公开(公告)号：US11385447B2

公开(公告)日：2022-07-12

申请号：US16511046

申请日：2019-07-15

Applicant: Bioptigen, Inc.

Inventor： Christopher Saxer ,  Al-Hafeez Z. Dhalla ,  Robert H. Hart ,  Eric L. Buckland

IPC: G02B21/00 ,  A61B3/10 ,  A61B3/12 ,  G02B21/08 ,  G02B27/00 ,  G02B5/00 ,  G02B7/00 ,  G02B21/02 ,  G02B21/06 ,  G02B21/22

Abstract: Surgical microscopes are provided including at least one ocular, an objective lens; a collimated space between the at least one ocular and the objective lens; an illumination system optically coupled into the collimated space of the surgical microscope, wherein an illumination from the illumination system is directed along a path at least partially contained within the collimated space of the surgical microscope and through the objective lens; and one of a field diaphragm and obscuration mask positioned within the illumination system, and outside of a field of view of the at least one ocular, wherein the one of the field diaphragm and the obscuration mask blocks, attenuates or diverts rays from the illumination system that reflect from a surface of the objective lens such that the reflected rays are not visible through the at least one ocular.

公开(公告)号：US20160298953A1

公开(公告)日：2016-10-13

申请号：US15190299

申请日：2016-06-23

Applicant: Bioptigen, Inc.

Inventor： Eric L. Buckland ,  Al-Hafeez Z. Dhalla ,  Nestor O. Farmiga ,  Mehran Ghofrani ,  Robert H. Hart ,  Andrew Murnan ,  Christopher Saxer

IPC: G01B9/02 ,  A61B3/10

CPC classification number: G01B9/02087 ,  A61B3/102 ,  G01B9/02004 ,  G01B9/02028 ,  G01B9/02044 ,  G01B9/02091

Abstract: An optical coherence tomography (OCT) system including a source of broadband optical radiation and a beamsplitter coupled to the source is provided. The beamsplitter divides the source radiation into a reference path and a sample path. The reference path includes an optical switch to switch the reference path between a first path having a first reference reflection at a first reference optical path length and a second path having a second reference reflection at a second reference optical path length. The system further includes a beam combiner that mixes source radiation reflected from a subject in the sample path with source radiation returned from the first reference reflection and the second reference reflection. A detection system detects a first wavelength dependent interferogram during the first time interval and a second wavelength dependent interferogram during the second time interval. A processor preconditions the first and second wavelength dependent interferograms.

Abstract translation: 提供了包括宽带光辐射源和耦合到源的分束器的光学相干断层摄影（OCT）系统。 分束器将源辐射分为参考路径和采样路径。 参考路径包括光开关，用于在具有第一参考光路长度的第一参考反射的第一路径和具有第二参考光路长度的第二参考反射的第二路径之间切换参考路径。 该系统还包括一个光束组合器，它将从样本路径中的被摄体反射的源辐射与从第一参考反射和第二参考反射返回的源辐射混合。 检测系统在第一时间间隔期间检测第一波长相关干涉图，并且在第二时间间隔期间检测第二波长相关干涉图。 处理器预处理第一和第二波长依赖干涉图。

公开(公告)号：US20170131533A1

公开(公告)日：2017-05-11

申请号：US14935545

申请日：2015-11-09

Applicant: Bioptigen, Inc.

Inventor： Christopher Saxer ,  Al-Hafeez Z. Dhalla ,  Robert H. Hart ,  Eric L. Buckland

IPC: G02B21/00 ,  G02B21/06 ,  G02B21/02 ,  G02B7/00 ,  G02B5/00 ,  G02B21/22

CPC classification number: G02B21/0012 ,  A61B3/102 ,  A61B3/12 ,  A61B3/1225 ,  G02B5/005 ,  G02B7/006 ,  G02B21/02 ,  G02B21/06 ,  G02B21/082 ,  G02B21/22 ,  G02B27/0018

Abstract: Field diaphragms for use in surgical microscopes are provided. The field diaphragms are positioned along an optical axis of a microscope illumination system. The field diaphragms include a frame portion configured to be received by the surgical microscope; and a non-circularly symmetric mask portion integrated with the frame portion. The mask portion is aligned such that marginal rays from an edge of the field diaphragm along a meridian of minimum diameter that reflect from a surface of an objective lens of the microscope reflect outside of an acceptance angle for relay through any ocular channel of the microscope.

公开(公告)号：US10048057B2

公开(公告)日：2018-08-14

申请号：US15190299

申请日：2016-06-23

Applicant: Bioptigen, Inc.

Inventor： Eric L. Buckland ,  Al-Hafeez Z. Dhalla ,  Nestor O. Farmiga ,  Mehran Ghofrani ,  Robert H. Hart ,  Andrew Murnan ,  Christopher Saxer

IPC: G01B9/02 ,  A61B3/10

Abstract: An optical coherence tomography (OCT) system including a source of broadband optical radiation and a beamsplitter coupled to the source is provided. The beamsplitter divides the source radiation into a reference path and a sample path. The reference path includes an optical switch to switch the reference path between a first path having a first reference reflection at a first reference optical path length and a second path having a second reference reflection at a second reference optical path length. The system further includes a beam combiner that mixes source radiation reflected from a subject in the sample path with source radiation returned from the first reference reflection and the second reference reflection. A detection system detects a first wavelength dependent interferogram during the first time interval and a second wavelength dependent interferogram during the second time interval. A processor preconditions the first and second wavelength dependent interferograms.

公开(公告)号：US09377291B2

公开(公告)日：2016-06-28

申请号：US14561772

申请日：2014-12-05

Applicant: Bioptigen, Inc.

Inventor： Eric L. Buckland ,  Al-Hafeez Z. Dhalla ,  Nestor O. Farmiga ,  Mehran Ghofrani ,  Robert H. Hart ,  Andrew Murnan ,  Christopher Saxer

IPC: G01B9/02 ,  A61B3/10

CPC classification number: G01B9/02087 ,  A61B3/102 ,  G01B9/02004 ,  G01B9/02028 ,  G01B9/02044 ,  G01B9/02091

Abstract: An optical coherence tomography (OCT) system including a source of broadband optical radiation and a beamsplitter coupled to the source is provided. The beamsplitter divides the source radiation into a reference path and a sample path. The reference path includes an optical switch to switch the reference path between a first path having a first reference reflector at a first reference optical path length and a second path having a second reference reflector at a second reference optical path length, different from the first reference optical path length. The system further includes a beam combiner that mixes source radiation reflected from a subject in the sample path with source radiation returned from the first reference reflector during a first time interval and the second reference reflector during a second time interval. A detection system detects a first wavelength dependent interferogram during the first time interval and a second wavelength dependent interferogram during the second time interval. A processor preconditions the first and second wavelength dependent interferograms; multiples the first preconditioned wavelength dependent interferogram and the second preconditioned wavelength dependent interferogram; and computes a first A-scan from the first wavelength dependent interferogram; a second A-scan from the second wavelength dependent interferogram; a spatial offset between the first and second A-scans derived from the multiplicative product of the preconditioned first and second wavelength dependent interferograms; and a combined A-scan from the first and second A-scans.

Abstract translation: 提供了包括宽带光辐射源和耦合到源的分束器的光学相干断层摄影（OCT）系统。 分束器将源辐射分为参考路径和采样路径。 参考路径包括一个光学开关，用于在具有第一参考光路长度的第一参考反射器的第一路径和第二参考反射器之间切换参考路径，第二路径具有第二参考光路长度，第二参考反射器不同于第一参考 光路长度。 该系统还包括一个光束组合器，它将来自采样通路中的被摄体反射的源辐射与在第一时间间隔期间从第一参考反射器返回的源辐射和第二时间间隔内的第二参考反射器混合。 检测系统在第一时间间隔期间检测第一波长相关干涉图，并且在第二时间间隔期间检测第二波长相关干涉图。 处理器预先规定第一和第二波长依赖干涉图; 第一预处理波长依赖干涉图和第二预处理波长依赖干涉图的倍数; 并从第一波长依赖干涉图计算第一A扫描; 来自第二波长依赖性干涉图的第二A扫描; 从预处理的第一和第二波长相关干涉图的乘积产生的第一和第二A-扫描之间的空间偏移; 以及来自第一和第二A扫描的组合的A扫描。

公开(公告)号：US10791255B2

公开(公告)日：2020-09-29

申请号：US15523002

申请日：2015-11-06

Applicant: Bioptigen, Inc.

Inventor： Mehran Ghofrani ,  Al-Hafeez Z. Dhalla ,  Christopher Saxer

IPC: H04N5/225 ,  A61B3/10 ,  G01B9/02 ,  A61B3/13

Abstract: A scanning optical system is provided including a source of optical radiation; an optical scanning beam delivery system for delivering optical radiation to a subject, wherein the optical scanning beam delivery system includes a plurality of optical elements including at least one steerable mirror; at least one actuator coupled to the at least one steerable mirror; a detection system for detecting optical radiation returned from a subject; a communications device including a user interface and configured to process a set of instructions at least partially responsive to inputs from the user interface; a controller comprising memory, a microcontroller and an field programmable gate array (FPGA), the microcontroller and FPGA receiving instructions derived from the communications device; and at least one actuator coupled to the at least one steerable mirror. The at least one actuator receives a first instruction set from the microcontroller in the form of sequential commands and a second instruction set from the FPGA in the form of concurrent commands. The first instruction set establishes a pattern of motion of the at least one steerable mirror at least partially responsive to inputs from the user interface of the communications device. The second instruction set modifies an attribute of the pattern of motion of the at least one steerable mirror in substantially real-time at least partially responsive to one or more triggering events.

公开(公告)号：US10409046B2

公开(公告)日：2019-09-10

申请号：US14935545

申请日：2015-11-09

Applicant: Bioptigen, Inc.

Inventor： Christopher Saxer ,  Al-Hafeez Z. Dhalla ,  Robert H. Hart ,  Eric L. Buckland

IPC: G02B21/00 ,  G02B21/06 ,  G02B27/00 ,  G02B5/00 ,  G02B7/00 ,  G02B21/02 ,  G02B21/22 ,  A61B3/12 ,  A61B3/10 ,  G02B21/08

Abstract: Field diaphragms for use in surgical microscopes are provided. The field diaphragms are positioned along an optical axis of a microscope illumination system. The field diaphragms include a frame portion configured to be received by the surgical microscope; and a non-circularly symmetric mask portion integrated with the frame portion. The mask portion is aligned such that marginal rays from an edge of the field diaphragm along a meridian of minimum diameter that reflect from a surface of an objective lens of the microscope reflect outside of an acceptance angle for relay through any ocular channel of the microscope.

公开(公告)号：US20150159992A1

公开(公告)日：2015-06-11

申请号：US14561772

申请日：2014-12-05

Applicant: Bioptigen, Inc.

Inventor： Eric L. Buckland ,  Al-Hafeez Z. Dhalla ,  Nestor O. Farmiga ,  Mehran Ghofrani ,  Robert H. Hart ,  Andrew Murnan ,  Christopher Saxer

IPC: G01B9/02

CPC classification number: G01B9/02087 ,  A61B3/102 ,  G01B9/02004 ,  G01B9/02028 ,  G01B9/02044 ,  G01B9/02091

Abstract: An optical coherence tomography (OCT) system including a source of broadband optical radiation and a beamsplitter coupled to the source is provided. The beamsplitter divides the source radiation into a reference path and a sample path. The reference path includes an optical switch to switch the reference path between a first path having a first reference reflector at a first reference optical path length and a second path having a second reference reflector at a second reference optical path length, different from the first reference optical path length. The system further includes a beam combiner that mixes source radiation reflected from a subject in the sample path with source radiation returned from the first reference reflector during a first time interval and the second reference reflector during a second time interval. A detection system detects a first wavelength dependent interferogram during the first time interval and a second wavelength dependent interferogram during the second time interval. A processor preconditions the first and second wavelength dependent interferograms; multiples the first preconditioned wavelength dependent interferogram and the second preconditioned wavelength dependent interferogram; and computes a first A-scan from the first wavelength dependent interferogram; a second A-scan from the second wavelength dependent interferogram; a spatial offset between the first and second A-scans derived from the multiplicative product of the preconditioned first and second wavelength dependent interferograms; and a combined A-scan from the first and second A-scans.

Abstract translation: 提供了包括宽带光辐射源和耦合到源的分束器的光学相干断层摄影（OCT）系统。 分束器将源辐射分为参考路径和采样路径。 参考路径包括一个光学开关，用于在具有第一参考光路长度的第一参考反射器的第一路径和第二参考反射器之间切换参考路径，第二路径具有第二参考光路长度，第二参考反射器不同于第一参考 光路长度。 该系统还包括一个光束组合器，它将来自采样通路中的被摄体反射的源辐射与在第一时间间隔期间从第一参考反射器返回的源辐射和第二时间间隔内的第二参考反射器混合。 检测系统在第一时间间隔期间检测第一波长相关干涉图，并且在第二时间间隔期间检测第二波长相关干涉图。 处理器预先规定第一和第二波长依赖干涉图; 第一预处理波长依赖干涉图和第二预处理波长依赖干涉图的倍数; 并从第一波长依赖干涉图计算第一A扫描; 来自第二波长依赖性干涉图的第二A扫描; 从预处理的第一和第二波长相关干涉图的乘积产生的第一和第二A-扫描之间的空间偏移; 以及来自第一和第二A扫描的组合的A扫描。