公开(公告)号：US12064427B2

公开(公告)日：2024-08-20

申请号：US18240076

申请日：2023-08-30

申请人： Celgene Corporation

发明人： Anjali Agrawal ,  Ming J. Chen ,  Shyam Babu Karki ,  Prajwal Gunwanth Thool ,  Dora Visky ,  Ruimin Xie

IPC分类号： A61K31/496 ,  A61K47/02 ,  A61K47/26 ,  A61K47/36

CPC分类号： A61K31/496 ,  A61K47/02 ,  A61K47/26 ,  A61K47/36

摘要： Provided herein are pharmaceutical compositions (e.g., oral dosage formulations) comprising (S)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, mixture of enantiomers, tautomer, isotopolog, or pharmaceutically acceptable salt thereof, and a carrier or diluent. Also provided herein are methods of preparing and methods of using the pharmaceutical compositions.

公开(公告)号：US20240358697A1

公开(公告)日：2024-10-31

申请号：US18767295

申请日：2024-07-09

申请人： Celgene Corporation

发明人： Anjali Agrawal ,  Ming J. Chen ,  Shyam Babu Karki ,  Prajwal Gunwanth Thool ,  Dora Visky ,  Ruimin Xie

IPC分类号： A61K31/496 ,  A61K47/02 ,  A61K47/26 ,  A61K47/36

CPC分类号： A61K31/496 ,  A61K47/02 ,  A61K47/26 ,  A61K47/36

摘要： Provided herein are pharmaceutical compositions (e.g., oral dosage formulations) comprising (S)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, mixture of enantiomers, tautomer, isotopolog, or pharmaceutically acceptable salt thereof, and a carrier or diluent. Also provided herein are methods of preparing and methods of using the pharmaceutical compositions.

公开(公告)号：US20240066026A1

公开(公告)日：2024-02-29

申请号：US18240076

申请日：2023-08-30

申请人： Celgene Corporation

发明人： Anjali Agrawal ,  Ming J. Chen ,  Shyam Babu Karki ,  Prajwal Gunwanth Thool ,  Dora Visky ,  Ruimin Xie

IPC分类号： A61K31/496 ,  A61K47/02 ,  A61K47/26 ,  A61K47/36

CPC分类号： A61K31/496 ,  A61K47/02 ,  A61K47/26 ,  A61K47/36

摘要： Provided herein are pharmaceutical compositions (e.g., oral dosage formulations) comprising (S)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, mixture of enantiomers, tautomer, isotopolog, or pharmaceutically acceptable salt thereof, and a carrier or diluent. Also provided herein are methods of preparing and methods of using the pharmaceutical compositions.

公开(公告)号：US11779580B2

公开(公告)日：2023-10-10

申请号：US16737721

申请日：2020-01-08

申请人： Celgene Corporation

发明人： Anjali Agrawal ,  Ming J. Chen ,  Shyam Babu Karki ,  Prajwal Gunwanth Thool ,  Dora Visky ,  Ruimin Xie

IPC分类号： A61K31/496 ,  A61K47/02 ,  A61K47/26 ,  A61K47/36

CPC分类号： A61K31/496 ,  A61K47/02 ,  A61K47/26 ,  A61K47/36

摘要： Provided herein are pharmaceutical compositions (e.g., oral dosage formulations) comprising (S)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, mixture of enantiomers, tautomer, isotopolog, or pharmaceutically acceptable salt thereof, and a carrier or diluent. Also provided herein are methods of preparing and methods of using the pharmaceutical compositions.

公开(公告)号：US20200215061A1

公开(公告)日：2020-07-09

申请号：US16737721

申请日：2020-01-08

申请人： Celgene Corporation

发明人： Anjali Agrawal ,  Ming J. Chen ,  Shyam Babu Karki ,  Prajwal Gunwanth Thool ,  Dora Visky ,  Ruimin Xie

IPC分类号： A61K31/496 ,  A61K47/26 ,  A61K47/36 ,  A61K47/02

摘要： Provided herein are pharmaceutical compositions (e.g., oral dosage formulations) comprising (S)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, mixture of enantiomers, tautomer, isotopolog, or pharmaceutically acceptable salt thereof, and a carrier or diluent. Also provided herein are methods of preparing and methods of using the pharmaceutical compositions.