公开(公告)号：US20130338394A1

公开(公告)日：2013-12-19

申请号：US13809739

申请日：2011-07-11

Applicant: Martina Eichenberger ,  Paul Hanselmann ,  Florencio Zaragoza Dörwald

Inventor： Martina Eichenberger ,  Paul Hanselmann ,  Florencio Zaragoza Dörwald

IPC: C07C67/31 ,  C07C69/14

CPC classification number: C07C67/31 ,  C07C51/58 ,  C07C51/62 ,  C07C67/14 ,  C07C67/343 ,  C07C69/14 ,  C07C69/738 ,  C07C53/48 ,  C07C59/21

Abstract: Enolate salts of 4-fluoro-2-hydroxymethylene-3-oxobutyrates of formula wherein R1 is C1-10 alkyl, R2 and R3 are independently hydrogen or fluorine, M is an alkali or alkaline earth metal, and n is 1 or 2, are prepared from enolate salts of the corresponding 4-fluoro-3-oxobutyrates and carbon monoxide. The enolate salts of formula I can be alkylated or acylated to obtain the corresponding enol ethers and esters. The 4-fluoro-3-oxobutyrate starting material can be prepared from 1,1-difluoroethyl methyl ethers by SbF5-catalyzed fluoromethane elimination followed by halogen exchange with lithium chloride, reacting the thus obtained fluoroacetyl chloride with ketene and quenching with the appropriate alcohol R1—OH.

Abstract translation: 4-氟-2-羟基亚甲基-3-氧代丁酸烯醇盐，其中R 1是C 1-10烷基，R 2和R 3独立地是氢或氟，M是碱金属或碱土金属，n是1或2是 由相应的4-氟-3-氧代丁酸乙酯和一氧化碳的烯醇盐制备。 式I的烯醇盐可以被烷基化或酰化以得到相应的烯醇醚和酯。 4-氟-3-氧代丁酸酯原料可以由1,1-二氟乙基甲基醚通过SbF 5催化的氟甲烷消除制备，随后与氯化锂进行卤素交换，使得到的氟乙酰氯与乙烯酮反应，并用适当的醇R 1 -哦。

公开(公告)号：US07053238B2

公开(公告)日：2006-05-30

申请号：US10891155

申请日：2004-07-15

Applicant: Takashi Okazoe ,  Kunio Watanabe ,  Daisuke Shirakawa ,  Masahiro Ito ,  Shin Tatematsu

Inventor： Takashi Okazoe ,  Kunio Watanabe ,  Daisuke Shirakawa ,  Masahiro Ito ,  Shin Tatematsu

IPC: C07C69/63

CPC classification number: C07C67/14 ,  C07C45/54 ,  C07C51/60 ,  C07C67/287 ,  C07C67/29 ,  C07C67/297 ,  C07C67/307 ,  C07C59/21 ,  C07C53/46 ,  C07C69/63

Abstract: A fluorinated polyvalent carbonyl compound is produced by an economically advantageous method from inexpensive materials without requiring a complicated synthetic process step. Namely, the present invention comprises reacting a polyvalent alcohol having at least two kinds of alcohol skeletons selected among a primary alcohol, a secondary alcohol and a tertiary alcohol, with an acid halide to obtain a polyvalent ester compound, fluorinating it in a liquid phase to obtain a perfluorinated polyvalent ester compound, and cleaving the ester bonds derived from primary and secondary alcohols in the perfluoropolyvalent ester compound to obtain a fluorinated polyvalent carbonyl compound.

公开(公告)号：US4603017A

公开(公告)日：1986-07-29

申请号：US720163

申请日：1985-04-05

Applicant: Hans Millauer ,  Gunter Siegemund ,  Werner Schwertfeger

Inventor： Hans Millauer ,  Gunter Siegemund ,  Werner Schwertfeger

IPC: C07C69/708 ,  C07C45/54 ,  C07C49/167 ,  C07C51/00 ,  C07C51/373 ,  C07C53/50 ,  C07C59/21 ,  C07C59/347 ,  C07C59/58 ,  C07C59/88 ,  C07C67/00 ,  C07C67/313 ,  C07C69/716 ,  C07C301/00 ,  C07C303/00 ,  C07C305/00 ,  C07C305/26 ,  C25B3/00 ,  C25B3/02 ,  C07C141/00

CPC classification number: C07C45/54 ,  C07C305/26 ,  C07C49/167 ,  C07C51/00 ,  C07C59/21

Abstract: Perfluorocarbonyl compounds of the formulae IV and V ##STR1## in which R.sub.f denotes perfluoroalkyl, R'.sub.f denotes perfluoroalkylene, R denotes F, Cl, perfluoroalkyl or --OR"' (R"'=alkyl, aryl or aralkyl) and n denotes a number from 0 to 10, are prepared, starting from compounds of the formula I ##STR2## in which R.sub.f, R'.sub.f and n have the same meaning as in the formulae IV and V and R" is F, Cl or perfluoroalkyl, by electrolysis in an electrolyte consisting of fluorosulfonic acid/alkali metal fluorosulfonate and, if necessary, esterification with R"'OH, and decomposition ##STR3## in the presence of catalytic amounts of alkali metal fluorides and/or aprotic N-bases. Most of the compounds IV and V are new; the latter are, above all, valuable heat transfer fluids, lubricating oils or intermediates for the preparation of other F-organic compounds.

Abstract translation: （IV）的全氟羰基化合物其中Rf表示全氟烷基，R'f表示全氟亚烷基，R表示F，Cl，全氟烷基或-OR“（R”'） =烷基，芳基或芳烷基），n表示0至10的数，从其中R f，R'f和n与式（I）中相同含义的式I的化合物 IV和V和R“是F，Cl或全氟烷基，通过在由氟磺酸/碱金属氟代磺酸盐组成的电解质中电解并在需要时与R”OH进行酯化，并在催化剂存在下分解“IMAGE” 碱金属氟化物和/或非质子N-碱的量。 大多数化合物IV和V是新的; 后者首先是有价值的传热流体，润滑油或用于制备其它F-有机化合物的中间体。

公开(公告)号：US3911002A

公开(公告)日：1975-10-07

申请号：US34782273

申请日：1973-04-04

Applicant: ETHYL CORP

Inventor： WIEGAND KARL E

IPC: C07C51/04 ,  C07C51/08 ,  C07C51/41 ,  C07F1/00 ,  C07C103/167

CPC classification number: C07F1/005 ,  C07C51/04 ,  C07C51/08 ,  C07C51/41 ,  C07C51/412 ,  C07C59/21 ,  C07C59/265

Abstract: It is disclosed that citric acid or its salts are obtained by the hydrolysis of a 3-carbamoyl-3-hydroxy-4-cyanobutyric acid or salt, that a 3-carbamoyl-3-hydroxy-4-cyanobutyric acid or salt is obtained from a 3-carbamoyl-3,4-epoxybutyric acid or salt, that a 3-carbamoyl-3,4-epoxybutyric acid or salt is obtained from a 3carbamoyl-3-hydroxy-4-halobutyric acid or salt, that a 3carbamoyl-3-hydroxy-4-halobutyric acid is obtained from a 3cyano-3-hydroxy-4-halobutyric acid or salt, that a 3-cyano-3hydroxy-4-halobutyric acid or salt is obtained from a 3-oxo-4halobutyric acid or salt, that a 3-oxo-4-halobutyric acid or salt is obtained from a 3-oxo-4-halobutyryl halide, and that a 3-oxo4-halobutyryl halide is obtained from diketene. Preferred halide compounds are compounds of chlorine.

Abstract translation: 公开了通过水解3-氨基甲酰基-3-羟基-4-氰基丁酸或其盐得到柠檬酸或其盐，得到3-氨基甲酰基-3-羟基-4-氰基丁酸或其盐由 3-氨基甲酰基-3,4-环氧丁酸或其盐，由3-氨基甲酰基-3-羟基-4-卤代丁酸或其盐得到3-氨基甲酰基-3,4-环氧丁酸或其盐，将3 - 氨基甲酰基-3-羟基-4-卤代丁酸得自3-氰基-3-羟基-4-卤代丁酸或其盐，得到3-氰基-3-羟基-4-卤代丁酸或其盐 3-氧代-4-卤代丁酸或其盐，由3-氧代-4-卤代丁酰卤得到3-氧代-4-卤代丁酸或其盐，得到3-氧代-4-卤代丁酰卤，由 双烯酮 优选的卤化物是氯的化合物。

公开(公告)号：US3701803A

公开(公告)日：1972-10-31

申请号：US3701803D

申请日：1969-07-02

Applicant: LONZA AG

Inventor： BOOSEN KARL-JOSEF

IPC: C07C59/195 ,  C07C51/00 ,  C07C51/04 ,  C07C51/58 ,  C07C67/00 ,  C07C59/32 ,  C07C59/36

CPC classification number: C07C51/04 ,  C07C51/58 ,  C07C59/195 ,  C07C59/185 ,  C07C59/21

Abstract: IN WHICH R1, R2 AND R3 EACH REPRESENT HYDROGEN OR R1 REPRESENTS HALOGEN (PREFERABLY CHLORINE OR BOMINE) AND R2 AND R3 EACH REPRESENTS HYDROGEN OR HALOGEN (PREFERABLY CHLORINE OR BROMINE) ARE OBTAINED BY CONVERTING DKETENE INTO AN ACETOACETIC ACID HALIDE OR HALOGENOACETOACETIC ACID HALIDE BY MEANS OF HYDROGEN HALIDE OR HALOGEN AT A TEMPERATURE OF FROM ABOUT-10 TO -40*C., AND THE ACETOACETIC ACID HALIDE OR HALOGENOACETOACETIC ACID HALIDE IS CONVERTED INTO THE CORRESPONDING ACID BY HYDROLYSIS WITH A STOICHIOMETRICALLY EQUIVALENT QUANTITY OF WATER.

R1CH2-CO-CR2R-COOH

THE HITHERTO-UNDESCRIBED CRYSTALLINE ACETOACETIC ACID AND HALOGENO-ACETOACETIC ACIDS OF THE FORMULA

公开(公告)号：US3321517A

公开(公告)日：1967-05-23

申请号：US55305166

申请日：1966-05-26

Applicant: DU PONT

Inventor： STANLEY SELMAN

IPC: C07C59/21 ,  C07D317/42 ,  C07D319/12

CPC classification number: C07C59/21 ,  C07D317/42 ,  C07D319/12

公开(公告)号：US3275504A

公开(公告)日：1966-09-27

申请号：US41335664

申请日：1964-11-23

Applicant: CROWN ZELLERBACH CORP

Inventor： HERSCHLER ROBERT J

IPC: C07C59/21

CPC classification number: C07C59/21

公开(公告)号：US20160062241A1

公开(公告)日：2016-03-03

申请号：US14833029

申请日：2015-08-21

Applicant: SEMICONDUCTOR MANUFACTURING INTERNATIONAL (SHANGHAI) CORPORATION

Inventor： HUAYONG HU

IPC: G03F7/32 ,  G03F7/11 ,  G03F7/09 ,  G03F7/20 ,  G03F7/16

CPC classification number: G03F7/325 ,  C07C51/00 ,  C07C51/14 ,  C07C55/08 ,  C07C55/12 ,  C07C55/14 ,  C07C55/32 ,  C07C59/21 ,  C07C59/295 ,  C07C59/315 ,  C07C59/347 ,  C07C229/24 ,  G03F7/0045 ,  G03F7/091 ,  G03F7/095 ,  G03F7/11 ,  G03F7/20

Abstract: A lithographic method includes forming a photoresist layer on a target layer, forming a photo-decomposable base (PDB) layer on the photo resist layer, performing an exposure operation using a mask, and performing a negative development treatment to form a patterned photoresist layer on the target layer. In some cases, the photo-decomposable base layer includes a self-generating top coating photo-decomposable base (TC-PDB) layer. The method can also include forming a top surface water-resistant coating in separate coating process. In some embodiments, a top surface water-resistant coating is self-generated during a photoresist coating process.

Abstract translation: 光刻方法包括在目标层上形成光致抗蚀剂层，在光致抗蚀剂层上形成可光分解的基底（PDB）层，使用掩模进行曝光操作，并进行负显影处理以形成图案化的光致抗蚀剂层 目标层。 在一些情况下，可光分解基层包括自发性顶涂层可分解碱（TC-PDB）层。 该方法还可以包括在单独的涂覆工艺中形成顶部表面防水涂层。 在一些实施方案中，在光致抗蚀剂涂覆过程中自发生顶表面防水涂层。

公开(公告)号：US20130052585A1

公开(公告)日：2013-02-28

申请号：US13219599

申请日：2011-08-26

Applicant: Ramakrishnan Ayothi ,  William D. Hinsberg ,  Sally A. Swanson ,  Gregory M. Wallraff

Inventor： Ramakrishnan Ayothi ,  William D. Hinsberg ,  Sally A. Swanson ,  Gregory M. Wallraff

IPC: G03F7/20 ,  G03F7/027 ,  C07C59/315 ,  C07C59/21 ,  C07C55/32 ,  C07C55/14 ,  C07C59/295 ,  C07C59/347 ,  C07C229/24 ,  C07C55/08 ,  C07C55/12 ,  G03F7/004 ,  C07D241/04

CPC classification number: C07C55/08 ,  C07C55/12 ,  C07C55/14 ,  C07C55/32 ,  C07C59/21 ,  C07C59/245 ,  C07C59/295 ,  C07C59/315 ,  C07C59/347 ,  C07C229/24 ,  C07D241/04 ,  G03F7/0045 ,  G03F7/0046 ,  G03F7/0397

Abstract: Provided are novel symmetrical and asymmetrical bifunctional photodecomposable bases (PDBs) with dicarboxylate anion groups that show increased imaging performance. Also provided are photoresist compositions prepared with the bifunctional dicarboxylated PDBs and lithography methods that use the photoresist compositions of the present invention.

Abstract translation: 提供了具有显示增加的成像性能的具有二羧酸阴离子基团的新颖的对称和不对称双功能可光分解碱（PDB）。 还提供了使用双功能二羧酸化PDB制备的光致抗蚀剂组合物和使用本发明的光致抗蚀剂组合物的光刻方法。

公开(公告)号：US20060223888A1

公开(公告)日：2006-10-05

申请号：US10539049

申请日：2003-12-16

Applicant: Frank Abbott ,  Stoyan Karagiozov

Inventor： Frank Abbott ,  Stoyan Karagiozov

IPC: A61K31/19 ,  C07C61/06 ,  C07C61/16 ,  C07C51/42

CPC classification number: C07F9/5352 ,  C07B2200/09 ,  C07C53/21 ,  C07C53/23 ,  C07C57/03 ,  C07C57/26 ,  C07C57/52 ,  C07C57/56 ,  C07C59/21 ,  C07C59/82 ,  C07C69/587 ,  C07C69/608 ,  C07C69/65 ,  C07C403/20 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18

Abstract: Analogues of valproic acid useful in treating neuroaffective disorders including convulsions, bipolar disorder, and migraine headache are disclosed. The analogues are halide liver substituted analogues, cyclic analogues, and conjugated diene analogues of valproic acid. Pharmaceutical compositions or prodrugs containing the analogues or pharmaceutically acceptable salts thereof are disclosed. Methods of malting the compounds and treating mammals with neuroaffective disorders are also disclosed.

Abstract translation: 公开了可用于治疗神经感染障碍（包括惊厥，双相情感障碍和偏头痛）的丙戊酸的类似物。 类似物是卤代乙酰取代的类似物，环状类似物和丙戊酸的共轭二烯类似物。 公开了含有其类似物或药学上可接受的盐的药物组合物或前药。 还公开了使用神经保护性障碍来发酵化合物和治疗哺乳动物的方法。