公开(公告)号：US20100040325A1

公开(公告)日：2010-02-18

申请号：US12462641

申请日：2009-08-05

申请人： Hus Tigli ,  Matthew Last ,  David Sandler

发明人： Hus Tigli ,  Matthew Last ,  David Sandler

IPC分类号： G02B6/42 ,  G02B6/26

CPC分类号： G02B6/359 ,  G02B6/3512 ,  G02B6/3542 ,  G02B6/3556 ,  G02B6/356 ,  G02B6/357 ,  G02B6/3582 ,  G02B6/3584

摘要： A low cost, multimode optical fiber switch in which a MEMS mirror is used to serially reflect input light from a plurality of input optical fibers into a single output fiber or from a single optical fiber into a plurality of output fibers. In a planned demonstration prototype the output fiber is located in the center of four input fibers. In other preferred embodiments of the present invention an array of MEMS mirrors are utilized with a large bundle of fibers containing both input and output fibers. Each MEMS mirror is adapted to reflect light from a number of input fibers one-at-a-time into a single output fiber or to reflect light from a single input fiber into a number of output fibers one-at-a-time.

摘要翻译： 一种低成本的多模光纤开关，其中使用MEMS反射镜将来自多个输入光纤的输入光线串行地反射到单个输出光纤或从单个光纤到多个输出光纤。 在计划的演示原型中，输出光纤位于四根输入光纤的中心。 在本发明的其它优选实施例中，利用包含输入和输出光纤的大束光纤利用MEMS反射镜阵列。 每个MEMS反射镜适于将来自多个输入光纤的光一次性地反射到单个输出光纤中，或者将来自单个输入光纤的光反射到多个输出光纤中。

公开(公告)号：US20090036327A1

公开(公告)日：2009-02-05

申请号：US12221129

申请日：2008-07-30

申请人： John Lawrence Ervin ,  Hus Tigli ,  Mark R. Kennedy

发明人： John Lawrence Ervin ,  Hus Tigli ,  Mark R. Kennedy

IPC分类号： C40B50/18

CPC分类号： G01N33/54353

摘要： A method which renders the 3D surface of the insides of the pores of porous silicon biochip appropriate for conducting studies on biomolecule interactions without labels.

摘要翻译： 使得多孔硅生物芯片的孔内部的3D表面适合于进行生物分子相互作用的标记的方法。

公开(公告)号：US20060063178A1

公开(公告)日：2006-03-23

申请号：US11196894

申请日：2005-08-04

申请人： Christine Rauh-Adelmann ,  Susant Patra ,  Hus Tigli ,  Peter Martin

发明人： Christine Rauh-Adelmann ,  Susant Patra ,  Hus Tigli ,  Peter Martin

IPC分类号： C12Q1/68 ,  G01N33/53 ,  G06F19/00 ,  C12M1/34

CPC分类号： G01N33/54373 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/565 ,  B01L9/527 ,  B01L2200/027 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2400/0487 ,  B01L2400/0655 ,  B01L2400/086 ,  G01N21/84 ,  G01N33/552

摘要： Methods and devices for the measurement of molecular binding interactions. Preferred embodiments provide real-time measurements of kinetic binding and disassociation of molecules including binding and disassociation of protein molecules with other protein molecules and with other molecules. In preferred embodiments ligands are immobilized within pores of a porous silicon interaction region produced in a silicon substrate, after which analytes suspended in a fluid are flowed over the porous silicon region. Binding reactions occur when analyte molecules diffuse closely enough to the ligands to become bound. Preferably the binding and subsequent disassociation reactions are observed utilizing a white light source and thin film interference techniques with spectrometers arranged to detect changes in indices of refraction in the region where the binding and disassociation reactions occur. In preferred embodiments both ligands and analytes are delivered by computer controlled robotic fluid flow control techniques to the porous silicon interaction regions through microfluidic flow channels.

公开(公告)号：US20050074237A1

公开(公告)日：2005-04-07

申请号：US10677590

申请日：2003-10-02

申请人： Brett Spivey ,  Eric Korevaar ,  Hus Tigli ,  Todd Barrett

发明人： Brett Spivey ,  Eric Korevaar ,  Hus Tigli ,  Todd Barrett

IPC分类号： H04Q11/00 ,  H04J14/00

CPC分类号： H04Q11/0062 ,  H04Q11/0071 ,  H04Q2011/0073

摘要： The present invention provides a large communication network suitable for nationwide or worldwide utilization. A plurality of area code nodes are connected with all-fiber-optic links with all-optical switches. A routing algorithm provides one or more communication links from each area code node to every other area code node so that information never has to change carrier wavelength as it travels the network. Each area code node contains circuits that are provided to connect individual users to the network.

摘要翻译： 本发明提供适用于全国或全球利用的大型通信网络。 多个区域代码节点与具有全光开关的全光纤链路连接。 路由算法提供从每个区域代码节点到每个其他区域代码节点的一个或多个通信链路，使得信息在传播网络时不必改变载波波长。 每个区域代码节点包含提供用于将各个用户连接到网络的电路。

公开(公告)号：US20050019956A1

公开(公告)日：2005-01-27

申请号：US10616251

申请日：2003-07-08

申请人： Peter Martin ,  Keiki-Pua Dancil ,  Arthur Morsell ,  Hus Tigli

发明人： Peter Martin ,  Keiki-Pua Dancil ,  Arthur Morsell ,  Hus Tigli

IPC分类号： B01L3/00 ,  G01N21/84 ,  G01N33/552 ,  G01N35/00

CPC分类号： B01L3/502753 ,  B01L3/5023 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/502746 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0487 ,  B01L2400/0655 ,  G01N21/77 ,  G01N33/552 ,  G01N2021/752 ,  G01N2021/755 ,  G01N2021/757 ,  G01N2021/758 ,  G01N2021/7779 ,  G01N2021/7796 ,  G01N2035/0097 ,  Y10S435/808

摘要： Methods and devices for the measurement of molecular binding interactions. Preferred embodiments provide real-time measurements of kinetic binding and disassociation of molecules including binding and disassociation of protein molecules with other protein molecules and with other molecules. In preferred embodiments ligands are immobilized within pores of a porous silicon interaction region produced in a silicon substrate, after which analytes suspended in a fluid are flowed over the porous silicon region. Binding reactions occur when analyte molecules diffuse closely enough to the ligands to become bound. Preferably the binding and subsequent disassociation reactions are observed utilizing a white light source and thin film interference techniques with spectrometers arranged to detect changes in indices of refraction in the region where the binding and disassociation reactions occur. In preferred embodiments both ligands and analytes are delivered by computer controlled robotic fluid flow control techniques to the porous silicon interaction regions through microfluidic flow channels.

摘要翻译： 用于测量分子结合相互作用的方法和装置。 优选的实施方案提供动力学结合和分离的实时测量，包括蛋白质分子与其它蛋白质分子和其它分子的结合和解离。 在优选的实施方案中，将配体固定在硅衬底中产生的多孔硅相互作用区域的孔内，之后悬浮在流体中的分析物流过多孔硅区域。 结合反应发生在分析物分子向配体扩散得足够接近以成为结合物时。 优选地，使用白光源和薄膜干涉技术观察结合和随后的分离反应，其中光谱仪布置成检测发生结合和解离反应的区域中的折射指数的变化。 在优选实施方案中，配体和分析物通过计算机控制的机器人流体控制技术通过微流体流动通道传递到多孔硅相互作用区域。

公开(公告)号：US08401385B2

公开(公告)日：2013-03-19

申请号：US12653723

申请日：2009-12-17

申请人： Brett Spivey ,  Eric Korevaar ,  Hus Tigli ,  Todd Barrett

发明人： Brett Spivey ,  Eric Korevaar ,  Hus Tigli ,  Todd Barrett

IPC分类号： H04J14/02

CPC分类号： H04Q11/0062 ,  H04J14/0212 ,  H04J14/0217 ,  H04J14/0234 ,  H04J14/0246 ,  H04J14/0247 ,  H04J14/025 ,  H04J14/0252 ,  H04J14/0257 ,  H04J14/028 ,  H04J14/0282 ,  H04J14/0284 ,  H04J14/0286 ,  H04J14/0298 ,  H04Q11/0071 ,  H04Q2011/0073

摘要： A large communication network suitable for nationwide or worldwide utilization. The present invention overthrows the conventional packet switching technologies with an all-optical network. The invention uses tunable laser sources to generate large number of highly stable narrow-band optical signals, each serving as a communication channel. With packet processing replaced by all-optical channels, the network become highly secure and scalable while harnessing the virtually unlimited capacity of fiber-optic. A large number of nodes (called area code nodes) are connected with all-fiber-optic links with all-optical switches. A routing algorithm provides one or more communication links from each area code node to every other area code node so that information never has to change carrier wavelength as it travels the network. Each area code node contains circuits that are provided to connect individual users to the network.

摘要翻译： 适合全国或全球利用的大型通信网络。 本发明用全光网络推翻了传统的分组交换技术。 本发明使用可调激光源产生大量高度稳定的窄带光信号，每个都用作通信信道。 随着数据包处理被全光通道所取代，网络变得高度安全和可扩展，同时利用光纤的无限容量。 大量节点（称为区域代码节点）与全光纤交换机全光纤链路连接。 路由算法提供从每个区域代码节点到每个其他区域代码节点的一个或多个通信链路，使得信息在传播网络时不必改变载波波长。 每个区域代码节点包含提供用于将各个用户连接到网络的电路。

公开(公告)号：US20120237217A1

公开(公告)日：2012-09-20

申请号：US12653723

申请日：2009-12-17

申请人： Brett Spivey ,  Eric Korevaar ,  Hus Tigli ,  Todd Barrett

发明人： Brett Spivey ,  Eric Korevaar ,  Hus Tigli ,  Todd Barrett

IPC分类号： H04J14/02 ,  H04Q11/00

CPC分类号： H04Q11/0062 ,  H04J14/0212 ,  H04J14/0217 ,  H04J14/0234 ,  H04J14/0246 ,  H04J14/0247 ,  H04J14/025 ,  H04J14/0252 ,  H04J14/0257 ,  H04J14/028 ,  H04J14/0282 ,  H04J14/0284 ,  H04J14/0286 ,  H04J14/0298 ,  H04Q11/0071 ,  H04Q2011/0073

摘要： A large communication network suitable for nationwide or worldwide utilization. The present invention overthrows the conventional packet switching technologies with an all-optical network. The invention uses tunable laser sources to generate large number of highly stable narrow-band optical signals, each serving as a communication channel. With packet processing replaced by all-optical channels, the network become highly secure and scalable while harnessing the virtually unlimited capacity of fiber-optic. A large number of nodes (called area code nodes) are connected with all-fiber-optic links with all-optical switches. A routing algorithm provides one or more communication links from each area code node to every other area code node so that information never has to change carrier wavelength as it travels the network. Each area code node contains circuits that are provided to connect individual users to the network.

摘要翻译： 适合全国或全球利用的大型通信网络。 本发明用全光网络推翻了传统的分组交换技术。 本发明使用可调激光源产生大量高度稳定的窄带光信号，每个都用作通信信道。 随着数据包处理被全光通道所取代，网络变得高度安全和可扩展，同时利用光纤的无限容量。 大量节点（称为区域代码节点）与全光纤交换机全光纤链路连接。 路由算法提供从每个区域代码节点到每个其他区域代码节点的一个或多个通信链路，使得信息在传播网络时不必改变载波波长。 每个区域代码节点包含提供用于将各个用户连接到网络的电路。

公开(公告)号：US20110206317A1

公开(公告)日：2011-08-25

申请号：US12661622

申请日：2010-03-18

申请人： Hus Tigli ,  Matthew Last ,  Yoshi Taketomi

发明人： Hus Tigli ,  Matthew Last ,  Yoshi Taketomi

IPC分类号： G02B6/26

CPC分类号： G02B6/359 ,  G02B6/3512 ,  G02B6/3542 ,  G02B6/3556 ,  G02B6/356 ,  G02B6/357 ,  G02B6/3582 ,  G02B6/3584

摘要： A scalable optical switch especially useful for switching multimode beams carried by optical fibers. Light from an input fiber is focused by a lens which is moved in an x-y direction perpendicular to the beam direction in order to switch the beam from one output fiber to a different fiber. In preferred embodiments the beam can be directed to any one of as many as 90 output fibers. Techniques for scaling the switch to produce N×N switches with N being large are described. Embodiments of the present invention can also be utilized to create more elaborate fiber optical switches such as an N×N switch and a N2×N switch.

摘要翻译： 一种可扩展的光开关，特别适用于切换由光纤承载的多模光束。 来自输入光纤的光由通过垂直于光束方向的x-y方向移动的透镜聚焦，以将光束从一个输出光纤切换到不同的光纤。 在优选实施例中，光束可以被引导到多达90个输出光纤中的任何一个。 描述了用于缩放开关以产生N为大的N×N个开关的技术。 本发明的实施例也可用于创建更精细的光纤开关，例如N×N开关和N2×N开关。

公开(公告)号：US07517656B2

公开(公告)日：2009-04-14

申请号：US10616251

申请日：2003-07-08

申请人： Peter Martin ,  Keiki-Pua Dancil ,  Arthur Lee Morsell ,  Hus Tigli

发明人： Peter Martin ,  Keiki-Pua Dancil ,  Arthur Lee Morsell ,  Hus Tigli

IPC分类号： C12M1/34

CPC分类号： B01L3/502753 ,  B01L3/5023 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/502746 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0487 ,  B01L2400/0655 ,  G01N21/77 ,  G01N33/552 ,  G01N2021/752 ,  G01N2021/755 ,  G01N2021/757 ,  G01N2021/758 ,  G01N2021/7779 ,  G01N2021/7796 ,  G01N2035/0097 ,  Y10S435/808

摘要： Methods and devices for the measurement of molecular binding interactions. Preferred embodiments provide real-time measurements of kinetic binding and disassociation of molecules including binding and disassociation of protein molecules with other protein molecules and with other molecules. In preferred embodiments ligands are immobilized within pores of a porous silicon interaction region produced in a silicon substrate, after which analytes suspended in a fluid are flowed over the porous silicon region. Binding reactions occur when analyte molecules diffuse closely enough to the ligands to become bound. Preferably the binding and subsequent disassociation reactions are observed utilizing a white light source and thin film interference techniques with spectrometers arranged to detect changes in indices of refraction in the region where the binding and disassociation reactions occur. In preferred embodiments both ligands and analytes are delivered by computer controlled robotic fluid flow control techniques to the porous silicon interaction regions through microfluidic flow channels.

摘要翻译： 用于测量分子结合相互作用的方法和装置。 优选的实施方案提供动力学结合和分离的实时测量，包括蛋白质分子与其它蛋白质分子和其它分子的结合和解离。 在优选的实施方案中，将配体固定在硅衬底中产生的多孔硅相互作用区域的孔内，之后悬浮在流体中的分析物流过多孔硅区域。 结合反应发生在分析物分子向配体扩散得足够接近以成为结合物时。 优选地，使用白光源和薄膜干涉技术观察结合和随后的分离反应，其中光谱仪布置成检测发生结合和解离反应的区域中的折射指数的变化。 在优选实施方案中，配体和分析物通过计算机控制的机器人流体控制技术通过微流体流动通道传递到多孔硅相互作用区域。

公开(公告)号：US20080301632A1

公开(公告)日：2008-12-04

申请号：US12221128

申请日：2008-07-30

申请人： John Lawrence Ervin ,  Hus Tigli

发明人： John Lawrence Ervin ,  Hus Tigli

IPC分类号： G06F9/44

CPC分类号： A63B69/18 ,  A63B69/0059 ,  A63B71/12

摘要： An easy way of introducing a controller into an instrument used to study biomolecular interactions without labels. By introducing a controller, which may be programmed using a graphical programming language, into the system the development time for that system can be made much shorter.

摘要翻译： 将控制器引入用于研究没有标签的生物分子相互作用的仪器的简单方法。 通过将可以使用图形编程语言编程的控制器引入系统，可以缩短该系统的开发时间。