公开(公告)号：US20190381009A1

公开(公告)日：2019-12-19

申请号：US16555504

申请日：2019-08-29

申请人： Brandeis University

发明人： John Lisman

IPC分类号： A61K31/417 ,  A61P25/28 ,  A61K31/4458 ,  A61K31/198 ,  A61K31/145

摘要： The present invention relates to the use of DBH inhibitors (e.g., disulfiram and Nepicastat), and pharmaceutical compositions thereof, for treating subjects with certain types of memory loss, for instance memory loss associated with a neurodegenerative disease, disorder, or condition, such as Alzheimer's Disease.

公开(公告)号：US20190255530A1

公开(公告)日：2019-08-22

申请号：US16400401

申请日：2019-05-01

申请人： Brandeis University ,  President and Fellows of Harvard College

发明人： Seth Fraden ,  Hakim Boukellal ,  Yanwei Jia ,  Seila Selimovic ,  Amy Rowat ,  Jeremy Agresti ,  David A. Weitz

IPC分类号： B01L3/00 ,  G01N1/28 ,  F17D1/12 ,  G01N15/02 ,  G01N15/14

摘要： Microfluidic structures and methods for manipulating fluids, fluid components, and reactions are provided. In one aspect, such structures and methods can allow production of droplets of a precise volume, which can be stored/maintained at precise regions of the device. In another aspect, microfluidic structures and methods described herein are designed for containing and positioning components in an arrangement such that the components can be manipulated and then tracked even after manipulation. For example, cells may be constrained in an arrangement in microfluidic structures described herein to facilitate tracking during their growth and/or after they multiply.

公开(公告)号：US20190168931A1

公开(公告)日：2019-06-06

申请号：US16272765

申请日：2019-02-11

申请人： Brandeis University

发明人： Daniel PERLMAN

IPC分类号： B65D47/40 ,  B65D47/06 ,  B65D23/06

摘要： Described herein is a glass bottle configured to improve the mechanics of liquid flow and prevent drip initiation. Additionally, the glass bottle eliminates dripping during pouring to enable drip-free pouring. The dripping is prevented over a full range of pouring angles, which vary depending on the amount of liquid held in the glass bottle. A method of making the glass bottle and a method of enabling drip-free pouring using the glass bottle are also disclosed.

公开(公告)号：US20190117748A1

公开(公告)日：2019-04-25

申请号：US16092137

申请日：2017-04-06

申请人： BRANDEIS UNIVERSITY

发明人： Isaac J. KRAUSS ,  Joel Sebastian TEMME

IPC分类号： A61K39/00 ,  C12N15/117 ,  C07H15/22 ,  A61K39/39 ,  C12N15/115 ,  A61P31/18

CPC分类号： A61K39/0005 ,  A61K39/39 ,  A61K2039/51 ,  A61K2039/545 ,  A61P31/18 ,  C07H15/22 ,  C07H21/04 ,  C12N15/10 ,  C12N15/115 ,  C12N15/117 ,  C12N2310/13 ,  C12N2310/16 ,  C12N2310/351 ,  C12N2320/30

摘要： Disclosed are oligonucleotides that binds specifically to HIV neutralizing monoclonal antibody 2G12 with a K4 value lower than 20 nM, the oligonucleotide comprising a predicted structure, at 37° C., having exactly one stem-loop whereby the loop comprises the nucleotide sequence of AACCNACGGANAAA (SEQ ID NO: 1), where N is a modified nucleoside base, and the stem includes at least 3 nucleotide base-pairs and one of the nucleotides in the stem includes a modified nucleoside base, wherein the modified nucleoside base has the structure -B-L-A where A is a branched-chain Man9 oligosaccharide, L is a linker molecule, and B is independently a pyrimidine or pyridine base linked to the sugar-phosphate backbone of the oligonucleotide. Immunogenic conjugates that include the oligonucleotide, and pharmaceutical compositions that include the oligonucleotide or the immunogenic conjugate are also disclosed. Various method of using the oligonucleotides, immunogenic conjugates, and pharmaceutical compositions are also disclosed.

公开(公告)号：US20190105643A1

公开(公告)日：2019-04-11

申请号：US16093899

申请日：2017-04-14

申请人： BRANDEIS UNIVERSITY

发明人： XIAO ZHOU ,  YONGWEI WU ,  LI DENG

IPC分类号： B01J31/02 ,  C07D453/00 ,  C07C249/02

摘要： Provided herein are cinchonium betaine catalysts and methods of promoting asymmetric imine isomerization reactions using the same.

公开(公告)号：US20190015464A1

公开(公告)日：2019-01-17

申请号：US15941339

申请日：2018-03-30

申请人： Brandeis University

发明人： DANIEL PERLMAN

IPC分类号： A61K35/747 ,  A61K35/745 ,  A61K35/742 ,  A61K9/00 ,  A61K9/14 ,  A23L33/135 ,  A23L25/10 ,  A23L33/115

CPC分类号： A61K35/747 ,  A23L25/10 ,  A23L33/115 ,  A23L33/135 ,  A23V2002/00 ,  A23Y2220/03 ,  A61K9/0056 ,  A61K9/14 ,  A61K35/741 ,  A61K35/742 ,  A61K35/745 ,  A61K47/44

摘要： The present technology relates to foodstuffs that contain a substantially anhydrous fatty food that is solid at room temperature and comprises a substantially anhydrous probiotic bacterial preparation dispersed therein. Methods of making such substantially anhydrous fatty foods are also disclosed

公开(公告)号：US10071379B2

公开(公告)日：2018-09-11

申请号：US15257017

申请日：2016-09-06

申请人： Brandeis University

发明人： Seth Fraden ,  Galder Cristobal-Azkarate

IPC分类号： G01N1/38 ,  B01L3/00 ,  C30B7/00 ,  C30B29/58 ,  B01L3/06 ,  B01L7/00

CPC分类号： B01L3/502784 ,  B01L3/06 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502746 ,  B01L7/54 ,  B01L2200/0621 ,  B01L2200/0642 ,  B01L2200/0668 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/1822 ,  B01L2400/0406 ,  B01L2400/0655 ,  C30B7/00 ,  C30B29/58 ,  G01N1/38 ,  G01N2001/386 ,  Y10T137/0318 ,  Y10T436/2575

摘要： Microfluidic structures and methods for manipulating fluids and reactions are provided. Such structures and methods may involve positioning fluid samples, e.g., in the form of droplets, in a carrier fluid (e.g., an oil, which may be immiscible with the fluid sample) in predetermined regions in a microfluidic network. In some embodiments, positioning of the droplets can take place in the order in which they are introduced into the microfluidic network (e.g., sequentially) without significant physical contact between the droplets. Because of the little or no contact between the droplets, there may be little or no coalescence between the droplets. Accordingly, in some such embodiments, surfactants are not required in either the fluid sample or the carrier fluid to prevent coalescence of the droplets. Structures and methods described herein also enable droplets to be removed sequentially from the predetermined regions.

公开(公告)号：US20170248779A1

公开(公告)日：2017-08-31

申请号：US15597506

申请日：2017-05-17

申请人： Brandeis University

发明人： Charles G. INGERSOLL ,  David J. DEROSIER ,  Gina TURRIGIANO ,  Marc NAHMANI

IPC分类号： G02B21/28 ,  G02B21/32 ,  G02B21/26 ,  G02B21/33

CPC分类号： G02B21/28 ,  G02B21/26 ,  G02B21/32 ,  G02B21/33

摘要： New systems and methods are described for maintaining a desired steady state temperature differential between two objects that may otherwise undergo heat transfer to restore thermal steady state. In one application, a cooling microscope assembly and its use with conventional optical microscopes are described for achieving super-resolution imaging. The assembly allows for the high resolution imaging of samples at cryogenic temperatures while maintaining the temperature of the objective lens above freezing by employing circulation systems and a coupling fluid between the sample and objective lens.

公开(公告)号：US09588025B2

公开(公告)日：2017-03-07

申请号：US14737865

申请日：2015-06-12

申请人： Brandeis University ,  President and Fellows of Harvard College

发明人： Seth Fraden ,  Hakim Boukellal ,  Yanwei Jia ,  Seila Selimovic ,  Amy Rowat ,  Jeremy Agresti ,  David A. Weitz

IPC分类号： F17D1/12 ,  B01L3/00 ,  G01N1/28 ,  G01N15/02 ,  G01N15/14 ,  G01N15/00

CPC分类号： B01L3/502784 ,  B01L3/502746 ,  B01L2200/0673 ,  B01L2300/0861 ,  B01L2300/087 ,  B01L2300/0877 ,  B01L2400/0487 ,  B01L2400/0688 ,  B01L2400/0694 ,  B01L2400/082 ,  F17D1/12 ,  G01N1/28 ,  G01N15/0272 ,  G01N15/1484 ,  G01N2015/0092 ,  Y10T137/0324 ,  Y10T137/0391 ,  Y10T137/0396 ,  Y10T137/2082 ,  Y10T137/218 ,  Y10T436/2575

摘要： Microfluidic structures and methods for manipulating fluids, fluid components, and reactions are provided. In one aspect, such structures and methods can allow production of droplets of a precise volume, which can be stored/maintained at precise regions of the device. In another aspect, microfluidic structures and methods described herein are designed for containing and positioning components in an arrangement such that the components can be manipulated and then tracked even after manipulation. For example, cells may be constrained in an arrangement in microfluidic structures described herein to facilitate tracking during their growth and/or after they multiply.

摘要翻译： 提供微流体结构和操作流体，流体组分和反应的方法。 在一个方面，这种结构和方法可以允许产生精确体积的液滴，其可被存储/保持在装置的精确区域。 在另一方面，本文所述的微流体结构和方法被设计用于在组件中容纳和定位组件，使得即使在操作之后也可以操纵组件并随后进行跟踪。 例如，细胞可以以本文所述的微流体结构的排列约束，以便于在其生长期间和/或在它们繁殖之后进行跟踪。

公开(公告)号：US20170007998A1

公开(公告)日：2017-01-12

申请号：US15257017

申请日：2016-09-06

申请人： Brandeis University

发明人： Seth Fraden ,  Galder Cristobal-Azkarate

IPC分类号： B01L3/00

CPC分类号： B01L3/502784 ,  B01L3/06 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502746 ,  B01L7/54 ,  B01L2200/0621 ,  B01L2200/0642 ,  B01L2200/0668 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/1822 ,  B01L2400/0406 ,  B01L2400/0655 ,  C30B7/00 ,  C30B29/58 ,  G01N1/38 ,  G01N2001/386 ,  Y10T137/0318 ,  Y10T436/2575

摘要： Microfluidic structures and methods for manipulating fluids and reactions are provided. Such structures and methods may involve positioning fluid samples, e.g., in the form of droplets, in a carrier fluid (e.g., an oil, which may be immiscible with the fluid sample) in predetermined regions in a microfluidic network. In some embodiments, positioning of the droplets can take place in the order in which they are introduced into the microfluidic network (e.g., sequentially) without significant physical contact between the droplets. Because of the little or no contact between the droplets, there may be little or no coalescence between the droplets. Accordingly, in some such embodiments, surfactants are not required in either the fluid sample or the carrier fluid to prevent coalescence of the droplets. Structures and methods described herein also enable droplets to be removed sequentially from the predetermined regions.

摘要翻译： 提供微流体结构和操纵流体和反应的方法。 这样的结构和方法可以涉及在微流体网络中的预定区域中将例如液​​滴形式的流体样品定位在载体流体（例如，可能与流体样品不混溶的油）中。 在一些实施例中，液滴的定位可以按照它们被引入微流体网络（例如，顺序地）而没有液滴之间的显着物理接触的顺序进行。 由于液滴之间很少或没有接触，所以液滴之间可能很少或没有聚结。 因此，在一些这样的实施方案中，在流体样品或载体流体中不需要表面活性剂以防止液滴的聚结。 本文所述的结构和方法还使得能够从预定区域顺序地去除液滴。