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    PROCESS FOR PREPARING A SOLID DOSAGE FORM
    1.
    发明申请
    PROCESS FOR PREPARING A SOLID DOSAGE FORM 审中-公开
    制备固体剂型的方法

    公开(公告)号：US20090326078A1

    公开(公告)日：2009-12-31

    申请号：US12306717

    申请日：2007-06-27

    申请人： Jean Paul Remon ,  Chris Vervaet ,  Yves Gonnissen

    发明人： Jean Paul Remon ,  Chris Vervaet ,  Yves Gonnissen

    IPC分类号： A61K47/26 ,  A61K47/10

    CPC分类号： A61K9/1623 ,  A61K9/2095

    摘要： This invention provides a process for preparing a solid dosage form, comprising:—preparing an aqueous slurry, solution or suspension of (a) a powder material, and (b) a mixture of one or more polyols and one or more maltodextrins, and—spray drying the resultant aqueous slurry, solution or suspension, thereby obtaining particles which are directly compressible into a solid dosage form being able to disintegrate in an aqueous medium within no more than 15 minutes.

    摘要翻译： 本发明提供了一种制备固体剂型的方法，包括： - 制备（a）粉末材料的水性浆液，溶液或悬浮液，和（b）一种或多种多元醇和一种或多种麦芽糖糊精的混合物， 喷雾干燥所得的含水浆料，溶液或悬浮液，从而获得直接压缩成固体剂型的颗粒，其能够在不超过15分钟的时间内在含水介质中分解。

    IMMEDIATE RELEASE PHARMACEUTICAL GRANULE COMPOSITIONS AND A CONTINUOUS PROCESS FOR MAKING THEM
    3.
    发明申请
    IMMEDIATE RELEASE PHARMACEUTICAL GRANULE COMPOSITIONS AND A CONTINUOUS PROCESS FOR MAKING THEM 失效
    立即发布药物颗粒组合物及其连续制备方法

    公开(公告)号：US20110008454A1

    公开(公告)日：2011-01-13

    申请号：US12815781

    申请日：2010-06-15

    申请人： Jean Paul Remon ,  Chris Vervaet

    发明人： Jean Paul Remon ,  Chris Vervaet

    IPC分类号： A61K9/16 ,  A61K31/165

    CPC分类号： A61K9/1652 ,  A61K9/1641 ,  A61K9/1694

    摘要： A pharmaceutical or veterinary granule composition in the form of a mixture consisting essentially of: (i) at least one drug classifiable as Class II or Class IV of the Biopharmaceutical Classification System, wherein said drug (i) constitutes from 0.5% to 20% by weight of the composition, and excipients, said pharmaceutical or veterinary granule composition providing a drug release of at least 70% within 10 minutes in water, (ii) a first excipient being a maltodextrin representing from 40% by weight to 80% by weight of said composition, (iii) a wetting amount of a second excipient being a polyethylene glycol having a weight number molecular weight between 300 and 5,000, said second excipient comprising a solid fraction and a liquid fraction, and representing from 15% to 40% by weight of said composition, and optionally one or more pharmaceutically acceptable fillers selected from the group consisting of hydrocolloids, glidants, lubricants, surfactants and diluents, wherein the weight ratio of said first excipient (ii) to said second excipient (iii) is in a range from 1:1 to 5:1.

    摘要翻译： 以混合物形式的药物或兽用颗粒组合物，其基本上由以下组成：（i）至少一种可分类为生物药物分类系统的II类或IV类的药物，其中所述药物（i）构成0.5％至20％ 所述组合物的重量和赋形剂，所述药物或兽用颗粒组合物在水中在10分钟内提供至少70％的药物释放，（ii）作为麦芽糖糊精的第一赋形剂，代表40重量％至80重量％ 所述组合物，（iii）第二赋形剂的润湿量，其为重量数分子量为300至5,000的聚乙二醇，所述第二赋形剂包含固体部分和液体部分，并且代表15重量％至40重量％ 的所述组合物，以及任选的一种或多种药学上可接受的填料，其选自水胶体，助流剂，润滑剂，表面活性剂和稀释剂，其中重量 所述第一赋形剂（ii）与所述第二赋形剂（iii）的比例在1:1至5:1的范围内。

    Pharmaceutical matrix pellets, tablets and composition for the preparation thereof
    6.
    发明授权
    Pharmaceutical matrix pellets, tablets and composition for the preparation thereof 失效
    药用基质颗粒，片剂及其制备用组合物

    公开(公告)号：US6132769A

    公开(公告)日：2000-10-17

    申请号：US619022

    申请日：1996-03-20

    申请人： Jean-Paul Remon ,  Chris Vervaet

    发明人： Jean-Paul Remon ,  Chris Vervaet

    IPC分类号： A61K9/16 ,  A61K9/22 ,  A61K9/26 ,  A61K47/36 ,  A61K47/44 ,  A61K9/20

    CPC分类号： A61K9/1652 ,  A61K9/1617

    摘要： The present invention relates to pharmaceutical matrix pellet formulations providing an adequate drug release profile. The matrix of said pellets is formed from:(a) a hydrophilic compound selected among the group consisting of starch, a starch derivative and mixture thereof, and(b) a hydrophobic compound selected among the group consisting of wax, micro-crystalline wax and mixture thereof.

    摘要翻译： 本发明涉及提供足够药物释放曲线的药物基质颗粒制剂。 所述颗粒的基质由以下物质形成：（a）选自淀粉，淀粉衍生物及其混合物的亲水性化合物，和（b）选自蜡，微晶蜡和 的混合物。

    Intravaginal delivery system
    7.
    发明授权
    Intravaginal delivery system 有权
    阴道分娩系统

    公开(公告)号：US09168303B2

    公开(公告)日：2015-10-27

    申请号：US14131495

    申请日：2012-07-12

    申请人： Jean Paul Remon ,  Chris Vervaet ,  Hans Verstraelen ,  Marleen Temmerman

    发明人： Jean Paul Remon ,  Chris Vervaet ,  Hans Verstraelen ,  Marleen Temmerman

    IPC分类号： A61K47/32 ,  A61K9/00 ,  A61K31/19 ,  A61K47/38

    CPC分类号： A61K47/32 ,  A61K9/0036 ,  A61K31/19 ,  A61K47/38

    摘要： The present invention in general relates to an intravaginal delivery system as well as uses thereof and methods for manufacturing and use of the same. In particular the present invention relates to an intravaginal delivery system for the controlled release of one or more organic acids, such as lactic acid; said intravaginal delivery system being characterized in that it comprises a combination of ethylene vinyl acetate (EVA) copolymers and carboxylic polymers, such as for example methacrylic acid-methacrylic ester copolymers.

    摘要翻译： 本发明一般涉及阴道内递送系统及其用途及其制造和使用方法。 特别地，本发明涉及用于控制释放一种或多种有机酸如乳酸的阴道内递送系统; 所述阴道内递送系统的特征在于其包含乙烯乙酸乙烯酯（EVA）共聚物和羧酸聚合物的组合，例如甲基丙烯酸 - 甲基丙烯酸酯共聚物。

    PROCESS AND APPARATUS FOR CONTINUOUS WET GRANULATION OF POWDER MATERIAL
    9.
    发明申请
    PROCESS AND APPARATUS FOR CONTINUOUS WET GRANULATION OF POWDER MATERIAL 有权
    连续湿法粉碎粉末材料的工艺和装置

    公开(公告)号：US20110108646A1

    公开(公告)日：2011-05-12

    申请号：US13009309

    申请日：2011-01-19

    申请人： Jean-Paul Remon ,  Chris Vervaet ,  Eseldin Keleb ,  An Vermeire

    发明人： Jean-Paul Remon ,  Chris Vervaet ,  Eseldin Keleb ,  An Vermeire

    IPC分类号： B02C21/00

    CPC分类号： B01J2/20 ,  A23P10/25 ,  A61K9/1623 ,  A61K9/1694 ,  A61K9/20 ,  B01J2/10

    摘要： An apparatus for wet granulating a powder material comprises:—a barrel having a granulation chamber and being provided with a first inlet (1) for receiving said powder material and for supplying it to said granulation chamber and with a second inlet (2) for receiving a granulating liquid and for supplying it to said granulation chamber, said granulation having an aperture (9) for discharge of granules from said barrel, and—a transporting means (S) for advancing said powder material toward the end of said granulation chamber while granulating it with the aid of said granulating liquid, said transporting means (S) comprising a first transport zone (4) at its rear end, an agglomeration zone (5) downstream from the first transport zone (4) and a second transport zone (8) at its front end, said first inlet (1) and said second inlet (2) being positioned above the first transport zone (4), wherein said aperture (9) has a shape tightly fitting the terminal portion of the transporting means (S) for directly discharging said granules from the granulation chamber. The apparatus is useful for continuously wet granulating biologically-active ingredient formulations, chemicals, detergents and foodstuffs.

    摘要翻译： 用于湿粉碎粉末材料的设备包括： - 具有造粒室的桶，并且设置有用于接收所述粉末材料并将其供应到所述造粒室的第一入口（1）和用于接收的第二入口（2） 造粒液体并将其供给到所述造粒室，所述造粒物具有用于从所述筒排出颗粒的孔（9），和用于将所述粉末材料朝着造粒室的端部推进的输送装置（S） 所述输送装置（S）在其后端包括第一输送区（4），第一输送区（4）下游的附聚区（5）和第二输送区（8） ）在其前端，所述第一入口（1）和所述第二入口（2）位于所述第一输送区（4）的上方，其中所述孔（9）具有紧密地配合所述输送装置 （S），用于从造粒室直接排出所述颗粒。 该设备可用于连续湿法制粒生物活性成分配方，化学品，洗涤剂和食品。

    Process and apparatus for continuous wet granulation of powder material
    10.
    发明授权
    Process and apparatus for continuous wet granulation of powder material 有权
    粉末材料连续湿法造粒的工艺和装置

    公开(公告)号：US07910030B2

    公开(公告)日：2011-03-22

    申请号：US10536520

    申请日：2003-11-26

    申请人： Jean-Paul Remon ,  Chris Vervaet ,  Eseldin Keleb ,  An Vermeire

    发明人： Jean-Paul Remon ,  Chris Vervaet ,  Eseldin Keleb ,  An Vermeire

    IPC分类号： B02C19/00

    CPC分类号： B01J2/20 ,  A23P10/25 ,  A61K9/1623 ,  A61K9/1694 ,  A61K9/20 ,  B01J2/10

    摘要： An apparatus for wet granulating a powder material comprises: —a barrel having a granulation chamber and being provided with a first inlet (1) for receiving said powder material and for supplying it to said granulation chamber and with a second inlet (2) for receiving a granulating liquid and for supplying it to said granulation chamber, said granulation having an aperture (9) for discharge of granules from said barrel, and —a transporting means (S) for advancing said powder material toward the end of said granulation chamber while granulating it with the aid of said granulating liquid, said transporting means (S) comprising a first transport zone (4) at its rear end, an agglomeration zone (5) downstream from the first transport zone (4) and a second transport zone (8) at its front end, said first inlet (1) and said second inlet (2) being positioned above the first transport zone (4), wherein said aperture (9) has a shape tightly fitting the terminal portion of the transporting means (S) for directly discharging said granules from the granulation chamber. The apparatus is useful for continuously wet granulating biologically-active ingredient formulations, chemicals, detergents and foodstuffs.

    摘要翻译： 用于湿粉碎粉末材料的设备包括： - 具有造粒室的桶，并且设置有用于接收所述粉末材料并将其供应到所述造粒室的第一入口（1）和用于接收的第二入口（2） 造粒液体并将其供给到造粒室，所述造粒物具有用于从所述筒排出颗粒的孔口（9），以及用于将所述粉末材料朝向造粒室的端部推进的输送装置（S），同时造粒 所述输送装置（S）在其后端包括第一输送区（4），第一输送区（4）下游的附聚区（5）和第二输送区（8） ），所述第一入口（1）和所述第二入口（2）位于所述第一输送区（4）的上方，其中所述孔（9）具有紧密配合所述输送口 ns（S），用于从造粒室直接排出所述颗粒。 该设备可用于连续湿法制粒生物活性成分配方，化学品，洗涤剂和食品。