公开(公告)号：US09599630B2

公开(公告)日：2017-03-21

申请号：US14151130

申请日：2014-01-09

Applicant: Dako Denmark A/S

Inventor： Doug Sweet ,  Marc Key ,  Gordon Feingold ,  Kristopher Buchanan ,  Bob Lathrop ,  John Favuzzi

IPC: G01N1/31 ,  G01N35/00 ,  G01N1/30

CPC classification number: G01N35/00732 ,  G01N1/30 ,  G01N1/31 ,  G01N1/312 ,  G01N35/00712 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/0099 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00366 ,  G01N2035/00376 ,  G01N2035/00435 ,  G01N2035/00881 ,  G01N2035/00891 ,  G16H50/20 ,  Y02A90/22 ,  Y02A90/26 ,  Y10S901/02 ,  Y10S901/41 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/25 ,  Y10T436/2575

Abstract: The present invention concerns an apparatus for staining tissue samples, said apparatus including a reagent section or reagent containers; at least one staining section or tissue samples, a robotic head or robotic element that may move reagent to a predetermined tissue sample, said robotic element being moveable above the reagent and the staining sections, a control element that may manage a staining process, a 2-D optical sensor to detect two-dimensional image data of a relevant property and that can feed the captured image data to the control element. By providing the robotic element with a 2-D optical sensor, a common image processor may be provided having multiple functions. By using a 2-D optical image processing system, the control system of the apparatus may easily be adapted to read various types of data presentations, just as actual images for sections of the apparatus may be identified in order to assess the condition of the apparatus. The optical sensor may be used to automatically identify the slides and the reagent containers present in the apparatus, just as the optical sensor may be used for checking if a slide is misplaced at or absent from a slide position, etc.

公开(公告)号：US09040284B2

公开(公告)日：2015-05-26

申请号：US13625115

申请日：2012-09-24

Applicant: DAKO Denmark A/S

Inventor： Kristopher Buchanan ,  Marc Key ,  John Favuzzi ,  Rosanne Welcher ,  Benno Guggenheimer ,  Robert Clark ,  Michael Barber ,  Bob Lathrop

IPC: G01N35/00 ,  G01N1/30 ,  G01N1/31

CPC classification number: G01N35/00732 ,  G01N1/30 ,  G01N1/31 ,  G01N1/312 ,  G01N35/00712 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/0099 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00366 ,  G01N2035/00376 ,  G01N2035/00435 ,  G01N2035/00881 ,  G01N2035/00891 ,  G16H50/20 ,  Y02A90/22 ,  Y02A90/26 ,  Y10S901/02 ,  Y10S901/41 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/25 ,  Y10T436/2575

Abstract: Systems and methods of sample processing and temperature control are disclosed. The invention may especially relate to temperature control, and may in some embodiments be methods of temperature control of an automated sample processing system and methods of automated sample processing. Specifically, the present invention provides temperature control in relation to sample processing systems and methods of processing samples, and in some embodiments provides temperature control in relation to sample carriers and processing materials such as reagents. Corresponding systems and devices are disclosed, including sample processing systems (1), sample carrier temperature regulation systems (60), reagent temperature regulation systems, sample processing control systems, and temperature regulation devices, among other embodiments. Scientific fields to which the present invention may have particular applicability include immunohistochemistry, hybridization, fluorescent in-situ hybridization, special staining, such as special staining of histological samples, microarray sample processing, and cytology, as well as potentially other chemical and biological applications.

Abstract translation: 公开了样品处理和温度控制的系统和方法。 本发明可以特别涉及温度控制，并且在一些实施例中可以是自动化样品处理系统的温度控制方法和自动样品处理方法。 具体地，本发明提供了与样品处理系统和处理样品的方法相关的温度控制，并且在一些实施例中提供了与样品载体和加工材料如试剂相关的温度控制。 公开了相应的系统和装置，包括样品处理系统（1），样品载体温度调节系统（60），试剂温度调节系统，样品处理控制系统和温度调节装置。 本发明可能具有特定适用性的科学领域包括免疫组织化学，杂交，荧光原位杂交，特殊染色，例如组织学样品的特殊染色，微阵列样品处理和细胞学，以及潜在的其它化学和生物应用。

公开(公告)号：US20140356935A1

公开(公告)日：2014-12-04

申请号：US14306606

申请日：2014-06-17

Applicant: DAKO DENMARK A/S

Inventor： Gordon Feingold ,  Marc Key ,  John Favuzzi ,  Rosanne Welcher

IPC: G01N35/00

CPC classification number: G01N35/00732 ,  G01N1/30 ,  G01N1/31 ,  G01N1/312 ,  G01N35/00712 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/0099 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00366 ,  G01N2035/00376 ,  G01N2035/00435 ,  G01N2035/00881 ,  G01N2035/00891 ,  G16H50/20 ,  Y02A90/22 ,  Y02A90/26 ,  Y10S901/02 ,  Y10S901/41 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/25 ,  Y10T436/2575

Abstract: A sample processing system that may be automated and methods are disclosed where samples are arranged on a carrier element and a process operation control system automatically processes the samples perhaps robotically with an operationally-influential exteriorly-consequential information monitor or a data capture element. Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element may cause notification of a person at some display that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to “watch” simulated operation in real time or long after completion of the actual processing.

Abstract translation: 公开了一种可以是自动化的样品处理系统和方法，其中样品被布置在载体元件上，并且过程操作控制系统可以机器人地自动处理样品，其具有操作上有影响力的外部信息监视器或数据捕获元件。 可以监视重要的过程细节以及对操作有影响的外部信息的信息，并且自动通知单元可能导致人们在某些可能是远程的显示器上的通知。 可以通知各种人员，例如管理员，供应商或具有诸如试剂重新排序等的某些动作的机会的制造商。 模拟运动显示可以包括在实际处理完成之后实时或长时间“监视”模拟操作。

公开(公告)号：US20160084862A1

公开(公告)日：2016-03-24

申请号：US14959741

申请日：2015-12-04

Applicant: Dako Denmark A/S

Inventor： Gordon Feingold ,  Marc Key ,  John Favuzzi ,  Rosanne Welcher

IPC: G01N35/00

CPC classification number: G01N35/00732 ,  G01N1/30 ,  G01N1/31 ,  G01N1/312 ,  G01N35/00712 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/0099 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00366 ,  G01N2035/00376 ,  G01N2035/00435 ,  G01N2035/00881 ,  G01N2035/00891 ,  G16H50/20 ,  Y02A90/22 ,  Y02A90/26 ,  Y10S901/02 ,  Y10S901/41 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/25 ,  Y10T436/2575

Abstract: A sample processing system that may be automated and methods are disclosed where samples are arranged on a carrier element and a process operation control system automatically processes the samples perhaps robotically with an operationally-influential exteriorly-consequential information monitor or a data capture element. Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element may cause notification of a person at some display that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to “watch” simulated operation in real time or long after completion of the actual processing.

Abstract translation: 公开了一种可以是自动化的样品处理系统和方法，其中样品被布置在载体元件上，并且过程操作控制系统可以机器人地自动处理样品，其具有操作上有影响力的外部信息监视器或数据捕获元件。 可以监视重要的过程细节以及对操作有影响的外部信息的信息，并且自动通知单元可能导致人们在可能是远程的某些显示器处的通知。 可以通知各种人员，例如管理员，供应商或具有诸如试剂重新排序等的某些动作的机会的制造商。 模拟运动显示可以包括在实际处理完成之后实时或长时间“监视”模拟操作。

公开(公告)号：US08788217B2

公开(公告)日：2014-07-22

申请号：US13747949

申请日：2013-01-23

Applicant: DAKO Denmark A/S

Inventor： Gordon Feingold ,  Marc Key ,  John Favuzzi ,  Rosanne Welcher

IPC: G01N35/00

CPC classification number: G01N35/00732 ,  G01N1/30 ,  G01N1/31 ,  G01N1/312 ,  G01N35/00712 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/0099 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00366 ,  G01N2035/00376 ,  G01N2035/00435 ,  G01N2035/00881 ,  G01N2035/00891 ,  G16H50/20 ,  Y02A90/22 ,  Y02A90/26 ,  Y10S901/02 ,  Y10S901/41 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/25 ,  Y10T436/2575

Abstract: A sample processing system that may be automated and methods are disclosed where samples are arranged on a carrier element and a process operation control system automatically processes the samples perhaps robotically with an operationally-influential exteriorly-consequential information monitor or a data capture element. Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element may cause notification of a person at some display that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to “watch” simulated operation in real time or long after completion of the actual processing.

Abstract translation: 公开了一种可以是自动化的样品处理系统和方法，其中样品被布置在载体元件上，并且过程操作控制系统可以机器人地自动处理样品，其具有操作上有影响力的外部信息监视器或数据捕获元件。 可以监视重要的过程细节以及对操作有影响的外部信息的信息，并且自动通知单元可能导致人们在可能是远程的某些显示器处的通知。 可以通知各种人员，例如管理员，供应商或具有诸如试剂重新排序等的某些动作的机会的制造商。 模拟运动显示可以包括在实际处理完成之后实时或长时间“监视”模拟操作。

公开(公告)号：US20130203103A1

公开(公告)日：2013-08-08

申请号：US13747949

申请日：2013-01-23

Applicant: DAKO Denmark A/S

Inventor： Gordon Feingold ,  Marc Key ,  John Favuzzi ,  Rosanne Welcher

IPC: G01N1/31

CPC classification number: G01N35/00732 ,  G01N1/30 ,  G01N1/31 ,  G01N1/312 ,  G01N35/00712 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/0099 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00366 ,  G01N2035/00376 ,  G01N2035/00435 ,  G01N2035/00881 ,  G01N2035/00891 ,  G16H50/20 ,  Y02A90/22 ,  Y02A90/26 ,  Y10S901/02 ,  Y10S901/41 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/25 ,  Y10T436/2575

Abstract: A sample processing system that may be automated and methods are disclosed where samples are arranged on a carrier element and a process operation control system automatically processes the samples perhaps robotically with an operationally-influential exteriorly-consequential information monitor or a data capture element. Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element may cause notification of a person at some display that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to “watch” simulated operation in real time or long after completion of the actual processing.

Abstract translation: 公开了一种可以是自动化的样品处理系统和方法，其中样品被布置在载体元件上，并且过程操作控制系统可以机器人地自动处理样品，其具有操作上有影响力的外部信息监视器或数据捕获元件。 可以监视重要的过程细节以及对操作有影响的外部信息的信息，并且自动通知单元可能导致人们在可能是远程的某些显示器处的通知。 可以通知各种人员，例如管理员，供应商或具有诸如试剂重新排序等的某些动作的机会的制造商。 模拟运动显示可以包括在实际处理完成之后实时或长时间“监视”模拟操作。

公开(公告)号：US10156580B2

公开(公告)日：2018-12-18

申请号：US14959741

申请日：2015-12-04

Applicant: Dako Denmark A/S

Inventor： Gordon Feingold ,  Marc Key ,  John Favuzzi ,  Rosanne Welcher

IPC: G01N35/00 ,  G01N1/30 ,  G01N1/31 ,  G16H50/20

Abstract: A sample processing system that may be automated and methods are disclosed where samples are arranged on a carrier element and a process operation control system automatically processes the samples perhaps robotically with an operationally-influential exteriorly-consequential information monitor or a data capture element. Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element may cause notification of a person at some display that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to “watch” simulated operation in real time or long after completion of the actual processing.

公开(公告)号：US20130084567A1

公开(公告)日：2013-04-04

申请号：US13625115

申请日：2012-09-24

Applicant: DAKO DENMARK A/S

Inventor： Kristopher Buchanan ,  Marc Key ,  John Favuzzi ,  Rosanne Welcher ,  Benno Guggenheimer ,  Robert Clark ,  Michael Barber ,  Bob Lathrop

IPC: G01N1/30

CPC classification number: G01N35/00732 ,  G01N1/30 ,  G01N1/31 ,  G01N1/312 ,  G01N35/00712 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/0099 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00366 ,  G01N2035/00376 ,  G01N2035/00435 ,  G01N2035/00881 ,  G01N2035/00891 ,  G16H50/20 ,  Y02A90/22 ,  Y02A90/26 ,  Y10S901/02 ,  Y10S901/41 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/25 ,  Y10T436/2575

Abstract: Systems and methods of sample processing and temperature control are disclosed. The invention may especially relate to temperature control, and may in some embodiments be methods of temperature control of an automated sample processing system and methods of automated sample processing. Specifically, the present invention provides temperature control in relation to sample processing systems and methods of processing samples, and in some embodiments provides temperature control in relation to sample carriers and processing materials such as reagents. Corresponding systems and devices are disclosed, including sample processing systems (1), sample carrier temperature regulation systems (60), reagent temperature regulation systems, sample processing control systems, and temperature regulation devices, among other embodiments. Scientific fields to which the present invention may have particular applicability include immunohistochemistry, hybridization, fluorescent in-situ hybridization, special staining, such as special staining of histological samples, microarray sample processing, and cytology, as well as potentially other chemical and biological applications.

Abstract translation: 公开了样品处理和温度控制的系统和方法。 本发明可以特别涉及温度控制，并且在一些实施例中可以是自动化样品处理系统的温度控制方法和自动样品处理方法。 具体地，本发明提供了与样品处理系统和处理样品的方法相关的温度控制，并且在一些实施例中提供了与样品载体和加工材料如试剂相关的温度控制。 公开了相应的系统和装置，包括样品处理系统（1），样品载体温度调节系统（60），试剂温度调节系统，样品处理控制系统和温度调节装置。 本发明可能具有特定适用性的科学领域包括免疫组织化学，杂交，荧光原位杂交，特殊染色，例如组织学样品的特殊染色，微阵列样品处理和细胞学，以及潜在的其它化学和生物应用。

公开(公告)号：US08673642B2

公开(公告)日：2014-03-18

申请号：US13758810

申请日：2013-02-04

Applicant: DAKO Denmark A/S

Inventor： Marc Key ,  Gordon Feingold ,  Rosanne Welcher

IPC: G01N35/00

CPC classification number: G01N35/00732 ,  G01N1/30 ,  G01N1/31 ,  G01N1/312 ,  G01N35/00712 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/0099 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00366 ,  G01N2035/00376 ,  G01N2035/00435 ,  G01N2035/00881 ,  G01N2035/00891 ,  G16H50/20 ,  Y02A90/22 ,  Y02A90/26 ,  Y10S901/02 ,  Y10S901/41 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/25 ,  Y10T436/2575

Abstract: A sample processing system 101 that may be automated and methods are disclosed where sample(s) 198 are arranged on a carrier element 197 and a process operation control system 171 automatically processes the sample(s) perhaps robotically according to an desired aggregation of event dictated by an input 173. Alteration of an initial aggregated event topology may be accepted while the system is processing an initial aggregation and varied-parameter robotic control simulation functionalities 606 may be accomplished to determine an enhanced sequence for processing. Suggested operator actions may be displayed that might further enhance the scheduling of the altered aggregated event topology together with an automatic operator need prompt 608 that may inform an operator of a need for a particular action in order to accomplish the desired tasks. Reversibility to proposed changes may be made available so that an operator may avoid having to activate proposed changes if they cause a processing result that is not acceptable.

Abstract translation: 公开了可以是自动化的样本处理系统101和方法，其中样本198布置在载体元件197上，并且过程操作控制系统171可以根据事件规定的所需聚合自动地处理样本 可以通过输入173.当系统正在处理初始聚合并且可变参数机器人控制时可以接受初始聚合事件拓扑的改变，可以实现功能606以确定用于处理的增强的序列。 可以显示建议的操作者动作，其可以进一步增强改变的聚合事件拓扑的调度以及可以通知操作者需要特定动作以实现所需任务的自动操作者需求提示608。 提出的改变的可逆性可以提供，以便操作者可以避免在导致不可接受的处理结果时激活所提出的改变。

公开(公告)号：US09229016B2

公开(公告)日：2016-01-05

申请号：US14306606

申请日：2014-06-17

Applicant: DAKO DENMARK A/S

Inventor： Gordon Feingold ,  Marc Key ,  John Favuzzi ,  Rosanne Welcher

IPC: G01N35/00 ,  G01N1/30 ,  G01N1/31

CPC classification number: G01N35/00732 ,  G01N1/30 ,  G01N1/31 ,  G01N1/312 ,  G01N35/00712 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/0099 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00366 ,  G01N2035/00376 ,  G01N2035/00435 ,  G01N2035/00881 ,  G01N2035/00891 ,  G16H50/20 ,  Y02A90/22 ,  Y02A90/26 ,  Y10S901/02 ,  Y10S901/41 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/25 ,  Y10T436/2575

Abstract: A sample processing system that may be automated and methods are disclosed where samples are arranged on a carrier element and a process operation control system automatically processes the samples perhaps robotically with an operationally-influential exteriorly-consequential information monitor or a data capture element. Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element may cause notification of a person at some display that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to “watch” simulated operation in real time or long after completion of the actual processing.

Abstract translation: 公开了一种可以是自动化的样品处理系统和方法，其中样品被布置在载体元件上，并且过程操作控制系统可以机器人地自动处理样品，其具有操作上有影响力的外部信息监视器或数据捕获元件。 可以监视重要的过程细节以及对操作有影响的外部信息的信息，并且自动通知单元可能导致人们在可能是远程的某些显示器处的通知。 可以通知各种人员，例如管理员，供应商或具有诸如试剂重新排序等的某些动作的机会的制造商。 模拟运动显示可以包括在实际处理完成之后实时或长时间“监视”模拟操作。