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    Surgical Microscopes Using Optical Coherence Tomography and Related Systems and Methods
    22.
    发明申请
    Surgical Microscopes Using Optical Coherence Tomography and Related Systems and Methods 有权
    手术显微镜使用光学相干断层扫描及相关系统和方法

    公开(公告)号：US20130265545A1

    公开(公告)日：2013-10-10

    申请号：US13836576

    申请日：2013-03-15

    Applicant: BIOPTIGEN, INC.

    Inventor： Eric L. Buckland ,  Nestor O. Farmiga ,  Robert H. Hart ,  Andrew Murnan ,  Christopher Saxer

    IPC: A61B3/10 ,  G01B9/02

    CPC classification number: A61B3/102 ,  A61B3/13 ,  A61B3/132 ,  A61B5/0066 ,  G01B9/02039 ,  G01B9/02091 ,  G02B1/11 ,  G02B21/0012 ,  G02B21/0048 ,  G02B21/006 ,  G02B21/02 ,  G02B21/025 ,  G02B27/0031 ,  G02B27/0955 ,  G02B27/141

    Abstract: Some embodiments of the present inventive concept provide optical coherence tomography (OCT) systems for integration with a microscope. The OCT system includes a sample arm coupled to the imaging path of a microscope. The sample arm includes an input beam zoom assembly including at least two movable lenses configured to provide shape control for an OCT signal beam; a scan assembly including at least one scanning mirror and configured for telecentric scanning of the OCT signal beam; and a beam expander configured to set the OCT signal beam diameter incident on the microscope objective. The shape control includes separable controls for numerical aperture and focal position of the imaged OCT beam.

    Abstract translation: 本发明构思的一些实施例提供了用于与显微镜集成的光学相干断层摄影（OCT）系统。 OCT系统包括耦合到显微镜的成像路径的样品臂。 所述采样臂包括输入光束变焦组件，其包括至少两个可移动透镜，所述可移动透镜被配置为提供OCT信号光束的形状控制 扫描组件，其包括至少一个扫描镜并被配置为用于远心扫描所述OCT信号光束; 以及光束扩展器，其被配置为设置入射在显微镜物镜上的OCT信号光束直径。 形状控制包括成像OCT束的数值孔​​径和焦点位置的可分离控制。

    Configurable optical beam scan drive sytems
    23.
    发明授权
    Configurable optical beam scan drive sytems 有权

    公开(公告)号：US10791255B2

    公开(公告)日：2020-09-29

    申请号：US15523002

    申请日：2015-11-06

    Applicant: Bioptigen, Inc.

    Inventor： Mehran Ghofrani ,  Al-Hafeez Z. Dhalla ,  Christopher Saxer

    IPC: H04N5/225 ,  A61B3/10 ,  G01B9/02 ,  A61B3/13

    Abstract: A scanning optical system is provided including a source of optical radiation; an optical scanning beam delivery system for delivering optical radiation to a subject, wherein the optical scanning beam delivery system includes a plurality of optical elements including at least one steerable mirror; at least one actuator coupled to the at least one steerable mirror; a detection system for detecting optical radiation returned from a subject; a communications device including a user interface and configured to process a set of instructions at least partially responsive to inputs from the user interface; a controller comprising memory, a microcontroller and an field programmable gate array (FPGA), the microcontroller and FPGA receiving instructions derived from the communications device; and at least one actuator coupled to the at least one steerable mirror. The at least one actuator receives a first instruction set from the microcontroller in the form of sequential commands and a second instruction set from the FPGA in the form of concurrent commands. The first instruction set establishes a pattern of motion of the at least one steerable mirror at least partially responsive to inputs from the user interface of the communications device. The second instruction set modifies an attribute of the pattern of motion of the at least one steerable mirror in substantially real-time at least partially responsive to one or more triggering events.

    Linearized variable-dispersion spectrometers and related assemblies
    27.
    发明授权
    Linearized variable-dispersion spectrometers and related assemblies 有权
    线性化可变色散光谱仪及相关组件

    公开(公告)号：US09304038B2

    公开(公告)日：2016-04-05

    申请号：US14322986

    申请日：2014-07-03

    Applicant: Bioptigen, Inc.

    Inventor： Christopher Saxer ,  Robert H. Hart ,  Eric L. Buckland ,  Peter Huening ,  Bradley A. Bower

    IPC: G01J3/28 ,  G01J3/02 ,  A61B3/10 ,  A61B5/00 ,  G01J3/14 ,  G01J3/18 ,  G01J3/12

    CPC classification number: G01J3/0208 ,  A61B3/1005 ,  A61B5/0066 ,  G01J3/14 ,  G01J3/1804 ,  G01J3/28 ,  G01J2003/1208

    Abstract: Wavenumber linear spectrometers are provided including an input configured to receive electromagnetic radiation from an external source; collimating optics configured to collimate the received electromagnetic radiation; a dispersive assembly including first and second diffractive gratings, wherein the first diffraction grating is configured in a first dispersive stage to receive the collimated electromagnetic radiation and wherein the dispersive assembly includes at least two dispersive stages configured to disperse the collimated input; and an imaging lens assembly configured to image the electromagnetic radiation dispersed by the at least two dispersive stages onto a linear detection array such that the variation in frequency spacing along the linear detection array is no greater than about 10%.

    Abstract translation: 提供波数线性光谱仪，其包括被配置为从外部源接收电磁辐射的输入; 准直光学器件，被配置成准直所接收的电磁辐射; 包括第一和第二衍射光栅的分散组件，其中所述第一衍射光栅被配置在第一色散级中以接收所述准直电磁辐射，并且其中所述色散组件包括被配置为分散所述准直输入的至少两个色散级; 以及成像透镜组件，被配置为将由至少两个色散级分散的电磁辐射成像到线性检测阵列上，使得沿着线性检测阵列的频率间隔的变化不大于约10％。

    Image Registration, Averaging, and Compounding for High Speed Extended Depth Optical Coherence Tomography
    29.
    发明申请
    Image Registration, Averaging, and Compounding for High Speed Extended Depth Optical Coherence Tomography 有权
    图像配准，平均和复合高速扩展深度光学相干断层扫描

    公开(公告)号：US20150159992A1

    公开(公告)日：2015-06-11

    申请号：US14561772

    申请日：2014-12-05

    Applicant: Bioptigen, Inc.

    Inventor： Eric L. Buckland ,  Al-Hafeez Z. Dhalla ,  Nestor O. Farmiga ,  Mehran Ghofrani ,  Robert H. Hart ,  Andrew Murnan ,  Christopher Saxer

    IPC: G01B9/02

    CPC classification number: G01B9/02087 ,  A61B3/102 ,  G01B9/02004 ,  G01B9/02028 ,  G01B9/02044 ,  G01B9/02091

    Abstract: An optical coherence tomography (OCT) system including a source of broadband optical radiation and a beamsplitter coupled to the source is provided. The beamsplitter divides the source radiation into a reference path and a sample path. The reference path includes an optical switch to switch the reference path between a first path having a first reference reflector at a first reference optical path length and a second path having a second reference reflector at a second reference optical path length, different from the first reference optical path length. The system further includes a beam combiner that mixes source radiation reflected from a subject in the sample path with source radiation returned from the first reference reflector during a first time interval and the second reference reflector during a second time interval. A detection system detects a first wavelength dependent interferogram during the first time interval and a second wavelength dependent interferogram during the second time interval. A processor preconditions the first and second wavelength dependent interferograms; multiples the first preconditioned wavelength dependent interferogram and the second preconditioned wavelength dependent interferogram; and computes a first A-scan from the first wavelength dependent interferogram; a second A-scan from the second wavelength dependent interferogram; a spatial offset between the first and second A-scans derived from the multiplicative product of the preconditioned first and second wavelength dependent interferograms; and a combined A-scan from the first and second A-scans.

    Abstract translation: 提供了包括宽带光辐射源和耦合到源的分束器的光学相干断层摄影（OCT）系统。 分束器将源辐射分为参考路径和采样路径。 参考路径包括一个光学开关，用于在具有第一参考光路长度的第一参考反射器的第一路径和第二参考反射器之间切换参考路径，第二路径具有第二参考光路长度，第二参考反射器不同于第一参考 光路长度。 该系统还包括一个光束组合器，它将来自采样通路中的被摄体反射的源辐射与在第一时间间隔期间从第一参考反射器返回的源辐射和第二时间间隔内的第二参考反射器混合。 检测系统在第一时间间隔期间检测第一波长相关干涉图，并且在第二时间间隔期间检测第二波长相关干涉图。 处理器预先规定第一和第二波长依赖干涉图; 第一预处理波长依赖干涉图和第二预处理波长依赖干涉图的倍数; 并从第一波长依赖干涉图计算第一A扫描; 来自第二波长依赖性干涉图的第二A扫描; 从预处理的第一和第二波长相关干涉图的乘积产生的第一和第二A-扫描之间的空间偏移; 以及来自第一和第二A扫描的组合的A扫描。

    Linearized Variable-Dispersion Spectrometers and Related Assemblies
    30.
    发明申请
    Linearized Variable-Dispersion Spectrometers and Related Assemblies 有权
    线性化可变色散光谱仪及相关组件

    公开(公告)号：US20140313509A1

    公开(公告)日：2014-10-23

    申请号：US14322986

    申请日：2014-07-03

    Applicant: Bioptigen, Inc.

    Inventor： Christopher Saxer ,  Robert H. Hart ,  Eric L. Buckland ,  Peter Huening ,  Bradley A. Bower

    IPC: G01J3/02 ,  G01J3/28

    CPC classification number: G01J3/0208 ,  A61B3/1005 ,  A61B5/0066 ,  G01J3/14 ,  G01J3/1804 ,  G01J3/28 ,  G01J2003/1208

    Abstract: Wavenumber linear spectrometers are provided including an input configured to receive electromagnetic radiation from an external source; collimating optics configured to collimate the received electromagnetic radiation; a dispersive assembly including first and second diffractive gratings, wherein the first diffraction grating is configured in a first dispersive stage to receive the collimated electromagnetic radiation and wherein the dispersive assembly includes at least two dispersive stages configured to disperse the collimated input; and an imaging lens assembly configured to image the electromagnetic radiation dispersed by the at least two dispersive stages onto a linear detection array such that the variation in frequency spacing along the linear detection array is no greater than about 10%.

    Abstract translation: 提供波数线性光谱仪，其包括被配置为从外部源接收电磁辐射的输入; 准直光学器件，被配置成准直所接收的电磁辐射; 包括第一和第二衍射光栅的分散组件，其中所述第一衍射光栅被配置在第一色散级中以接收所述准直电磁辐射，并且其中所述色散组件包括被配置为分散所述准直输入的至少两个色散级; 以及成像透镜组件，被配置为将由至少两个色散级分散的电磁辐射成像到线性检测阵列上，使得沿着线性检测阵列的频率间隔的变化不大于约10％。

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