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公开(公告)号：US20130267985A1
公开(公告)日：2013-10-10
申请号：US13990547
申请日：2011-12-12
IPC分类号： A61M25/10
CPC分类号： A61M25/104 , A61B18/04 , A61B18/28 , A61B2018/0022 , A61B2018/00386 , A61B2018/00404 , A61B2018/00821 , A61B2018/046 , A61B2218/002
摘要： A balloon catheter of novel configuration, which is capable of both efficiently heating a heating element by using a laser light and of ensuring durability by avoiding the laser light directly heating members other than the heating element. Provided is a balloon catheter with a balloon disposed in a distal end section of a shaft and wherein: a tightly wound coil shaped heating element is housed and arranged in the balloon; an optical fiber that irradiates a laser light inside the heating element is disposed; and a supply path that supplies a fluid to inside the balloon through an inside of the heating element and a discharge path that discharges the fluid from inside the balloon through a discharge port positioned on an outside of the heating element are disposed.
摘要翻译： 一种新颖的构造的气囊导管，其能够通过使用激光有效地加热加热元件，并且通过避免激光直接加热加热元件以外的加热构件来确保耐久性。 本发明提供一种气囊导管，其具有设置在轴的远端部分中的气囊，并且其中：紧密卷绕的线圈状加热元件容纳并布置在气囊中; 设置在加热元件内照射激光的光纤; 以及通过加热元件的内部向气囊内部供给流体的供给路径以及通过位于加热元件的外侧的排出口从气囊内部排出流体的排出路径。
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公开(公告)号：US20070167934A1
公开(公告)日：2007-07-19
申请号：US10589803
申请日：2005-02-21
申请人： Tsunenori Arai , Noriko Usami
发明人： Tsunenori Arai , Noriko Usami
IPC分类号： A61B18/18
CPC分类号： A61B18/20 , A61B2017/00508
摘要： To provide a device and method for closing a sheath removal hole formed for introducing a vessel catheter by laser welding when diagnosis or treatment inside a blood vessel is performed by means of the catheter. The device for closing the sheath removal hole formed in the wall of the blood vessel by laser welding, comprising welding laser generating means, means for transmitting the welding laser, and means for monitoring the position of an end of the welding laser transmitting means, wherein the welding laser is radiated when the end of the welding laser transmitting means is located in the vessel wall.
摘要翻译： 提供一种用于通过导管进行血管内的诊断或治疗时，通过激光焊接来闭合形成用于引入血管导管的鞘去除孔的装置和方法。 用于通过激光焊接封闭在血管壁形成的护套移除孔的装置，包括焊接激光产生装置，用于传送焊接激光的装置，以及用于监测焊接激光发射装置的端部位置的装置，其中 当焊接激光发射装置的端部位于容器壁中时，焊接激光器被辐射。
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公开(公告)号：US09233235B2
公开(公告)日：2016-01-12
申请号：US13990547
申请日：2011-12-12
CPC分类号： A61M25/104 , A61B18/04 , A61B18/28 , A61B2018/0022 , A61B2018/00386 , A61B2018/00404 , A61B2018/00821 , A61B2018/046 , A61B2218/002
摘要： A balloon catheter of novel configuration, which is capable of both efficiently heating a heating element by using a laser light and of ensuring durability by avoiding the laser light directly heating members other than the heating element. Provided is a balloon catheter with a balloon disposed in a distal end section of a shaft and wherein: a tightly wound coil shaped heating element is housed and arranged in the balloon; an optical fiber that irradiates a laser light inside the heating element is disposed; and a supply path that supplies a fluid to inside the balloon through an inside of the heating element and a discharge path that discharges the fluid from inside the balloon through a discharge port positioned on an outside of the heating element are disposed.
摘要翻译： 一种新颖的构造的气囊导管，其能够通过使用激光有效地加热加热元件，并且通过避免激光直接加热加热元件以外的加热构件来确保耐久性。 本发明提供一种气囊导管，其具有设置在轴的远端部分中的气囊，并且其中：紧密卷绕的线圈状加热元件容纳并布置在气囊中; 设置在加热元件内照射激光的光纤; 以及通过加热元件的内部向气囊内部供给流体的供给路径以及通过位于加热元件的外侧的排出口从气囊内部排出流体的排出路径。
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4.发明申请公开(公告)号：US20130289672A1
公开(公告)日：2013-10-31
申请号：US13976801
申请日：2011-12-22
申请人： Shiho Hakomori , Tsunenori Arai , Arisa Ito , Mei Takahashi
发明人： Shiho Hakomori , Tsunenori Arai , Arisa Ito , Mei Takahashi
IPC分类号： A61N5/06
CPC分类号： A61N5/0613 , A61B5/06 , A61B18/24 , A61B2018/00351 , A61B2018/00648 , A61B2090/065 , A61N5/0601 , A61N5/062
摘要： To provide a laser therapy apparatus that is capable of determining a contact state between a tip portion of a laser catheter and a tissue, which includes a buried state of the tip portion in the tissue, a laser therapy system, and a determination method.
摘要翻译： 提供一种能够确定激光导管的前端部分和组织之间的接触状态的激光治疗装置，其包括组织中的尖端部分的埋藏状态，激光治疗系统和确定方法。
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公开(公告)号：US20080021416A1
公开(公告)日：2008-01-24
申请号：US11783185
申请日：2007-04-06
申请人： Tsunenori Arai , Eriko Suga , Erika Yamashita
发明人： Tsunenori Arai , Eriko Suga , Erika Yamashita
IPC分类号： A61M23/00
CPC分类号： A61B1/0051 , A61B1/00167 , A61B1/0052 , A61B1/0055 , A61B1/07 , A61M25/0054 , A61M25/0074 , A61M25/0158 , A61M2025/0064 , G02B23/2476
摘要： A thin tube is provided that is inserted into a lumen of a living body so as to be used, which can detect the flexed direction of the forward end of itself with the use of a sensor disposed at such forward end upon light irradiation. The forward end of the thin tube is allowed to be flexed to a desired direction with the use of an actuator disposed at such forward end. Such thin tube for medical use is inserted into the lumen of a living body so as to be used for internal observation or internal treatment and contains a device for sensing light irradiation and/or an actuator that is operated via light irradiation at its forward end and a light transmission means, such light transmission means being used for irradiating the device and/or the actuator with light and such device or actuator functioning for monitoring and/or controlling the degree of flection of the forward end of such thin tube, is provided.
摘要翻译： 提供了一种细管，其被插入到使用的活体的内腔中，其可以通过使用在光照射时在这样的前端设置的传感器来检测其自身的前端的弯曲方向。 通过使用设置在这样的前端的致动器，允许细管的前端弯曲到期望的方向。 这种用于医疗用途的细管被插入生物体的内腔中，以用于内部观察或内部处理，并且包含用于感测光照射的装置和/或通过其前端的光照射操作的致动器， 提供了一种光传输装置，这种光传输装置用于用光照射装置和/或致动器，并且用于监测和/或控制这种细管的前端的弯曲度的这种装置或致动器。
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6.发明申请Photodynamic therapy equipment, method for controlling photodynamic therapy equipment and method of photodynamic method 审中-公开光动力治疗设备，光动力治疗设备的控制方法及光动力学方法公开(公告)号：US20060282132A1
公开(公告)日：2006-12-14
申请号：US10560821
申请日：2003-12-19
IPC分类号： A61N5/06
CPC分类号： A61N5/062 , A61N5/0601
摘要： The invention provides PDT equipment which can absolutely treat the deep lesioned part with preserving the superficial membrane of the healthy region. Photodynamic therapy equipment 1 for treating lesioned part by using a photosensitive substance, which is activated by the light having a peak intensity of a predetermined range but is almost not activated by the light having the peak intensity out of the predetermined range, equipped with an irradiation means 13 irradiating into the body a pulsed light of the wavelength having the potential for activating the photosensitive substance, and a control means 22 controlling the peak intensity of the light irradiated by the irradiation means, and the control means 22 allows the irradiation means 13 to irradiate the light having the high peak intensity in order that the light arriving at the deep-lying lesioned part 41 is to achieve the peak intensity of the predetermined range.
摘要翻译： 本发明提供PDT设备，其可以通过保存健康区域的表面膜来绝对治疗深部损伤部位。 光动力治疗设备1，用于通过使用感光物质来治疗损伤部分，该感光物质由具有预定范围的峰值强度但几乎不被具有峰值强度超出预定范围的光激活的光，其具有照射 装置13向身体照射具有用于激活感光物质的波长的脉冲光;以及控制装置22，其控制由照射装置照射的光的峰值强度，并且控制装置22允许照射装置13 照射具有高峰值强度的光，以便到达深层损伤部分41的光达到预定范围的峰值强度。
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公开(公告)号：US20060047264A1
公开(公告)日：2006-03-02
申请号：US10536335
申请日：2003-12-02
IPC分类号： A61M25/00
CPC分类号： A61B1/0055
摘要： A fluororesin tube body (10) of an endoscope flexible tube (1) is small in diameter and thin in wall thickness to such a degree that it is difficult to maintain its cross-sectional shape by itself when the flexible tube (1) is bent to the limit. A braid (20) woven from a plurality of flat bands (21) to form a tubular shape is disposed around the tube body (10). The mesh openings of the braid (20) are filled with filling adhesive (30), which bonds the tube body (10) and the braid (20) together. The filling adhesive (30) has enough elasticity to allow deformation of the braid (20) during the bending operation and enough adhesive strength to maintain the bond between the tube body (10) and the braid (20) even when the filling adhesive (30) is elastically deformed. Consequently, the braid (20) restricts the cross-sectional deformation of the tube body (10). Thus, the limit curvature of the flexible tube (1) can be increased.
摘要翻译： 内窥镜柔性管（1）的氟树脂管体（10）的直径小，壁厚薄，难以在柔性管（1）弯曲时自身保持截面形状 到极限 从管体（10）的周围配置由多个平带（21）编织而形成管状的编织物（20）。 编织物（20）的网眼开口填充有将管体（10）和编织物（20）结合在一起的填充粘合剂（30）。 填充粘合剂（30）具有足够的弹性，以允许在弯曲操作期间编织物（20）的变形和足够的粘合强度，以便即使在填充粘合剂（30）的情况下也保持管体（10）和编织物（20）之间的结合 ）弹性变形。 因此，编织物（20）限制管体（10）的横截面变形。 因此，可以增加柔性管（1）的极限曲率。
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公开(公告)号：US20130172863A1
公开(公告)日：2013-07-04
申请号：US13583140
申请日：2011-03-07
申请人： Shiho Hakomori , Takashi Yamaguchi , Koshi Tamamura , Tsunenori Arai , Arisa Ito
发明人： Shiho Hakomori , Takashi Yamaguchi , Koshi Tamamura , Tsunenori Arai , Arisa Ito
IPC分类号： A61B18/24
CPC分类号： A61B18/24 , A61B5/0071 , A61B5/0084 , A61B5/0402 , A61B5/1459 , A61B5/6885 , A61B5/7285 , A61N5/062
摘要： A photodynamic therapy apparatus as a determining apparatus is the photodynamic therapy apparatus for irradiating a tissue having absorbed photo-sensitive pharmaceutical, the photo-sensitive pharmaceutical absorbing an excitation light and emitting fluorescence, or a tissue absorbing the excitation light and emitting fluorescence, with the excitation light emitted from a tip portion of a laser catheter, including a connector, a light source, and a light detection unit. The laser catheter is capable of being attached/detached to/from the connector. The light source outputs the excitation light to the laser catheter via the connector. The light detection unit detects intensity or a spectrum of the fluorescence, the fluorescence being entered from the laser catheter via the connector, to determine whether the tip portion of the laser catheter contacts the tissue or not.
摘要翻译： 作为决定装置的光动力治疗装置是用于对具有吸收光敏药物的组织，吸收激发光并发出荧光的感光药物或吸收激发光并发出荧光的组织进行照射的光动力治疗装置， 从包括连接器，光源和光检测单元的激光导管的尖端部分发射的激发光。 激光导管能够连接到/从连接器分离。 光源通过连接器将激发光输出到激光导管。 光检测单元检测荧光的强度或光谱，荧光从激光导管经由连接器进入，以确定激光导管的尖端部分是否与组织接触。
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9.发明申请SYSTEM FOR PREVENTING BLOOD CHARRING AT LASER BEAM EMITTING SITE OF LASER CATHETER 审中-公开用于防止激光束激光发射场发生血液充血的系统公开(公告)号：US20130046293A1
公开(公告)日：2013-02-21
申请号：US13583566
申请日：2011-03-01
申请人： Tsunenori Arai , Arisa Ito , Mei Takahashi
发明人： Tsunenori Arai , Arisa Ito , Mei Takahashi
IPC分类号： A61B18/18
CPC分类号： A61B18/24 , A61B18/245 , A61B2018/00785
摘要： This invention provides a method and a system for preventing charring at a laser beam emitting site during treatment or diagnosis using a laser catheter for applying a laser beam. The method is intended to control laser beam irradiation of an apparatus equipped with a laser catheter comprising a laser beam transmission means and a laser beam emitting site used for diagnosis or treatment with the irradiation of the inside of a blood vessel or heart cavity with a laser beam. The method for controlling laser beam irradiation is intended to prevent blood charring at a laser emission site of an apparatus equipped with a laser catheter, and the method comprises a step of controlling a laser beam output in accordance with temporal changes in the intensity of the diffuse reflected light beam by erythrocytes applied to the inside of a blood vessel or heart cavity.
摘要翻译： 本发明提供一种用于在使用激光导管施加激光束的治疗或诊断期间防止激光束发射部位的炭化的方法和系统。 该方法旨在控制配备有激光导管的装置的激光束照射，该激光导管包括激光束传输装置和用于诊断或治疗的激光束发射部位，用激光照射血管或心腔内 光束。 用于控制激光束照射的方法旨在防止装备有激光导管的装置的激光发射部位处的血液烧焦，并且该方法包括根据扩散的强度的时间变化来控制激光束输出的步骤 反射光束被红细胞施加到血管或心脏腔内。
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10.发明申请PHOTODYNAMIC THERAPEUTIC AGENT HAVING CELL-SPECIFIC ACTIVE ACCUMULATION PROPERTIES 审中-公开具有细胞特异性活性成分特性的光动力治疗剂公开(公告)号：US20120164210A1
公开(公告)日：2012-06-28
申请号：US12998931
申请日：2009-12-17
CPC分类号： A61K41/0071 , A61K9/127 , A61K31/409 , A61K31/78 , A61K47/6849 , A61K47/6933 , C08F20/34 , C08F30/02
摘要： The present invention relates to a cancer-cell-specific polymer compound containing a photosensitizer for photodynamic therapy and having a surface to which an antibody against a cancer-cell-specific antigen binds. An object of the present invention is to provide a photodynamic therapeutic agent that can reach the cancer tissue at a low concentration via active targeting and makes complications (e.g., sunlight hypersensitivity) associated with photodynamic therapy unlikely to occur.
摘要翻译： 本发明涉及含有用于光动力学治疗的光敏剂并具有针对癌细胞特异性抗原的抗体结合的表面的癌细胞特异性聚合物化合物。 本发明的目的是提供一种能够通过活性靶向以低浓度达到癌组织的光动力治疗剂，并且与光动力学治疗相关的并发症（例如，阳光超敏反应）不太可能发生。
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