公开(公告)号：US11344217B2

公开(公告)日：2022-05-31

申请号：US14896806

申请日：2014-09-05

Applicant: Massachusetts Institute of Technology

Inventor： Michael J. Cima ,  Matthew Li ,  Christophoros C. Vassiliou ,  Negar Tavassolian ,  Lina Avancini Colucci

IPC: A61B5/055 ,  G01R33/50 ,  G01R33/383 ,  A61B5/00 ,  A61B5/02 ,  G01R33/44 ,  G01R33/46 ,  A61B5/145

Abstract: The invention features methods for detecting the hydration state or vascular volume of a subject using a device capable of nuclear magnetic resonance (NMR) measurement. The methods involve exposing a portion of a tissue of the subject in vivo to a magnetic field and RF pulse from the device to excite hydrogen nuclei of water within the tissue portion, and measuring a relaxation parameter of the hydrogen nuclei in the tissue portion, the relaxation parameter being a quantitative measure of the hydration state or vascular volume of the subject as a whole. The invention also features devices and computer-readable storage media for performing the methods of the invention.