公开(公告)号：US20130249348A1

公开(公告)日：2013-09-26

申请号：US13739328

申请日：2013-01-11

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： Yet-Ming Chiang ,  Michael J. Cima ,  Timothy E. Chin

IPC: F03G7/00

CPC classification number: F03G7/005 ,  H01M2/16 ,  H01M4/485 ,  H01M4/505 ,  H01M4/525 ,  H01M4/587 ,  H01M6/30 ,  H01M2004/021 ,  H01M2010/4292

Abstract: The present invention provides systems, devices, and related methods, involving electrochemical actuation. In some cases, application of a voltage or current to a system or device of the invention may generate a volumetric or dimensional change, which may produce mechanical work. For example, at least a portion of the system may be constructed and arranged to be displaced from a first orientation to a second orientation. Systems such as these may be useful in various applications, including pumps (e.g., infusion pumps) and drug delivery devices, for example.

公开(公告)号：US11344217B2

公开(公告)日：2022-05-31

申请号：US14896806

申请日：2014-09-05

Applicant: Massachusetts Institute of Technology

Inventor： Michael J. Cima ,  Matthew Li ,  Christophoros C. Vassiliou ,  Negar Tavassolian ,  Lina Avancini Colucci

IPC: A61B5/055 ,  G01R33/50 ,  G01R33/383 ,  A61B5/00 ,  A61B5/02 ,  G01R33/44 ,  G01R33/46 ,  A61B5/145

Abstract: The invention features methods for detecting the hydration state or vascular volume of a subject using a device capable of nuclear magnetic resonance (NMR) measurement. The methods involve exposing a portion of a tissue of the subject in vivo to a magnetic field and RF pulse from the device to excite hydrogen nuclei of water within the tissue portion, and measuring a relaxation parameter of the hydrogen nuclei in the tissue portion, the relaxation parameter being a quantitative measure of the hydration state or vascular volume of the subject as a whole. The invention also features devices and computer-readable storage media for performing the methods of the invention.

公开(公告)号：US10967122B2

公开(公告)日：2021-04-06

申请号：US15745367

申请日：2016-08-05

Applicant: Massachusetts Institute of Technology

Inventor： Michael J. Cima

IPC: A61M5/142 ,  A61K9/00 ,  A61K31/57

Abstract: Abstract of the Disclosure Implantable drug delivery devices and methods of making and using the same are provided. The implantable drug delivery devices permit selective activation and deactivation of drug delivery while subcutaneously implanted in a patient without the use of electronic equipment or power. The devices include a bistable member that has two stable states. In a first stable state, the bistable member does not close off a fluidic pathway between a drug reservoir and a drug release aperture, thereby allowing drug release from the device. In a second stable state, the bistable member closes off or narrows the fluidic pathway, thereby reducing or preventing drug release from the device. A patient or another person can reversibly change the bistable member between the first and second stable states by applying pressure on the patient's skin over the site of implantation and/or manipulating the device through the patient's skin at the site of implantation.

公开(公告)号：US10646691B2

公开(公告)日：2020-05-12

申请号：US15412240

申请日：2017-01-23

Applicant: Massachusetts Institute of Technology

Inventor： Michael J. Cima ,  Heejin Lee

IPC: A61M25/00 ,  A61M25/01 ,  A61K9/00 ,  A61K31/167 ,  A61M31/00

Abstract: An implantable medical device is provided for controlled drug delivery within the bladder, or other body vesicle. The device may include at least one drug reservoir component comprising a drug; and a vesicle retention frame which comprises an elastic wire having a first end, an opposing second end, and an intermediate region therebetween, wherein the drug reservoir component is attached to the intermediate region of the vesicle retention frame. The retention frame prevents accidental voiding of the device from the bladder, and it preferably has a spring constant selected for the device to effectively stay in the bladder during urination while minimizing the irritation of the bladder.

公开(公告)号：US20200000382A1

公开(公告)日：2020-01-02

申请号：US16490634

申请日：2018-03-03

Applicant: Massachusetts Institute of Technology ,  Brigham and Women's Hospital

Inventor： Gregory James Ekchian ,  Michael J. Cima ,  Robert Cormack ,  Larissa Lee ,  Ehud Jeruham Schmidt

IPC: A61B5/145 ,  A61B5/055 ,  A61B5/1473 ,  A61B5/00 ,  A61N5/10 ,  G01R33/50 ,  G01R33/56 ,  G01R33/28

Abstract: An oxygen sensor is provided for measuring a dissolved oxygen concentration when deployed or implanted at a tissue site. The oxygen sensor includes a solid-state contrast agent for oxygen. The oxygen sensor is configured to indicate the dissolved oxygen concentration of a tissue when subjected to a magnetic resonance based method. The oxygen sensor may be used to map tumor oxygenation levels and for adaptive planning in brachytherapy.

公开(公告)号：US20190001053A1

公开(公告)日：2019-01-03

申请号：US15745367

申请日：2016-08-05

Applicant: Massachusetts Institute of Technology

Inventor： Michael J. Cima

IPC: A61M5/142 ,  A61K9/00 ,  A61K31/57

Abstract: Abstract of the Disclosure Implantable drug delivery devices and methods of making and using the same are provided. The implantable drug delivery devices permit selective activation and deactivation of drug delivery while subcutaneously implanted in a patient without the use of electronic equipment or power. The devices include a bistable member that has two stable states. In a first stable state, the bistable member does not close off a fluidic pathway between a drug reservoir and a drug release aperture, thereby allowing drug release from the device. In a second stable state, the bistable member closes off or narrows the fluidic pathway, thereby reducing or preventing drug release from the device. A patient or another person can reversibly change the bistable member between the first and second stable states by applying pressure on the patient's skin over the site of implantation and/or manipulating the device through the patient's skin at the site of implantation.

公开(公告)号：US10006841B2

公开(公告)日：2018-06-26

申请号：US15190634

申请日：2016-06-23

Applicant: Massachusetts Institute of Technology ,  Lahey Clinic Foundation, Inc.

Inventor： Michael J. Cima ,  Gregory J. Ekchian ,  Christophoros C. Vassiliou ,  Vincent H. Liu ,  Christoph Wald ,  Sebastian Flacke ,  Fredric D. Gordon

IPC: C12M1/34 ,  C12Q1/70 ,  G01N33/53 ,  G01N1/34 ,  A61F2/01 ,  G01N33/543 ,  G01N33/569

CPC classification number: G01N1/34 ,  A61F2/01 ,  G01N33/5302 ,  G01N33/5306 ,  G01N33/54313 ,  G01N33/56983

Abstract: Trapping devices and methods are provided for capturing a medical analyte, in blood or another biological fluid. The device may include a structural substrate and a binding agent, such as an antibody, affixed to the structural substrate, wherein the binding agent is capable of binding or attaching with a medical analyte, such as a viral particle, and the device is configured for placement in a biological cavity or vessel (containing a biological fluid) in a patient. The trapping device, which may be in a twisted coil shape, is configured to trap at least some of the medical analyte, such a viral particle, present in the biological fluid. The method may include deploying a trapping device into the patient's blood vessel; after a period following the deployment, removing the trapping device from the biological cavity or blood vessel; and then analyzing the trapping device for the presence of the medical analyte.

公开(公告)号：US20160354034A1

公开(公告)日：2016-12-08

申请号：US15172464

申请日：2016-06-03

Applicant: Massachusetts Institute of Technology

Inventor： Kevin C. Spencer ,  Jay Christopher Sy ,  Michael J. Cima

IPC: A61B5/00 ,  A61M37/00 ,  A61N1/05 ,  A61B5/04 ,  A61B5/0476

CPC classification number: A61B5/686 ,  A61B5/04001 ,  A61B5/0476 ,  A61B5/0478 ,  A61B5/6868 ,  A61B2562/125 ,  A61B2562/14 ,  A61M37/00 ,  A61N1/0534 ,  A61N1/0536 ,  A61N1/0551

Abstract: Systems, devices, and methods are provided for reducing scar formation about a neural implant due to brain tissue and neural implant movement. In an embodiment, a neural implant is provided which has a surface coating that matches one or more mechanical properties, such as elastic modulus, of the brain tissue, thereby reduce scar formation about the neural implant due to normal brain micromotion.

Abstract translation: 提供了系统，装置和方法，用于减少由于脑组织和神经植入物运动引起的关于神​​经植入物的瘢痕形成。 在一个实施例中，提供神经植入物，其具有匹配脑组织的一个或多个机械性质（例如弹性模量）的表面涂层，从而由于正常的脑微动作而减少关于神经植入物的瘢痕形成。

公开(公告)号：US20160341639A1

公开(公告)日：2016-11-24

申请号：US15190634

申请日：2016-06-23

Applicant: Massachusetts Institute of Technology ,  Lahey Clinic Foundation, Inc.

Inventor： Michael J. Cima ,  Gregory J. Ekchian ,  Christophoros C. Vassiliou ,  Vincent H. Liu ,  Christoph Wald ,  Sebastian Flacke ,  Fredric D. Gordon

IPC: G01N1/34 ,  G01N33/53 ,  A61F2/01 ,  G01N33/569

CPC classification number: G01N1/34 ,  A61F2/01 ,  G01N33/5302 ,  G01N33/5306 ,  G01N33/54313 ,  G01N33/56983

Abstract: Trapping devices and methods are provided for capturing a medical analyte, in blood or another biological fluid. The device may include a structural substrate and a binding agent, such as an antibody, affixed to the structural substrate, wherein the binding agent is capable of binding or attaching with a medical analyte, such as a viral particle, and the device is configured for placement in a biological cavity or vessel (containing a biological fluid) in a patient. The trapping device, which may be in a twisted coil shape, is configured to trap at least some of the medical analyte, such a viral particle, present in the biological fluid. The method may include deploying a trapping device into the patient's blood vessel; after a period following the deployment, removing the trapping device from the biological cavity or blood vessel; and then analyzing the trapping device for the presence of the medical analyte.

Abstract translation: 提供捕获装置和方法用于捕获血液或其它生物流体中的医学分析物。 该装置可以包括结构底物和粘附到结构底物上的结合剂，例如抗体，其中结合剂能够与医学分析物例如病毒颗粒结合或附着，并且该装置被配置用于 放置在患者体内的生物腔或血管（含有生物流体）中。 可以处于扭曲线圈形状的捕获装置构造成捕获存在于生物流体中的至少一些医学分析物（例如病毒颗粒）。 该方法可以包括将捕获装置部署到患者的血管中; 在部署之后一段时间后，将捕获装置从生物腔或血管中取出; 然后分析捕获装置是否存在医用分析物。