公开(公告)号：US20240293327A1

公开(公告)日：2024-09-05

申请号：US18656164

申请日：2024-05-06

申请人： MATRIPHARM INTERNATIONAL INC.

发明人： Mircea-Alexandru MATEESCU ,  Tien Canh LE

IPC分类号： A61K9/20 ,  A61K31/155 ,  A61K31/606 ,  A61K47/36

CPC分类号： A61K9/2054 ,  A61K9/2059 ,  A61K31/155 ,  A61K31/606 ,  A61K47/36

摘要： The present document describes a dosage form for delivery of an active ingredient comprising: a first carboxylated polymer having carboxyl groups, having a degree of substitution of at least 0.2, a molecular weight of at least 200 kDa, and at least 30% of said carboxyl groups being complexed with a divalent cation; alone or in a co-complex with at least one of a) a control release polymer chosen from an insoluble polymer or a polymer having a reduced water solubility at 30° C., and a soluble polymer; and b) a second carboxylated polymer having carboxyl groups complexed with a divalent cation. The document also describes processes of making a carboxylated polymer having carboxyl groups, having a degree of substitution of at least 0.2, a molecular weight of at least 200 kDa, and at least 30% of said carboxyl groups being complexed with a divalent cation, and an inclusion complex, a co-complex, or both comprising the same.

公开(公告)号：US20240293311A1

公开(公告)日：2024-09-05

申请号：US18575483

申请日：2022-06-30

申请人： BIOPOLIMERI S.R.L.

发明人： Vincenzo Maria DE BENEDICTIS ,  Piera Angela RAMIRES

IPC分类号： A61K9/06 ,  A61K45/06 ,  A61K47/10 ,  A61K47/36

CPC分类号： A61K9/06 ,  A61K45/06 ,  A61K47/10 ,  A61K47/36

摘要： The present invention refers to hyaluronic acid crosslinked with polyglycerol polyglycidyl ether containing local anesthetic agents, to a process for its preparation and its use in therapy, cosmetics and as a carrier.

公开(公告)号：US20240293309A1

公开(公告)日：2024-09-05

申请号：US18656131

申请日：2024-05-06

申请人： MARENDA PHARMACEUTICALS LLC

发明人： Andrew FAVARA ,  Marc KARETNY

IPC分类号： A61K9/00 ,  A61K9/08 ,  A61K9/16 ,  A61K9/20 ,  A61K31/192 ,  A61K47/12 ,  A61K47/26 ,  A61K47/36 ,  A61K47/44 ,  A61P29/00

CPC分类号： A61K9/0056 ,  A61K9/0053 ,  A61K9/009 ,  A61K9/08 ,  A61K9/1623 ,  A61K9/1652 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/205 ,  A61K9/2068 ,  A61K31/192 ,  A61K47/12 ,  A61K47/26 ,  A61K47/36 ,  A61K47/44 ,  A61P29/00

摘要： Disclosed is a dry powder oral formulation that includes an active pharmaceutical ingredient (API), a lecithin powder, a galactomannan, one or more sweetening agents, one or more flavoring agents and an organic acid in a pharmaceutically acceptable preparation. Also disclosed are an excipient composition in absence of an API and methods of making and using the formulations and compositions. Also disclosed is a chewable, swallowable, and/or orally disintegrating tablet comprising an API, a lecithin powder, a galactomannan, one or more sweetening agents, one or more flavoring agents and an organic acid in a pharmaceutically acceptable preparation.

公开(公告)号：US12076437B2

公开(公告)日：2024-09-03

申请号：US17862962

申请日：2022-07-12

申请人： Brown University

发明人： Kareen L. K. Coulombe ,  Stephanie Roser ,  Fabiola Munarin ,  Alicia Minor

IPC分类号： A61K9/06 ,  A61K38/18 ,  A61K38/30 ,  A61K47/36 ,  A61K47/42

CPC分类号： A61K9/06 ,  A61K38/1825 ,  A61K38/1858 ,  A61K38/1866 ,  A61K38/30 ,  A61K47/36 ,  A61K47/42

摘要： The invention provides a highly versatile system to promote vascularization in ischemic tissue. The system is composed of a fully defined, customizable hydrogel loaded with a potent cocktail of proangiogenic growth factors. The hydrogel's mechanical, degradation, and factor release behavior can be tailored to the specifications of any given target tissue or ischemic disease state. The growth factor cocktail can be optimized for maximal vessel density or size to meet the perfusion specifications required by the tissue. The embodiments of the disclosure concern methods and compositions of the system, with examples of preparation for both injectable and implantable delivery modes.

公开(公告)号：US20240277638A1

公开(公告)日：2024-08-22

申请号：US18681394

申请日：2022-08-08

申请人： PHARMA-DATA S.A.

发明人： Ioannis PSARRAKIS ,  Konstantinos LIOUMIS

IPC分类号： A61K31/165 ,  A61K9/08 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/36 ,  A61K47/38

CPC分类号： A61K31/165 ,  A61K9/08 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/36 ,  A61K47/38

摘要： Described is a stable buffered aqueous colchicine solution or suspension being free of benzyl alcohol, comprising colchicine, a water miscible solvent and a preservative, characterized in that the solution comprises 0.01-1.0 w/v % colchicine, 2.5-15.0 w/v % glycerol and 0.05-1 w/v % preservative, the pH of the solution or suspension being 4.5-7.0. A method for the preparation thereof is also disclosed.

公开(公告)号：US12064427B2

公开(公告)日：2024-08-20

申请号：US18240076

申请日：2023-08-30

申请人： Celgene Corporation

发明人： Anjali Agrawal ,  Ming J. Chen ,  Shyam Babu Karki ,  Prajwal Gunwanth Thool ,  Dora Visky ,  Ruimin Xie

IPC分类号： A61K31/496 ,  A61K47/02 ,  A61K47/26 ,  A61K47/36

CPC分类号： A61K31/496 ,  A61K47/02 ,  A61K47/26 ,  A61K47/36

摘要： Provided herein are pharmaceutical compositions (e.g., oral dosage formulations) comprising (S)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, mixture of enantiomers, tautomer, isotopolog, or pharmaceutically acceptable salt thereof, and a carrier or diluent. Also provided herein are methods of preparing and methods of using the pharmaceutical compositions.

公开(公告)号：US20240268431A1

公开(公告)日：2024-08-15

申请号：US18291942

申请日：2022-07-28

申请人： N.V. Nutricia

发明人： Maria DEL RAYO HERNANDEZ SANCHEZ ,  Jordan Nicolaas VAN DER WEL

IPC分类号： A23L33/115 ,  A23L29/219 ,  A23L33/00 ,  A23L33/125 ,  A23L33/175 ,  A23P10/47 ,  A61K31/202 ,  A61K47/36 ,  A61K47/44

CPC分类号： A23L33/115 ,  A23L29/219 ,  A23L33/125 ,  A23L33/175 ,  A23L33/40 ,  A23P10/47 ,  A61K31/202 ,  A61K47/36 ,  A61K47/44

摘要： The present invention relates to a use of octenylsuccinyl anhydride substituted starch (OSA starch) for increasing the dry weight content and/or the fat content of a liquid composition that is subjected to a spray-drying step, and also to a process for preparing powders. The present invention enables the spray-drying of emulsions that contain a high amount of fat. The present invention also relates to the powder products obtainable by the process and nutritional products such as an infant milk powder, grow up milk, toddler milk or as a medical nutritional product that can be formulated therewith.

公开(公告)号：US12059394B2

公开(公告)日：2024-08-13

申请号：US17266320

申请日：2019-08-05

申请人： Givaudan France Naturals SAS

发明人： Pascale Elizabeth Renée Fanca-Berthon ,  Leila Denise Falcao ,  Mathieu Tenon ,  Maryline Vinal ,  Simona Birtic

IPC分类号： A61K31/12 ,  A61K36/185 ,  A61K47/36

CPC分类号： A61K31/12 ,  A61K36/185 ,  A61K47/36

摘要： The present invention relates to methods and uses of compositions comprising curcumin; in particular, methods and uses relating to improving the bioaccessibility, bioavailability, bioefficacy and/or bioactivity of curcuminoids in mammals.

公开(公告)号：US20240261412A1

公开(公告)日：2024-08-08

申请号：US18564462

申请日：2022-05-30

申请人： AKAY NATURAL INGREDIENTS PRIVATE LIMITED

发明人： Krishnakumar ILLATHU MADHAVAMENON ,  Balu Paulose MALIAKEL

IPC分类号： A61K47/36 ,  A61K9/107 ,  A61K31/047 ,  A61K31/05 ,  A61K31/07 ,  A61K31/122 ,  A61K31/352 ,  A61K31/355 ,  A61K31/375 ,  A61K31/409 ,  A61K31/4375 ,  A61K31/593 ,  A61K33/04 ,  A61K33/06 ,  A61K33/26 ,  A61K33/30

CPC分类号： A61K47/36 ,  A61K9/107 ,  A61K31/047 ,  A61K31/05 ,  A61K31/07 ,  A61K31/122 ,  A61K31/352 ,  A61K31/355 ,  A61K31/375 ,  A61K31/409 ,  A61K31/4375 ,  A61K31/593 ,  A61K33/04 ,  A61K33/06 ,  A61K33/26 ,  A61K33/30

摘要： The present disclosure relates to a nutraceutical composition and a process for its preparation. The nutraceutical composition comprises a bioactive substance, galactomannan mixture for the delivery of hydrophilic and hydrophobic bioactive substances. The nutraceutical composition of the present disclosure provides stable composition and enhances the concentration and duration of a bioactive substance in the systemic circulation and its efficacy.

公开(公告)号：US12053574B2

公开(公告)日：2024-08-06

申请号：US16626410

申请日：2017-06-29

申请人： KOREA UNITED PHARM. INC.

发明人： Won Ho Kang ,  Youn Woong Choi ,  Dae Chul Ha ,  Seung Jin Yang ,  Gweon Hee Yu ,  Kyu Yeol Nam ,  Kyu Chul Jang

IPC分类号： A61M15/00 ,  A61K9/00 ,  A61K47/26 ,  A61K47/36

CPC分类号： A61M15/0005 ,  A61K9/0075 ,  A61K47/26 ,  A61K47/36

摘要： The present invention relates to a dry powder inhaler. The dry powder inhaler includes an inhaler housing, a drug container configured to be provided in the inhaler housing and accommodate the dry powder drug, a drug inlet configured to be disposed above the drug container and through which the dry powder drug is inhaled, and a mesh network configured to be installed on a path of the drug inlet and have a mesh part for collision with the dry powder drug formed therein.