公开(公告)号：US08889829B2

公开(公告)日：2014-11-18

申请号：US13702994

申请日：2010-09-03

Applicant: Paridhi Bhandari ,  Dhananjaya Dendukuri ,  Vijayakumar Ganapathy ,  Srinivasan Kandaswamy ,  Diya Lewis

Inventor： Paridhi Bhandari ,  Dhananjaya Dendukuri ,  Vijayakumar Ganapathy ,  Srinivasan Kandaswamy ,  Diya Lewis

IPC: A61K38/17 ,  C07K17/02 ,  D01C3/02 ,  G01N33/544 ,  C07K14/435

CPC classification number: C07K17/02 ,  C07K14/435 ,  D01C3/02 ,  G01N33/544 ,  G01N2333/43578 ,  Y02A50/58

Abstract: In one aspect, the invention provides a method for making a hydrophilic-silk composition. The method includes providing at least one strand of silk fiber, treating the silk fiber with an alkaline solution to provide at least one strand of degummed silk fiber, and treating the degummed silk fiber with a treatment solution to provide a hydrophilic-silk composition. The degummed silk fiber or the hydrophilic-silk composition is further immobilized with at least one reagent to make a silk-based diagnostic composition. The invention provides a silk-based diagnostic composition made by the method of the invention, and a diagnostic device that comprises the silk-based diagnostic composition. In another aspect, the invention provides a method of making a diagnostic device. The method includes providing at least one strand of a diagnostic-fiber composition, providing at least one strand of a hydrophobic-fiber composition, inter-weaving the at least one strand of the diagnostic-fiber composition and the at least one strand of the hydrophobic-fiber composition. In one embodiment, the diagnostic-fiber composition and the hydrophobic-fiber composition are both based on silk.

Abstract translation: 一方面，本发明提供了一种制备亲水丝组合物的方法。 所述方法包括提供至少一股丝纤维，用碱性溶液处理丝纤维，以提供至少一股脱胶丝纤维，用处理溶液处理脱胶丝纤维以提供亲水丝组合物。 脱胶丝纤维或亲水丝组合物进一步用至少一种试剂固定，制成丝状诊断组合物。 本发明提供了一种通过本发明的方法制造的基于丝绸的诊断组合物，以及包含丝基诊断组合物的诊断装置。 另一方面，本发明提供一种制造诊断装置的方法。 该方法包括提供诊断纤维组合物的至少一条链，提供疏水纤维组合物的至少一条链，编织诊断纤维组合物的至少一条链和疏水性纤维组合物的至少一条链 - 纤维成分。 在一个实施方案中，诊断纤维组合物和疏水 - 纤维组合物均基于丝。

公开(公告)号：US20130109837A1

公开(公告)日：2013-05-02

申请号：US13702994

申请日：2010-09-03

Applicant: Paridhi Bhandari ,  Dhananjaya Dendukuri ,  Vijayakumar Ganapathy ,  Srinivasan Kandaswamy ,  Diya Lewis

Inventor： Paridhi Bhandari ,  Dhananjaya Dendukuri ,  Vijayakumar Ganapathy ,  Srinivasan Kandaswamy ,  Diya Lewis

IPC: C07K17/02 ,  C07K14/435

CPC classification number: C07K17/02 ,  C07K14/435 ,  D01C3/02 ,  G01N33/544 ,  G01N2333/43578 ,  Y02A50/58

Abstract: In one aspect, the invention provides a method for making a hydrophilic-silk composition. The method includes providing at least one strand of silk fiber, treating the silk fiber with an alkaline solution to provide at least one strand of degummed silk fiber, and treating the degummed silk fiber with a treatment solution to provide a hydrophilic-silk drophilic-silk composition. The degummed silk fiber or the hydrophilic-silk composition is further immobilized with at least one reagent to make a silk-based diagnostic composition. The invention provides a silk-based diagnostic composition made by the method of the invention, and a diagnostic device that comprises the silk-based diagnostic composition. In another aspect, the invention provides a method of making a diagnostic device. The method includes providing at least one strand of a diagnostic-fiber composition, providing at least one strand of a hydrophobic-fiber composition, inter-weaving the at least one strand of the diagnostic-fiber composition and the at least one strand of the hydrophobic-fiber composition. In one embodiment, the diagnostic-fiber composition and the hydrophobic-fiber composition are both based on silk.

Abstract translation: 一方面，本发明提供了一种制备亲水丝组合物的方法。 该方法包括提供至少一股丝纤维，用碱性溶液处理丝纤维，以提供至少一股脱胶丝纤维，用处理溶液处理脱胶丝纤维，得到亲水丝亲水丝 组成。 脱胶丝纤维或亲水丝组合物进一步用至少一种试剂固定，制成丝状诊断组合物。 本发明提供了一种通过本发明的方法制造的基于丝绸的诊断组合物，以及包含丝基诊断组合物的诊断装置。 另一方面，本发明提供一种制造诊断装置的方法。 该方法包括提供诊断纤维组合物的至少一条链，提供疏水纤维组合物的至少一条链，编织诊断纤维组合物的至少一条链和疏水性纤维组合物的至少一条链 - 纤维成分。 在一个实施方案中，诊断纤维组合物和疏水 - 纤维组合物均基于丝。

公开(公告)号：US20120270337A1

公开(公告)日：2012-10-25

申请号：US13504048

申请日：2009-12-28

Applicant: Dhananjaya Dendukuri ,  Srinivasan Kandaswamy ,  Malatesh Kurubar

Inventor： Dhananjaya Dendukuri ,  Srinivasan Kandaswamy ,  Malatesh Kurubar

IPC: B05D7/22 ,  G01N33/53

CPC classification number: B01L1/00 ,  B01L3/50 ,  B01L3/502 ,  B01L3/5021 ,  B01L3/5023 ,  B01L2300/069

Abstract: The invention relates to a method for making a diagnostic element. The method comprises providing a shaped channel comprising at least one holding port and an inlet passage and outlet passage on either side of the holding port; flowing in a diagnostic gel into the inlet passage of the shaped channel; and encapsulating the diagnostic gel in the at least one holding port to form a diagnostic element. The invention also provides a method for using a diagnostic element, wherein the method comprises flowing sample through the diagnostic gel to provide an analyte diagnostic gel; analyzing the analyte diagnostic gel.

Abstract translation: 本发明涉及一种制造诊断元件的方法。 该方法包括提供成形通道，该通道包括至少一个保持口和在保持口两侧的入口通道和出口通道; 在诊断凝胶中流入成形通道的入口通道; 并将所述诊断凝胶封装在所述至少一个保持端口中以形成诊断元件。 本发明还提供了一种使用诊断元件的方法，其中所述方法包括使样品流过诊断凝胶以提供分析物诊断凝胶; 分析分析物诊断凝胶。

公开(公告)号：US08709354B2

公开(公告)日：2014-04-29

申请号：US13702947

申请日：2010-09-03

Applicant: Paridhi Bhandari ,  Dhananjaya Dendukuri ,  Vijayakumar Ganapathy ,  Srinivasan Kandaswamy ,  Diya Lewis

Inventor： Paridhi Bhandari ,  Dhananjaya Dendukuri ,  Vijayakumar Ganapathy ,  Srinivasan Kandaswamy ,  Diya Lewis

IPC: B01L3/00

CPC classification number: B01L3/50273 ,  B01L3/5023 ,  B01L3/502707 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/161 ,  B01L2400/0406 ,  D03D25/00 ,  G01N33/5302

Abstract: In one aspect, the invention provides a method for making a hydrophilic-silk composition. The method includes providing at least one strand of silk fiber, treating the silk fiber with an alkaline solution to provide at least one strand of degummed silk fiber, and treating the degummed silk fiber with a treatment solution to provide a hydrophilic-silk composition. The degummed silk fiber or the hydrophilic-silk composition is further immobilized with at least one reagent to make a silk-based diagnostic composition. The invention provides a silk-based diagnostic composition made by the method of the invention, and a diagnostic device that comprises the silk-based diagnostic composition. In another aspect, the invention provides a method of making a diagnostic device. The method includes providing at least one strand of a diagnostic-fiber composition, providing at least one strand of a hydrophobic-fiber composition, inter-weaving the at least one strand of the diagnostic-fiber composition and the at least one strand of the hydrophobic-fiber composition. In one embodiment, the diagnostic-fiber composition and the hydrophobic-fiber composition are both based on silk.

Abstract translation: 一方面，本发明提供了一种制备亲水丝组合物的方法。 所述方法包括提供至少一股丝纤维，用碱性溶液处理丝纤维，以提供至少一股脱胶丝纤维，用处理溶液处理脱胶丝纤维以提供亲水丝组合物。 脱胶丝纤维或亲水丝组合物进一步用至少一种试剂固定，制成丝状诊断组合物。 本发明提供了一种通过本发明的方法制造的基于丝绸的诊断组合物，以及包含丝基诊断组合物的诊断装置。 另一方面，本发明提供一种制造诊断装置的方法。 该方法包括提供诊断纤维组合物的至少一条链，提供疏水纤维组合物的至少一条链，编织诊断纤维组合物的至少一条链和疏水性纤维组合物的至少一条链 - 纤维成分。 在一个实施方案中，诊断纤维组合物和疏水 - 纤维组合物均基于丝。

公开(公告)号：US20130095506A1

公开(公告)日：2013-04-18

申请号：US13702947

申请日：2010-09-03

Applicant: Paridhi Bhandari ,  Dhananjaya Dendukuri ,  Vijayakumar Ganapathy ,  Srinivasan Kandaswamy ,  Diya Lewis

Inventor： Paridhi Bhandari ,  Dhananjaya Dendukuri ,  Vijayakumar Ganapathy ,  Srinivasan Kandaswamy ,  Diya Lewis

IPC: B01L3/00 ,  D03D25/00 ,  G01N33/53

CPC classification number: B01L3/50273 ,  B01L3/5023 ,  B01L3/502707 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/161 ,  B01L2400/0406 ,  D03D25/00 ,  G01N33/5302

Abstract: In one aspect, the invention provides a method for making a hydrophilic-silk composition. The method includes providing at least one strand of silk fiber, treating the silk fiber with an alkaline solution to provide at least one strand of degummed silk fiber, and treating the degummed silk fiber with a treatment solution to provide a hydrophilic-silk composition. The degummed silk fiber or the hydrophilic-silk composition is further immobilized with at least one reagent to make a silk-based diagnostic composition. The invention provides a silk-based diagnostic composition made by the method of the invention, and a diagnostic device that comprises the silk-based diagnostic composition. In another aspect, the invention provides a method of making a diagnostic device. The method includes providing at least one strand of a diagnostic-fiber composition, providing at least one strand of a hydrophobic-fiber composition, inter-weaving the at least one strand of the diagnostic-fiber composition and the at least one strand of the hydrophobic-fiber composition. In one embodiment, the diagnostic-fiber composition and the hydrophobic-fiber composition are both based on silk.

Abstract translation: 一方面，本发明提供了一种制备亲水丝组合物的方法。 所述方法包括提供至少一股丝纤维，用碱性溶液处理丝纤维，以提供至少一股脱胶丝纤维，用处理溶液处理脱胶丝纤维以提供亲水丝组合物。 脱胶丝纤维或亲水丝组合物进一步用至少一种试剂固定，制成丝状诊断组合物。 本发明提供了一种通过本发明的方法制造的基于丝绸的诊断组合物，以及包含丝基诊断组合物的诊断装置。 另一方面，本发明提供一种制造诊断装置的方法。 该方法包括提供诊断纤维组合物的至少一条链，提供疏水纤维组合物的至少一条链，编织诊断纤维组合物的至少一条链和疏水性纤维组合物的至少一条链 - 纤维成分。 在一个实施方案中，诊断纤维组合物和疏水 - 纤维组合物均基于丝。

公开(公告)号：US20120264654A1

公开(公告)日：2012-10-18

申请号：US13504053

申请日：2009-12-28

Applicant: Dhananjaya Dendukuri ,  Srinivasan Kandaswamy ,  Malatesh Kurubar ,  Reeta Katiyar ,  Lakshmi P. Sivakumaran ,  Nikhil Vastarey

Inventor： Dhananjaya Dendukuri ,  Srinivasan Kandaswamy ,  Malatesh Kurubar ,  Reeta Katiyar ,  Lakshmi P. Sivakumaran ,  Nikhil Vastarey

IPC: G01N30/16 ,  C40B60/12 ,  C12M1/34

CPC classification number: B01L3/5027 ,  B01L3/502 ,  B01L2200/027 ,  B01L2200/10 ,  B01L2300/069 ,  B01L2300/0825

Abstract: The invention relates to a diagnostic element. The diagnostic element comprises an inlet passage, a holding port and an outlet passage. The holding port is capable of encapsulating a diagnostic gel. The invention also relates to a diagnostic device that comprises at least one inlet port, a preparation port, a diagnostic element that comprises an inlet passage, a holding port, an outlet passage and an outlet port.

Abstract translation: 本发明涉及诊断元件。 诊断元件包括入口通道，保持口和出口通道。 保持口能够封装诊断凝胶。 本发明还涉及一种诊断装置，其包括至少一个入口，准备口，诊断元件，其包括入口通道，保持口，出口通道和出口。