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公开(公告)号：US11896969B2
公开(公告)日：2024-02-13
申请号：US17012108
申请日：2020-09-04
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： Christopher Belisle , Xuemei He , Hong Chen , Yueping Xu , Jiali Liao
CPC classification number: B01J41/14 , B01J41/07 , B01J47/014 , B01J47/02 , C07K1/18 , C12N9/88 , C12Y402/01045 , B01J2220/52
Abstract: Chromatography resins having anionic exchange-hydrophobic mixed mode ligands and methods of using such resins are provided.
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12.发明授权公开(公告)号：US11731108B2
公开(公告)日：2023-08-22
申请号：US17696917
申请日：2022-03-17
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： Christopher Belisle , Jiali Liao , Edwin Lozano
IPC: B01J20/28 , B01D15/38 , B01J20/30 , C07K1/16 , B01J20/285 , B01J20/289
CPC classification number: B01J20/285 , B01D15/3809 , B01D15/3847 , B01J20/289 , B01J20/28085 , B01J20/3042 , C07K1/165 , B01J2220/52
Abstract: The subject invention pertains to proteins are purified by a mixed-mode chromatography system formed by attaching a ligand with cation exchange and hydrophobic 1,3-dioxoisoindolin-2-yl group functionalities to a large-pore support matrix, the only linkage between the ligand and the support matrix being a chain having a backbone of one, two, three, four, or five atoms between the hydrophobic group and the support matrix.
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Patent Agency Ranking
公开(公告)号：US11590486B2
公开(公告)日：2023-02-28
申请号：US17008212
申请日：2020-08-31
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Jiali Liao , Lee Olech , Hong Chen , Xuemei He , Russell Frost
Abstract: A method for manufacturing a mixed-mode chromatography medium is provided. The method can include, for example, oxidizing diol groups on diol-functionalized solid particles having pores of a median diameter of 0.5 micron or greater with substantially no pores of 0.1 micron or less in diameter and having a diol density of from about 200 to about 300 μmol/mL to aldehyde groups, thereby converting said diol-functionalized solid particles to aldehyde-functionalized solid particles; and coupling amine-functionalized ligands to said aldehyde-functionalized solid particles, said amine-functionalized ligands comprising an amine-substituted hydrophobic group joined to an acid moiety selected from the group consisting of a carboxyl group and a sulfo group.
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公开(公告)号：US10934366B2
公开(公告)日：2021-03-02
申请号：US15714736
申请日：2017-09-25
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： Jiali Liao , Tom Berkelman
Abstract: Methods and kits for purifying protein-nanoparticle conjugates are provided. In some embodiments, a multimodal medium having a size exclusion mode and a capture mode is used to purify the protein-nanoparticle conjugates.
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公开(公告)号：US10583429B2
公开(公告)日：2020-03-10
申请号：US14657701
申请日：2015-03-13
Inventor： Steven Cramer , James Woo , Hong Chen , Jiali Liao , Russell Frost
Abstract: The present disclosure is directed to mixed mode chromatography media comprising a ligand directly attached to a solid support. In some aspects, the ligand has a chemical formula of The mixed mode chromatography media is useful for binding and purifying proteins from a solution.
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公开(公告)号：US20180085735A1
公开(公告)日：2018-03-29
申请号：US15714368
申请日：2017-09-25
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： Jiali Liao , Christopher Belisle
IPC: B01J20/24 , C07K1/22 , C07K1/36 , C07K14/435 , C07K16/00 , B01J20/04 , B01J20/28 , B01J20/285 , B01D15/38
Abstract: Polymer-filled ceramic apatites and their uses are provided.
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公开(公告)号：US20150377869A1
公开(公告)日：2015-12-31
申请号：US14749022
申请日：2015-06-24
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Tom Berkelman , Jiali Liao
IPC: G01N33/533 , C07K1/34 , G01N33/58 , C07K16/00
CPC classification number: G01N33/533 , A61K47/6929 , C07K1/34 , C07K16/00 , G01N33/54346
Abstract: Methods of purifying antibody-nanoparticle conjugates with size exclusion chromatography are provided.
Abstract translation: 提供了具有尺寸排阻色谱法纯化抗体 - 纳米颗粒缀合物的方法。
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