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公开(公告)号：US08414684B2
公开(公告)日：2013-04-09
申请号：US12791732
申请日：2010-06-01
Applicant: Yan Liu , Christopher A. Pohl , Michael McAdams , Hamish Small , Zhongqing Lu , Milton Liu , Khosro Moshfegh
Inventor： Yan Liu , Christopher A. Pohl , Michael McAdams , Hamish Small , Zhongqing Lu , Milton Liu , Khosro Moshfegh
CPC classification number: B01D19/0073 , B01D19/0031 , B01D19/0036 , G01N30/32 , G01N30/96 , G01N2030/146
Abstract: A degas assembly including a low pressure fluid channel for carrying a wash fluid at a first pressure, a pressurized channel for carrying eluent including a gas at a second pressure higher than the first pressure, and a degas separator defining a fluid barrier between the low pressure fluid channel and pressurized fluid channel, the separator configured to retain liquid in the pressurized fluid channel and allow gas to flow through the separator to the low pressure fluid channel. The pressurized fluid channel may extend along an outer periphery of the low pressure fluid channel. The eluent may be received from an eluent generator at a pressure of at least about 3300 psi, and in various embodiments up to about 5000 psi. A liquid chromatography system and method are also disclosed.
Abstract translation: 一种脱气组件，包括用于在第一压力下承载洗涤流体的低压流体通道，用于承载包含在高于第一压力的第二压力的气体的洗脱液的加压通道，以及限定低压下的流体阻挡层的脱气分离器 流体通道和加压流体通道，分离器构造成将液体保持在加压流体通道中并允许气体通过分离器流动到低压流体通道。 加压流体通道可以沿着低压流体通道的外周延伸。 洗脱液可以在至少约3300psi的压力下从洗脱液发生器接收，并且在各种实施方案中可高达约5000psi。 还公开了液相色谱系统和方法。
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公开(公告)号：US20110290726A1
公开(公告)日：2011-12-01
申请号：US12791732
申请日：2010-06-01
Applicant: Yan Liu , Christopher A. Pohl , Michael McAdams , Hamish Small , Zhongqing Lu , Milton Liu , Khosro Moshfegh
Inventor： Yan Liu , Christopher A. Pohl , Michael McAdams , Hamish Small , Zhongqing Lu , Milton Liu , Khosro Moshfegh
IPC: B01D19/00
CPC classification number: B01D19/0073 , B01D19/0031 , B01D19/0036 , G01N30/32 , G01N30/96 , G01N2030/146
Abstract: A degas assembly including a low pressure fluid channel for carrying a wash fluid at a first pressure, a pressurized channel for carrying eluent including a gas at a second pressure higher than the first pressure, and a degas separator defining a fluid barrier between the low pressure fluid channel and pressurized fluid channel, the separator configured to retain liquid in the pressurized fluid channel and allow gas to flow through the separator to the low pressure fluid channel. The pressurized fluid channel may extend along an outer periphery of the low pressure fluid channel. The eluent may be received from an eluent generator at a pressure of at least about 3300 psi, and in various embodiments up to about 5000 psi. A liquid chromatography system and method are also disclosed.
Abstract translation: 一种脱气组件，包括用于在第一压力下承载洗涤流体的低压流体通道，用于承载包含在高于第一压力的第二压力的气体的洗脱液的加压通道，以及限定低压下的流体阻挡层的脱气分离器 流体通道和加压流体通道，分离器构造成将液体保持在加压流体通道中并允许气体通过分离器流动到低压流体通道。 加压流体通道可以沿着低压流体通道的外周延伸。 洗脱液可以在至少约3300psi的压力下从洗脱液发生器接收，并且在各种实施方案中可高达约5000psi。 还公开了液相色谱系统和方法。
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公开(公告)号：US20100144051A1
公开(公告)日：2010-06-10
申请号：US12706944
申请日：2010-02-17
Applicant: Yan Liu , Hamish Small , Nebojsa Avdalovic
Inventor： Yan Liu , Hamish Small , Nebojsa Avdalovic
CPC classification number: G01N30/96 , C25B1/16 , C25B1/22 , G01N30/02 , G01N30/34 , G01N2030/965 , Y10T436/25 , B01D15/36 , B01D15/426
Abstract: Method and apparatus for generating an acid or base, e.g. for chromatographic analysis of anions. For generating a base the method includes the steps of providing a cation source in a cation source reservoir, flowing an aqueous liquid stream through a base generation chamber separated from the cation source reservoir by a barrier (e.g. a charged membrane) substantially preventing liquid flow while providing a cation transport bridge, applying an electric potential between an anode cation source reservoir and a cathode in the base generation chamber to electrolytically generate hydroxide ions therein and to cause cations in the cation source reservoir to electromigrate and to be transported across the barrier toward the cathode to combine with the transported cations to form cation hydroxide, and removing the cation hydroxide in an aqueous liquid stream as an effluent from the first base generation chamber. Suitable cation sources include a salt solution, a cation hydroxide solution or cation exchange resin.
Abstract translation: 用于产生酸或碱的方法和设备，例如， 用于阴离子的色谱分析。 为了产生碱，该方法包括以下步骤：在阳离子源储存器中提供阳离子源，使水性液体流通过基本上防止液体流动的屏障（例如带电膜）与阳离子源储存器分离的碱性产生室流动， 提供阳离子输送桥，在基底产生室中的阳极阳离子源储存器和阴极之间施加电位以在其中电解产生氢氧根离子，并使阳离子源储存器中的阳离子电迁移并穿过屏障向着 阴极与所运送的阳离子结合以形成阳离子氢氧化物，并且以水溶液流中的阳离子氢氧化物作为来自第一碱基产生室的流出物除去。 合适的阳离子源包括盐溶液，阳离子氢氧化物溶液或阳离子交换树脂。
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公开(公告)号：US06955922B1
公开(公告)日：2005-10-18
申请号：US09612118
申请日：2000-07-07
Applicant: Yan Liu , Hamish Small , Nebojsa Avdalovic
Inventor： Yan Liu , Hamish Small , Nebojsa Avdalovic
IPC: G01N30/26 , B01D15/08 , B01J39/26 , B01J41/20 , C25B1/16 , C25B1/22 , G01N30/02 , G01N30/34 , G01N30/60 , G01N30/96
CPC classification number: G01N30/96 , C25B1/16 , C25B1/22 , G01N30/02 , G01N30/34 , G01N2030/965 , Y10T436/25 , B01D15/36 , B01D15/426
Abstract: Method and apparatus for generating an acid or base, e.g. for chromatographic analysis of anions. For generating a base the method includes the steps of providing a cation source in a cation source reservoir, flowing an aqueous liquid stream through a base generation chamber separated from the cation source reservoir by a barrier (e.g. a charged membrane) substantially preventing liquid flow while providing a cation transport bridge, applying an electric potential between an anode cation source reservoir and a cathode in the base generation chamber to electrolytically generate hydroxide ions therein and to cause cations in the cation source reservoir to electromigrate and to be transported across the barrier toward the cathode to combine with the transported cations to form cation hydroxide, and removing the cation hydroxide in an aqueous liquid stream as an effluent from the first base generation chamber. Suitable cation sources include a salt solution, a cation hydroxide solution or cation exchange resin.
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25.发明授权
公开(公告)号：US4696904A
公开(公告)日：1987-09-29
申请号：US843423
申请日：1986-03-24
Applicant: Timothy S. Stevens , Hamish Small
Inventor： Timothy S. Stevens , Hamish Small
CPC classification number: G01N30/34 , G01N2030/342 , G01N30/02
Abstract: The invention is the novel combination of liquid chromatographic separation of water from other components of an injected sample followed by electrochemical detection and quantitation of the separated water.
Abstract translation: 本发明是从注射样品的其他组分的液相色谱分离水的新型组合，然后进行电化学检测和分离的水的定量。
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Patent Agency Ranking
公开(公告)号：US4280923A
公开(公告)日：1981-07-28
申请号：US970493
申请日：1978-12-18
Applicant: Hamish Small , Jitka K. Solc
Inventor： Hamish Small , Jitka K. Solc
IPC: B01D15/08 , B01J20/291 , B01J20/32 , B01D17/00
CPC classification number: B01J20/291 , B01D15/34 , B01J20/103 , B01J20/261 , B01J20/262 , B01J20/264 , B01J20/28004 , B01J20/28019 , B01J20/28047 , B01J20/286 , B01J20/3092 , B01J20/3204 , B01J20/321 , B01J20/3217 , B01J20/327 , B01J20/3272 , B01J20/3293 , B01J2220/54 , B01J2220/58 , Y10T428/2993 , Y10T428/2998
Abstract: Colloidal particles are fractionated by size and dissolved polymers are fractionated by molecular weight by passing a polar solvent dispersion containing one or both through a bed of surface-bonded particles wherein the particles consist of a nonswellable inert core with a polar solvent-swellable surface coating of bonded organic polymer. The core can be either an insoluble cross-linked organic polymer gel or an inorganic solid such as silica or alumina.
Abstract translation: 胶体颗粒按尺寸分级，溶解的聚合物通过分子量分级，通过使含有一个或两个的极性溶剂分散体通过表面键合的颗粒床，其中颗粒由非易失性的惰性芯组成，极性溶剂溶胀表面涂层 粘合有机聚合物。 核心可以是不溶性交联的有机聚合物凝胶或无机固体如二氧化硅或氧化铝。
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27.发明授权
公开(公告)号：US4252644A
公开(公告)日：1981-02-24
申请号：US42674
申请日：1979-05-25
Applicant: Hamish Small , Timothy S. Stevesn
Inventor： Hamish Small , Timothy S. Stevesn
CPC classification number: B01D15/361 , B01J20/3221 , B01J39/26 , B01J41/20 , B01J47/006 , G01N30/96 , B01J2220/54
Abstract: An ion exchange composition comprising an insoluble substrate of a synthetic resin having ion exchanging sites at least on its available surface; and a finely divided, insoluble material comprising synthetic resin particles of from about 0.1 to about 5 microns median diameter (with respect to volume) having, at least on their outer surfaces, ion exchanging sites which attract the ion exchanging sites of the substrate, irreversibly attached as a monolayer to the available surface of the substrate. The composition is used for removal and separatin of ions, and is especially useful in liquid ion exchange chromatography. For example, a chromatographic separation of halide ions is effected with high speed and resolution by contacting an aqueous solution thereof with a bed of the ion exchange composition which consists of surface sulfonated resin beads of a styrene-divinylbenzene copolymer to the surface of which is irreversibly attached a monolayer of quaternary ammonium styrene-divinylbenzene copolymer resin particles in the hydroxy form, and then eluting the bed with an aqueous sodium hydroxide solution.
Abstract translation: 一种离子交换组合物，其包含至少在其可用表面上具有离子交换位点的合成树脂的不溶性底物; 和细碎的不溶性材料，其包含约0.1至约5微米中等直径（相对于体积）的合成树脂颗粒，其至少在其外表面上具有吸引衬底的离子交换位点的离子交换位点，不可逆地 作为单层附着到基材的可用表面。 该组合物用于离子的去除和分离，并且在液体离子交换层析中特别有用。 例如，通过使其水溶液与由苯乙烯 - 二乙烯基苯共聚物的表面磺化树脂珠组成的离子交换组合物的床接触，使其卤化物离子的色谱分离以高速和分辨率进行，其表面不可逆地 连接单羟乙基季铵苯乙烯 - 二乙烯基苯共聚物树脂颗粒，然后用氢氧化钠水溶液洗脱床。
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公开(公告)号：US4017262A
公开(公告)日：1977-04-12
申请号：US611107
申请日：1975-09-08
Applicant: Hamish Small , Timothy S. Stevens
Inventor： Hamish Small , Timothy S. Stevens
IPC: B01J39/26 , G01N30/40 , G01N30/46 , G01N30/52 , G01N30/60 , G01N30/96 , G01N27/08 , G01N31/04 , G01N31/08
CPC classification number: G01N30/461 , B01J39/26 , G01N30/96 , G01N2030/402 , G01N2030/525 , G01N2030/965
Abstract: Apparatus and method for chromatographic quantitative analysis of a solution containing a plurality of species of cations. A sample of the solution is added to a first ion exchange resin bed containing cation exchange resin and eluted therefrom with a solution of developing reagent consisting of either AgNO.sub.3 or BaCl.sub.2, chromatographic separation of the cationic species being achieved as elution proceeds. The effluent from the first ion exchange resin bed is passed through a second ion exchange resin bed containing anion exchange resin in a form appropriate to the precipitation of whichever metal ion is provided by the developing reagent, i.e., chloride or sulfate forms. As elution proceeds the cations exit from the second ion exchange bed without destroying the ionic separation achieved in the first ion exchange resin bed. Each separated cationic species is quantitatively sensed by a detector such as a conductivity cell on exiting from the second ion exchange resin bed.
Abstract translation: 用于色谱定量分析含有多种阳离子的溶液的装置和方法。 将溶液样品加入到含有阳离子交换树脂的第一离子交换树脂床上，并用由AgNO 3或BaCl 2组成的显影剂的溶液洗脱，洗脱进行时实现阳离子物质的色谱分离。 来自第一离子交换树脂床的流出物通过含有阴离子交换树脂的第二离子交换树脂床，其形式适于沉淀出由显影剂提供的任何金属离子，即氯化物或硫酸盐形式。 随着洗脱进行，阳离子从第二离子交换床离开而不破坏在第一离子交换树脂床中实现的离子分离。 每个分离的阳离子物质通过诸如从第二离子交换树脂床离开的电导率池的检测器进行定量检测。
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公开(公告)号：US08628652B2
公开(公告)日：2014-01-14
申请号：US13364078
申请日：2012-02-01
Applicant: Hamish Small , Yan Liu , Christopher A. Pohl
Inventor： Hamish Small , Yan Liu , Christopher A. Pohl
IPC: B01D61/44
CPC classification number: G01N30/96 , B01D61/427 , F04B17/00 , G01N30/32 , G01N30/34 , G01N30/6095
Abstract: A continuous electrochemical pump comprising a water generator compartment, an anode compartment on one side of said generator compartment, a cation exchange barrier, separating the generator compartment from the anode compartment, it first electrode in electrical communication with the anode compartment, a cathode compartment adjacent the generator chamber, an anion exchange barrier, separating the generation compartment from the cathode compartment, and a second electrode in electrical communication with the cathode compartment. Use of the pump as a sample concentrator. A feedback loop for the pump. A reservoir, with or without an intermediate piston, on the output side of the pump.
Abstract translation: 一种连续电化学泵，包括水发生器室，在所述发生器室的一侧上的阳极室，阳离子交换屏障，将发电机室与阳极隔室分离，第一电极与阳极室电连通，阴极室相邻 所述发生器室，阴离子交换屏障，将所述发电室与所述阴极室分开，以及与所述阴极室电连通的第二电极。 使用泵作为样品浓缩器。 泵的反馈回路。 在泵的输出侧具有或不具有中间活塞的储存器。
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公开(公告)号：US07153476B2
公开(公告)日：2006-12-26
申请号：US10176879
申请日：2002-06-21
Applicant: Yan Liu , Hamish Small , Nebojsa Avdalovic
Inventor： Yan Liu , Hamish Small , Nebojsa Avdalovic
CPC classification number: G01N30/96 , C25B1/16 , C25B1/22 , G01N30/02 , G01N30/34 , G01N2030/965 , Y10T436/25 , B01D15/36 , B01D15/426
Abstract: Method and apparatus for generating an acid or base, e.g. for chromatographic analysis of anions. For generating a base the method includes the steps of providing a cation source in a cation source reservoir, flowing an aqueous liquid stream through a base generation chamber separated from the cation source reservoir by a barrier (e.g. a charged membrane) substantially preventing liquid flow while providing a cation transport bridge, applying an electric potential between an anode cation source reservoir and a cathode in the base generation chamber to electrolytically generate hydroxide ions therein and to cause cations in the cation source reservoir to electromigrate and to be transported across the barrier toward the cathode to combine with the transported cations to form cation hydroxide, and removing the cation hydroxide in an aqueous liquid stream as an effluent from the first base generation chamber. Suitable cation sources include a salt solution, a cation hydroxide solution or cation exchange resin.
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