公开(公告)号：US08894931B2

公开(公告)日：2014-11-25

申请号：US13076007

申请日：2011-03-30

Applicant: Yuichi Hamada ,  Daigo Fukuma

Inventor： Yuichi Hamada ,  Daigo Fukuma

IPC: G01N33/50 ,  G01N35/00 ,  G01N1/31 ,  G01N15/14

CPC classification number: G01N35/00663 ,  G01N1/31 ,  G01N15/14 ,  G01N35/00712 ,  G01N35/00732 ,  G01N2035/00673 ,  G01N2035/00772 ,  G01N2035/00782 ,  G01N2035/00811 ,  G01N2035/00851 ,  G01N2035/009 ,  G01N2035/0091 ,  Y10T436/11

Abstract: A sample analyzer comprising: a reagent container set section for setting a reagent container; a reader/writer configured to read out an information from the recording medium attached to the reagent container set in the reagent container set section and configured to write an information on the recording medium; a writing instruction section configured to issue an instruction to write the information on the recording medium; and a controller configured to control the reader/writer to write the information on the recording medium attached to the reagent container set in the reagent container set section if the kind information read out from the recording medium indicates the specific reagent and the writing instruction section has issued the writing instruction. Also, a method of writing information on a recording medium attached to a reagent container.

Abstract translation: 一种样品分析装置，其特征在于，包括：试剂容器设定部，其设置试剂容器; 读取器/写入器，被配置为从安装在试剂容器组部分中的试剂容器的记录介质读出信息，并将其配置为在记录介质上写入信息; 写入指令部，被配置为发出在所述记录介质上写入所述信息的指令; 以及控制器，其被配置为如果从记录介质读出的种类信息指示特定试剂并且写入指令部分具有如下信息，则控制读取器/写入器将信息写入安装在试剂容器集部分中的试剂容器上的记录介质上 发出书面指示。 另外，在附着于试剂容器的记录介质上写入信息的方法。

公开(公告)号：US08852506B2

公开(公告)日：2014-10-07

申请号：US13074478

申请日：2011-03-29

Applicant: Yuichi Hamada ,  Keisuke Kuwano

Inventor： Yuichi Hamada ,  Keisuke Kuwano

IPC: G01N35/00 ,  G01N35/10 ,  G01N35/04 ,  G01N1/31 ,  G01N15/14

CPC classification number: G01N35/00712 ,  G01N1/31 ,  G01N15/14 ,  G01N35/00663 ,  G01N35/00732 ,  G01N35/1002 ,  G01N2035/00673 ,  G01N2035/00811 ,  G01N2035/009 ,  G01N2035/0091 ,  G01N2035/0405 ,  G01N2035/0436 ,  Y10T436/11

Abstract: A sample analyzer comprising: a first container set section in which a first reagent container, wherein the first container set section includes a first operating section which is operated by a user when setting the first reagent container; a first detector configured to detect an operation of the first operating section; a second container set section in which a second reagent container, wherein the second container set section includes a second operating section which is operated by the user when setting the second reagent container; a second detector configured to detect an operation of the second operating section; an output section; and a controller configured to control the output section to output a predetermined notification, if the second detector detects the operation of the second operating section by the user when it is required to set the first reagent container in the first container set section.

Abstract translation: 1.一种样本分析装置，其特征在于，具备：第一容器集合部，在所述第一容器集合部中，第一容器集合部，其具有第一操作部，所述第一操作部在设置所述第一试剂容器时由使用者操作; 第一检测器，被配置为检测第一操作部的操作; 第二容器设置部，其中第二试剂容器，其中第二容器设置部分包括在设置第二试剂容器时由使用者操作的第二操作部分; 第二检测器，被配置为检测第二操作部分的操作; 输出部分; 以及控制器，被配置为当要求将第一试剂容器设置在第一容器组部分中时，如果第二检测器检测到用户的第二操作部分的操作，则控制输出部分输出预定通知。

公开(公告)号：US20140286838A1

公开(公告)日：2014-09-25

申请号：US14299178

申请日：2014-06-09

Applicant: DAKO DENMARK A/S

Inventor： Lars Winther ,  Marc Key ,  Kristopher Buchanan ,  John Favuzzi ,  Benno Guggenheimer

IPC: G01N1/31

CPC classification number: G01N35/00732 ,  G01N1/30 ,  G01N1/31 ,  G01N1/312 ,  G01N35/00712 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/0099 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00366 ,  G01N2035/00376 ,  G01N2035/00435 ,  G01N2035/00881 ,  G01N2035/00891 ,  G16H50/20 ,  Y02A90/22 ,  Y02A90/26 ,  Y10S901/02 ,  Y10S901/41 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/25 ,  Y10T436/2575

Abstract: The present invention concerns an apparatus for automatic processing at least one biological sample accommodated on a carrier member, such as slide by applying a predetermined amount of reagents in a predetermined sequence according to a processing protocol, said apparatus comprising; a housing frame; at least one processing section for accommodating at least one slide, the at least one processing section is provided within the housing; a hood cover protecting the at least one processing section in said housing; wherein the hood cover completely encloses the processing section defining an interior space; and wherein the apparatus further comprises climate control device provided to control the environment within the interior space.

Abstract translation: 本发明涉及一种用于根据处理方案以预定顺序施加预定量的试剂来自动处理容纳在载体构件（例如载玻片）上的至少一种生物样品的装置，所述装置包括： 一个框架; 至少一个处理部分，用于容纳至少一个滑块，所述至少一个处理部分设置在所述壳体内; 保护所述壳体中的至少一个处理部分的罩盖; 其中所述罩盖完全包围限定内部空间的所述处理部分; 并且其中所述装置还包括设置用于控制所述内部空间内的环境的气候控制装置。

公开(公告)号：US20140250969A1

公开(公告)日：2014-09-11

申请号：US13793574

申请日：2013-03-11

Applicant: ANALOG DEVICES TECHNOLOGY

Inventor： Kamatchi Saravanan Alagarsamy ,  William A. Clark ,  Jishnu Choyi ,  James M. Lee ,  Vikas Choudhary

IPC: B81B7/02

CPC classification number: B81B7/02 ,  B81B7/008 ,  B81C99/005 ,  G01N35/00712

Abstract: A MEMS sensor includes a micro-electromechanical structure, a detection circuit, and a self-test circuit to test the health of the MEMS sensor during runtime operations. The self-test circuit is configured to inject into the micro-electromechanical structure a plurality of injected test signals that are broad-band frequency-varying frequency signals, which are based on spread spectrum based modulation. The injected test signals may a magnitude that is below an observable threshold of the sensor signal as well as a test-signal bandwidth that overlaps with a substantial portion of the sensor bandwidth, including the stimulus of interest.

Abstract translation: MEMS传感器包括微机电结构，检测电路和自检电路，以在运行时操作期间测试MEMS传感器的健康状况。 自检电路被配置为向微机电结构中注入多个基于扩频调制的宽带频率变化频率信号的注入测试信号。 注入的测试信号的幅度可能低于传感器信号的可观察阈值，以及与传感器带宽的大部分重叠的测试信号带宽，包括感兴趣的刺激。

公开(公告)号：US08784735B2

公开(公告)日：2014-07-22

申请号：US13964562

申请日：2013-08-12

Applicant: Lars Winther ,  Marc Key ,  Kristopher Buchanan ,  John Favuzzi ,  Benno Guggenheimer

Inventor： Lars Winther ,  Marc Key ,  Kristopher Buchanan ,  John Favuzzi ,  Benno Guggenheimer

IPC: G01N35/00

CPC classification number: G01N35/00732 ,  G01N1/30 ,  G01N1/31 ,  G01N1/312 ,  G01N35/00712 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/0099 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00366 ,  G01N2035/00376 ,  G01N2035/00435 ,  G01N2035/00881 ,  G01N2035/00891 ,  G16H50/20 ,  Y02A90/22 ,  Y02A90/26 ,  Y10S901/02 ,  Y10S901/41 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/25 ,  Y10T436/2575

Abstract: The present invention concerns an apparatus for automatic processing at least one biological sample accommodated on a carrier member, such as a slide by applying a predetermined amount of reagents in a predetermined sequence according to a processing protocol, said apparatus comprising; a housing frame; at least one processing section for accommodating at least one slide, the at least one processing section is provided within the housing; a hood cover protecting the at least one processing section in said housing; wherein the hood cover completely encloses the processing section defining an interior space; and wherein the apparatus further comprises climate control device provided to control the environment within the interior space.

Abstract translation: 本发明涉及一种用于根据处理方案以预定顺序施加预定量的试剂来自动处理容纳在载体构件如载玻片上的至少一种生物样品的装置，所述装置包括： 一个框架; 至少一个处理部分，用于容纳至少一个滑块，所述至少一个处理部分设置在所述壳体内; 保护所述壳体中的至少一个处理部分的罩盖; 其中所述罩盖完全包围限定内部空间的所述处理部分; 并且其中所述装置还包括设置用于控制所述内部空间内的环境的气候控制装置。

公开(公告)号：US20140186218A1

公开(公告)日：2014-07-03

申请号：US14151130

申请日：2014-01-09

Applicant: Doug SWEET ,  Marc KEY ,  Gordon FEINGOLD ,  Kristopher BUCHANAN ,  Bob LATHROP ,  John FAVUZZI

Inventor： Doug SWEET ,  Marc KEY ,  Gordon FEINGOLD ,  Kristopher BUCHANAN ,  Bob LATHROP ,  John FAVUZZI

IPC: G01N1/31

CPC classification number: G01N35/00732 ,  G01N1/30 ,  G01N1/31 ,  G01N1/312 ,  G01N35/00712 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/0099 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00366 ,  G01N2035/00376 ,  G01N2035/00435 ,  G01N2035/00881 ,  G01N2035/00891 ,  G16H50/20 ,  Y02A90/22 ,  Y02A90/26 ,  Y10S901/02 ,  Y10S901/41 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/25 ,  Y10T436/2575

Abstract: The present invention concerns an apparatus for staining tissue samples, said apparatus including a reagent section or reagent containers; at least one staining section or tissue samples, a robotic head or robotic element that may move reagent to a predetermined tissue sample, said robotic element being moveable above the reagent and the staining sections, a control element that may manage a staining process, a 2-D optical sensor to detect two-dimensional image data of a relevant property and that can feed the captured image data to the control element. By providing the robotic element with a 2-D optical sensor, a common image processor may be provided having multiple functions. By using a 2-D optical image processing system, the control system of the apparatus may easily be adapted to read various types of data presentations, just as actual images for sections of the apparatus may be identified in order to assess the condition of the apparatus. The optical sensor may be used to automatically identify the slides and the reagent containers present in the apparatus, just as the optical sensor may be used for checking if a slide is misplaced at or absent from a slide position, etc.

Abstract translation: 本发明涉及用于染色组织样本的装置，所述装置包括试剂部分或试剂容器; 至少一个染色部分或组织样品，可将试剂移动到预定组织样品的机器人头部或机器人元件，所述机器人元件可在试剂和染色部分上方移动，可控制染色过程的控制元件，2 -D光学传感器以检测相关属性的二维图像数据，并且可以将捕获的图像数据馈送到控制元件。 通过向机器人元件提供2-D光学传感器，可以提供具有多种功能的公共图像处理器。 通过使用2-D光学图像处理系统，装置的控制系统可以容易地适于读取各种类型的数据呈现，就像可以识别装置的部分的实际图像以便评估装置的状况 。 可以使用光学传感器来自动识别装置中存在的载玻片和试剂容器，就像光学传感器可用于检查幻灯片是否位于滑动位置或不存在滑动位置等。

公开(公告)号：US20140038232A1

公开(公告)日：2014-02-06

申请号：US14053977

申请日：2013-10-15

Applicant: Marc Key ,  Gordon Feingold ,  Rosanne Welcher

Inventor： Marc Key ,  Gordon Feingold ,  Rosanne Welcher

IPC: G01N1/30

CPC classification number: G01N35/00732 ,  G01N1/30 ,  G01N1/31 ,  G01N1/312 ,  G01N35/00712 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/0099 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00366 ,  G01N2035/00376 ,  G01N2035/00435 ,  G01N2035/00881 ,  G01N2035/00891 ,  G16H50/20 ,  Y02A90/22 ,  Y02A90/26 ,  Y10S901/02 ,  Y10S901/41 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/25 ,  Y10T436/2575

Abstract: A sample processing system 101 that may be automated and methods are disclosed where sample(s) 198 are arranged on a carrier element 197 and a process operation control system 171 automatically processes the sample(s) perhaps robotically according to an desired aggregation of event dictated by an input 173. Alteration of an initial aggregated event topology may be accepted while the system is processing an initial aggregation and varied-parameter robotic control simulation functionalities 606 may be accomplished to determine an enhanced sequence for processing. Suggested operator actions may be displayed that might further enhance the scheduling of the altered aggregated event topology together with an automatic operator need prompt 608 that may inform an operator of a need for a particular action in order to accomplish the desired tasks. Reversibility to proposed changes may be made available so that an operator may avoid having to activate proposed changes if they cause a processing result that is not acceptable.

Abstract translation: 公开了可以是自动化的样本处理系统101和方法，其中样本198布置在载体元件197上，并且过程操作控制系统171可以根据事件规定的所需聚合自动地处理样本 可以通过输入173.当系统正在处理初始聚合并且可变参数机器人控制时可以接受初始聚合事件拓扑的改变，可以实现功能606以确定用于处理的增强的序列。 可以显示建议的操作者动作，其可以进一步增强改变的聚合事件拓扑的调度以及可以通知操作者需要特定动作以实现所需任务的自动操作者需求提示608。 提出的改变的可逆性可以提供，以便操作者可以避免在导致不可接受的处理结果时激活所提出的改变。

公开(公告)号：US08529836B2

公开(公告)日：2013-09-10

申请号：US13493969

申请日：2012-06-11

Applicant: Lars Winther ,  Marc Key ,  Kristopher Buchanan ,  John Favuzzi ,  Benno Guggenheimer

Inventor： Lars Winther ,  Marc Key ,  Kristopher Buchanan ,  John Favuzzi ,  Benno Guggenheimer

IPC: G01N35/00

CPC classification number: G01N35/00732 ,  G01N1/30 ,  G01N1/31 ,  G01N1/312 ,  G01N35/00712 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/0099 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00366 ,  G01N2035/00376 ,  G01N2035/00435 ,  G01N2035/00881 ,  G01N2035/00891 ,  G16H50/20 ,  Y02A90/22 ,  Y02A90/26 ,  Y10S901/02 ,  Y10S901/41 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/25 ,  Y10T436/2575

Abstract: The present invention concerns an apparatus for automatic processing at least one biological sample accommodated on a carrier member, such as a slide by applying a predetermined amount of reagents in a predetermined sequence according to a processing protocol, said apparatus comprising; a housing frame; at least one processing section for accommodating at least one slide, the at least one processing section is provided within the housing; a hood cover protecting the at least one processing section in said housing; wherein the hood cover completely encloses the processing section defining an interior space; and wherein the apparatus further comprises climate control device provided to control the environment within the interior space.

Abstract translation: 本发明涉及一种用于根据处理方案以预定顺序施加预定量的试剂来自动处理容纳在载体构件如载玻片上的至少一种生物样品的装置，所述装置包括： 一个框架; 至少一个处理部分，用于容纳至少一个滑块，所述至少一个处理部分设置在所述壳体内; 保护所述壳体中的至少一个处理部分的罩盖; 其中所述罩盖完全包围限定内部空间的所述处理部分; 并且其中所述装置还包括设置用于控制所述内部空间内的环境的气候控制装置。

公开(公告)号：US20130217108A1

公开(公告)日：2013-08-22

申请号：US13758810

申请日：2013-02-04

Applicant: DAKO DENMARK A/S

Inventor： Marc Key ,  Gordon Feingold ,  Rosanne Welcher

IPC: G01N1/31

CPC classification number: G01N35/00732 ,  G01N1/30 ,  G01N1/31 ,  G01N1/312 ,  G01N35/00712 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/0099 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00366 ,  G01N2035/00376 ,  G01N2035/00435 ,  G01N2035/00881 ,  G01N2035/00891 ,  G16H50/20 ,  Y02A90/22 ,  Y02A90/26 ,  Y10S901/02 ,  Y10S901/41 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/25 ,  Y10T436/2575

Abstract: A sample processing system 101 that may be automated and methods are disclosed where sample(s) 198 are arranged on a carrier element 197 and a process operation control system 171 automatically processes the sample(s) perhaps robotically according to an desired aggregation of event dictated by an input 173. Alteration of an initial aggregated event topology may be accepted while the system is processing an initial aggregation and varied-parameter robotic control simulation functionalities 606 may be accomplished to determine an enhanced sequence for processing. Suggested operator actions may be displayed that might further enhance the scheduling of the altered aggregated event topology together with an automatic operator need prompt 608 that may inform an operator of a need for a particular action in order to accomplish the desired tasks. Reversibility to proposed changes may be made available so that an operator may avoid having to activate proposed changes if they cause a processing result that is not acceptable.

Abstract translation: 公开了可以是自动化的样本处理系统101和方法，其中样本198布置在载体元件197上，并且过程操作控制系统171可以根据事件规定的所需聚合自动地处理样本 可以通过输入173.当系统正在处理初始聚合并且可变参数机器人控制时可以接受初始聚合事件拓扑的改变，可以实现功能606以确定用于处理的增强的序列。 可以显示建议的操作者动作，其可以进一步增强改变的聚合事件拓扑的调度以及可以通知操作者需要特定动作以实现所需任务的自动操作者需求提示608。 提出的改变的可逆性可以提供，以便操作者可以避免在导致不可接受的处理结果时激活所提出的改变。

公开(公告)号：US20120310422A1

公开(公告)日：2012-12-06

申请号：US13493969

申请日：2012-06-11

Applicant: Lars Winther ,  Marc Key ,  Kristopher Buchanan ,  John Favuzzi ,  Benno Guggenheimer

Inventor： Lars Winther ,  Marc Key ,  Kristopher Buchanan ,  John Favuzzi ,  Benno Guggenheimer

IPC: G05D7/00

CPC classification number: G01N35/00732 ,  G01N1/30 ,  G01N1/31 ,  G01N1/312 ,  G01N35/00712 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/0099 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00366 ,  G01N2035/00376 ,  G01N2035/00435 ,  G01N2035/00881 ,  G01N2035/00891 ,  G16H50/20 ,  Y02A90/22 ,  Y02A90/26 ,  Y10S901/02 ,  Y10S901/41 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/25 ,  Y10T436/2575

Abstract: The present invention concerns an apparatus for automatic processing at least one biological sample accommodated on a carrier member, such as a slide by applying a predetermined amount of reagents in a predetermined sequence according to a processing protocol, said apparatus comprising; a housing frame; at least one processing section for accommodating at least one slide, the at least one processing section is provided within the housing; a hood cover protecting the at least one processing section in said housing; wherein the hood cover completely encloses the processing section defining an interior space; and wherein the apparatus further comprises climate control device provided to control the environment within the interior space.

Abstract translation: 本发明涉及一种用于根据处理方案以预定顺序施加预定量的试剂来自动处理容纳在载体构件如载玻片上的至少一种生物样品的装置，所述装置包括： 一个框架; 至少一个处理部分，用于容纳至少一个滑块，所述至少一个处理部分设置在所述壳体内; 保护所述壳体中的至少一个处理部分的罩盖; 其中所述罩盖完全包围限定内部空间的所述处理部分; 并且其中所述装置还包括设置用于控制所述内部空间内的环境的气候控制装置。