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    Immediate release pharmaceutical granule compositions and a continuous process for making them
    11.
    发明授权
    Immediate release pharmaceutical granule compositions and a continuous process for making them 失效
    立即释放药物颗粒组合物和制备它们的连续方法

    公开(公告)号：US08349366B2

    公开(公告)日：2013-01-08

    申请号：US12815715

    申请日：2010-06-15

    申请人： Jean Paul Remon ,  Chris Vervaet

    发明人： Jean Paul Remon ,  Chris Vervaet

    IPC分类号： A61K9/14

    CPC分类号： A61K9/1652 ,  A61K9/1641 ,  A61K9/1694

    摘要： A pharmaceutical or veterinary granule composition in the form of a mixture consisting essentially of: (i) at least one drug classifiable as Class II or Class IV of the Biopharmaceutical Classification System, wherein said drug (i) constitutes from above about 20% to 50% by weight of the composition, said pharmaceutical or veterinary granule composition providing a drug release of at least 70% within 10 minutes in water, (ii) a first excipient being a maltodextrin representing from 40% by weight to 85% by weight of said composition, (iii) a wetting amount of a second excipient being a polyethylene glycol having a weight number molecular weight between 300 and 5,000, said second excipient comprising a solid fraction and a liquid fraction, and representing from 15% to 40% by weight of said composition, and optionally one or more pharma-ceutically acceptable fillers selected from the group consisting of hydrocolloids, glidants, lubricants, surfactants and diluents, wherein the weight ratio of said first excipient (ii) to said second excipient (iii) is in a range from 1:1 to 5:1.

    摘要翻译： 基本上由以下组成的混合物的药物或兽用颗粒组合物：（i）至少一种可分类为生物制药分类系统的II类或IV类的药物，其中所述药物（i）构成高于约20％至50 所述药物或兽用颗粒组合物在水中在10分钟内提供至少70％的药物释放，（ii）作为麦芽糖糊精的第一赋形剂代表所述组合物的40重量％至85重量％ 组合物，（iii）第二赋形剂的润湿量，其为重量数分子量为300至5,000的聚乙二醇，所述第二赋形剂包含固体部分和液体部分，并且占所述第二赋形剂的15重量％至40重量％ 所述组合物和任选的一种或多种选自水胶体，助流剂，润滑剂，表面活性剂和稀释剂的药物可接受的填料，其中重量比 所述第一赋形剂（ii）与所述第二赋形剂（iii）的比例为1：1至5：1。

    Immediate release pharmaceutical granule compositions and a continuous process for making them
    12.
    发明授权
    Immediate release pharmaceutical granule compositions and a continuous process for making them 失效
    立即释放药物颗粒组合物和制备它们的连续方法

    公开(公告)号：US08337897B2

    公开(公告)日：2012-12-25

    申请号：US12815781

    申请日：2010-06-15

    申请人： Jean Paul Remon ,  Chris Vervaet

    发明人： Jean Paul Remon ,  Chris Vervaet

    IPC分类号： A61K9/14

    CPC分类号： A61K9/1652 ,  A61K9/1641 ,  A61K9/1694

    摘要： A pharmaceutical or veterinary granule composition in the form of a mixture consisting essentially of: (i) at least one drug classifiable as Class II or Class IV of the Biopharmaceutical Classification System, wherein said drug (i) constitutes from 0.5% to 20% by weight of the composition, and excipients, said pharmaceutical or veterinary granule composition providing a drug release of at least 70% within 10 minutes in water, (ii) a first excipient being a maltodextrin representing from 40% by weight to 80% by weight of said composition, (iii) a wetting amount of a second excipient being a polyethylene glycol having a weight number molecular weight between 300 and 5,000, said second excipient comprising a solid fraction and a liquid fraction, and representing from 15% to 40% by weight of said composition, and optionally one or more pharmaceutically acceptable fillers selected from the group consisting of hydrocolloids, glidants, lubricants, surfactants and diluents, wherein the weight ratio of said first excipient (ii) to said second excipient (iii) is in a range from 1:1 to 5:1.

    摘要翻译： 以混合物形式的药物或兽用颗粒组合物，其基本上由以下组成：（i）至少一种可分类为生物药物分类系统的II类或IV类的药物，其中所述药物（i）构成0.5％至20％ 所述组合物的重量和赋形剂，所述药物或兽用颗粒组合物在水中在10分钟内提供至少70％的药物释放，（ii）作为麦芽糖糊精的第一赋形剂，代表40重量％至80重量％ 所述组合物，（iii）第二赋形剂的润湿量，其为重量数分子量为300至5,000的聚乙二醇，所述第二赋形剂包含固体部分和液体部分，并且代表15重量％至40重量％ 的所述组合物，以及任选的一种或多种药学上可接受的填料，其选自水胶体，助流剂，润滑剂，表面活性剂和稀释剂，其中重量 所述第一赋形剂（ii）与所述第二赋形剂（iii）的比例在1:1至5:1的范围内。

    PROCESS FOR PREPARING A SOLID DOSAGE FORM
    13.
    发明申请
    PROCESS FOR PREPARING A SOLID DOSAGE FORM 审中-公开
    制备固体剂型的方法

    公开(公告)号：US20090326078A1

    公开(公告)日：2009-12-31

    申请号：US12306717

    申请日：2007-06-27

    申请人： Jean Paul Remon ,  Chris Vervaet ,  Yves Gonnissen

    发明人： Jean Paul Remon ,  Chris Vervaet ,  Yves Gonnissen

    IPC分类号： A61K47/26 ,  A61K47/10

    CPC分类号： A61K9/1623 ,  A61K9/2095

    摘要： This invention provides a process for preparing a solid dosage form, comprising:—preparing an aqueous slurry, solution or suspension of (a) a powder material, and (b) a mixture of one or more polyols and one or more maltodextrins, and—spray drying the resultant aqueous slurry, solution or suspension, thereby obtaining particles which are directly compressible into a solid dosage form being able to disintegrate in an aqueous medium within no more than 15 minutes.

    摘要翻译： 本发明提供了一种制备固体剂型的方法，包括： - 制备（a）粉末材料的水性浆液，溶液或悬浮液，和（b）一种或多种多元醇和一种或多种麦芽糖糊精的混合物， 喷雾干燥所得的含水浆料，溶液或悬浮液，从而获得直接压缩成固体剂型的颗粒，其能够在不超过15分钟的时间内在含水介质中分解。

    Beeswax mimetic substances and methods of operating beehives
    14.
    发明授权
    Beeswax mimetic substances and methods of operating beehives 失效
    蜂蜡模拟物质和操作蜂箱的方法

    公开(公告)号：US06585557B1

    公开(公告)日：2003-07-01

    申请号：US09868672

    申请日：2001-08-09

    申请人： Jean Paul Remon ,  Franciscus Joanna Jacobs

    发明人： Jean Paul Remon ,  Franciscus Joanna Jacobs

    IPC分类号： A01K5100

    CPC分类号： A01K47/04 ,  A01K51/00

    摘要： A beeswax mimetic substance is described which comprises or consists essentially of a synthetic or semisynthetic wax, in particular a microcrystalline wax. The wax preferably has a relatively narrow range of mean carbon chain length. An apiculture accessory using the wax and a method of operating beehives using the wax to reduce disease and pests in beehives is described.

    摘要翻译： 描述了蜂蜡模拟物质，其包含或基本上由合成或半合成蜡，特别是微晶蜡组成。 蜡优选具有相对较窄的平均碳链长度范围。 描述了使用蜡的养蜂配件和使用蜡来操作蜂蜜以减少蜂巢中的疾病和害虫的方法。

    Method for testing the toxicity of chemical substances using gastropods
    15.
    发明授权
    Method for testing the toxicity of chemical substances using gastropods 有权
    使用腹足类动物测试化学物质的毒性的方法

    公开(公告)号：US06436630B1

    公开(公告)日：2002-08-20

    申请号：US09763930

    申请日：2001-04-25

    申请人： Jean Paul Remon ,  Els Adriaens

    发明人： Jean Paul Remon ,  Els Adriaens

    IPC分类号： C12Q100

    CPC分类号： C12Q1/32 ,  C12Q1/42 ,  G01N33/48 ,  G01N33/92 ,  G01N2333/43504

    摘要： An in vivo and an in vitro toxicity test method is described using an organisim or part of an organism from the class Gastropoda. The method is particularly useful for toxicity testing of chemical substances intended for application to human or animal mucosa, such as the intestinal, vaginal, buccal, nasal or respiratory mucosa. The test method may be used both as a screening test and also as a quantitative toxicity test suitable for ranking the toxicity of chemical substances.

    摘要翻译： 使用来自类腹足纲的生物体的组织或部分来描述体内和体外毒性试验方法。 该方法对于用于人或动物粘膜（例如肠，阴道，口腔，鼻腔或呼吸道粘膜）的化学物质的毒性测试特别有用。 测试方法既可用作筛选试验，也可用作适用于化学物质毒性排序的定量毒性试验。

    Cushioning wax beads for making solid shaped articles
    17.
    发明授权
    Cushioning wax beads for making solid shaped articles 有权
    用于制成固体成型制品的缓冲蜡珠

    公开(公告)号：US06923984B1

    公开(公告)日：2005-08-02

    申请号：US09831422

    申请日：2000-07-26

    申请人： Jean Paul Remon

    发明人： Jean Paul Remon

    IPC分类号： A61J3/07 ,  A61J1/03 ,  A61K9/20 ,  A61K9/26 ,  A61K9/28 ,  A61K47/06 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/32 ,  A61K47/44

    CPC分类号： A61K9/2077

    摘要： Biologically inactive cushioning beads comprise at least one compressible cushioning component consisting essentially of a microcrystalline hydrocarbon wax or a natural wax, the said wax being at least 30% by weight of the biologically inactive cushioning beads. Such beads are useful for making solid shaped articles containing biologically active ingredients by compression.

    摘要翻译： 生物惰性缓冲珠粒包含至少一种可压缩缓冲组分，其基本上由微晶烃蜡或天然蜡组成，所述蜡为生物活性缓冲珠的至少30重量％。 这种珠可用于通过压缩制备含有生物活性成分的固体成形制品。

    High release solid preparation, preparation and use thereof
    19.
    发明授权
    High release solid preparation, preparation and use thereof 失效
    高释放固体制剂，其制备和用途

    公开(公告)号：US06368634B1

    公开(公告)日：2002-04-09

    申请号：US08537793

    申请日：1996-02-27

    申请人： Jean Paul Remon

    发明人： Jean Paul Remon

    IPC分类号： A61K950

    CPC分类号： A61K9/1652 ,  A61K9/1617

    摘要： A solid preparation for a substantially immediate release of an active agent with low or very low solubility, which contains the active agent dissolved in a solubilizer, said dissolved active agent being contained in solid particles which are agglomerated into a system of agglomerated particles which is not a matrix or gelling forming agent.

    摘要翻译： 用于基本上立即释放具有低或非常低的溶解度的活性剂的固体制剂，其含有溶解在增溶剂中的活性剂，所述溶解的活性剂包含在固体颗粒中，所述固体颗粒凝聚成不是聚集颗粒的体系 基质或胶凝形成剂。

    Xanthohumol-based compositions
    20.
    发明授权
    Xanthohumol-based compositions 有权

    公开(公告)号：US11224558B2

    公开(公告)日：2022-01-18

    申请号：US16604245

    申请日：2018-04-12

    申请人： Jean Paul Remon

    发明人： Jean Paul Remon

    IPC分类号： A61K8/02 ,  A23L33/00 ,  A61K8/04 ,  A61K8/06 ,  A61K8/35 ,  A61K8/81 ,  A61K9/00 ,  A61K9/08 ,  A61K9/14 ,  A61K9/20 ,  A61K9/48 ,  A61K31/12 ,  A61K31/79

    摘要： This invention relates to xanthohumol-based compositions, yielded in a hot-melt extrusion process (HME) using one or more water-soluble nutritionally and/or cosmetically acceptable thermoplastic polymers, such as selected from hydroxypropylmethyl-cellulose (HPMC), a vinylpyrrolidone-vinyl acetate copolymer, and combinations thereof. The present invention also relates to topical and oral formulations comprising such extruded xanthohumol-based compositions, as well as the use of one or more water-soluble nutritionally and/or cosmetically acceptable thermoplastic polymers in a hot-melt extrusion process of xanthohumol.