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    Soluble hydrophobic core carrier compositions for delivery of therapeutic agents, methods of making and using the same
    11.
    发明授权
    Soluble hydrophobic core carrier compositions for delivery of therapeutic agents, methods of making and using the same 有权
    用于递送治疗剂的可溶性疏水性核心载体组合物，制备和使用它们的方法

    公开(公告)号：US08999930B2

    公开(公告)日：2015-04-07

    申请号：US12711564

    申请日：2010-02-24

    Applicant: Gerardo M. Castillo ,  Elijah M. Bolotin

    Inventor： Gerardo M. Castillo ,  Elijah M. Bolotin

    IPC: A61K38/00 ,  A61K38/22 ,  A61K38/26 ,  A61K47/48 ,  A61K47/42

    CPC classification number: C07K17/02 ,  A61K38/00 ,  A61K47/42 ,  A61K47/542 ,  A61K47/60 ,  A61K47/645

    Abstract: The present invention relates to a soluble hydrophobic-core carrier composition comprising (i) a linear polymeric backbone; (ii) a plurality of hydrophilic polymeric protective chains covalently linked and pendant to the polymeric backbone and (iii) at least one hydrophobic moiety covalently linked and pendant to the polymeric backbone. In certain embodiments, the weight ratio of hydrophilic protective chains to hydrophobic moieties in the carrier is at least 15:1. In other embodiments, at least 90% of the residues of the polymeric backbone are coupled to a hydrophilic polymeric protective chain or a hydrophobic moiety. In other embodiments, the composition further comprises (iv) a hydrophobic load molecule dissociably linked to the hydrophobic moiety of the carrier.

    Abstract translation: 本发明涉及一种可溶性疏水核心载体组合物，其包含（i）直链聚合物骨架; （ii）多个亲水聚合保护链共价连接并悬挂于聚合物主链，和（iii）至少一个共价连接并垂饰于聚合物主链的疏水部分。 在某些实施方案中，载体中亲水性保护链与疏水部分的重量比为至少15:1。 在其它实施方案中，聚合物主链的至少90％的残基与亲水聚合物保护链或疏水部分偶联。 在其它实施方案中，组合物还包含（iv）与载体的疏水部分可离解连接的疏水负载分子。

    Methods of making a diagnostic composition and compositions therefrom
    13.
    发明授权
    Methods of making a diagnostic composition and compositions therefrom 有权
    制备诊断组合物及其组合物的方法

    公开(公告)号：US08889829B2

    公开(公告)日：2014-11-18

    申请号：US13702994

    申请日：2010-09-03

    Applicant: Paridhi Bhandari ,  Dhananjaya Dendukuri ,  Vijayakumar Ganapathy ,  Srinivasan Kandaswamy ,  Diya Lewis

    Inventor： Paridhi Bhandari ,  Dhananjaya Dendukuri ,  Vijayakumar Ganapathy ,  Srinivasan Kandaswamy ,  Diya Lewis

    IPC: A61K38/17 ,  C07K17/02 ,  D01C3/02 ,  G01N33/544 ,  C07K14/435

    CPC classification number: C07K17/02 ,  C07K14/435 ,  D01C3/02 ,  G01N33/544 ,  G01N2333/43578 ,  Y02A50/58

    Abstract: In one aspect, the invention provides a method for making a hydrophilic-silk composition. The method includes providing at least one strand of silk fiber, treating the silk fiber with an alkaline solution to provide at least one strand of degummed silk fiber, and treating the degummed silk fiber with a treatment solution to provide a hydrophilic-silk composition. The degummed silk fiber or the hydrophilic-silk composition is further immobilized with at least one reagent to make a silk-based diagnostic composition. The invention provides a silk-based diagnostic composition made by the method of the invention, and a diagnostic device that comprises the silk-based diagnostic composition. In another aspect, the invention provides a method of making a diagnostic device. The method includes providing at least one strand of a diagnostic-fiber composition, providing at least one strand of a hydrophobic-fiber composition, inter-weaving the at least one strand of the diagnostic-fiber composition and the at least one strand of the hydrophobic-fiber composition. In one embodiment, the diagnostic-fiber composition and the hydrophobic-fiber composition are both based on silk.

    Abstract translation: 一方面，本发明提供了一种制备亲水丝组合物的方法。 所述方法包括提供至少一股丝纤维，用碱性溶液处理丝纤维，以提供至少一股脱胶丝纤维，用处理溶液处理脱胶丝纤维以提供亲水丝组合物。 脱胶丝纤维或亲水丝组合物进一步用至少一种试剂固定，制成丝状诊断组合物。 本发明提供了一种通过本发明的方法制造的基于丝绸的诊断组合物，以及包含丝基诊断组合物的诊断装置。 另一方面，本发明提供一种制造诊断装置的方法。 该方法包括提供诊断纤维组合物的至少一条链，提供疏水纤维组合物的至少一条链，编织诊断纤维组合物的至少一条链和疏水性纤维组合物的至少一条链 - 纤维成分。 在一个实施方案中，诊断纤维组合物和疏水 - 纤维组合物均基于丝。

    METHOD FOR SELECTING A CANDIDATE DRUG COMPOUND
    14.
    发明申请
    METHOD FOR SELECTING A CANDIDATE DRUG COMPOUND 审中-公开
    选择候选药物化合物的方法

    公开(公告)号：US20140296478A1

    公开(公告)日：2014-10-02

    申请号：US14201593

    申请日：2014-03-07

    Applicant: PEPSCAN SYSTEMS B.V.

    Inventor： Peter TIMMERMAN ,  Joris BELD ,  Robbert H. MELOEN ,  Wouter C. PUIJK

    IPC: C07K17/02

    CPC classification number: G01N33/54306 ,  C07K17/02 ,  C40B30/04 ,  G01N33/54353

    Abstract: The disclosure relates to the field of candidate drug testing and drug development. Described are methods for providing a compound composed of at least one molecule attached via at least two linkages to a molecular scaffold, the method comprising providing a scaffold comprising at least a first and a second reactive group; providing at least one molecule able to react with the at least first and second reactive group; and contacting the scaffold with at least one molecule to form at least two linkages between the scaffold and the molecule in a coupling reaction, wherein the formation of a linkage accelerates the formation of a consecutive linkage. The coupling reaction may be performed in solution, such as an aqueous solution. Furthermore, described is a method for selecting a candidate drug compound comprising providing a library of the compounds and determining the binding of a target molecule to the compounds.

    Abstract translation: 本公开涉及候选药物检测和药物开发领域。 描述了提供由至少一个分子通过至少两个键连接到分子支架上的化合物的方法，所述方法包括提供包含至少第一和第二反应性基团的支架; 提供至少一个能够与所述至少第一和第二反应性基团反应的分子; 以及使所述支架与至少一个分子接触以在偶联反应中在所述支架和所述分子之间形成至少两个连接，其中所述连接的形成加速连续连接的形成。 偶联反应可以在溶液中进行，例如水溶液。 此外，描述了选择候选药物化合物的方法，包括提供化合物文库并确定靶分子与化合物的结合。

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