知搜-全球专利检索

  1. Login
  2. Sign Up

Search Results

29 records (took 0.019 seconds)

    Intravesical drug delivery devices
    1.
    发明授权
    Intravesical drug delivery devices 有权

    公开(公告)号：US11612718B2

    公开(公告)日：2023-03-28

    申请号：US16847862

    申请日：2020-04-14

    Applicant: Massachusetts Institute of Technology

    Inventor： Michael J. Cima ,  Heejin Lee

    IPC: A61M25/01 ,  A61K9/00 ,  A61K31/167 ,  A61M31/00

    Abstract: An implantable medical device is provided for controlled drug delivery within the bladder, or other body vesicle. The device may include at least one drug reservoir component comprising a drug; and a vesicle retention frame which comprises an elastic wire having a first end, an opposing second end, and an intermediate region therebetween, wherein the drug reservoir component is attached to the intermediate region of the vesicle retention frame. The retention frame prevents accidental voiding of the device from the bladder, and it preferably has a spring constant selected for the device to effectively stay in the bladder during urination while minimizing the irritation of the bladder.

    Single-sided magnets for remote nuclear magnetic resonance measurements
    3.
    发明授权
    Single-sided magnets for remote nuclear magnetic resonance measurements 有权

    公开(公告)号：US10564237B2

    公开(公告)日：2020-02-18

    申请号：US15957429

    申请日：2018-04-19

    Applicant: Massachusetts Institute of Technology

    Inventor： Ashvin Bashyam ,  Michael J. Cima ,  Matthew Li

    IPC: G01R33/38 ,  A61B5/055 ,  G01R33/383

    Abstract: A Unilateral Linear Halbach magnet configuration includes a central magnetized region recessed relative to adjacent magnetized regions disposed on opposite sides of the central magnetized region. The Unilateral Linear Halbach magnet configuration further includes side (or outer) magnetized regions disposed adjacent the center-adjacent magnetized regions. The center and center-adjacent magnetized regions have like-pointing magnetization vectors while the magnetization vectors of the side magnetized regions point in directions orthogonal to the magnetization vectors of the center and center-adjacent regions. Further, the magnetization vectors of the side magnetized regions point in opposite directions.

    IMPLANTABLE DEVICE FOR INTRAPERITONEAL DRUG DELIVERY
    6.
    发明申请
    IMPLANTABLE DEVICE FOR INTRAPERITONEAL DRUG DELIVERY 审中-公开

    公开(公告)号：US20180339143A1

    公开(公告)日：2018-11-29

    申请号：US16047521

    申请日：2018-07-27

    Applicant: Massachusetts Institute of Technology ,  The General Hospital Corporation

    Inventor： Michael J. Cima ,  Hongye Ye ,  Marcela Del Carmen ,  Michael Birrer

    IPC: A61M31/00 ,  A61K31/282 ,  A61M1/28

    Abstract: Drug delivery devices, medicaments, and methods are provided for the intraperitoneal treatment of ovarian cancer. An implantable device for drug delivery includes an elongated, flexible device having a housing defining a reservoir that contains a drug in solid or semi-solid form, and configured to be wholly deployed within the peritoneal cavity of a patient and continuously release a therapeutically effective amount of the drug over a period of at least 24 hours. A medicament includes cisplatin for administration into the peritoneal cavity of a patient continuously over a treatment period of at least 24 hours. A method of drug delivery includes implanting within the peritoneal cavity of a patient an elongated, flexible device having a reservoir containing a drug, solubilizing the drug at least in part with peritoneal fluid, and releasing an effective amount of the solubilized drug from the reservoir continuously for a period of at least 24 hours.

    MEDICAMENT, METHOD, AND DRUG DELIVERY DEVICE FOR TREATMENT OF OVARIAN CANCER
    7.
    发明申请
    MEDICAMENT, METHOD, AND DRUG DELIVERY DEVICE FOR TREATMENT OF OVARIAN CANCER 审中-公开
    用于治疗卵巢癌的药物，方法和药物递送装置

    公开(公告)号：US20150080847A1

    公开(公告)日：2015-03-19

    申请号：US14400216

    申请日：2013-05-09

    Applicant: Massachusetts Institute of Technology ,  The General Hospital Corporation

    Inventor： Michael J. Cima ,  Hongye Ye ,  Marcela Del Carmen ,  Michael Birrer

    IPC: A61M31/00

    CPC classification number: A61M31/002 ,  A61K31/282 ,  A61M1/28 ,  A61M2202/06 ,  A61M2205/04 ,  A61M2210/1017

    Abstract: Drug delivery devices, medicaments, and methods are provided for the intraperitoneal treatment of ovarian cancer. An implantable device for drug delivery includes an elongated, flexible device having a housing defining a reservoir that contains a drug in solid or semi-solid form, and configured to be wholly deployed within the peritoneal cavity of a patient and continuously release a therapeutically effective amount of the drug over a period of at least 24 hours. A medicament includes cisplatin for administration into the peritoneal cavity of a patient continuously over a treatment period of at least 24 hours. A method of drug delivery includes implanting within the peritoneal cavity of a patient an elongated, flexible device having a reservoir containing a drug, solubilizing the drug at least in part with peritoneal fluid, and releasing an effective amount of the solubilized drug from the reservoir continuously for a period of at least 24 hours.

    Abstract translation: 提供了药物递送装置，药物和方法用于卵巢癌的腹膜内治疗。 用于药物递送的可植入装置包括细长的柔性装置，其具有限定储存器的壳体，所述储存器包含固体或半固体形式的药物，并且构造成完全展开在患者的腹膜腔内并连续释放治疗有效量 的药物至少24小时。 药物包括用于在至少24小时的治疗期间连续施用于患者腹膜腔的顺铂。 药物递送的方法包括在患者的腹腔内植入细长的柔性装置，其具有含有药物的储存器，至少部分地使腹膜液溶解药物，并连续释放有效量的溶解药物 至少24小时。

    Intravesical drug delivery devices
    8.
    发明授权
    Intravesical drug delivery devices 有权

    公开(公告)号：US12296127B2

    公开(公告)日：2025-05-13

    申请号：US18125810

    申请日：2023-03-24

    Applicant: Massachusetts Institute of Technology

    Inventor： Michael J. Cima ,  Heejin Lee

    IPC: A61M31/00 ,  A61K9/00 ,  A61K31/167 ,  A61M25/01

    Abstract: An implantable medical device is provided for controlled drug delivery within the bladder, or other body vesicle. The device may include at least one drug reservoir component comprising a drug; and a vesicle retention frame which comprises an elastic wire having a first end, an opposing second end, and an intermediate region therebetween, wherein the drug reservoir component is attached to the intermediate region of the vesicle retention frame. The retention frame prevents accidental voiding of the device from the bladder, and it preferably has a spring constant selected for the device to effectively stay in the bladder during urination while minimizing the irritation of the bladder.

    METHODS AND SYSTEMS FOR ASSESSMENT OF LIVER FIBROSIS AND STEATOSIS
    10.
    发明申请
    METHODS AND SYSTEMS FOR ASSESSMENT OF LIVER FIBROSIS AND STEATOSIS 有权

    公开(公告)号：US20220110580A1

    公开(公告)日：2022-04-14

    申请号：US17496879

    申请日：2021-10-08

    Applicant: Massachusetts Institute of Technology

    Inventor： Ashvin Bashyam ,  Christopher Frangieh ,  Michael J. Cima

    IPC: A61B5/00 ,  G01R33/563 ,  G01R33/50

    Abstract: Methods for assessing steatosis and fibrosis in a patient's liver include (i) measuring a diffusion-weighted relaxometry signal of the liver, or portion thereof; and determining a fibrosis content of the liver or portion thereof based on the measured diffusion-weighted relaxometry signal, or (ii) measuring a relaxometry signal of the liver, or portion thereof; and determining a fat content of the liver or portion thereof based on the measured relaxometry signal. A system for such non-invasive sensing includes a static magnetic field source; RF transmitter coils connected to a pulse sequence generator; RF receiver coils configured to detect a magnetic field generated within liver tissues; and a signal acquisition and processor system configured to acquire signals from the RF receiver coils and perform a relaxation time (T2) relaxometry measurement, wherein the RF transmitter coils and pulse sequence generator are configured to apply a varying magnetic field to the liver tissues.

Patent Agency Ranking