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    Image Registration, Averaging, and Compounding for High Speed Extended Depth Optical Coherence Tomography
    1.
    发明申请
    Image Registration, Averaging, and Compounding for High Speed Extended Depth Optical Coherence Tomography 审中-公开
    图像配准，平均和复合高速扩展深度光学相干断层扫描

    公开(公告)号：US20160298953A1

    公开(公告)日：2016-10-13

    申请号：US15190299

    申请日：2016-06-23

    Applicant: Bioptigen, Inc.

    Inventor： Eric L. Buckland ,  Al-Hafeez Z. Dhalla ,  Nestor O. Farmiga ,  Mehran Ghofrani ,  Robert H. Hart ,  Andrew Murnan ,  Christopher Saxer

    IPC: G01B9/02 ,  A61B3/10

    CPC classification number: G01B9/02087 ,  A61B3/102 ,  G01B9/02004 ,  G01B9/02028 ,  G01B9/02044 ,  G01B9/02091

    Abstract: An optical coherence tomography (OCT) system including a source of broadband optical radiation and a beamsplitter coupled to the source is provided. The beamsplitter divides the source radiation into a reference path and a sample path. The reference path includes an optical switch to switch the reference path between a first path having a first reference reflection at a first reference optical path length and a second path having a second reference reflection at a second reference optical path length. The system further includes a beam combiner that mixes source radiation reflected from a subject in the sample path with source radiation returned from the first reference reflection and the second reference reflection. A detection system detects a first wavelength dependent interferogram during the first time interval and a second wavelength dependent interferogram during the second time interval. A processor preconditions the first and second wavelength dependent interferograms.

    Abstract translation: 提供了包括宽带光辐射源和耦合到源的分束器的光学相干断层摄影（OCT）系统。 分束器将源辐射分为参考路径和采样路径。 参考路径包括光开关，用于在具有第一参考光路长度的第一参考反射的第一路径和具有第二参考光路长度的第二参考反射的第二路径之间切换参考路径。 该系统还包括一个光束组合器，它将从样本路径中的被摄体反射的源辐射与从第一参考反射和第二参考反射返回的源辐射混合。 检测系统在第一时间间隔期间检测第一波长相关干涉图，并且在第二时间间隔期间检测第二波长相关干涉图。 处理器预处理第一和第二波长依赖干涉图。

    Hybrid Telescope for Optical Beam Delivery and Related Systems and Methods
    7.
    发明申请
    Hybrid Telescope for Optical Beam Delivery and Related Systems and Methods 有权
    用于光束交付的混合望远镜及相关系统和方法

    公开(公告)号：US20140354950A1

    公开(公告)日：2014-12-04

    申请号：US14295664

    申请日：2014-06-04

    Applicant: Bioptigen, Inc.

    Inventor： Eric L. Buckland ,  Andrew Murnan ,  Nestor O. Farmiga ,  Robert H. Hart ,  Christopher Saxer

    IPC: A61B3/10 ,  G02B26/10 ,  G02B26/08

    CPC classification number: A61B3/102 ,  A61B3/1025 ,  G01B9/02038 ,  G01B9/02042 ,  G01B9/02091 ,  G02B19/0014 ,  G02B23/2407

    Abstract: Optical coherence tomography (OCT) imaging systems are provided including a source of broadband optical radiation coupled to a sample arm of the OCT imaging system; a beam shaping optical assembly in the sample arm, the beam shaping optical assembly being configured to receive optical radiation from the source as a beam of optical radiation and to shape the spatial profile of the beam of optical radiation; a scan mirror assembly coupled to the beam shaping optical assembly; and objective lens assembly coupled to the beam shaping optical assembly. The beam shaping optical assembly includes a lens assembly configured to change a NA of the OCT system without changing a focus; to change a focus of the OCT system without changing a NA of the system; or to change both the NA and the focus of the OCT system responsive to a control input.

    Abstract translation: 提供了光学相干断层摄影（OCT）成像系统，其包括耦合到OCT成像系统的样本臂的宽带光辐射源; 光束整形光学组件被配置为从光源接收作为光辐射束的光辐射并且对光辐射束的空间分布进行整形; 耦合到光束整形光学组件的扫描镜组件; 以及耦合到光束整形光学组件的物镜组件。 光束整形光学组件包括配置成改变OCT系统的NA而不改变焦点的透镜组件; 改变OCT系统的重点，而不改变系统的NA; 或者响应于控制输入来改变OCT系统的NA和焦点。

    Hybrid telescope for optical beam delivery and related systems
    9.
    发明授权
    Hybrid telescope for optical beam delivery and related systems 有权

    公开(公告)号：US10271725B2

    公开(公告)日：2019-04-30

    申请号：US15826966

    申请日：2017-11-30

    Applicant: Bioptigen, Inc.

    Inventor： Eric L. Buckland ,  Andrew Murnan ,  Nestor O. Farmiga ,  Robert H. Hart ,  Christopher Saxer

    IPC: A61B3/10 ,  G01B9/02 ,  G02B19/00 ,  G02B23/24

    Abstract: Optical coherence tomography (OCT) imaging systems are provided including a source of broadband optical radiation coupled to a sample arm of the OCT imaging system; a beam shaping optical assembly in the sample arm, the beam shaping optical assembly being configured to receive optical radiation from the source as a beam of optical radiation and to shape the spatial profile of the beam of optical radiation; a scan mirror assembly coupled to the beam shaping optical assembly; and objective lens assembly coupled to the beam shaping optical assembly. The beam shaping optical assembly includes a lens assembly configured to change a NA of the OCT system without changing a focus; to change a focus of the OCT system without changing a NA of the system; or to change both the NA and the focus of the OCT system responsive to a control input.

    Ball cage assemblies for centration of axially thick lenses and related methods and systems
    10.
    发明授权
    Ball cage assemblies for centration of axially thick lenses and related methods and systems 有权
    用于轴向厚透镜中心的球笼组件及相关方法和系统

    公开(公告)号：US09513453B2

    公开(公告)日：2016-12-06

    申请号：US14573001

    申请日：2014-12-17

    Applicant: Bioptigen, Inc.

    Inventor： Nestor O. Farmiga

    IPC: G02B7/02 ,  G02B27/62 ,  F21V17/02

    CPC classification number: G02B7/02 ,  F21V17/02 ,  G02B7/023 ,  G02B27/62 ,  Y10T29/49876 ,  Y10T29/53913

    Abstract: A ball cage centered lens assembly is provided including an axially thick lens; an outer mechanical cell; an intermediate cage positioned between the axially thick lens and the outer mechanical cell; a plurality of deformable elements positioned within the cage, between the axially thick lens and the mechanical cell, and in contact with the axially thick lens and the outer mechanical cell.

    Abstract translation: 提供了一种球笼中心透镜组件，其包括轴向厚的透镜; 外部机械电池; 位于轴向厚透镜和外机械单元之间的中间笼; 多个可变形元件，定位在保持架内，在轴向厚的透镜和机械单元之间，并且与轴向厚的透镜和外部机械单元接触。

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