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    Method For Detecting Gluten
    2.
    发明申请
    Method For Detecting Gluten 有权
    检测面筋的方法

    公开(公告)号：US20080152780A1

    公开(公告)日：2008-06-26

    申请号：US11630818

    申请日：2005-06-01

    Applicant: Jan Wouter Drijfhout ,  Frits Koning ,  Elisabeth Hermine Adriane Spaenij-Dekking

    Inventor： Jan Wouter Drijfhout ,  Frits Koning ,  Elisabeth Hermine Adriane Spaenij-Dekking

    IPC: A23L1/10 ,  G01N33/00 ,  G01N33/566 ,  A01H5/00

    CPC classification number: G01N33/564

    Abstract: Provided is a mAb-based method for the detection of T cell stimulatory epitopes known to be involved in CD. The method has many advantages compared to the existing methods for the detection of gluten since it is the first method that can; (i) detect T cell stimulatory epitopes of gluten; (ii) detect the epitopes separately, (iii) detect T cell stimulatory epitopes present on gliadin and glutenin homologues present in other cereals also known to be involved in CD; and (iv) detect T cell stimulatory epitopes on both intact proteins and small protein fragments. The new method is a valuable tool in the screening of basic ingredients, semi manufactured ingredients and food products that are intended to be used in the gluten free diet of CD patients. Moreover the new method can also be used for the screening of cereals and different wheat varieties for the level of toxicity for CD patients. Thereby the method can help in the selection of cereals and wheat varieties with low toxicity which might form the basis for future breeding programs. In the future these cereals will be used for the production of safe food for CD patients.

    Abstract translation: 提供了用于检测已知参与CD的T细胞刺激表位的基于mAb的方法。 该方法与现有的面筋检测方法相比具有许多优点，因为它是可以的第一种方法; （i）检测麸质的T细胞刺激表位; （ii）分别检测表位，（iii）检测存在于也已知参与CD的其他谷物中存在的麦醇溶蛋白和谷蛋白同源物上的T细胞刺激表位; 和（iv）检测完整蛋白质和小蛋白质片段上的T细胞刺激表位。 新方法是筛选用于CD患者无麸质饮食的基本成分，半成品和食品的有价值的工具。 此外，新方法还可用于筛选谷物和不同小麦品种的CD患者的毒性水平。 因此，该方法可以帮助选择低毒的谷物和小麦品种，这可能成为未来育种计划的基础。 将来这些谷物将用于生产CD患者的安全食品。

    Method for detecting gluten
    5.
    发明授权
    Method for detecting gluten 有权
    检测麸质的方法

    公开(公告)号：US07993869B2

    公开(公告)日：2011-08-09

    申请号：US11630818

    申请日：2005-06-01

    Applicant: Jan Wouter Drijfhout ,  Frits Koning ,  Elisabeth Hermine Adriane Spaenij-Dekking

    Inventor： Jan Wouter Drijfhout ,  Frits Koning ,  Elisabeth Hermine Adriane Spaenij-Dekking

    IPC: G01N33/53 ,  G01N33/531 ,  G01N33/543 ,  G01N33/563

    CPC classification number: G01N33/564

    Abstract: Provided is a mAb-based method for the detection of T cell stimulatory epitopes known to be involved in CD. The method has many advantages compared to the existing methods for the detection of gluten since it is the first method that can; (i) detect T cell stimulatory epitopes of gluten; (ii) detect the epitopes separately, (iii) detect T cell stimulatory epitopes present on gliadin and glutenin homologues present in other cereals also known to be involved in CD; and (iv) detect T cell stimulatory epitopes on both intact proteins and small protein fragments. The new method is a valuable tool in the screening of basic ingredients, semi manufactured ingredients and food products that are intended to be used in the gluten free diet of CD patients. Moreover the new method can also be used for the screening of cereals and different wheat varieties for the level of toxicity for CD patients. Thereby the method can help in the selection of cereals and wheat varieties with low toxicity which might form the basis for future breeding programs. In the future these cereals will be used for the production of safe food for CD patients.

    Abstract translation: 提供了用于检测已知参与CD的T细胞刺激表位的基于mAb的方法。 该方法与现有的面筋检测方法相比具有许多优点，因为它是可以的第一种方法; （i）检测麸质的T细胞刺激表位; （ii）分别检测表位，（iii）检测存在于也已知参与CD的其他谷物中存在的麦醇溶蛋白和谷蛋白同源物上的T细胞刺激表位; 和（iv）检测完整蛋白质和小蛋白质片段上的T细胞刺激表位。 新方法是筛选用于CD患者无麸质饮食的基本成分，半成品和食品的有价值的工具。 此外，新方法还可用于筛选谷物和不同小麦品种的CD患者的毒性水平。 因此，该方法可以帮助选择低毒的谷物和小麦品种，这可能成为未来育种计划的基础。 将来这些谷物将用于生产CD患者的安全食品。

    Peptide inhibitors of toxins derived from LL-37
    7.
    发明授权
    Peptide inhibitors of toxins derived from LL-37 有权
    衍生自LL-37的毒素肽抑制剂

    公开(公告)号：US07807617B2

    公开(公告)日：2010-10-05

    申请号：US10543521

    申请日：2004-01-27

    Applicant: Johannes Jakobus Grote ,  Jan Wouter Drijfhout

    Inventor： Johannes Jakobus Grote ,  Jan Wouter Drijfhout

    IPC: C07K14/00

    CPC classification number: C07K14/4723 ,  A61K38/00 ,  A61K48/00

    Abstract: The invention relates to a peptidic compound with affinity to bacterial and fungal toxins, especially to lipopolysaccharide or lipoteichoic acid. The peptidic compound includes an amino acid sequence X1KEFX2RIVX3RIKX4FLRX5LVX6, wherein X1 represents the N-terminal part: X2 is K or E; X3 is Q or E; X4 is D or R; X5 is N or E; X6 represents the C-terminal part: an amino acid of the core sequence is optionally derivatized; the N-terminal part is acetylated, and/or the C-terminal part is amidated, and/or the sequence differs from the native amino acid sequence X1KEFKRIVQRIKDFLRNLVX6.

    Abstract translation: 本发明涉及对细菌和真菌毒素，特别是对脂多糖或脂磷壁酸具有亲和力的肽化合物。 肽化合物包括氨基酸序列X1KEFX2RIVX3RIKX4FLRX5LVX6，其中X1表示N-末端部分：X2是K或E; X3是Q或E; X4是D或R; X5为N或E; X6表示C末端部分：核心序列的氨基酸任选被衍生化; N-末端部分被乙酰化，和/或C末端部分酰化，和/或该序列与天然氨基酸序列X1KEFKRIVQRIKDFLRNLVX6不同。

    Synthetic Protein as Tumor-Specific Vaccine
    8.
    发明申请
    Synthetic Protein as Tumor-Specific Vaccine 审中-公开
    合成蛋白作为肿瘤特异性疫苗

    公开(公告)号：US20090028874A1

    公开(公告)日：2009-01-29

    申请号：US10583837

    申请日：2003-12-24

    Applicant: Sjoerd Henricus Van Der Burg ,  Jan Wouter Drijfhout

    Inventor： Sjoerd Henricus Van Der Burg ,  Jan Wouter Drijfhout

    IPC: A61K39/395 ,  C07K1/00 ,  A61K39/00 ,  A61P31/00 ,  A61K38/00

    CPC classification number: C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/55561 ,  C12N7/00 ,  C12N2710/20022

    Abstract: The invention provides a GMP compatible method to chemically synthesize proteins which may be advantageously used in compositions for vaccination that are free of biological contaminants. The method uses conventional synthesis of peptides and linking these to yield synthetic proteins that preferably comprise all T cell epitopes for an antigen. Preferably an adjuvant is covalently attached to a synthetic protein to yield a fully synthetic vaccine. The invention is illustrated mainly by using HPV protein directed immunity as a model.

    Abstract translation: 本发明提供了用于化学合成蛋白质的GMP相容方法，其可有利地用于没有生物污染物的疫苗接种组合物中。 该方法使用肽的常规合成并将其连接以产生合成蛋白，其优选包含用于抗原的所有T细胞表位。 优选地，佐剂共价连接到合成蛋白以产生完全合成的疫苗。 本发明主要通过使用HPV蛋白质定向免疫作为模型来说明。

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