公开(公告)号：US3911002A

公开(公告)日：1975-10-07

申请号：US34782273

申请日：1973-04-04

Applicant: ETHYL CORP

Inventor： WIEGAND KARL E

IPC: C07C51/04 ,  C07C51/08 ,  C07C51/41 ,  C07F1/00 ,  C07C103/167

CPC classification number: C07F1/005 ,  C07C51/04 ,  C07C51/08 ,  C07C51/41 ,  C07C51/412 ,  C07C59/21 ,  C07C59/265

Abstract: It is disclosed that citric acid or its salts are obtained by the hydrolysis of a 3-carbamoyl-3-hydroxy-4-cyanobutyric acid or salt, that a 3-carbamoyl-3-hydroxy-4-cyanobutyric acid or salt is obtained from a 3-carbamoyl-3,4-epoxybutyric acid or salt, that a 3-carbamoyl-3,4-epoxybutyric acid or salt is obtained from a 3carbamoyl-3-hydroxy-4-halobutyric acid or salt, that a 3carbamoyl-3-hydroxy-4-halobutyric acid is obtained from a 3cyano-3-hydroxy-4-halobutyric acid or salt, that a 3-cyano-3hydroxy-4-halobutyric acid or salt is obtained from a 3-oxo-4halobutyric acid or salt, that a 3-oxo-4-halobutyric acid or salt is obtained from a 3-oxo-4-halobutyryl halide, and that a 3-oxo4-halobutyryl halide is obtained from diketene. Preferred halide compounds are compounds of chlorine.

Abstract translation: 公开了通过水解3-氨基甲酰基-3-羟基-4-氰基丁酸或其盐得到柠檬酸或其盐，得到3-氨基甲酰基-3-羟基-4-氰基丁酸或其盐由 3-氨基甲酰基-3,4-环氧丁酸或其盐，由3-氨基甲酰基-3-羟基-4-卤代丁酸或其盐得到3-氨基甲酰基-3,4-环氧丁酸或其盐，将3 - 氨基甲酰基-3-羟基-4-卤代丁酸得自3-氰基-3-羟基-4-卤代丁酸或其盐，得到3-氰基-3-羟基-4-卤代丁酸或其盐 3-氧代-4-卤代丁酸或其盐，由3-氧代-4-卤代丁酰卤得到3-氧代-4-卤代丁酸或其盐，得到3-氧代-4-卤代丁酰卤，由 双烯酮 优选的卤化物是氯的化合物。

公开(公告)号：US3882146A

公开(公告)日：1975-05-06

申请号：US35578573

申请日：1973-04-30

Applicant: ETHYL CORP

Inventor： WIEGAND KARL E

IPC: C07D207/32 ,  C07D207/337 ,  C07D27/22

CPC classification number: C07D207/337

Abstract: A process for producing pyrryl-2-acetonitriles by reacting in a homogeneous system a 2-(N,N-dialkylaminomethyl)-pyrrole with an alkylating agent such as dimethylsulfate, methyl iodide or benzyl chloride forming a quaternary salt and reacting the resultant reaction mixture with an aqueous alkali metal cyanide solution such as aqueous sodium cyanide in which the reaction is conducted in a substantially inert solvent selected from oxygen- and nitrogen-containing aliphatic hydrocarbons boiling in the range from about 50* to about 130*C, for example, acetonitrile, tetrahydrofuran, acetone, etc.

Abstract translation: 通过在均相体系中使2-（N，N-二烷基氨基甲基） - 吡咯与烷基化剂如硫酸二甲酯，甲基碘或苄基氯反应形成季盐，制备吡咯-2-乙腈的方法，并使所得反应混合物 与碱金属氰化物水溶液如氰化钠水溶液反应，其中反应在基本惰性的溶剂中进行，所述惰性溶剂选自沸点在约50℃至约130℃范围内的含氧和含氮脂族烃，例如， 乙腈，四氢呋喃，丙酮等