公开(公告)号：US20130289672A1

公开(公告)日：2013-10-31

申请号：US13976801

申请日：2011-12-22

Applicant: Shiho Hakomori ,  Tsunenori Arai ,  Arisa Ito ,  Mei Takahashi

Inventor： Shiho Hakomori ,  Tsunenori Arai ,  Arisa Ito ,  Mei Takahashi

IPC: A61N5/06

CPC classification number: A61N5/0613 ,  A61B5/06 ,  A61B18/24 ,  A61B2018/00351 ,  A61B2018/00648 ,  A61B2090/065 ,  A61N5/0601 ,  A61N5/062

Abstract: To provide a laser therapy apparatus that is capable of determining a contact state between a tip portion of a laser catheter and a tissue, which includes a buried state of the tip portion in the tissue, a laser therapy system, and a determination method.

Abstract translation: 提供一种能够确定激光导管的前端部分和组织之间的接触状态的激光治疗装置，其包括组织中的尖端部分的埋藏状态，激光治疗系统和确定方法。

公开(公告)号：US20130046293A1

公开(公告)日：2013-02-21

申请号：US13583566

申请日：2011-03-01

Applicant: Tsunenori Arai ,  Arisa Ito ,  Mei Takahashi

Inventor： Tsunenori Arai ,  Arisa Ito ,  Mei Takahashi

IPC: A61B18/18

CPC classification number: A61B18/24 ,  A61B18/245 ,  A61B2018/00785

Abstract: This invention provides a method and a system for preventing charring at a laser beam emitting site during treatment or diagnosis using a laser catheter for applying a laser beam. The method is intended to control laser beam irradiation of an apparatus equipped with a laser catheter comprising a laser beam transmission means and a laser beam emitting site used for diagnosis or treatment with the irradiation of the inside of a blood vessel or heart cavity with a laser beam. The method for controlling laser beam irradiation is intended to prevent blood charring at a laser emission site of an apparatus equipped with a laser catheter, and the method comprises a step of controlling a laser beam output in accordance with temporal changes in the intensity of the diffuse reflected light beam by erythrocytes applied to the inside of a blood vessel or heart cavity.

Abstract translation: 本发明提供一种用于在使用激光导管施加激光束的治疗或诊断期间防止激光束发射部位的炭化的方法和系统。 该方法旨在控制配备有激光导管的装置的激光束照射，该激光导管包括激光束传输装置和用于诊断或治疗的激光束发射部位，用激光照射血管或心腔内 光束。 用于控制激光束照射的方法旨在防止装备有激光导管的装置的激光发射部位处的血液烧焦，并且该方法包括根据扩散的强度的时间变化来控制激光束输出的步骤 反射光束被红细胞施加到血管或心脏腔内。

公开(公告)号：US20130123642A1

公开(公告)日：2013-05-16

申请号：US13583531

申请日：2011-03-07

Applicant: Takashi Yamaguchi ,  Shiho Hakomori ,  Koshi Tamamura ,  Tsunenori Arai ,  Arisa Ito ,  Jun Uchiyama

Inventor： Takashi Yamaguchi ,  Shiho Hakomori ,  Koshi Tamamura ,  Tsunenori Arai ,  Arisa Ito ,  Jun Uchiyama

IPC: A61B5/00

CPC classification number: A61B5/0071 ,  A61B5/0084 ,  A61B5/0402 ,  A61B5/4848 ,  A61B5/6852 ,  A61B5/6869 ,  A61B18/24 ,  A61B2018/00351 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0602 ,  A61N2005/0626

Abstract: A photodynamic therapy apparatus as an estimating apparatus is an apparatus for irradiating a tissue having absorbed photo-sensitive pharmaceutical, the photo-sensitive pharmaceutical absorbing an excitation light and emitting fluorescence, with the excitation light emitted from a tip portion of a laser the catheter, including a connector, a light source, and a light detection unit. The laser the catheter is capable of being attached/detached to/from the connector. The light source outputs the excitation light to the laser the catheter via the connector. The light detection unit detects intensity or a spectrum of the fluorescence, the fluorescence being entered from the laser the catheter via the connector, to estimate whether the tissue has changed because of reaction between the excitation light emitted from the tip portion of the laser the catheter and the photo-sensitive pharmaceutical absorbed in the tissue.

Abstract translation: 作为估计装置的光动力治疗装置是一种用于从吸收了光敏药物的组织照射吸光激发光并发射荧光的光敏药物与从激光器的尖端部分发射的激发光的导管的装置， 包括连接器，光源和光检测单元。 激光器能够将导管与连接器连接/分离。 光源通过连接器将激发光输出到激光导管。 光检测单元检测荧光的强度或光谱，荧光通过连接器从激光导入导管，以估计组织是否因激光的尖端部分发射的激发光之间的反应而发生变化 和吸收在组织中的感光药物。

公开(公告)号：US20120330293A1

公开(公告)日：2012-12-27

申请号：US13581105

申请日：2011-02-25

Applicant: Tsunenori Arai ,  Arisa Ito

Inventor： Tsunenori Arai ,  Arisa Ito

IPC: A61B18/24

CPC classification number: A61B18/24 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61N5/0601 ,  A61N5/0603 ,  A61N5/062

Abstract: This invention provides a catheter used for blocking abnormal conduction in the cardiac muscle using photodynamic therapy or treating arrhythmia and a method for evaluating the therapeutic effects of the catheter. The catheter has a structure that freely bends at its end, which is used for performing photodynamic ablation of cardiac muscle tissue via photochemical reactions in the blood vessel or cardiac lumen. The catheter comprises a light-emitting window for applying a light beam transmitted through an optical fiber to a target site of cardiac muscle tissue and at least two electrodes for potential measurement in the periphery of the light-emitting window.

Abstract translation: 本发明提供一种用于使用光动力学治疗或治疗心律失常来阻断心肌异常传导的导管和用于评估导管的治疗效果的方法。 导管具有在其端部自由弯曲的结构，其用于通过血管或心脏腔中的光化学反应进行心肌组织的光动力消融。 导管包括用于将通过光纤传输的光束施加到心脏肌肉组织的靶位点的发光窗口和用于在发光窗口的周边进行电位测量的至少两个电极。

公开(公告)号：US09277865B2

公开(公告)日：2016-03-08

申请号：US13583531

申请日：2011-03-07

Applicant: Takashi Yamaguchi ,  Shiho Hakomori ,  Koshi Tamamura ,  Tsunenori Arai ,  Arisa Ito ,  Jun Uchiyama

Inventor： Takashi Yamaguchi ,  Shiho Hakomori ,  Koshi Tamamura ,  Tsunenori Arai ,  Arisa Ito ,  Jun Uchiyama

IPC: A61B6/00 ,  A61B5/00 ,  A61N5/06 ,  A61B18/24 ,  A61B18/00 ,  A61B5/0402

CPC classification number: A61B5/0071 ,  A61B5/0084 ,  A61B5/0402 ,  A61B5/4848 ,  A61B5/6852 ,  A61B5/6869 ,  A61B18/24 ,  A61B2018/00351 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0602 ,  A61N2005/0626

Abstract: A photodynamic therapy apparatus as an estimating apparatus is an apparatus for irradiating a tissue having absorbed photo-sensitive pharmaceutical, the photo-sensitive pharmaceutical absorbing an excitation light and emitting fluorescence, with the excitation light emitted from a tip portion of a laser catheter, including a connector, a light source, and a light detection unit. The laser catheter is capable of being attached to and detached from the connector. The light source outputs the excitation light to the laser catheter via the connector. The light detection unit detects intensity or a spectrum of the fluorescence, the fluorescence being entered from the laser catheter via the connector, to estimate whether the tissue has changed because of reaction between the excitation light emitted from the tip portion of the laser catheter and the photo-sensitive pharmaceutical absorbed in the tissue.

Abstract translation: 作为估计装置的光动力治疗装置是一种用于照射具有吸收光敏药物的组织的装置，所述光敏药物吸收激发光并发射荧光的激发光与从激光导管的尖端部分发射的激发光，包括 连接器，光源和光检测单元。 激光导管能够连接到连接器上并从连接器上拆下。 光源通过连接器将激发光输出到激光导管。 光检测单元检测荧光的强度或光谱，荧光从激光导管经由连接器进入，以估计组织是否由于从激光导管的尖端部分发射的激发光与第 光敏药物吸收在组织中。

公开(公告)号：US20130172697A1

公开(公告)日：2013-07-04

申请号：US13583547

申请日：2011-03-07

Applicant: Koshi Tamamura ,  Shiho Hakomori ,  Takashi Yamaguchi ,  Tsunenori Arai ,  Arisa Ito

Inventor： Koshi Tamamura ,  Shiho Hakomori ,  Takashi Yamaguchi ,  Tsunenori Arai ,  Arisa Ito

IPC: A61B5/1459

CPC classification number: A61B5/1459 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0402 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0602

Abstract: [Object] To provide a calculation apparatus and a calculation method capable of calculating pharmaceutical concentration in a tissue in real time.[Solving Means] A photodynamic therapy apparatus as a calculation apparatus is an apparatus for irradiating a tissue having absorbed photo-sensitive pharmaceutical, the photo-sensitive pharmaceutical absorbing an excitation light and emitting fluorescence, with the excitation light emitted from a tip portion of a laser catheter, including a connector, a light source, and a light detection unit. The laser catheter is capable of being attached/detached to/from the connector. The light source outputs the excitation light to the laser catheter via the connector. The light detection unit detects intensity of the fluorescence, the fluorescence being entered from the laser catheter via the connector, to calculate concentration of the photo-sensitive pharmaceutical in a tissue, the tip portion of the laser catheter contacting the tissue.

Abstract translation: 提供能够实时计算组织中的药物浓度的计算装置和计算方法。 解决方案作为计算装置的光动力治疗装置是一种用于照射具有吸收光敏药物的组织的装置，所述光敏药物吸收激发光并发射荧光的光敏药物与从 激光导管，包括连接器，光源和光检测单元。 激光导管能够连接到/从连接器分离。 光源通过连接器将激发光输出到激光导管。 光检测单元检测荧光的强度，荧光从激光导管经由连接器进入，以计算组织中感光药物的浓度，激光导管的尖端部分接触组织。

公开(公告)号：US20130172863A1

公开(公告)日：2013-07-04

申请号：US13583140

申请日：2011-03-07

Applicant: Shiho Hakomori ,  Takashi Yamaguchi ,  Koshi Tamamura ,  Tsunenori Arai ,  Arisa Ito

Inventor： Shiho Hakomori ,  Takashi Yamaguchi ,  Koshi Tamamura ,  Tsunenori Arai ,  Arisa Ito

IPC: A61B18/24

CPC classification number: A61B18/24 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0402 ,  A61B5/1459 ,  A61B5/6885 ,  A61B5/7285 ,  A61N5/062

Abstract: A photodynamic therapy apparatus as a determining apparatus is the photodynamic therapy apparatus for irradiating a tissue having absorbed photo-sensitive pharmaceutical, the photo-sensitive pharmaceutical absorbing an excitation light and emitting fluorescence, or a tissue absorbing the excitation light and emitting fluorescence, with the excitation light emitted from a tip portion of a laser catheter, including a connector, a light source, and a light detection unit. The laser catheter is capable of being attached/detached to/from the connector. The light source outputs the excitation light to the laser catheter via the connector. The light detection unit detects intensity or a spectrum of the fluorescence, the fluorescence being entered from the laser catheter via the connector, to determine whether the tip portion of the laser catheter contacts the tissue or not.

Abstract translation: 作为决定装置的光动力治疗装置是用于对具有吸收光敏药物的组织，吸收激发光并发出荧光的感光药物或吸收激发光并发出荧光的组织进行照射的光动力治疗装置， 从包括连接器，光源和光检测单元的激光导管的尖端部分发射的激发光。 激光导管能够连接到/从连接器分离。 光源通过连接器将激发光输出到激光导管。 光检测单元检测荧光的强度或光谱，荧光从激光导管经由连接器进入，以确定激光导管的尖端部分是否与组织接触。

公开(公告)号：US20130267985A1

公开(公告)日：2013-10-10

申请号：US13990547

申请日：2011-12-12

Applicant: Tsunenori Arai ,  Natsumi Shimazaki ,  Katsuya Miyagawa ,  Yuuki Nishimura ,  Misa Kakinoki

Inventor： Tsunenori Arai ,  Natsumi Shimazaki ,  Katsuya Miyagawa ,  Yuuki Nishimura ,  Misa Kakinoki

IPC: A61M25/10

CPC classification number: A61M25/104 ,  A61B18/04 ,  A61B18/28 ,  A61B2018/0022 ,  A61B2018/00386 ,  A61B2018/00404 ,  A61B2018/00821 ,  A61B2018/046 ,  A61B2218/002

Abstract: A balloon catheter of novel configuration, which is capable of both efficiently heating a heating element by using a laser light and of ensuring durability by avoiding the laser light directly heating members other than the heating element. Provided is a balloon catheter with a balloon disposed in a distal end section of a shaft and wherein: a tightly wound coil shaped heating element is housed and arranged in the balloon; an optical fiber that irradiates a laser light inside the heating element is disposed; and a supply path that supplies a fluid to inside the balloon through an inside of the heating element and a discharge path that discharges the fluid from inside the balloon through a discharge port positioned on an outside of the heating element are disposed.

Abstract translation: 一种新颖的构造的气囊导管，其能够通过使用激光有效地加热加热元件，并且通过避免激光直接加热加热元件以外的加热构件来确保耐久性。 本发明提供一种气囊导管，其具有设置在轴的远端部分中的气囊，并且其中：紧密卷绕的线圈状加热元件容纳并布置在气囊中; 设置在加热元件内照射激光的光纤; 以及通过加热元件的内部向气囊内部供给流体的供给路径以及通过位于加热元件的外侧的排出口从气囊内部排出流体的排出路径。

公开(公告)号：US20070167934A1

公开(公告)日：2007-07-19

申请号：US10589803

申请日：2005-02-21

Applicant: Tsunenori Arai ,  Noriko Usami

Inventor： Tsunenori Arai ,  Noriko Usami

IPC: A61B18/18

CPC classification number: A61B18/20 ,  A61B2017/00508

Abstract: To provide a device and method for closing a sheath removal hole formed for introducing a vessel catheter by laser welding when diagnosis or treatment inside a blood vessel is performed by means of the catheter. The device for closing the sheath removal hole formed in the wall of the blood vessel by laser welding, comprising welding laser generating means, means for transmitting the welding laser, and means for monitoring the position of an end of the welding laser transmitting means, wherein the welding laser is radiated when the end of the welding laser transmitting means is located in the vessel wall.

Abstract translation: 提供一种用于通过导管进行血管内的诊断或治疗时，通过激光焊接来闭合形成用于引入血管导管的鞘去除孔的装置和方法。 用于通过激光焊接封闭在血管壁形成的护套移除孔的装置，包括焊接激光产生装置，用于传送焊接激光的装置，以及用于监测焊接激光发射装置的端部位置的装置，其中 当焊接激光发射装置的端部位于容器壁中时，焊接激光器被辐射。

公开(公告)号：US09233235B2

公开(公告)日：2016-01-12

申请号：US13990547

申请日：2011-12-12

Applicant: Tsunenori Arai ,  Natsumi Shimazaki ,  Katsuya Miyagawa ,  Yuuki Nishimura ,  Misa Kakinoki

Inventor： Tsunenori Arai ,  Natsumi Shimazaki ,  Katsuya Miyagawa ,  Yuuki Nishimura ,  Misa Kakinoki

IPC: A61B18/28 ,  A61M25/10 ,  A61B18/04 ,  A61B18/00

CPC classification number: A61M25/104 ,  A61B18/04 ,  A61B18/28 ,  A61B2018/0022 ,  A61B2018/00386 ,  A61B2018/00404 ,  A61B2018/00821 ,  A61B2018/046 ,  A61B2218/002

Abstract: A balloon catheter of novel configuration, which is capable of both efficiently heating a heating element by using a laser light and of ensuring durability by avoiding the laser light directly heating members other than the heating element. Provided is a balloon catheter with a balloon disposed in a distal end section of a shaft and wherein: a tightly wound coil shaped heating element is housed and arranged in the balloon; an optical fiber that irradiates a laser light inside the heating element is disposed; and a supply path that supplies a fluid to inside the balloon through an inside of the heating element and a discharge path that discharges the fluid from inside the balloon through a discharge port positioned on an outside of the heating element are disposed.

Abstract translation: 一种新颖的构造的气囊导管，其能够通过使用激光有效地加热加热元件，并且通过避免激光直接加热加热元件以外的加热构件来确保耐久性。 本发明提供一种气囊导管，其具有设置在轴的远端部分中的气囊，并且其中：紧密卷绕的线圈状加热元件容纳并布置在气囊中; 设置在加热元件内照射激光的光纤; 以及通过加热元件的内部向气囊内部供给流体的供给路径以及通过位于加热元件的外侧的排出口从气囊内部排出流体的排出路径。