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    Skin Permeation Device for Analyte Sensing or Transdermal Drug Delivery
    11.
    发明申请
    Skin Permeation Device for Analyte Sensing or Transdermal Drug Delivery 有权

    公开(公告)号：US20130137951A1

    公开(公告)日：2013-05-30

    申请号：US13746673

    申请日：2013-01-22

    Applicant: Echo Therapeutics, Inc.

    Inventor： Han Chuang ,  Juan P. Eslava ,  James P. Hurley ,  Debashis Ghosh ,  Keith Krystyniak ,  Scott C. Kellogg

    IPC: A61B18/14 ,  A61N1/30 ,  A61B5/145

    CPC classification number: A61B18/14 ,  A61B5/0531 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/14542 ,  A61B5/442 ,  A61B5/7239 ,  A61B17/54 ,  A61B18/20 ,  A61B18/203 ,  A61B2017/00761 ,  A61B2017/00765 ,  A61B2017/320004 ,  A61B2018/00452 ,  A61B2018/00642 ,  A61M2037/0007 ,  A61N1/042 ,  A61N1/0424 ,  A61N1/0436 ,  A61N1/044 ,  A61N1/30 ,  A61N1/327 ,  A61N1/328

    Abstract: Devices, systems, kits and methods for increasing the skin's permeability controlled by measured skin electrical parameter are described herein. They may be used for transdermal drug delivery and/or analyte extraction or measurement. The controlled abrasion device contains (i) a hand piece, (ii) an abrasive tip, (iii) a feedback control mechanism, (iv) two or more electrodes, and (v) an electrical motor. Preferably the feedback control mechanism is an internal feedback control mechanism. In this embodiment, the abrasive tip contains two electrodes, i.e. both the source electrode and the return electrode. In another embodiment, the feedback control mechanism is an external feedback control. In the preferred embodiment for external feedback control, the device contains a co-axial or concentric arrangement of the two electrodes. In this embodiment, the abrasive tip contains the source electrode and the return electrode is located at the proximal end of the hand piece. The abrasive tip can be made of any material with a surface that can abrade skin. The material can be conductive or non-conductive. The controlled abrasion device may be provided in a kit, where the kit contains the device, one or more abrasive tips, optionally with a wetting fluid. The method for increasing the skin's permeability requires applying the controlled abrasion device to a portion of the skin's surface for a short period of time. The desired level of skin impedance, and thus the resulting permeability of the treated site, can be set at a predetermined value. Alternatively, the level of skin impedance can be selected based on the desired level of skin integrity, the subject's sensation of discomfort, or the duration of the application. The device contains a control mechanism which uses an appropriate algorithm or signal processing on the conductivity information provided by the electrodes to determine when the desired level of skin permeability has been reached. Once the desired level has been reached, the abrasion device is removed and either a drug delivery composition or device or an analyte sensor is applied to the treated site.

    Microstructures for delivering a composition cutaneously to skin
    12.
    发明授权
    Microstructures for delivering a composition cutaneously to skin 有权
    用于将组合物皮肤递送到皮肤的微结构

    公开(公告)号：US08216190B2

    公开(公告)日：2012-07-10

    申请号：US11351818

    申请日：2006-02-09

    Applicant: Vladimir Gartstein ,  Faiz Feisal Sherman

    Inventor： Vladimir Gartstein ,  Faiz Feisal Sherman

    IPC: A61M5/00 ,  A61M31/00 ,  A61B17/34

    CPC classification number: A61M37/0015 ,  A45D26/0004 ,  A61B17/205 ,  A61B17/322 ,  A61B17/54 ,  A61B2017/00761 ,  A61B2017/00765 ,  A61B2017/320008 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0038 ,  A61M2037/0046 ,  A61M2037/0053

    Abstract: An improved method and apparatus is provided as a system to deliver a composition, preferably a medical or pharmaceutical composition or active, through the stratum corneum of skin, without introducing bleeding or damage to tissue, and absent pain or other trauma. The dimensions and shapes of the microelements are controlled so as to control the penetration depth into the skin. The microelements can be “hollow” such that passageways are created therethrough to allow the composition to flow from a chamber, through the microelements, and into the skin. Alternatively, the microelements can be “solid,” and the composition is applied directly to the skin just before or just after the microelements are applied to the skin surface to create the openings in the stratum corneum.

    Abstract translation: 提供了一种改进的方法和装置，作为通过皮肤角质层递送组合物，优选医药或药物组合物或活性物质的系统，而不引起对组织的渗血或损伤，以及不存在疼痛或其他创伤。 控制微量元素的尺寸和形状以控制进入皮肤的穿透深度。 微量元件可以是“中空”的，使得通过其形成以允许组合物从腔室，微量元件流入皮肤。 或者，微量元素可以是“固体”，并且组合物在微元件施用于皮肤表面之前或之后直接施用于皮肤以在角质层中产生开口。

    Noninvasive measuring device for substance in blood via nail and a nail evaporation device
    14.
    发明授权
    Noninvasive measuring device for substance in blood via nail and a nail evaporation device 有权
    通过钉子和指甲蒸发装置的血液中物质的无创测量装置

    公开(公告)号：US08145286B2

    公开(公告)日：2012-03-27

    申请号：US11606155

    申请日：2006-11-30

    Applicant: Tsunenori Arai ,  Yuki Kawase ,  Yasunobu Oka ,  Narushi Ito

    Inventor： Tsunenori Arai ,  Yuki Kawase ,  Yasunobu Oka ,  Narushi Ito

    IPC: A61B5/1455

    CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B18/203 ,  A61B2017/00765 ,  A61B2018/00452

    Abstract: A device and method for optically measuring a substance in blood using the nail as an optical window are provided. A device for optically measuring a test substance in blood by using the nail as an optical window and correcting or eliminating fluctuation of a measurement value based on optical characteristics of the nail plate, comprising irradiation means applying light within a wavelength range for measuring absorption by the test substance to the nail of a subject, detection means detecting light diffused/reflected from or transmitted through the body of the subject, and processing means processing a signal obtained by the detection means to convert the signal into a concentration of the test substance.

    Abstract translation: 提供了使用钉子作为光学窗口来光学测量血液中的物质的装置和方法。 一种用于通过使用指甲作为光学窗口来对血液中的测试物质进行光学测量的装置，并且基于所述指甲板的光学特性来校正或消除测量值的波动，所述装置包括：在波长范围内施加用于测量吸收的光的照射装置 检测物体到受试者的指甲，检测装置，其检测从被检体的身体扩散/反射或透过的物体，以及处理装置，对由检测装置获得的信号进行处理，将该信号转换成检测物质的浓度。

    METHODS AND APPARATUS FOR EXPRESSING BODY FLUID FROM AN INCISION
    16.
    发明申请
    METHODS AND APPARATUS FOR EXPRESSING BODY FLUID FROM AN INCISION 审中-公开
    用于从体内表达体液的方法和装置

    公开(公告)号：US20110046515A1

    公开(公告)日：2011-02-24

    申请号：US12938784

    申请日：2010-11-03

    Applicant: Joel S. Douglas ,  Jeffrey N. Roe ,  Henry M. Grage

    Inventor： Joel S. Douglas ,  Jeffrey N. Roe ,  Henry M. Grage

    IPC: A61B5/151

    CPC classification number: A61B5/15194 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150076 ,  A61B5/150083 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/15111 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/1519 ,  A61B10/0045 ,  A61B2010/008 ,  A61B2017/00765 ,  A61B2562/0295

    Abstract: A sample of a body fluid such as blood or interstitial fluid is obtained from a body by lancing a portion of a user's skin, preferably in an area other than a finger tip, to form an incision. After the needle has been removed from the incision, a force is applied to depress the skin in a manner forming a ring of depressed body tissue in surrounding relationship to the incision, causing the incision to bulge and the sides of the incision to open, whereby body fluid is forced out through the opening of the incision. A stimulator member is mounted to an end of a lancet-carrying housing for applying the force. The stimulator member can be movable relative to the housing, and can be either heated or vibrated to promote movement of the body fluid.

    Abstract translation: 体液例如血液或间质液的样品通过使用者的皮肤的一部分优选在指尖以外的区域穿刺而从身体获得，以形成切口。 在针从切口移除之后，施加力以形成与切口周围关系的形成凹陷的身体组织的环的方式来压下皮肤，导致切口凸起并且切口的两侧打开，由此 体液通过切口的开口被迫出来。 刺激构件安装到用于施加力的刺血针承载壳体的端部。 刺激器构件可以相对于壳体可移动，并且可以被加热或振动以促进体液的移动。

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