A61K2039/70 , C07K14/30 , C12N1/36 , C12N2750/10021 , C12N2750/10034 , C12N2750/10063 , C12N2770/10034
Abstract: This invention provides an immunogenic composition including a soluble portion of a Mycoplasma hyopneumoniae (M.hyo) whole cell preparation, wherein the soluble portion of the M.hyo preparation is substantially free of both (i) IgG and (ii) immunocomplexes comprised of antigen bound to immunoglobulin.
Abstract translation: 本发明提供了包含猪肺炎支原体（M.hyo）全细胞制剂的可溶性部分的免疫原性组合物，其中M.hyo制剂的可溶部分基本上不含（i）IgG和（ii）由抗原组成的免疫复合物 与免疫球蛋白结合。
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公开(公告)号：US10206993B2
公开(公告)日：2019-02-19
申请号：US15480973
申请日：2017-04-06
Applicant: Zoetis Services LLC
Inventor： Gregory P. Nitzel , Jeffrey E. Galvin , John Keith Garrett , James R. Kulawik, II , Tracy L. Ricker , Megan Marie Smutzer
IPC: A61K39/12 , C12N7/00 , A61K39/02 , A61K39/295 , A61K39/00
Abstract: This invention provides a multivalent immunogenic composition including a soluble portion of a Mycoplasma hyopneumoniae (M.hyo) whole cell preparation; a porcine circovirus type 2 (PCV2) antigen; and a Lawsonia intracellularis antigen, wherein the soluble portion of the M.hyo preparation is substantially free of both (i) IgG and (ii) immunocomplexes comprised of antigen bound to immunoglobulin.
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