公开(公告)号：US20220110580A1

公开(公告)日：2022-04-14

申请号：US17496879

申请日：2021-10-08

Applicant: Massachusetts Institute of Technology

Inventor： Ashvin Bashyam ,  Christopher Frangieh ,  Michael J. Cima

IPC: A61B5/00 ,  G01R33/563 ,  G01R33/50

Abstract: Methods for assessing steatosis and fibrosis in a patient's liver include (i) measuring a diffusion-weighted relaxometry signal of the liver, or portion thereof; and determining a fibrosis content of the liver or portion thereof based on the measured diffusion-weighted relaxometry signal, or (ii) measuring a relaxometry signal of the liver, or portion thereof; and determining a fat content of the liver or portion thereof based on the measured relaxometry signal. A system for such non-invasive sensing includes a static magnetic field source; RF transmitter coils connected to a pulse sequence generator; RF receiver coils configured to detect a magnetic field generated within liver tissues; and a signal acquisition and processor system configured to acquire signals from the RF receiver coils and perform a relaxation time (T2) relaxometry measurement, wherein the RF transmitter coils and pulse sequence generator are configured to apply a varying magnetic field to the liver tissues.

公开(公告)号：US20240132916A1

公开(公告)日：2024-04-25

申请号：US18276471

申请日：2022-02-09

Applicant: The Broad Institute, Inc. ,  Massachusetts Institute of Technology

Inventor： Feng Zhang ,  Michael Segel ,  Alim Ladha ,  Michelle Walsh ,  Christopher Frangieh

IPC: C12N15/90 ,  C12N9/22 ,  C12N15/11

CPC classification number: C12N15/907 ,  C12N9/22 ,  C12N15/11 ,  C12N2310/20 ,  C12N2800/90

Abstract: Systems and methods for targeted gene modification, targeted insertion, perturbation of gene transcripts, and nucleic acid editing. Novel nucleic acid targeting systems comprise components of CRISPR systems and non-LTR retrotransposon elements.

公开(公告)号：US20220218221A1

公开(公告)日：2022-07-14

申请号：US17604673

申请日：2020-04-24

Applicant: Massachusetts Institute of Technology

Inventor： Michael J Cima ,  Ashvin Bashyam ,  Christopher Frangieh

IPC: A61B5/055 ,  G01R33/383 ,  G01R33/44 ,  G01R33/38 ,  A61B5/00

Abstract: Devices and methods are provided for non-invasive sensing of tissue fluid distribution in a patient. The device includes one or more magnets configured to provide a static magnetic field source; one or more RF transmitter coils connected to a pulse sequence generator which are configured to apply a varying magnetic field to tissues of the patient; one or more RF receiver coils configured to detect a magnetic field generated within tissues of the patient; and a signal acquisition and processor system configured to acquire signals from the RF receiver coils and perform an NMR measurement of a relaxation parameter of hydrogen nuclei within a muscle tissue site of the patient. A single-sided MR sensor device may include permanent magnets arranged in a unilateral linear Halbach array; and RF coils and a processor which are configured to produce a depth-resolved, diffusion-weighted, multicomponent T2 relaxometry measurements of intramuscular fluid shifts in a patient.