公开(公告)号：US20100101670A1

公开(公告)日：2010-04-29

申请号：US12513381

申请日：2007-11-05

Applicant: David Juncker ,  Vito Logiudice ,  Matthieu Nannini

Inventor： David Juncker ,  Vito Logiudice ,  Matthieu Nannini

IPC: F15C1/06 ,  F16K31/02 ,  B44C1/22

CPC classification number: F16K99/0001 ,  F16K99/0015 ,  F16K99/0026 ,  F16K99/0034 ,  F16K99/0051 ,  F16K2099/0074 ,  F16K2099/0084 ,  Y10T137/2224

Abstract: The present invention relates to a microvalve for controlling a fluid flow in a microchannel, to a microfluidic circuit using the microvalve, and to a manufacturing method thereof. The microvalve has a first electrode located on a portion of the microchannel, a second electrode over the microchannel and substantially aligned with the first electrode forming a membrane with substantially no resilience. In function, upon application of an electric force on the first and second electrodes, the second electrode draws nearer the first electrode, thus obstructing the microchannel. The microfluidic circuit comprises multiple microchannels and at least one microvalve affixed to one of the multiple microchannels, wherein the at least one microvalve is adapted to indirectly actuate a flexible valve adapted to regulate a flow of fluid in another one of a multiplicity of microchannels.

Abstract translation: 本发明涉及一种用于控制微通道中的流体流动的微型阀以及使用该微型阀的微流体回路及其制造方法。 微型阀具有位于微通道的一部分上的第一电极，在微通道上方的第二电极，并且基本上与第一电极对准，基本上没有弹性。 在功能上，当在第一和第二电极上施加电力时，第二电极越靠近第一电极，从而阻碍微通道。 所述微流体回路包括多个微通道和至少一个固定到所述多个微通道中的一个微通道的微型阀，其中所述至少一个微阀适于间接致动适于调节多个微通道中的另一微通道中的流体流动的柔性阀。

公开(公告)号：US20090139590A1

公开(公告)日：2009-06-04

申请号：US12277009

申请日：2008-11-24

Applicant: Paulo Gaspar Jorge Marques

Inventor： Paulo Gaspar Jorge Marques

IPC: F15C1/06 ,  C03C8/02 ,  B81B1/00 ,  C03C8/14

CPC classification number: B81C1/00071 ,  B01J19/2485 ,  B81B2201/058 ,  C03C3/093 ,  C03C8/12 ,  C03C8/14 ,  C03C8/24 ,  Y10T137/2224 ,  Y10T137/87249

Abstract: A zirconium- and alumina-containing silicate glass suitable for use as a frit with refractory materials such as alumina is disclosed, the silicate glass comprising a glass composition in mole percent (mol %) of:2

Abstract translation: 公开了适合用作耐火材料如氧化铝的玻璃料的含锆和氧化铝的硅酸盐玻璃，所述硅酸盐玻璃包含摩尔百分比（摩尔％）为：2 15mol％，其中SiO 2，AlO 3和ZrO 2的总摩尔％ 大于82但小于86，并且其中B 2 O 3，Na 2 O，K 2 O，碱土金属和镧系元素的总摩尔百分数大于13并且小于18.玻璃杯（200,600），复合材料（600）和微流体装置（12 ）也被公开。

公开(公告)号：US20080295909A1

公开(公告)日：2008-12-04

申请号：US12127328

申请日：2008-05-27

Applicant: Laurie E. Locascio ,  Francisco Javier Atencia-Fernandez ,  Susan Barnes

Inventor： Laurie E. Locascio ,  Francisco Javier Atencia-Fernandez ,  Susan Barnes

IPC: F15C1/06 ,  B01L3/00 ,  B81B1/00

CPC classification number: B01J19/0046 ,  B01F5/0646 ,  B01F5/0647 ,  B01F5/0655 ,  B01F13/0059 ,  B01J2219/00367 ,  B01J2219/00599 ,  B01J2219/0065 ,  B01L3/06 ,  B01L3/502707 ,  B01L3/502723 ,  B01L3/502784 ,  B01L2200/0642 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0874 ,  B01L2400/0406 ,  B81B2201/058 ,  B81C1/00111 ,  C40B50/08 ,  C40B60/14 ,  Y10T137/2224

Abstract: A three dimensional microfluidic device for passive sorting and storing of liquid plugs is provided with homogeneous surfaces from the exposure of a photopolymer through binary masking motifs, i.e., arrays of opaque pixels on a transparency mask. The device includes sub-millimeter three-dimensional relief microstructures to aid in the channeling of fluids. The microstructures have topographically modulated features smaller than 100 micrometers.

Abstract translation: 提供了一种用于液体塞的被动分类和储存的三维微流体装置，其具有均匀的表面，其通过二元掩蔽图案曝光光聚合物，即在透明掩模上的不透明像素阵列。 该装置包括亚毫米三维浮雕微结构以帮助流体的引导。 微结构具有小于100微米的形貌调制特征。

公开(公告)号：US20080257438A1

公开(公告)日：2008-10-23

申请号：US12080794

申请日：2008-04-03

Applicant: Mark Y. Wang ,  Zhiliang Wan ,  Harshal Surangalikar ,  Guanghua Wu ,  Erhan Ata

Inventor： Mark Y. Wang ,  Zhiliang Wan ,  Harshal Surangalikar ,  Guanghua Wu ,  Erhan Ata

IPC: F15C1/06

CPC classification number: F15C5/00 ,  B01L3/502738 ,  B01L2300/1833 ,  B01L2400/0427 ,  B01L2400/0442 ,  B01L2400/0688 ,  F16K99/0017 ,  F16K99/0019 ,  F16K99/0051 ,  Y10T137/2196 ,  Y10T137/2224

Abstract: This invention relates to a systems and methods of controlling the flow of a fluid in a capillary or microfluidic channel. A first pair of electrodes can influence the wetting of a fluid front at a relatively hydrophobic surface in the channel. A second pair of electrodes can electrolytically generate a bubble that can stop fluid flow when it contacts the hydrophobic surface. Flow of a fluid in a channel can be stopped on contact with the hydrophobic surface and restarted when an electrostatic field reduces the contact angle of the fluid at the hydrophobic surface. The electrostatic field can be removed and the fluid stopped again when an electrolytically generated bubble contacts the hydrophobic surface to reestablish the blocking contact angle of the fluid, gas and surface.

Abstract translation: 本发明涉及一种控制毛细管或微流体通道中的流体流动的系统和方法。 第一对电极可以影响通道中相对疏水的表面处的流体前沿的润湿。 第二对电极可以电解产生气泡，当气泡接触疏水表面时可以阻止流体流动。 通道中的流体的流动可以在与疏水表面接触时停止，并且当静电场减小疏水表面处的流体的接触角时重新开始。 当电解产生的气泡接触疏水表面以重新建立流体，气体和表面的阻塞接触角时，可以去除静电场并再次停止流体。

公开(公告)号：US20080210321A1

公开(公告)日：2008-09-04

申请号：US11934212

申请日：2007-11-02

Applicant: Marc A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer ,  Stephen R. Quake

Inventor： Marc A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer ,  Stephen R. Quake

IPC: F15C1/06

CPC classification number: F15C1/06 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2300/0861 ,  B01L2300/0887 ,  B01L2400/046 ,  B01L2400/0481 ,  B01L2400/0655 ,  C12Q1/6874 ,  F04B43/043 ,  F16K1/20 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0046 ,  F16K99/0048 ,  F16K99/0051 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/0078 ,  F16K2099/008 ,  F16K2099/0094 ,  Y10T137/2224 ,  Y10T137/87981 ,  C12Q2535/125

Abstract: A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

公开(公告)号：US20080115849A1

公开(公告)日：2008-05-22

申请号：US11603030

申请日：2006-11-22

Applicant: Jing-Tang Yang ,  Chi-Ko Chen ,  Kun-Chih Tsai

Inventor： Jing-Tang Yang ,  Chi-Ko Chen ,  Kun-Chih Tsai

IPC: F15C1/06

CPC classification number: F15C1/22 ,  Y10T137/2224 ,  Y10T137/2229

Abstract: A micro-fluidic oscillator comprises a main body and a cover body for covering the main body. An oscillation chamber is disposed on the main body to provide an oscillation space for fluid. A sudden-expansion micro-nozzle is connected with one end of the oscillation chamber, and an outlet passage is connected with the other end of the oscillation chamber. Two fluid-separating bodies are located at the connection positions of the outlet passage and the oscillation chamber, respectively. Two feedback channels are located outside two attachment walls. The sudden-expansion micro-nozzle is used to break the viscous shear stress between fluid and the walls and to generate unstable flow and oscillation. Moreover, the two feedback channels have different lengths, inside diameters and alternate outlet positions to further enhance the oscillation of fluid.

Abstract translation: 微流体振荡器包括主体和用于覆盖主体的盖体。 振荡室设置在主体上，为流体提供振荡空间。 突然膨胀的微型喷嘴与振荡室的一端连接，出口通道与振荡室的另一端连接。 两个流体分离体分别位于出口通道和振荡室的连接位置。 两个反馈通道位于两个附件墙外。 突然膨胀的微型喷嘴用于破坏流体和壁之间的粘性剪切应力，并产生不稳定的流动和振荡。 此外，两个反馈通道具有不同的长度，内径和替代的出口位置，以进一步增强流体的振荡。

公开(公告)号：US20070199603A1

公开(公告)日：2007-08-30

申请号：US11710167

申请日：2007-02-23

Applicant: Koichi Ono

Inventor： Koichi Ono

IPC: F15C1/06

CPC classification number: B01L3/502746 ,  B01L2200/0684 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2400/0406 ,  B01L2400/0688 ,  B01L2400/086 ,  Y10T137/218 ,  Y10T137/2224

Abstract: A first liquid fed into a first flow passage 6 of a fluid handling apparatus travels to the open end thereof on the side of a second flow passage 7 due to capillarity. The movement of the first liquid is uniformed on the cross section of the flow passage by the function of a capillarity promoting portion 220 or 230 of the bottom 21 of the first flow passage 6. Then, the movement of a second liquid fed into the second flow passage 7 is uniformed on the cross section of the flow passage by the function of the capillarity promoting portion 220 or 230 of the bottom 21 of the second flow passage 7. Thus, the movement of the front end of the second liquid is substantially uniformed to surely extrude gas from the second flow passage 7 to the outside via a fourth flow passage 10.

Abstract translation: 进入流体处理装置的第一流动通道6的第一液体由于毛细作用而行进到第二流动通道7侧的开口端。 通过第一流路6的底部21的毛细作用促进部分220或230的作用，第一液体的运动在流动通道的横截面上是均匀的。 然后，通过第二流路7的底部21的毛细作用促进部220或230的作用，供给到第二流路7的第二液体的运动在流路的截面上均匀。 因此，第二液体的前端的运动基本上是均匀的，从而可靠地将气体从第二流动通道7经由第四流动通道10挤出到外部。

公开(公告)号：US20060124184A1

公开(公告)日：2006-06-15

申请号：US10525400

申请日：2003-08-21

Applicant: Gregor Ocvirk ,  Carlo Effenhuaser ,  Karl-Heinz Koelker

Inventor： Gregor Ocvirk ,  Carlo Effenhuaser ,  Karl-Heinz Koelker

IPC: F15C1/06

CPC classification number: F16K51/00 ,  B01F7/16 ,  B01F13/0059 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/0086 ,  B01L3/502707 ,  B01L2200/12 ,  B01L2300/0681 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2400/084 ,  Y10T137/0329 ,  Y10T137/0352 ,  Y10T137/0491 ,  Y10T137/2224

Abstract: The invention relates to the technical field of microfluidic channel structures. The invention discloses a microfluidic channel system with a high aspect ratio as well as a process for producing the microfluidic system. The process according to the invention enables the production of channel structures with aspect ratios of any magnitude without the process being limited by the manufacturing conditions to certain materials for the channel system. The channel system can thus be optimally adapted to a desired field of application.

Abstract translation: 本发明涉及微流体通道结构的技术领域。 本发明公开了具有高纵横比的微流体通道系统以及用于生产微流体系统的方法。 根据本发明的方法使得能够生产具有任何幅度的纵横比的通道结构，而不会使制造条件限制于通道系统的某些材料。 因此，信道系统可以最佳地适应于期望的应用领域。

公开(公告)号：US07032607B2

公开(公告)日：2006-04-25

申请号：US10220785

申请日：2001-03-01

Applicant: John Robert Burns

Inventor： John Robert Burns

IPC: F15C1/06 ,  F15B21/00

CPC classification number: B01F13/0072 ,  B01F5/0256 ,  B01F2013/1091 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00813 ,  B01J2219/00833 ,  B01J2219/00835 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00909 ,  B01L3/565 ,  G01N35/08 ,  Y10T137/0396 ,  Y10T137/2082 ,  Y10T137/2224

Abstract: A capillary reactor distribution device comprising first and second capillary pathways (2, 3) which meet at a junction (5) and a third capillary pathway (4) which leads away from the junction (5), the capillary pathways (2, 3, 4) being dimensioned such that, when first and second immiscible fluids (14, 15) are fed along respectively the first and second capillary pathways (2, 3) under predetermined laminar flow conditions, the first and second fluids (14, 15) chop each other into discrete slugs (16, 17) which pass along the third capillary pathway (4). Molecular mixing between the fluids (14, 15) takes place by way of axial diffusion between adjacent slugs (16, 17) and by way of internal circulation within each slug (16, 17) as the slugs (16, 17) progress along the third capillary pathway (4).

Abstract translation: 一种毛细管反应器分配装置，包括在结（5）处相交的第一和第二毛细通道（2,3）和离开接合点（5）引导的第三毛细通道（4），毛细管路径（2,3， 4）的尺寸使得当在预定的层流条件下第一和第二不混溶流体（14,15）分别沿着第一和第二毛细通路（2,3）进料时，第一和第二流体（14,15） 彼此分离成沿着第三毛细通路（4）通过的离散块塞（16,17）。 流体（14,15）之间的分子混合通过在相邻的块塞（16,17）之间的轴向扩散并且随着絮块（16,17）沿着 第三毛细血管通路（4）。

公开(公告)号：US20050045238A1

公开(公告)日：2005-03-03

申请号：US10926976

申请日：2004-08-27

Applicant: Jing-Tang Yang ,  Jia-Hui Chen ,  Ker-Jer Huang ,  Alex Chen

Inventor： Jing-Tang Yang ,  Jia-Hui Chen ,  Ker-Jer Huang ,  Alex Chen

IPC: F15C5/00 ,  F16K99/00 ,  F15C1/06

CPC classification number: F16K99/0001 ,  F15C5/00 ,  F16K99/0017 ,  F16K2099/0074 ,  F16K2099/008 ,  F16K2099/0084 ,  Y10T137/2224

Abstract: The present invention discloses a novel micro valve device, comprising a micro fluidic channel, which is formed by combining two hydrophobic plates, and the micro/nano structure on the wall surfaces of the channel are used to manipulate the mobility of the fluid in the channel. The function of the micro/nano structure mentioned above is to alter the micro or nano surface pattern on the wall surfaces of the channel. According to the relation between the surface pattern and the surface tension, the textured areas on the wall surfaces can change the mobility of the fluid in the channel. This effect is used as a switch in new types of micro valve devices for biomedical tests. Methods of making the micro valve device are described and include generating a micro/nano structure on the surfaces of the channel. The temporal control of different valve resistances can be achieved with different lengths, shapes, depths and materials of the micro/nano structures.

Abstract translation: 本发明公开了一种新颖的微阀装置，其包括通过组合两个疏水板形成的微流体通道，并且通道的壁表面上的微/纳米结构用于操纵流体在通道中的流动性 。 上述微/纳米结构的功能是改变通道壁表面上的微观或纳米表面图案。 根据表面图案和表面张力之间的关系，壁表面上的纹理化区域可以改变通道中流体的流动性。 这种效应用作用于生物医学测试的新型微型阀装置中的开关。 描述制造微型阀装置的方法，包括在通道的表面上产生微/纳米结构。 可以通过微/纳米结构的不同长度，形状，深度和材料实现不同阀阻的时间控制。